SK8552001A3 - A method for the high level expression of active lymphotoxin-'beta' receptor immunoglobulin chimeric proteins and their purification - Google Patents
A method for the high level expression of active lymphotoxin-'beta' receptor immunoglobulin chimeric proteins and their purification Download PDFInfo
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- SK8552001A3 SK8552001A3 SK855-2001A SK8552001A SK8552001A3 SK 8552001 A3 SK8552001 A3 SK 8552001A3 SK 8552001 A SK8552001 A SK 8552001A SK 8552001 A3 SK8552001 A3 SK 8552001A3
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- protein
- fusion
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- 238000010172 mouse model Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11275298P | 1998-12-17 | 1998-12-17 | |
| PCT/US1999/029873 WO2000036092A2 (en) | 1998-12-17 | 1999-12-16 | METHOD FOR THE HIGH LEVEL EXPRESSION OF ACTIVE LYMPHOTOXIN-β RECEPTOR IMMUNOGLOBULIN CHIMERIC PROTEINS AND THEIR PURIFICATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK8552001A3 true SK8552001A3 (en) | 2001-12-03 |
Family
ID=22345666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK855-2001A SK8552001A3 (en) | 1998-12-17 | 1999-12-16 | A method for the high level expression of active lymphotoxin-'beta' receptor immunoglobulin chimeric proteins and their purification |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US7585946B2 (de) |
| EP (3) | EP3006563A1 (de) |
| JP (4) | JP4878676B2 (de) |
| KR (3) | KR20020013482A (de) |
| CN (2) | CN101289512A (de) |
| AT (1) | ATE536372T1 (de) |
| AU (2) | AU777232B2 (de) |
| BR (1) | BR9916325B1 (de) |
| CA (1) | CA2354539A1 (de) |
| CY (1) | CY1117003T1 (de) |
| CZ (1) | CZ20012156A3 (de) |
| DK (2) | DK1141248T3 (de) |
| EA (1) | EA005270B1 (de) |
| EE (1) | EE200100324A (de) |
| ES (1) | ES2554482T5 (de) |
| HK (1) | HK1223398A1 (de) |
| HU (1) | HUP0200064A2 (de) |
| IL (3) | IL143670A0 (de) |
| IS (1) | IS5959A (de) |
| NO (1) | NO20012991L (de) |
| NZ (3) | NZ538599A (de) |
| PT (1) | PT2374872E (de) |
| SG (1) | SG123531A1 (de) |
| SI (1) | SI2374872T2 (de) |
| SK (1) | SK8552001A3 (de) |
| TR (2) | TR200504220T2 (de) |
| WO (1) | WO2000036092A2 (de) |
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| US5925351A (en) * | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
| US7060667B1 (en) | 1998-01-30 | 2006-06-13 | Biogen Idec Ma, Inc. | Treatment of follicular lymphomas using inhibitors of the LT pathway |
| TR200100974T2 (tr) * | 1998-10-09 | 2001-11-21 | Biogen, Inc. | Virütik kaynaklı sistematik şok ve solunum zorluğunun,lenfotoksin beta yolunu bloke etmek suretiyle geri çevrilmesi |
| US20020168367A1 (en) * | 2000-04-28 | 2002-11-14 | Planet Biotechnology Incorporated | Novel immunoadhesins for treating and preventing viral and bacterial diseases |
| US7951378B2 (en) | 2000-04-28 | 2011-05-31 | Planet Biotechnology Inc. | Immunoadhesin comprising a chimeric ICAM-1 molecule produced in a plant |
| ATE325865T1 (de) * | 2001-01-16 | 2006-06-15 | Regeneron Pharma | Isolierung von sezernierte proteine exprimierenden zellen |
| US20090137416A1 (en) | 2001-01-16 | 2009-05-28 | Regeneron Pharmaceuticals, Inc. | Isolating Cells Expressing Secreted Proteins |
| CN100473664C (zh) * | 2002-12-20 | 2009-04-01 | 拜奥根Idec马萨诸塞公司 | 多价淋巴毒素β受体激动剂及其治疗用途 |
| TWI328614B (en) | 2002-12-23 | 2010-08-11 | Bristol Myers Squibb Co | Product quality enhancement in mammalian cell culture processes for protein production |
| EP1575998A4 (de) | 2002-12-23 | 2007-07-25 | Bristol Myers Squibb Co | Verfahren zur kultivierung vonsäugetierzellen zur proteinproduktion |
| WO2005024012A1 (en) * | 2003-09-11 | 2005-03-17 | Novozymes A/S | Increased expression of a modified polypeptide |
| WO2005063813A2 (en) * | 2003-12-23 | 2005-07-14 | Applied Research Systems Ars Holding N.V. | Process for the production of tumor necrosis factor-binding proteins |
| WO2007115230A2 (en) * | 2006-03-30 | 2007-10-11 | University Of Medicine And Dentistry Of New Jersey | A strategy for homo- or hetero-dimerization of various proteins in solutions and in cells |
| NZ576032A (en) | 2006-10-12 | 2012-03-30 | Genentech Inc | Antibodies to lymphotoxin-alpha |
| NZ576424A (en) | 2006-10-20 | 2012-09-28 | Biogen Idec Inc | Treatment of demyelinating disorders with soluble lymphotoxin-beta-receptor |
| US8338376B2 (en) * | 2006-10-20 | 2012-12-25 | Biogen Idec Ma Inc. | Compositions comprising variant LT-B-R-IG fusion proteins |
| CA2680792A1 (en) * | 2007-03-15 | 2008-09-18 | Biogen Idec Ma Inc. | Treatment of autoimmune disorders |
| TW200902708A (en) | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| JP2011514895A (ja) * | 2008-02-29 | 2011-05-12 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 精製免疫グロブリン融合タンパク質およびその精製方法 |
| US9540426B2 (en) | 2009-10-06 | 2017-01-10 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
| LT2563906T (lt) | 2010-04-26 | 2018-02-26 | Novartis Ag | Cho ląstelių kultivavimo būdas |
| EP2723759A4 (de) * | 2011-06-24 | 2015-01-28 | Reddys Lab Ltd Dr | Aufreinigung von chimärem protein |
| ES2651483T3 (es) | 2011-08-17 | 2018-01-26 | Ares Trading S.A. | Método para preparar la forma activa de la proteína de fusión TNRF-Fc |
| EP2906683B1 (de) | 2012-10-15 | 2017-05-31 | Bristol-Myers Squibb Company | Säugerzellkulturverfahren zur proteinproduktion |
| TWI864338B (zh) | 2012-11-14 | 2024-12-01 | 美商再生元醫藥公司 | 重組細胞表面捕捉蛋白質 |
| AU2016286108B2 (en) | 2015-06-30 | 2021-03-11 | Pfizer Inc. | BTLA fusion protein agonists and uses thereof |
| KR101936049B1 (ko) | 2015-10-15 | 2019-01-08 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 생산방법 |
| CN105400721A (zh) * | 2015-12-11 | 2016-03-16 | 湖南农业大学 | 一种快速筛选具有抗菌活性芽孢杆菌的方法 |
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| US2906096A (en) | 1953-12-14 | 1959-09-29 | Pacific Ind Mfg Co | Precision control system for press brakes or the like |
| WO1991000347A1 (en) | 1989-07-04 | 1991-01-10 | Novo Nordisk A/S | Method of producing proteins with fviii activity and/or fviii derivatives |
| US5605690A (en) * | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
| DK0536299T3 (da) * | 1990-06-27 | 2001-07-09 | Univ California | Overfladekompleksbundet lymfotolksin |
| US7030080B2 (en) * | 1990-06-27 | 2006-04-18 | Biogen, Inc. | Lymphotoxin-β, lymphotoxin-β complexes, pharmaceutical preparations and therapeutic uses thereof |
| US5670149A (en) * | 1990-06-27 | 1997-09-23 | Biogen, Inc. | Lymphotoxin-β, Lymphotoxin-β complexes, pharmaceutical preparations and therapeutic uses thereof |
| ES2139598T3 (es) | 1990-07-10 | 2000-02-16 | Medical Res Council | Procedimientos para la produccion de miembros de parejas de union especifica. |
| NZ260103A (en) * | 1990-11-30 | 1996-10-28 | Bio Technology General Corp | Somatotropin with alterations in the alpha-helix-1 region |
| US5656272A (en) * | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
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| US5726039A (en) * | 1994-07-21 | 1998-03-10 | Yissum Research Development Co. Of The Hebrew University Of Jerusalem | Vectors and transformed host cells for recombinant protein production at reduced temperatures |
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| US5925351A (en) * | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
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-
1999
- 1999-11-16 TR TR2005/042202005/04220T patent/TR200504220T2/xx unknown
- 1999-12-16 BR BRPI9916325-0A patent/BR9916325B1/pt not_active IP Right Cessation
- 1999-12-16 KR KR1020017007475A patent/KR20020013482A/ko not_active Ceased
- 1999-12-16 AT AT99967350T patent/ATE536372T1/de active
- 1999-12-16 JP JP2000588341A patent/JP4878676B2/ja not_active Expired - Lifetime
- 1999-12-16 CN CNA2008100903968A patent/CN101289512A/zh active Pending
- 1999-12-16 EA EA200100670A patent/EA005270B1/ru not_active IP Right Cessation
- 1999-12-16 CN CNB998156957A patent/CN100387708C/zh not_active Expired - Fee Related
- 1999-12-16 ES ES10011212T patent/ES2554482T5/es not_active Expired - Lifetime
- 1999-12-16 KR KR1020067009941A patent/KR100732934B1/ko not_active Expired - Fee Related
- 1999-12-16 NZ NZ538599A patent/NZ538599A/en not_active IP Right Cessation
- 1999-12-16 EP EP15183033.8A patent/EP3006563A1/de not_active Withdrawn
- 1999-12-16 SI SI9931079T patent/SI2374872T2/sl unknown
- 1999-12-16 EP EP99967350A patent/EP1141248B1/de not_active Expired - Lifetime
- 1999-12-16 SK SK855-2001A patent/SK8552001A3/sk unknown
- 1999-12-16 CA CA002354539A patent/CA2354539A1/en not_active Abandoned
- 1999-12-16 DK DK99967350.2T patent/DK1141248T3/da active
- 1999-12-16 HU HU0200064A patent/HUP0200064A2/hu unknown
- 1999-12-16 TR TR2001/01703T patent/TR200101703T2/xx unknown
- 1999-12-16 NZ NZ549623A patent/NZ549623A/en not_active IP Right Cessation
- 1999-12-16 SG SG200200026A patent/SG123531A1/en unknown
- 1999-12-16 IL IL14367099A patent/IL143670A0/xx unknown
- 1999-12-16 CZ CZ20012156A patent/CZ20012156A3/cs unknown
- 1999-12-16 PT PT100112127T patent/PT2374872E/pt unknown
- 1999-12-16 DK DK10011212.7T patent/DK2374872T4/en active
- 1999-12-16 KR KR1020077017658A patent/KR20070091227A/ko not_active Ceased
- 1999-12-16 AU AU23644/00A patent/AU777232B2/en not_active Ceased
- 1999-12-16 WO PCT/US1999/029873 patent/WO2000036092A2/en not_active Ceased
- 1999-12-16 EP EP10011212.7A patent/EP2374872B2/de not_active Expired - Lifetime
- 1999-12-16 EE EEP200100324A patent/EE200100324A/xx unknown
- 1999-12-16 NZ NZ529276A patent/NZ529276A/en active IP Right Revival
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2001
- 2001-01-23 US US09/767,370 patent/US7585946B2/en not_active Expired - Fee Related
- 2001-05-31 IS IS5959A patent/IS5959A/is unknown
- 2001-06-15 NO NO20012991A patent/NO20012991L/no not_active Application Discontinuation
-
2005
- 2005-01-07 AU AU2005200042A patent/AU2005200042B2/en not_active Ceased
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2009
- 2009-08-17 US US12/542,614 patent/US8283138B2/en not_active Expired - Fee Related
-
2010
- 2010-03-30 JP JP2010079856A patent/JP2010158252A/ja not_active Withdrawn
- 2010-05-11 IL IL205698A patent/IL205698A/en not_active IP Right Cessation
-
2012
- 2012-07-19 US US13/553,604 patent/US8709759B2/en not_active Expired - Fee Related
-
2013
- 2013-02-12 JP JP2013024500A patent/JP5777171B2/ja not_active Expired - Lifetime
- 2013-12-01 IL IL229738A patent/IL229738A0/en unknown
-
2014
- 2014-09-12 JP JP2014186243A patent/JP2014239697A/ja not_active Withdrawn
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2015
- 2015-11-26 CY CY20151101065T patent/CY1117003T1/el unknown
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2016
- 2016-10-11 HK HK16111728.8A patent/HK1223398A1/en unknown
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