SK287890B6 - Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use - Google Patents

Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use Download PDF

Info

Publication number: SK287890B6
Authority: SK; Slovakia
Prior art keywords: traf2; proteins; sequence; binding; protein
Prior art date: 1996-04-02

Application number

SK50017-2007A

Other languages

English (en)

Slovak (sk)

Inventor

David Wallach

Nikolai Malinin

Mark Boldin

Andrei Kovalenko

Igor Mett

Original Assignee

Yeda Research And Development Co., Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-02

Filing date

1997-04-01

Publication date

2012-03-02

1996-04-02 Priority claimed from IL11780096A external-priority patent/IL117800A0/xx

1996-08-26 Priority claimed from IL11913396A external-priority patent/IL119133A0/xx

1997-04-01 Application filed by Yeda Research And Development Co., Ltd. filed Critical Yeda Research And Development Co., Ltd.

2012-03-02 Publication of SK287890B6 publication Critical patent/SK287890B6/sk

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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Microbiology (AREA)
Toxicology (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Rheumatology (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

SK50017-2007A 1996-04-02 1997-04-01 Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use SK287890B6 (sk)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IL11780096A IL117800A0 (en)	1996-04-02	1996-04-02	Modulators of TNF receptor associated factor (TRAF) their preparation and use
IL11913396A IL119133A0 (en)	1996-08-26	1996-08-26	Modulators of TNF receptor associated factor (TRAF) their preparation and use
PCT/IL1997/000117 WO1997037016A1 (en)	1996-04-02	1997-04-01	Modulators of tnf receptor associated factor (traf), their preparation and use

Publications (1)

Publication Number	Publication Date
SK287890B6 true SK287890B6 (sk)	2012-03-02

Family

ID=26323248

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
SK50017-2007A SK287890B6 (sk)	1996-04-02	1997-04-01	Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use
SK50016-2007A SK287889B6 (sk)	1996-04-02	1997-04-01	Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use
SK1361-98A SK287085B6 (sk)	1996-04-02	1997-04-01	Izolovaný polypeptid, ktorý sa viaže na TRAF2 a modeluje aktivitu NF-kB, DNA sekvencia, ktorá ho kóduje, farmaceutický prostriedok s ich obsahom a ich použitie

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
SK50016-2007A SK287889B6 (sk)	1996-04-02	1997-04-01	Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use
SK1361-98A SK287085B6 (sk)	1996-04-02	1997-04-01	Izolovaný polypeptid, ktorý sa viaže na TRAF2 a modeluje aktivitu NF-kB, DNA sekvencia, ktorá ho kóduje, farmaceutický prostriedok s ich obsahom a ich použitie

Country Status (22)

Country	Link
US (2)	US7485456B1 (de)
EP (1)	EP0894130B1 (de)
JP (1)	JP4180114B2 (de)
CN (1)	CN1197966C (de)
AT (1)	ATE380866T1 (de)
AU (1)	AU732793B2 (de)
BG (1)	BG64755B1 (de)
BR (1)	BR9708518A (de)
CA (1)	CA2250085C (de)
CZ (3)	CZ299682B6 (de)
DE (1)	DE69738370T2 (de)
DK (1)	DK0894130T3 (de)
EA (1)	EA004309B1 (de)
EE (1)	EE04783B1 (de)
ES (1)	ES2294796T3 (de)
HU (1)	HU226328B1 (de)
NO (1)	NO327054B1 (de)
NZ (1)	NZ331902A (de)
PT (1)	PT894130E (de)
SK (3)	SK287890B6 (de)
UA (1)	UA71889C2 (de)
WO (1)	WO1997037016A1 (de)

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UA71889C2 (uk) *	1996-04-02	2005-01-17	Йєда Рісерч Енд Дівелопмент Ко. Лтд.	Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування
US5843721A (en) *	1997-07-03	1998-12-01	Tularik Inc.	Nucleic acids encoding human NIK protein
JP2003525567A (ja) *	1997-11-07	2003-09-02	ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー	分泌蛋白およびそれらをコードするポリヌクレオチド
US6265538B1 (en) *	1998-02-27	2001-07-24	The Regents Of The University Of California	Inhibitor of the inflammatory response induced by the TNFA and IL-1
DE69928244T2 (de)	1998-05-06	2006-08-10	Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw.	Inhibitoren der nf-kb aktivierung
AU767973B2 (en) *	1998-08-18	2003-11-27	Abbott Gmbh & Co. Kg	TPL-2/COT kinase and methods of use
IL131719A0 (en) *	1999-09-02	2001-03-19	Yeda Res & Dev	Iren protein its preparation and use
GB9930616D0 (en)	1999-12-24	2000-02-16	Mathilda & Terence Kennedy Ins	Activation and inhibition of the immune system
US20040109854A1 (en) *	2001-02-21	2004-06-10	Zang-Hee Lee	Novel traf6 inhibiting protein
ATE334696T1 (de)	2001-06-22	2006-08-15	Vlaams Interuniv Inst Biotech	Abin zum schutz gegen hepatitis
AU2003222415B2 (en) *	2002-04-18	2009-02-05	Yeda Research And Development Co. Ltd.	Derivatives of the IL-2 receptor gamma chain, their production and use
IL158287A0 (en) *	2003-10-07	2004-05-12	Yeda Res & Dev	Antibodies to nik, their preparation and use
WO2005033145A1 (en) *	2003-10-07	2005-04-14	Yeda Research And Development Co. Ltd.	Antibodies to nik, their preparation and use
ES2469670T3 (es) *	2003-11-30	2014-06-18	Yeda Research And Development Co., Ltd.	Métodos y agentes para inmunomodulaci�n y métodos para identificar inmunomoduladores
IL173104A0 (en) *	2006-01-12	2006-06-11	Yeda Res & Dev	Siva and ubiquintination
WO2010011944A2 (en)	2008-07-25	2010-01-28	Wagner Richard W	Protein screeing methods
GB201012420D0 (en)	2010-07-23	2010-09-08	Univ Erasmus Medical Ct	Foetal heamoglobin inhibitor
CN103108650A (zh)	2010-08-25	2013-05-15	Atyr医药公司	与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CN102382850A (zh) *	2010-09-01	2012-03-21	山东新时代药业有限公司	新型人肿瘤坏死因子受体-Fc融合基因及其产物蛋白
KR20130133051A (ko)	2011-03-16	2013-12-05	에프. 호프만-라 로슈 아게	6,5-헤테로사이클릭 프로파길릭 알콜 화합물 및 이의 용도
PT2726101T (pt)	2011-06-30	2018-11-21	Genzyme Corp	Inibidores da ativação de células t
US9549981B2 (en)	2011-07-19	2017-01-24	Philogen S.P.A.	Sequential antibody therapy
UY34317A (es)	2011-09-12	2013-02-28	Genzyme Corp	Anticuerpo antireceptor de célula T (alfa)/ß
US10441654B2 (en)	2014-01-24	2019-10-15	Children's Hospital Of Eastern Ontario Research Institute Inc.	SMC combination therapy for the treatment of cancer
CN105986001B (zh) *	2015-02-12	2019-12-03	上海交通大学	一种基于膜结合蛋白和荧光互补的高通量猎物拮抗剂筛选方法
CN108026172B (zh)	2015-06-26	2022-04-29	赛诺菲生物技术公司	单克隆抗il-1racp抗体
MA55529A (fr)	2019-04-03	2022-02-09	Genzyme Corp	Polypeptides de liaison anti-alpha bêta tcr à fragmentation réduite
EP4590704A1 (de)	2022-09-21	2025-07-30	Sanofi Biotechnology	Humanisierter anti-il-1r3-antikörper und verfahren zur verwendung

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AU6692996A (en)	1995-08-08	1997-03-05	Tularik Inc.	Inhibitors of apoptosis
US5804412A (en) *	1996-04-01	1998-09-08	The Regents Of The University Of California	Nucleic acids encoding sorting nexins and methods of using same
UA71889C2 (uk) *	1996-04-02	2005-01-17	Йєда Рісерч Енд Дівелопмент Ко. Лтд.	Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування
KR20000010805A (ko)	1996-05-08	2000-02-25	웨인 씨. 제쉬크	알킬 폴리글리코시드 에테르 카르복실레이트
US5843721A (en) *	1997-07-03	1998-12-01	Tularik Inc.	Nucleic acids encoding human NIK protein

1997
- 1997-01-04 UA UA98105743A patent/UA71889C2/uk unknown
- 1997-04-01 AU AU21755/97A patent/AU732793B2/en not_active Expired
- 1997-04-01 CZ CZ0318398A patent/CZ299682B6/cs not_active IP Right Cessation
- 1997-04-01 EA EA199800885A patent/EA004309B1/ru not_active IP Right Cessation
- 1997-04-01 DE DE69738370T patent/DE69738370T2/de not_active Expired - Lifetime
- 1997-04-01 CA CA002250085A patent/CA2250085C/en not_active Expired - Lifetime
- 1997-04-01 SK SK50017-2007A patent/SK287890B6/sk not_active IP Right Cessation
- 1997-04-01 DK DK97914534T patent/DK0894130T3/da active
- 1997-04-01 EE EE9800322A patent/EE04783B1/xx unknown
- 1997-04-01 JP JP53509997A patent/JP4180114B2/ja not_active Expired - Lifetime
- 1997-04-01 EP EP97914534A patent/EP0894130B1/de not_active Expired - Lifetime
- 1997-04-01 AT AT97914534T patent/ATE380866T1/de active
- 1997-04-01 CZ CZ20060018A patent/CZ299094B6/cs not_active IP Right Cessation
- 1997-04-01 CN CNB971951934A patent/CN1197966C/zh not_active Expired - Lifetime
- 1997-04-01 SK SK50016-2007A patent/SK287889B6/sk not_active IP Right Cessation
- 1997-04-01 BR BR9708518A patent/BR9708518A/pt not_active Application Discontinuation
- 1997-04-01 NZ NZ331902A patent/NZ331902A/en not_active IP Right Cessation
- 1997-04-01 US US09/155,676 patent/US7485456B1/en not_active Expired - Fee Related
- 1997-04-01 PT PT97914534T patent/PT894130E/pt unknown
- 1997-04-01 ES ES97914534T patent/ES2294796T3/es not_active Expired - Lifetime
- 1997-04-01 WO PCT/IL1997/000117 patent/WO1997037016A1/en not_active Ceased
- 1997-04-01 HU HU9902429A patent/HU226328B1/hu unknown
- 1997-04-01 CZ CZ20060017A patent/CZ298866B6/cs not_active IP Right Cessation
- 1997-04-01 SK SK1361-98A patent/SK287085B6/sk not_active IP Right Cessation
1998
- 1998-09-29 NO NO19984551A patent/NO327054B1/no not_active IP Right Cessation
- 1998-10-07 BG BG102817A patent/BG64755B1/bg unknown
2009
- 2009-02-03 US US12/365,136 patent/US8236507B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1997037016A1 (en)	1997-10-09
BG102817A (en)	1999-05-31
EA199800885A1 (ru)	1999-04-29
PT894130E (pt)	2008-01-14
JP2000507826A (ja)	2000-06-27
DE69738370T2 (de)	2008-12-04
DE69738370D1 (de)	2008-01-24
CZ299094B6 (cs)	2008-04-23
NO984551L (no)	1998-11-24
HUP9902429A3 (en)	2001-11-28
EE9800322A (et)	1999-04-15
JP4180114B2 (ja)	2008-11-12
CZ298866B6 (cs)	2008-02-27
SK287889B6 (sk)	2012-03-02
CA2250085A1 (en)	1997-10-09
AU2175597A (en)	1997-10-22
ATE380866T1 (de)	2007-12-15
NO327054B1 (no)	2009-04-14
HK1018910A1 (en)	2000-01-07
BG64755B1 (bg)	2006-02-28
BR9708518A (pt)	1999-08-03
CZ318398A3 (cs)	1999-05-12
US20090291888A1 (en)	2009-11-26
EP0894130A1 (de)	1999-02-03
HUP9902429A2 (hu)	1999-10-28
CN1197966C (zh)	2005-04-20
HU226328B1 (en)	2008-09-29
US7485456B1 (en)	2009-02-03
EP0894130B1 (de)	2007-12-12
CZ299682B6 (cs)	2008-10-15
SK136198A3 (en)	1999-05-07
DK0894130T3 (da)	2008-01-07
CA2250085C (en)	2009-10-20
NZ331902A (en)	2000-02-28
EE04783B1 (et)	2007-02-15
NO984551D0 (no)	1998-09-29
ES2294796T3 (es)	2008-04-01
UA71889C2 (uk)	2005-01-17
EA004309B1 (ru)	2004-02-26
AU732793B2 (en)	2001-05-03
US8236507B2 (en)	2012-08-07
SK287085B6 (sk)	2009-11-05
CN1221449A (zh)	1999-06-30

Legal Events

Date	Code	Title	Description
2017-06-02	MK4A	Patent expired	Expiry date: 20170401

Publication	Publication Date	Title
US8236507B2 (en)	2012-08-07	Modulators of TNF receptor associated factor (TRAF), their preparation and use
FI121273B (fi)	2010-09-15	FAS/APO1-reseptorien toiminnan modulaattorit
US20070154905A1 (en)	2007-07-05	Modulators of the function of fas receptors and other proteins
US20090075889A1 (en)	2009-03-19	Iren protein, its preparation and use
NO327854B1 (no)	2009-10-05	DNA-sekvens, replikerbar ekspresjonsvektor, transformert eukaryot eller prokaryot vertscelle; RAP-2 protein, isoform, fragment, funksjonell analog eller derivater derav samt fremgangsmate for fremstilling og anvendelse derav; farmasoytisk preparat, anvendelse av en rekombinant dyrevirusvektor og en vektor kodende for ribozym sekvens.
AU767924B2 (en)	2003-11-27	Modulators of TNF receptor associated factor (TRAF), their preparation and use
KR100552547B1 (ko)	2006-05-12	Tnf수용체연합된인자(traf)조절물질,이의제조및이의용도
IL126428A (en)	2010-02-17	Modulators of tnf receptor associated factor (traf), their preparation and use
JP2009148285A (ja)	2009-07-09	Ｔｎｆ／ｎｇｆレセプターファミリーおよびほかのタンパク質のレセプター機能調節物質
HK1051876B (en)	2009-08-28	Iren protein, its preparation and use