SK33599A3 - Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase - Google Patents

Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase Download PDF

Info

Publication number: SK33599A3
Authority: SK; Slovakia
Prior art keywords: alkyl; group; mixture; tumor cells; aryl
Prior art date: 1996-09-13

Application number

SK335-99A

Other languages

English (en)

Slovak (sk)

Inventor

Arthur G Taveras

F George Njoroge

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-13

Filing date

1997-09-11

Publication date

2000-03-13

1997-09-11 Application filed by Schering Corp filed Critical Schering Corp

2000-03-13 Publication of SK33599A3 publication Critical patent/SK33599A3/sk

Links

0 Bc1cc(Cl)cc2c1[C@@](*)(C(CC1)CCN1C(C(C1CCN(CC(N(CC)CC)=O)CC1)C(Cc1cc(*C)cnc11)c3cc(Cl)cc(B)c3[C@]1(C(CC1)CCN1C(CC1CCN(CC(NCc3ccccc3)=O)CC1)=O)N)=O)c1ncc(CC)cc1CC2 Chemical compound Bc1cc(Cl)cc2c1[C@@](*)(C(CC1)CCN1C(C(C1CCN(CC(N(CC)CC)=O)CC1)C(Cc1cc(*C)cnc11)c3cc(Cl)cc(B)c3[C@]1(C(CC1)CCN1C(CC1CCN(CC(NCc3ccccc3)=O)CC1)=O)N)=O)c1ncc(CC)cc1CC2 0.000 description 3
JHSYCLOCVVGGKS-SCTYSBSDSA-N Bc1cnc([C@](C)(C(CC2)CCN2C(CC2CCN(CC(N[C@@H]([C@@H]([C@H]([C@H]3O)O)O)O[C@@H]3O)=O)CC2)=O)c(c(CC2)cc(Cl)c3)c3Br)c2c1 Chemical compound Bc1cnc([C@](C)(C(CC2)CCN2C(CC2CCN(CC(N[C@@H]([C@@H]([C@H]([C@H]3O)O)O)O[C@@H]3O)=O)CC2)=O)c(c(CC2)cc(Cl)c3)c3Br)c2c1 JHSYCLOCVVGGKS-SCTYSBSDSA-N 0.000 description 1
GDTVNQXOZLOZQJ-GZSPERRVSA-N Bc1cnc([C@]2(c(c(CC3)cc(Cl)c4)c4[BrH]C(C4)C2CCN4C(CC2CCN(CC(N4C5=CC=CCC5CC4)=O)CC2)=O)N)c3c1 Chemical compound Bc1cnc([C@]2(c(c(CC3)cc(Cl)c4)c4[BrH]C(C4)C2CCN4C(CC2CCN(CC(N4C5=CC=CCC5CC4)=O)CC2)=O)N)c3c1 GDTVNQXOZLOZQJ-GZSPERRVSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Cosmetics (AREA)
Confectionery (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Plant Substances (AREA)

SK335-99A 1996-09-13 1997-09-11 Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase SK33599A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US71192596A	1996-09-13	1996-09-13
PCT/US1997/015905 WO1998011099A1 (fr)	1996-09-13	1997-09-11	Derives substitues de la benzocycloheptapyridine servant a inhiber la farnesyl-proteine transferase

Publications (1)

Publication Number	Publication Date
SK33599A3 true SK33599A3 (en)	2000-03-13

Family

ID=24860067

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK335-99A SK33599A3 (en)	1996-09-13	1997-09-11	Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase

Country Status (20)

Country	Link
EP (1)	EP0931079B1 (fr)
JP (1)	JP2001500508A (fr)
KR (1)	KR20000036103A (fr)
CN (1)	CN1122031C (fr)
AT (1)	ATE209201T1 (fr)
AU (1)	AU4337797A (fr)
BR (1)	BR9711477A (fr)
CA (1)	CA2264513C (fr)
CZ (1)	CZ87499A3 (fr)
DE (1)	DE69709774T2 (fr)
ES (1)	ES2163195T3 (fr)
HU (1)	HUP9904056A3 (fr)
ID (1)	ID22156A (fr)
IL (1)	IL128929A0 (fr)
NO (1)	NO991229L (fr)
NZ (1)	NZ334437A (fr)
PL (1)	PL332253A1 (fr)
SK (1)	SK33599A3 (fr)
TR (1)	TR199901205T2 (fr)
WO (1)	WO1998011099A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA985205B (en) *	1997-06-17	1998-12-15	Schering Corp	Novel n-substituted urea inhibitors of arnesyl-protein transferase
US6358968B1 (en)	1997-06-17	2002-03-19	Schering Corporation	N-substituted urea inhibitors of farnesyl-protein transferase
US6509346B2 (en)	1998-01-21	2003-01-21	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en)	1998-01-21	2003-09-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
AU2331999A (en)	1998-01-21	1999-08-09	Kyowa Hakko Kogyo Co. Ltd.	Chemokine receptor antagonists and methods of use therefor
CA2318088A1 (fr)	1998-01-21	1999-07-29	Yoshisuke Nakasato	Antagonistes du recepteur de la chemokine et procedes d'emploi desdits antagonistes
US6503926B2 (en)	1998-09-04	2003-01-07	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en)	1998-09-04	2001-09-11	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en)	1998-09-04	2007-09-18	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en)	2001-11-21	2009-06-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
TWI291467B (en)	2002-11-13	2007-12-21	Millennium Pharm Inc	CCR1 antagonists and methods of use therefor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL111235A (en) *	1993-10-15	2001-03-19	Schering Plough Corp	Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) *	1993-10-15	1998-02-17	Schering Corporation	Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL125062A (en) *	1995-12-22	2003-11-23	Schering Corp	Tricyclic amides and pharmaceutical compositions containing them for inhibition of g-protein function and for treatment of proliferative diseases

1997
- 1997-09-11 JP JP10513763A patent/JP2001500508A/ja not_active Ceased
- 1997-09-11 WO PCT/US1997/015905 patent/WO1998011099A1/fr not_active Ceased
- 1997-09-11 HU HU9904056A patent/HUP9904056A3/hu unknown
- 1997-09-11 ES ES97941478T patent/ES2163195T3/es not_active Expired - Lifetime
- 1997-09-11 AT AT97941478T patent/ATE209201T1/de not_active IP Right Cessation
- 1997-09-11 CN CN97199527A patent/CN1122031C/zh not_active Expired - Fee Related
- 1997-09-11 PL PL97332253A patent/PL332253A1/xx unknown
- 1997-09-11 CZ CZ99874A patent/CZ87499A3/cs unknown
- 1997-09-11 EP EP97941478A patent/EP0931079B1/fr not_active Expired - Lifetime
- 1997-09-11 CA CA002264513A patent/CA2264513C/fr not_active Expired - Fee Related
- 1997-09-11 NZ NZ334437A patent/NZ334437A/xx unknown
- 1997-09-11 DE DE69709774T patent/DE69709774T2/de not_active Expired - Fee Related
- 1997-09-11 SK SK335-99A patent/SK33599A3/sk unknown
- 1997-09-11 IL IL12892997A patent/IL128929A0/xx unknown
- 1997-09-11 BR BR9711477A patent/BR9711477A/pt unknown
- 1997-09-11 TR TR1999/01205T patent/TR199901205T2/xx unknown
- 1997-09-11 AU AU43377/97A patent/AU4337797A/en not_active Abandoned
- 1997-09-11 KR KR1019997002125A patent/KR20000036103A/ko not_active Withdrawn
- 1997-09-11 ID IDW990087A patent/ID22156A/id unknown
1999
- 1999-03-12 NO NO991229A patent/NO991229L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2163195T3 (es)	2002-01-16
ID22156A (id)	1999-09-09
NO991229L (no)	1999-05-12
ATE209201T1 (de)	2001-12-15
NO991229D0 (no)	1999-03-12
WO1998011099A1 (fr)	1998-03-19
IL128929A0 (en)	2000-02-17
EP0931079B1 (fr)	2001-11-21
CA2264513C (fr)	2004-03-30
CN1236364A (zh)	1999-11-24
DE69709774T2 (de)	2002-08-08
CN1122031C (zh)	2003-09-24
HUP9904056A3 (en)	2001-10-29
EP0931079A1 (fr)	1999-07-28
NZ334437A (en)	2000-09-29
DE69709774D1 (de)	2002-02-21
AU4337797A (en)	1998-04-02
HUP9904056A2 (hu)	2000-04-28
KR20000036103A (ko)	2000-06-26
JP2001500508A (ja)	2001-01-16
HK1018443A1 (en)	1999-12-24
BR9711477A (pt)	1999-08-24
TR199901205T2 (xx)	1999-07-21
CA2264513A1 (fr)	1998-03-19
CZ87499A3 (cs)	1999-08-11
PL332253A1 (en)	1999-08-30

Publication	Publication Date	Title
US6239140B1 (en)	2001-05-29	Compounds useful for inhibition of farnesyl protein transferase
US5945429A (en)	1999-08-31	Compounds useful for inhibition of farnesyl protein transferase
US6387905B2 (en)	2002-05-14	Compounds useful for inhibition of farnesyl protein transferase
US6040305A (en)	2000-03-21	Compounds useful for inhibition of farnesyl protein transferase
EP0989977A1 (fr)	2000-04-05	Composes tricycliques de carboxy piperidylacetamide utilises pour inhiber une fonction g-proteine et traiter des maladies proliferatives (inhibiteurs de farnesyl proteine transferase)
EP0927178B1 (fr)	2002-02-27	Composes tricycliques inhibant la fonction de la proteine g et traitant les maladies proliferantes
SK33599A3 (en)	2000-03-13	Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase
EP0934303B1 (fr)	2004-12-29	Composes servant a inhiber la farnesyl proteine transferase
EP1019400B1 (fr)	2004-08-11	Composes de la benzo (5,6) cycloheptapyridine utilises comme inhibiteurs de la farnesyl transferase
EP0991644B1 (fr)	2003-04-16	Urees cycliques benzo(5,6)cycloheptapyridine et lactames utiles comme inhibiteurs de farnesyl proteine transferase
US6071907A (en)	2000-06-06	Tricyclic compounds useful as FPT inhibitors
US6689789B2 (en)	2004-02-10	Compounds useful for inhibition of farnesyl protein transferase
CA2293373C (fr)	2008-09-23	Derives de benzo(5,6)cyclohepta(1,2b)pyridine s'utilisant comme inhibiteurs de transferase de proteine de farnesyl
EP0942906B1 (fr)	2004-11-03	Composes utiles pour inhiber la farnesyl-proteine transferase
EP0927179B1 (fr)	2003-08-13	Derives substitues de la benzocycloheptapyridine utiles pour l'inhibition de la farnesyl transferase
AU7815398A (en)	1999-01-04	Benzo(5,6)cyclohepta(1,2B)pyridine derivatives useful for inhibition of farnesyl protein transferase
HK1018443B (en)	2002-04-19	Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase
MXPA99012062A (en)	2000-09-04	Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors