SK33599A3 - Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase - Google Patents

Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase Download PDF

Info

Publication number: SK33599A3
Authority: SK; Slovakia
Prior art keywords: alkyl; group; mixture; tumor cells; aryl
Prior art date: 1996-09-13

Application number

SK335-99A

Other languages

English (en)

Slovak (sk)

Inventor

Arthur G Taveras

F George Njoroge

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-13

Filing date

1997-09-11

Publication date

2000-03-13

1997-09-11 Application filed by Schering Corp filed Critical Schering Corp

2000-03-13 Publication of SK33599A3 publication Critical patent/SK33599A3/sk

Links

0 Bc1cc(Cl)cc2c1[C@@](*)(C(CC1)CCN1C(C(C1CCN(CC(N(CC)CC)=O)CC1)C(Cc1cc(*C)cnc11)c3cc(Cl)cc(B)c3[C@]1(C(CC1)CCN1C(CC1CCN(CC(NCc3ccccc3)=O)CC1)=O)N)=O)c1ncc(CC)cc1CC2 Chemical compound Bc1cc(Cl)cc2c1[C@@](*)(C(CC1)CCN1C(C(C1CCN(CC(N(CC)CC)=O)CC1)C(Cc1cc(*C)cnc11)c3cc(Cl)cc(B)c3[C@]1(C(CC1)CCN1C(CC1CCN(CC(NCc3ccccc3)=O)CC1)=O)N)=O)c1ncc(CC)cc1CC2 0.000 description 3
JHSYCLOCVVGGKS-SCTYSBSDSA-N Bc1cnc([C@](C)(C(CC2)CCN2C(CC2CCN(CC(N[C@@H]([C@@H]([C@H]([C@H]3O)O)O)O[C@@H]3O)=O)CC2)=O)c(c(CC2)cc(Cl)c3)c3Br)c2c1 Chemical compound Bc1cnc([C@](C)(C(CC2)CCN2C(CC2CCN(CC(N[C@@H]([C@@H]([C@H]([C@H]3O)O)O)O[C@@H]3O)=O)CC2)=O)c(c(CC2)cc(Cl)c3)c3Br)c2c1 JHSYCLOCVVGGKS-SCTYSBSDSA-N 0.000 description 1
GDTVNQXOZLOZQJ-GZSPERRVSA-N Bc1cnc([C@]2(c(c(CC3)cc(Cl)c4)c4[BrH]C(C4)C2CCN4C(CC2CCN(CC(N4C5=CC=CCC5CC4)=O)CC2)=O)N)c3c1 Chemical compound Bc1cnc([C@]2(c(c(CC3)cc(Cl)c4)c4[BrH]C(C4)C2CCN4C(CC2CCN(CC(N4C5=CC=CCC5CC4)=O)CC2)=O)N)c3c1 GDTVNQXOZLOZQJ-GZSPERRVSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Confectionery (AREA)
Enzymes And Modification Thereof (AREA)
Cosmetics (AREA)
Indole Compounds (AREA)
Medicines Containing Plant Substances (AREA)

SK335-99A 1996-09-13 1997-09-11 Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase SK33599A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US71192596A	1996-09-13	1996-09-13
PCT/US1997/015905 WO1998011099A1 (en)	1996-09-13	1997-09-11	Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase

Publications (1)

Publication Number	Publication Date
SK33599A3 true SK33599A3 (en)	2000-03-13

Family

ID=24860067

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK335-99A SK33599A3 (en)	1996-09-13	1997-09-11	Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase

Country Status (20)

Country	Link
EP (1)	EP0931079B1 (de)
JP (1)	JP2001500508A (de)
KR (1)	KR20000036103A (de)
CN (1)	CN1122031C (de)
AT (1)	ATE209201T1 (de)
AU (1)	AU4337797A (de)
BR (1)	BR9711477A (de)
CA (1)	CA2264513C (de)
CZ (1)	CZ87499A3 (de)
DE (1)	DE69709774T2 (de)
ES (1)	ES2163195T3 (de)
HU (1)	HUP9904056A3 (de)
ID (1)	ID22156A (de)
IL (1)	IL128929A0 (de)
NO (1)	NO991229L (de)
NZ (1)	NZ334437A (de)
PL (1)	PL332253A1 (de)
SK (1)	SK33599A3 (de)
TR (1)	TR199901205T2 (de)
WO (1)	WO1998011099A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6358968B1 (en)	1997-06-17	2002-03-19	Schering Corporation	N-substituted urea inhibitors of farnesyl-protein transferase
IL133389A0 (en) *	1997-06-17	2001-04-30	Schering Corp	Novel n-substituted urea inhibitors of farnesyl-protein transferase
US6509346B2 (en)	1998-01-21	2003-01-21	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en)	1998-01-21	2003-09-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6433165B1 (en)	1998-01-21	2002-08-13	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
BR9910144A (pt)	1998-01-21	2002-04-02	Millennium Pharm Inc	Antagonistas de receptores de quimiocinas e seu uso
US6503926B2 (en)	1998-09-04	2003-01-07	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en)	1998-09-04	2001-09-11	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en)	1998-09-04	2007-09-18	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en)	2001-11-21	2009-06-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
TWI291467B (en)	2002-11-13	2007-12-21	Millennium Pharm Inc	CCR1 antagonists and methods of use therefor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL111235A (en) *	1993-10-15	2001-03-19	Schering Plough Corp	Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) *	1993-10-15	1998-02-17	Schering Corporation	Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
SK86198A3 (en) *	1995-12-22	1999-02-11	Schering Corp	Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases

1997
- 1997-09-11 NZ NZ334437A patent/NZ334437A/xx unknown
- 1997-09-11 JP JP10513763A patent/JP2001500508A/ja not_active Ceased
- 1997-09-11 DE DE69709774T patent/DE69709774T2/de not_active Expired - Fee Related
- 1997-09-11 WO PCT/US1997/015905 patent/WO1998011099A1/en not_active Ceased
- 1997-09-11 AT AT97941478T patent/ATE209201T1/de not_active IP Right Cessation
- 1997-09-11 KR KR1019997002125A patent/KR20000036103A/ko not_active Withdrawn
- 1997-09-11 SK SK335-99A patent/SK33599A3/sk unknown
- 1997-09-11 IL IL12892997A patent/IL128929A0/xx unknown
- 1997-09-11 EP EP97941478A patent/EP0931079B1/de not_active Expired - Lifetime
- 1997-09-11 AU AU43377/97A patent/AU4337797A/en not_active Abandoned
- 1997-09-11 CA CA002264513A patent/CA2264513C/en not_active Expired - Fee Related
- 1997-09-11 ID IDW990087A patent/ID22156A/id unknown
- 1997-09-11 HU HU9904056A patent/HUP9904056A3/hu unknown
- 1997-09-11 TR TR1999/01205T patent/TR199901205T2/xx unknown
- 1997-09-11 CN CN97199527A patent/CN1122031C/zh not_active Expired - Fee Related
- 1997-09-11 ES ES97941478T patent/ES2163195T3/es not_active Expired - Lifetime
- 1997-09-11 PL PL97332253A patent/PL332253A1/xx unknown
- 1997-09-11 CZ CZ99874A patent/CZ87499A3/cs unknown
- 1997-09-11 BR BR9711477A patent/BR9711477A/pt unknown
1999
- 1999-03-12 NO NO991229A patent/NO991229L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NZ334437A (en)	2000-09-29
HUP9904056A2 (hu)	2000-04-28
DE69709774D1 (de)	2002-02-21
CZ87499A3 (cs)	1999-08-11
PL332253A1 (en)	1999-08-30
TR199901205T2 (xx)	1999-07-21
NO991229L (no)	1999-05-12
ATE209201T1 (de)	2001-12-15
IL128929A0 (en)	2000-02-17
JP2001500508A (ja)	2001-01-16
EP0931079A1 (de)	1999-07-28
DE69709774T2 (de)	2002-08-08
AU4337797A (en)	1998-04-02
CA2264513C (en)	2004-03-30
HK1018443A1 (en)	1999-12-24
CN1236364A (zh)	1999-11-24
KR20000036103A (ko)	2000-06-26
ES2163195T3 (es)	2002-01-16
ID22156A (id)	1999-09-09
NO991229D0 (no)	1999-03-12
BR9711477A (pt)	1999-08-24
EP0931079B1 (de)	2001-11-21
CN1122031C (zh)	2003-09-24
CA2264513A1 (en)	1998-03-19
HUP9904056A3 (en)	2001-10-29
WO1998011099A1 (en)	1998-03-19

Publication	Publication Date	Title
US6239140B1 (en)	2001-05-29	Compounds useful for inhibition of farnesyl protein transferase
US5945429A (en)	1999-08-31	Compounds useful for inhibition of farnesyl protein transferase
US6387905B2 (en)	2002-05-14	Compounds useful for inhibition of farnesyl protein transferase
US6040305A (en)	2000-03-21	Compounds useful for inhibition of farnesyl protein transferase
EP0989977A1 (de)	2000-04-05	Trizyklische carboxy piperidylacetamid derivate zur inhibirrung der g-protein funktion und zur behandlung proliferativer krankheiten (farnesyl protein transferase inhibitoren)
EP0927178B1 (de)	2002-02-27	Tricyclische verbindungen zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen
SK33599A3 (en)	2000-03-13	Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase
EP0934303B1 (de)	2004-12-29	Trizyklische verbindungen mit farnesyl protein transferase inhibierender wirkung
EP1019400B1 (de)	2004-08-11	Benzo[5,6]cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren
EP0991644B1 (de)	2003-04-16	Cyclische harnstoff- und lactamderivate von benzo(5,6)cycloheptapyridinen zur verwendung als farnesyl-protein-transferase-hemmer
US6071907A (en)	2000-06-06	Tricyclic compounds useful as FPT inhibitors
US6689789B2 (en)	2004-02-10	Compounds useful for inhibition of farnesyl protein transferase
CA2293373C (en)	2008-09-23	Benzo(5,6)cyclohepta(1,2b)pyridine derivatives useful for inhibition of farnesyl protein transferase
EP0942906B1 (de)	2004-11-03	Verbindungen als inhibitoren von farnesylprotein-transferase
EP0927179B1 (de)	2003-08-13	Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl protein transferase inhibitoren
AU7815398A (en)	1999-01-04	Benzo(5,6)cyclohepta(1,2B)pyridine derivatives useful for inhibition of farnesyl protein transferase
HK1018443B (en)	2002-04-19	Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase
MXPA99012062A (en)	2000-09-04	Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors