SK86394A3 - 3-arylindole and 3-arylindazole derivatives and their use - Google Patents
3-arylindole and 3-arylindazole derivatives and their use Download PDFInfo
- Publication number
- SK86394A3 SK86394A3 SK863-94A SK86394A SK86394A3 SK 86394 A3 SK86394 A3 SK 86394A3 SK 86394 A SK86394 A SK 86394A SK 86394 A3 SK86394 A3 SK 86394A3
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- trifluoromethyl
- atom
- optionally substituted
- lower alkyl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 claims abstract 10
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 6
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 6
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 6
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 5
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 5
- 208000028017 Psychotic disease Diseases 0.000 claims abstract 4
- 229910052736 halogen Inorganic materials 0.000 claims abstract 4
- 150000002367 halogens Chemical class 0.000 claims abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 4
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 3
- 239000001257 hydrogen Substances 0.000 claims abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 3
- 125000003282 alkyl amino group Chemical group 0.000 claims abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 claims abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims abstract 2
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 claims abstract 2
- -1 3- (4-fluorophenyl) -5-methyl- [1- [2- [3- (2-propyl) imidazolidin 2-on-1-yl] ethyl] -4-piperidyl] Chemical class 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 claims 1
- LZSPHUKWGNMGSE-UHFFFAOYSA-N 1-[2-[4-[3-(4-fluorophenyl)-5-methylindol-1-yl]piperidin-1-yl]ethyl]imidazolidin-2-one Chemical compound C12=CC(C)=CC=C2N(C2CCN(CCN3C(NCC3)=O)CC2)C=C1C1=CC=C(F)C=C1 LZSPHUKWGNMGSE-UHFFFAOYSA-N 0.000 claims 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 210000004556 brain Anatomy 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 238000010304 firing Methods 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 210000004515 ventral tegmental area Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK9284A DK8492D0 (da) | 1992-01-23 | 1992-01-23 | Behandling af psykoser |
| PCT/DK1993/000021 WO1993014758A1 (en) | 1992-01-23 | 1993-01-22 | Use of 3-arylindole and 3-arylindazole derivatives for the treatment of psychoses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK86394A3 true SK86394A3 (en) | 1995-04-12 |
Family
ID=8089556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK863-94A SK86394A3 (en) | 1992-01-23 | 1993-01-22 | 3-arylindole and 3-arylindazole derivatives and their use |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0621781A1 (cs) |
| JP (1) | JPH07503240A (cs) |
| AU (1) | AU670063B2 (cs) |
| CA (1) | CA2128699A1 (cs) |
| CZ (1) | CZ176494A3 (cs) |
| DK (1) | DK8492D0 (cs) |
| NO (1) | NO942686L (cs) |
| RU (1) | RU94035658A (cs) |
| SK (1) | SK86394A3 (cs) |
| WO (1) | WO1993014758A1 (cs) |
| ZA (1) | ZA93491B (cs) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK206591D0 (da) * | 1991-12-23 | 1991-12-23 | Lundbeck & Co As H | Behandling af psykoser |
| ES2226129T3 (es) * | 1997-05-30 | 2005-03-16 | Banyu Pharmaceutical Co., Ltd. | Derivados de 2-0x0imidazol. |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
| GB8908085D0 (en) * | 1989-04-11 | 1989-05-24 | Lundbeck & Co As H | New therapeutic use |
| DK181190D0 (da) * | 1990-07-30 | 1990-07-30 | Lundbeck & Co As H | 3-aryl-indol- eller 3-aryl-indazolderivater |
-
1992
- 1992-01-23 DK DK9284A patent/DK8492D0/da not_active Application Discontinuation
-
1993
- 1993-01-22 AU AU34494/93A patent/AU670063B2/en not_active Ceased
- 1993-01-22 ZA ZA93491A patent/ZA93491B/xx unknown
- 1993-01-22 WO PCT/DK1993/000021 patent/WO1993014758A1/en not_active Ceased
- 1993-01-22 JP JP5512865A patent/JPH07503240A/ja active Pending
- 1993-01-22 EP EP93903188A patent/EP0621781A1/en not_active Withdrawn
- 1993-01-22 SK SK863-94A patent/SK86394A3/sk unknown
- 1993-01-22 CA CA002128699A patent/CA2128699A1/en not_active Abandoned
- 1993-01-22 CZ CZ941764A patent/CZ176494A3/cs unknown
-
1994
- 1994-07-18 NO NO942686A patent/NO942686L/no unknown
- 1994-07-22 RU RU94035658/14A patent/RU94035658A/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2128699A1 (en) | 1993-08-05 |
| ZA93491B (en) | 1993-08-23 |
| NO942686D0 (no) | 1994-07-18 |
| RU94035658A (ru) | 1996-06-20 |
| JPH07503240A (ja) | 1995-04-06 |
| AU670063B2 (en) | 1996-07-04 |
| DK8492D0 (da) | 1992-01-23 |
| AU3449493A (en) | 1993-09-01 |
| CZ176494A3 (en) | 1995-04-12 |
| WO1993014758A1 (en) | 1993-08-05 |
| NO942686L (no) | 1994-07-18 |
| EP0621781A1 (en) | 1994-11-02 |
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