SK287687B6 - Izolovaný polypeptid kódovaný génom podobným génu pre lipázu, prostriedok majúci fosfolipázovú účinnosť, farmaceutický prostriedok, antigénny fragment a izolovaná nukleová kyselina, biologicky aktívny prostriedok, vektor, rekombinovaná hostiteľská bunka, prostriedok využiteľný na transfekáciu cieľovej bunky, spôsob výroby polypeptidu a polypeptid takto vyrobený, protilátka, hybridomná bunka, spôsob in vitro sceeningu, spôsob in vitro enzymatickej hydrolýzy, použitie polypeptidu a protilátky a - Google Patents

Izolovaný polypeptid kódovaný génom podobným génu pre lipázu, prostriedok majúci fosfolipázovú účinnosť, farmaceutický prostriedok, antigénny fragment a izolovaná nukleová kyselina, biologicky aktívny prostriedok, vektor, rekombinovaná hostiteľská bunka, prostriedok využiteľný na transfekáciu cieľovej bunky, spôsob výroby polypeptidu a polypeptid takto vyrobený, protilátka, hybridomná bunka, spôsob in vitro sceeningu, spôsob in vitro enzymatickej hydrolýzy, použitie polypeptidu a protilátky a Download PDF

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Publication number
SK287687B6
SK287687B6 SK753-99A SK75399A SK287687B6 SK 287687 B6 SK287687 B6 SK 287687B6 SK 75399 A SK75399 A SK 75399A SK 287687 B6 SK287687 B6 SK 287687B6
Authority
SK
Slovakia
Prior art keywords
polypeptide
seq
nucleic acid
lipase
isolated
Prior art date
Application number
SK753-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK75399A3 (en
Inventor
Michael C. Jaye
Kim-Anh Thi Doan
John A. Krawiec
Kevin J. Lynch
Dilip V. Amin
Victoria J. South
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of SK75399A3 publication Critical patent/SK75399A3/sk
Publication of SK287687B6 publication Critical patent/SK287687B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SK753-99A 1996-12-06 1997-12-05 Izolovaný polypeptid kódovaný génom podobným génu pre lipázu, prostriedok majúci fosfolipázovú účinnosť, farmaceutický prostriedok, antigénny fragment a izolovaná nukleová kyselina, biologicky aktívny prostriedok, vektor, rekombinovaná hostiteľská bunka, prostriedok využiteľný na transfekáciu cieľovej bunky, spôsob výroby polypeptidu a polypeptid takto vyrobený, protilátka, hybridomná bunka, spôsob in vitro sceeningu, spôsob in vitro enzymatickej hydrolýzy, použitie polypeptidu a protilátky a SK287687B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3278396P 1996-12-06 1996-12-06
US3225496P 1996-12-06 1996-12-06
PCT/US1997/022331 WO1998024888A2 (fr) 1996-12-06 1997-12-05 Polypeptides llg de la famille des triacylglycerol lipases, compositions et procedes destines a l'utilisation de ceux-ci dans des hydrolyses enzymatiques, et therapies geniques et protidiques

Publications (2)

Publication Number Publication Date
SK75399A3 SK75399A3 (en) 2001-02-12
SK287687B6 true SK287687B6 (sk) 2011-06-06

Family

ID=26708180

Family Applications (1)

Application Number Title Priority Date Filing Date
SK753-99A SK287687B6 (sk) 1996-12-06 1997-12-05 Izolovaný polypeptid kódovaný génom podobným génu pre lipázu, prostriedok majúci fosfolipázovú účinnosť, farmaceutický prostriedok, antigénny fragment a izolovaná nukleová kyselina, biologicky aktívny prostriedok, vektor, rekombinovaná hostiteľská bunka, prostriedok využiteľný na transfekáciu cieľovej bunky, spôsob výroby polypeptidu a polypeptid takto vyrobený, protilátka, hybridomná bunka, spôsob in vitro sceeningu, spôsob in vitro enzymatickej hydrolýzy, použitie polypeptidu a protilátky a

Country Status (21)

Country Link
US (4) US6395530B1 (fr)
EP (1) EP0948609B1 (fr)
JP (2) JP4615634B2 (fr)
KR (1) KR100516561B1 (fr)
CN (2) CN1167793C (fr)
AP (1) AP1313A (fr)
AT (1) ATE291080T1 (fr)
AU (1) AU750891B2 (fr)
BG (1) BG64798B1 (fr)
BR (1) BR9713847A (fr)
CA (1) CA2273823C (fr)
CZ (1) CZ299055B6 (fr)
DE (2) DE69732789T2 (fr)
EA (1) EA003293B1 (fr)
ES (1) ES2239367T3 (fr)
IL (2) IL129986A0 (fr)
NO (1) NO326140B1 (fr)
OA (1) OA11057A (fr)
PL (1) PL191624B1 (fr)
SK (1) SK287687B6 (fr)
WO (1) WO1998024888A2 (fr)

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KR100516561B1 (ko) 1996-12-06 2005-09-22 아벤티스 파마슈티칼스 인크. 사람 리파제-유사 유전자에 의해 암호화된 폴리펩타이드, 조성물 및 방법
US7008776B1 (en) * 1996-12-06 2006-03-07 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
US7692067B2 (en) * 2002-09-18 2010-04-06 Mendel Biotechnology, Inc. Yield and stress tolerance in transgenic plants
NZ531180A (en) * 1999-03-26 2005-06-24 Aventis Pharma Inc Compositions and methods for effecting the levels of cholesterol using the LIPG polypeptide
GB9920334D0 (en) * 1999-08-28 1999-11-03 Glaxo Group Ltd Method
US6337187B1 (en) 1999-11-05 2002-01-08 Millennium Pharmaceuticals, Inc. 18891, a novel human lipase
WO2001032885A2 (fr) * 1999-11-05 2001-05-10 Millennium Pharmaceuticals, Inc. 18892, nouvelle lipase humaine
AU2001296325A1 (en) * 2000-09-25 2002-04-02 Millennium Pharmaceuticals, Inc. 47647, a human lipase and uses therefor
US7507808B2 (en) * 2002-12-12 2009-03-24 Isis Pharmaceuticals, Inc. Modulation of endothelial lipase expression
CN102250854B (zh) * 2011-07-01 2013-03-27 浙江商达环保有限公司 用于处理油脂污染物的脂肪酶、编码基因及其应用
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
MA41035A (fr) * 2014-08-19 2017-08-15 Shire Human Genetic Therapies Lipoprotéine lipase pour le traitement d'affections liées à une hypertriglycéridémie, y compris la pancréatite aiguë
TWI688575B (zh) * 2014-09-11 2020-03-21 日商塩野義製藥股份有限公司 阻礙血管內皮脂酶之酵素活性的人類化單株抗體
WO2024236336A1 (fr) * 2023-05-17 2024-11-21 Institut National de la Santé et de la Recherche Médicale Variant de lipc dans le traitement de l'hypercholestérolémie et d'une maladie cardiovasculaire athéroscléreuse

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Also Published As

Publication number Publication date
ATE291080T1 (de) 2005-04-15
US20030108538A1 (en) 2003-06-12
CA2273823C (fr) 2007-06-05
EA199900522A1 (ru) 2000-02-28
OA11057A (en) 2002-03-08
HK1068636A1 (zh) 2005-04-29
SK75399A3 (en) 2001-02-12
DE948609T1 (de) 2000-03-09
DE69732789D1 (de) 2005-04-21
HK1024929A1 (en) 2000-10-27
AU750891B2 (en) 2002-08-01
AP9901548A0 (en) 1999-06-30
JP4615634B2 (ja) 2011-01-19
ES2239367T3 (es) 2005-09-16
IL129986A0 (en) 2000-02-29
BR9713847A (pt) 2000-02-29
US7579447B2 (en) 2009-08-25
WO1998024888A2 (fr) 1998-06-11
JP5416053B2 (ja) 2014-02-12
IL129986A (en) 2006-07-05
EA003293B1 (ru) 2003-04-24
CN100497610C (zh) 2009-06-10
KR20000069336A (ko) 2000-11-25
NO992735D0 (no) 1999-06-04
WO1998024888A3 (fr) 1998-08-13
US20120114660A1 (en) 2012-05-10
CN1240000A (zh) 1999-12-29
EP0948609B1 (fr) 2005-03-16
JP2001505769A (ja) 2001-05-08
CZ299055B6 (cs) 2008-04-09
BG64798B1 (bg) 2006-04-28
CN1167793C (zh) 2004-09-22
US20070101451A1 (en) 2007-05-03
AP1313A (en) 2004-10-04
CZ9902003A3 (cs) 2000-10-11
US7056720B2 (en) 2006-06-06
KR100516561B1 (ko) 2005-09-22
EP0948609A2 (fr) 1999-10-13
JP2010284171A (ja) 2010-12-24
PL191624B1 (pl) 2006-06-30
NO992735L (no) 1999-08-05
US8343494B2 (en) 2013-01-01
NO326140B1 (no) 2008-10-06
US6395530B1 (en) 2002-05-28
AU5690598A (en) 1998-06-29
CN1539849A (zh) 2004-10-27
BG103472A (en) 2001-01-31
DE69732789T2 (de) 2005-08-11
CA2273823A1 (fr) 1998-06-11

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20151205