SK8222003A3 - Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy - Google Patents

Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy Download PDF

Info

Publication number: SK8222003A3
Authority: SK; Slovakia
Prior art keywords: hyaluronic acid; biological material; acid; group; use according
Prior art date: 2000-12-28

Application number

SK822-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Lanfranco Callegaro

Maurilio Marcacci

Fede Sergio Di

Original Assignee

Fidia Advanced Biopolymers Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-28

Filing date

2001-12-27

Publication date

2003-10-07

2000-12-28 Priority claimed from ITMI20002845 external-priority patent/IT1320141B1/it

2001-04-12 Priority claimed from IT2001PD000090A external-priority patent/ITPD20010090A1/it

2001-12-27 Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl

2003-10-07 Publication of SK8222003A3 publication Critical patent/SK8222003A3/sk

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 48
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3852—Cartilage, e.g. meniscus

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Dermatology (AREA)
Medicinal Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Transplantation (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
Botany (AREA)
Cell Biology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Materials For Medical Uses (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

SK822-2003A 2000-12-28 2001-12-27 Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy SK8222003A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ITMI20002845 IT1320141B1 (it)	2000-12-28	2000-12-28	Uso di materiale biologico comprendente matrici tridimensionali diderivati di acido ialuronico per la preparazione di impianti in
IT2001PD000090A ITPD20010090A1 (it)	2001-04-12	2001-04-12	Strumentario per l'impianto in chirurgia artroscopica di materiale biologico comprendente cellule supportate su matrici tridimensionali bioi
PCT/EP2001/015341 WO2002053201A1 (en)	2000-12-28	2001-12-27	Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy

Publications (1)

Publication Number	Publication Date
SK8222003A3 true SK8222003A3 (en)	2003-10-07

Family

ID=26332765

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK822-2003A SK8222003A3 (en)	2000-12-28	2001-12-27	Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy

Country Status (14)

Country	Link
US (1)	US7722616B2 (cs)
EP (1)	EP1355684B1 (cs)
JP (1)	JP3839777B2 (cs)
AT (1)	ATE455565T1 (cs)
AU (1)	AU2002219226B2 (cs)
BR (1)	BR0116641A (cs)
CA (1)	CA2433131C (cs)
CZ (1)	CZ20031828A3 (cs)
DE (1)	DE60141166D1 (cs)
ES (1)	ES2340141T3 (cs)
NO (1)	NO20032977L (cs)
PL (1)	PL361732A1 (cs)
SK (1)	SK8222003A3 (cs)
WO (1)	WO2002053201A1 (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2340141T3 (es) *	2000-12-28	2010-05-31	Fidia Advanced Biopolymers S.R.L.	Uso de material biologico que contiene matrices tisulares soporte trisimensionales de derivados del acido hialuronico para la preparacion de implantes de artroscopia y un kit para instrumentos para implantar dicho material biologico mediante artroscopia.
ITPD20040053A1 (it) *	2004-02-27	2004-05-27	Fidia Advanced Biopolymers Srl	Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi
US8697139B2 (en)	2004-09-21	2014-04-15	Frank M. Phillips	Method of intervertebral disc treatment using articular chondrocyte cells
WO2008067655A1 (en) *	2006-12-05	2008-06-12	Q6 Biomaterials Inc.	Biocompatible hydrogel-based scaffolds
CN101134784B (zh) *	2007-08-16	2010-06-16	暨南大学	琼脂糖与透明质酸接枝物及其制备方法与应用
CN111787886A (zh)	2018-01-02	2020-10-16	卡尔蒂希尔(2009)公司	用于促进细胞和组织生长的优化固体基质的植入工具和方案
KR102463375B1 (ko) *	2020-02-07	2022-11-07	한국과학기술연구원	콜라겐을 포함하는 마이크로 젤 조성물 및 제조 방법

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4851521A (en) *	1985-07-08	1989-07-25	Fidia, S.P.A.	Esters of hyaluronic acid
US5736372A (en) *	1986-11-20	1998-04-07	Massachusetts Institute Of Technology	Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5623987A (en) *	1992-08-04	1997-04-29	Ergenics, Inc.	Modular manifold gas delivery system
US5906827A (en) *	1994-06-03	1999-05-25	Creative Biomolecules, Inc.	Matrix for the manufacture of autogenous replacement body parts
US5769899A (en) *	1994-08-12	1998-06-23	Matrix Biotechnologies, Inc.	Cartilage repair unit
US5919196A (en)	1995-02-16	1999-07-06	Arthrex, Inc.	Method and apparatus for osteochondral autograft transplantation
AU5931896A (en) *	1995-06-07	1996-12-30	Advanced Tissue Sciences, Inc.	Apparatus and method for sterilizing, seeding, culturing, st oring, shipping, and testing replacement cartilage tissue co nstructs
US5842477A (en) *	1996-02-21	1998-12-01	Advanced Tissue Sciences, Inc.	Method for repairing cartilage
US5755791A (en) *	1996-04-05	1998-05-26	Purdue Research Foundation	Perforated submucosal tissue graft constructs
WO1997045533A1 (en) *	1996-05-28	1997-12-04	The Regents Of The University Of Michigan	Engineering oral tissues
US5921987A (en) *	1996-09-13	1999-07-13	Depuy Orthopaedic Technology, Inc.	Articular cartilage transplant instrument set
US6378527B1 (en) *	1998-04-08	2002-04-30	Chondros, Inc.	Cell-culture and polymer constructs
US6835377B2 (en) *	1998-05-13	2004-12-28	Osiris Therapeutics, Inc.	Osteoarthritis cartilage regeneration
US6224630B1 (en) *	1998-05-29	2001-05-01	Advanced Bio Surfaces, Inc.	Implantable tissue repair device
ITPD980149A1 (it) *	1998-06-17	1999-12-17	Fidia Advanced Biopolymers Srl	Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la
JP2002522168A (ja)	1998-08-14	2002-07-23	ベリゲントランスプランタツィオーンセルビスインテルナツィオナル（フォウテーエスイー）アーゲー	軟骨細胞移植のための方法、器具および材料
US6530956B1 (en) *	1998-09-10	2003-03-11	Kevin A. Mansmann	Resorbable scaffolds to promote cartilage regeneration
WO2000021470A1 (en) *	1998-10-12	2000-04-20	Therics, Inc.	Composites for tissue regeneration and methods of manufacture thereof
IT1302534B1 (it) *	1998-12-21	2000-09-05	Fidia Advanced Biopolymers Srl	Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
US6333029B1 (en) *	1999-06-30	2001-12-25	Ethicon, Inc.	Porous tissue scaffoldings for the repair of regeneration of tissue
US6652872B2 (en) *	1999-07-06	2003-11-25	Ramat At Tel Aviv University Ltd.	Scaffold formed of tissue treated to eliminate cellular and cytosolic elements
US7033603B2 (en) *	1999-08-06	2006-04-25	Board Of Regents The University Of Texas	Drug releasing biodegradable fiber for delivery of therapeutics
CA2379909C (en) *	1999-08-06	2011-01-04	Board Of Regents, The University Of Texas System	Drug releasing biodegradable fiber implant
ES2340141T3 (es) *	2000-12-28	2010-05-31	Fidia Advanced Biopolymers S.R.L.	Uso de material biologico que contiene matrices tisulares soporte trisimensionales de derivados del acido hialuronico para la preparacion de implantes de artroscopia y un kit para instrumentos para implantar dicho material biologico mediante artroscopia.

2001
- 2001-12-27 ES ES01272673T patent/ES2340141T3/es not_active Expired - Lifetime
- 2001-12-27 SK SK822-2003A patent/SK8222003A3/sk unknown
- 2001-12-27 WO PCT/EP2001/015341 patent/WO2002053201A1/en not_active Ceased
- 2001-12-27 PL PL36173201A patent/PL361732A1/xx unknown
- 2001-12-27 EP EP01272673A patent/EP1355684B1/en not_active Expired - Lifetime
- 2001-12-27 JP JP2002554150A patent/JP3839777B2/ja not_active Expired - Fee Related
- 2001-12-27 BR BR0116641-7A patent/BR0116641A/pt not_active IP Right Cessation
- 2001-12-27 AU AU2002219226A patent/AU2002219226B2/en not_active Ceased
- 2001-12-27 DE DE60141166T patent/DE60141166D1/de not_active Expired - Lifetime
- 2001-12-27 US US10/250,408 patent/US7722616B2/en not_active Expired - Fee Related
- 2001-12-27 AT AT01272673T patent/ATE455565T1/de active
- 2001-12-27 CA CA2433131A patent/CA2433131C/en not_active Expired - Lifetime
- 2001-12-27 CZ CZ20031828A patent/CZ20031828A3/cs unknown
2003
- 2003-06-27 NO NO20032977A patent/NO20032977L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2433131C (en)	2012-10-23
NO20032977D0 (no)	2003-06-27
EP1355684A1 (en)	2003-10-29
DE60141166D1 (de)	2010-03-11
PL361732A1 (en)	2004-10-04
EP1355684B1 (en)	2010-01-20
CA2433131A1 (en)	2002-07-11
BR0116641A (pt)	2004-02-17
AU2002219226B2 (en)	2007-03-22
WO2002053201A1 (en)	2002-07-11
US7722616B2 (en)	2010-05-25
NO20032977L (no)	2003-08-21
JP3839777B2 (ja)	2006-11-01
CZ20031828A3 (cs)	2003-11-12
JP2004516892A (ja)	2004-06-10
US20040044416A1 (en)	2004-03-04
ES2340141T3 (es)	2010-05-31
ATE455565T1 (de)	2010-02-15

Legal Events

Date	Code	Title	Description
2011-02-04	FB9A	Suspension of patent application procedure

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