SK35198A3 - Heteroaryl-substituted acryloylguanidine derivatives and medicinal composition thereof - Google Patents

Heteroaryl-substituted acryloylguanidine derivatives and medicinal composition thereof Download PDF

Info

Publication number
SK35198A3
SK35198A3 SK351-98A SK35198A SK35198A3 SK 35198 A3 SK35198 A3 SK 35198A3 SK 35198 A SK35198 A SK 35198A SK 35198 A3 SK35198 A3 SK 35198A3
Authority
SK
Slovakia
Prior art keywords
group
substituted
optionally substituted
alkylamino
alkoxy
Prior art date
Application number
SK351-98A
Other languages
English (en)
Slovak (sk)
Inventor
Kazumi Kikuchi
Akira Toyoshima
Toshio Okazaki
Masahiro Takanashi
Isao Yanagisawa
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of SK35198A3 publication Critical patent/SK35198A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK351-98A 1995-09-20 1996-09-19 Heteroaryl-substituted acryloylguanidine derivatives and medicinal composition thereof SK35198A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24171695 1995-09-20
PCT/JP1996/002696 WO1997011055A1 (fr) 1995-09-20 1996-09-19 Derives d'acryloylguanidine a substitution heteroaryle et leurs composition medicinale

Publications (1)

Publication Number Publication Date
SK35198A3 true SK35198A3 (en) 1999-06-11

Family

ID=17078479

Family Applications (1)

Application Number Title Priority Date Filing Date
SK351-98A SK35198A3 (en) 1995-09-20 1996-09-19 Heteroaryl-substituted acryloylguanidine derivatives and medicinal composition thereof

Country Status (13)

Country Link
EP (1) EP0861831A4 (fr)
KR (1) KR19990063589A (fr)
CN (1) CN1196721A (fr)
AU (1) AU702092B2 (fr)
BR (1) BR9610530A (fr)
CA (1) CA2232497A1 (fr)
CZ (1) CZ84098A3 (fr)
HU (1) HUP9901336A3 (fr)
NO (1) NO981241L (fr)
PL (1) PL326033A1 (fr)
SK (1) SK35198A3 (fr)
WO (1) WO1997011055A1 (fr)
ZA (1) ZA967800B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997004781A1 (fr) * 1995-08-02 1997-02-13 Smithkline Beecham Corporation Antagonistes des recepteurs a l'endotheline
CA2283404A1 (fr) * 1997-03-06 1998-09-11 Jun Sasamori Derives de cycloalca¬b|pyridine-3-carbonylguanidine, leur procede de production et medicaments les contenant
JP2003507468A (ja) * 1999-08-23 2003-02-25 スミスクライン・ビーチャム・コーポレイション 脂肪酸シンターゼ阻害剤
EP1695716A2 (fr) * 2000-12-26 2006-08-30 Sankyo Company, Limited Compositions médicinales contenant un diuretique et un agent renforcant la résistance a l'insuline
CA2579724A1 (fr) 2004-06-16 2006-01-26 Wyeth Derives d'amino-5,5-diphenylimidazolone servant a inhiber la beta-secretase
CA2578600A1 (fr) 2004-06-16 2006-01-26 Wyeth Diphenylimidazopyrimidine et -imidazole amines utilisees comme inhibiteurs de b-secretase
CN101103034A (zh) 2005-01-14 2008-01-09 惠氏公司 抑制β-分泌酶的氨基-咪唑酮
EP1844035A1 (fr) 2005-02-01 2007-10-17 Wyeth Aminopyridines constituant des inhibiteurs de la beta-secretase
WO2006088694A1 (fr) 2005-02-14 2006-08-24 Wyeth THIÉNYL- ET FURYLACYLGUANIDINE SUBSTITUÉES ET MÉTHODES D'EMPLOI DESDITS COMPOSÉS EN TANT QUE RÉGULATEURS DE LA β-SECRÉTASE
AU2006214627A1 (en) 2005-02-14 2006-08-24 Wyeth Azolylacylguanidines as beta-secretase inhibitors
TW200738683A (en) 2005-06-30 2007-10-16 Wyeth Corp Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation
BRPI0613578A2 (pt) 2005-06-30 2012-01-17 Wyeth Corp composito da fórmula i; uso de um composto de fórmula i; e composição farmacêutica
RU2008106936A (ru) 2005-09-26 2009-11-10 Вайет (Us) Соединения амино-5-[4-(дифторметокси)фенил]-5-фенилимидазолона для ингибирования бета-секретазы
WO2007100536A1 (fr) 2006-02-24 2007-09-07 Wyeth COMPOSES DE DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] POUR L'INHIBITION DE LA β-SECRETASE
US7700606B2 (en) 2006-08-17 2010-04-20 Wyeth Llc Imidazole amines as inhibitors of β-secretase
PE20090617A1 (es) 2007-03-23 2009-05-08 Wyeth Corp Compuestos amino-5-[-4-(difluorometoxi)fenil]-5-fenilimidazolona para la inhibicion de -secretasa
WO2018065288A1 (fr) 2016-10-07 2018-04-12 Bayer Cropscience Aktiengesellschaft Dérivés de 2-[2-phényl-1-(sulfonylméthyl)vinyl]-imidazo[4,5-b]pyridine et composés apparentés utilisés comme pesticides en protection des plantes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
EP0556674B1 (fr) * 1992-02-15 1996-06-19 Hoechst Aktiengesellschaft Benzoylguanidines 3,5-substitués avec une activité antiarrhythmique et une activité inhibitrice de la prolifération des cellules
JP3162572B2 (ja) * 1993-04-28 2001-05-08 住友製薬株式会社 インドロイルグアニジン誘導体
US5401758A (en) * 1993-10-07 1995-03-28 Bristol-Myers Squibb Company Pyridinyl cyanoguanidine compounds
DE4430861A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Heterocyclyl-benzoylguanidine
JPH0959245A (ja) * 1995-08-25 1997-03-04 Yamanouchi Pharmaceut Co Ltd Ｎ−（２−プロペノイル）グアニジン誘導体

Also Published As

Publication number Publication date
ZA967800B (en) 1997-04-03
NO981241L (no) 1998-05-20
CZ84098A3 (cs) 1998-09-16
HUP9901336A2 (hu) 1999-08-30
EP0861831A1 (fr) 1998-09-02
BR9610530A (pt) 1999-07-06
CA2232497A1 (fr) 1997-03-27
EP0861831A4 (fr) 1998-11-11
WO1997011055A1 (fr) 1997-03-27
PL326033A1 (en) 1998-08-17
NO981241D0 (no) 1998-03-19
AU702092B2 (en) 1999-02-11
CN1196721A (zh) 1998-10-21
MX9802238A (es) 1998-08-30
KR19990063589A (ko) 1999-07-26
AU7000796A (en) 1997-04-09
HUP9901336A3 (en) 2000-02-28

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