SK872003A3 - Preparation with vascular protective and anti-oxidative effect and use thereof - Google Patents
Preparation with vascular protective and anti-oxidative effect and use thereof Download PDFInfo
- Publication number
- SK872003A3 SK872003A3 SK87-2003A SK872003A SK872003A3 SK 872003 A3 SK872003 A3 SK 872003A3 SK 872003 A SK872003 A SK 872003A SK 872003 A3 SK872003 A3 SK 872003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- ldl
- terpinene
- oxidation
- composition according
- composition
- Prior art date
Links
- 230000002792 vascular Effects 0.000 title claims abstract description 7
- 230000001681 protective effect Effects 0.000 title claims abstract description 5
- 230000003078 antioxidant effect Effects 0.000 title claims description 7
- 238000002360 preparation method Methods 0.000 title abstract description 6
- 229930006978 terpinene Natural products 0.000 claims abstract description 11
- 150000003507 terpinene derivatives Chemical class 0.000 claims abstract description 11
- 239000000341 volatile oil Substances 0.000 claims abstract description 8
- YKFLAYDHMOASIY-UHFFFAOYSA-N terpinene-gamma Natural products CC(C)C1=CCC(C)=CC1 YKFLAYDHMOASIY-UHFFFAOYSA-N 0.000 claims description 35
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- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 7
- 239000000047 product Substances 0.000 claims description 6
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 235000013912 Ceratonia siliqua Nutrition 0.000 description 2
- 240000008886 Ceratonia siliqua Species 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
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- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 2
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- 210000004026 tunica intima Anatomy 0.000 description 2
- CTMLKIKAUFEMLE-FTNGGYTGSA-N (2s)-4-[(e)-2-[(2s)-2-carboxy-6-hydroxy-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3-dihydroindol-1-yl]ethenyl]-2,3-dihydropyridine-2,6-dicarboxylic acid Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC2=C1N(\C=C\C=1C[C@H](N=C(C=1)C(O)=O)C(O)=O)[C@H](C(O)=O)C2 CTMLKIKAUFEMLE-FTNGGYTGSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 108010071619 Apolipoproteins Proteins 0.000 description 1
- 102000007592 Apolipoproteins Human genes 0.000 description 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 240000008620 Fagopyrum esculentum Species 0.000 description 1
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
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- 150000001299 aldehydes Chemical class 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
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- 235000013539 calcium stearate Nutrition 0.000 description 1
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- 210000004351 coronary vessel Anatomy 0.000 description 1
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
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- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
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- 235000019359 magnesium stearate Nutrition 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
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- 229920000642 polymer Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
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- 235000019165 vitamin E Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Vascular Medicine (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10038640A DE10038640A1 (de) | 2000-07-28 | 2000-07-28 | Präparat mit gefäßschützender und antioxidativer Wirkung sowie dessen Verwendung |
| PCT/DE2001/002082 WO2002009685A1 (de) | 2000-07-28 | 2001-05-28 | Präparat mit gefässschützender und antioxidativer wirkung sowie dessen verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK872003A3 true SK872003A3 (en) | 2003-06-03 |
Family
ID=7651698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK87-2003A SK872003A3 (en) | 2000-07-28 | 2001-05-28 | Preparation with vascular protective and anti-oxidative effect and use thereof |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20040047922A1 (cs) |
| EP (1) | EP1305013A1 (cs) |
| JP (1) | JP2004513077A (cs) |
| CN (1) | CN1444475A (cs) |
| AU (1) | AU2001267324A1 (cs) |
| BR (1) | BR0112663A (cs) |
| CA (1) | CA2411907A1 (cs) |
| CZ (1) | CZ2003194A3 (cs) |
| DE (2) | DE10038640A1 (cs) |
| EE (1) | EE200300044A (cs) |
| MX (1) | MXPA03000718A (cs) |
| NO (1) | NO20030412L (cs) |
| NZ (1) | NZ523185A (cs) |
| PL (1) | PL364992A1 (cs) |
| RU (1) | RU2003105695A (cs) |
| SK (1) | SK872003A3 (cs) |
| WO (1) | WO2002009685A1 (cs) |
| ZA (1) | ZA200210123B (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6616942B1 (en) | 1999-03-29 | 2003-09-09 | Soft Gel Technologies, Inc. | Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing |
| US7588786B2 (en) | 2001-11-14 | 2009-09-15 | Jarrow Formulas, Inc. | Eutectic-based self-nanoemulsified drug delivery system |
| KR20060082791A (ko) * | 2003-06-25 | 2006-07-19 | 찰스 에르윈 | 코엔자임 q10의 전달을 증가시키기 위한 화학적 배합물 및방법 |
| US20080089877A1 (en) * | 2003-08-14 | 2008-04-17 | Udell Ronald G | Super Absorption Coenzyme Q10 |
| US8105583B2 (en) * | 2003-09-29 | 2012-01-31 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
| US8124072B2 (en) | 2003-09-29 | 2012-02-28 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
| US7169385B2 (en) * | 2003-09-29 | 2007-01-30 | Ronald G. Udell | Solubilized CoQ-10 and carnitine |
| US8343541B2 (en) | 2007-03-15 | 2013-01-01 | Soft Gel Technologies, Inc. | Ubiquinol and alpha lipoic acid compositions |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1343561A (en) * | 1972-03-23 | 1974-01-10 | Hisamitsu Pharmaceutical Co | Substances for use in the treatment of gallstones |
| US4246287A (en) * | 1979-10-26 | 1981-01-20 | International Flavors & Fragrances Inc. | Flavoring with fenchyl ethyl ether |
| JPS60172925A (ja) * | 1984-02-17 | 1985-09-06 | Kao Corp | 胆石溶解剤 |
| JPS60204722A (ja) * | 1984-03-28 | 1985-10-16 | Junichi Iwamura | 高脂血症改善・予防剤 |
| CA2073353C (fr) * | 1990-11-14 | 2003-10-28 | Alexandre Zysman | Composes amphiphiles non-ioniques derives du glycerol, leur procede de preparation, composes intermediaires correspondants et compositions contenant lesdits composes |
| AU659625B2 (en) * | 1991-01-18 | 1995-05-25 | Clilco, Ltd. | Lice-repellant compositions |
| JPH08275728A (ja) * | 1995-04-06 | 1996-10-22 | New Aqua Gijutsu Kenkyusho:Kk | Dha油を主成分とする食用油 |
| US5891465A (en) * | 1996-05-14 | 1999-04-06 | Biozone Laboratories, Inc. | Delivery of biologically active material in a liposomal formulation for administration into the mouth |
| EP1021177A4 (en) * | 1997-02-04 | 2002-05-15 | John V Kosbab | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF VASCULAR DEGENERATIVE DISEASES |
| US5925335A (en) * | 1997-06-12 | 1999-07-20 | C.S. Bioscience Inc. | Dental formulation |
| DE19915102A1 (de) * | 1999-04-01 | 2000-10-05 | Pohl Boskamp Gmbh Chem Pharma | Verwendung von Limonen zur Behandlung oxidativer Zellschädigungen |
| US20020048551A1 (en) * | 1999-04-06 | 2002-04-25 | Keller Brian C. | Delivery of biologically active material in a liposomal formulation for administration into the mouth |
-
2000
- 2000-07-28 DE DE10038640A patent/DE10038640A1/de not_active Withdrawn
-
2001
- 2001-05-28 EE EEP200300044A patent/EE200300044A/xx unknown
- 2001-05-28 CN CN01813403A patent/CN1444475A/zh active Pending
- 2001-05-28 DE DE10192998T patent/DE10192998D2/de not_active Expired - Fee Related
- 2001-05-28 CZ CZ2003194A patent/CZ2003194A3/cs unknown
- 2001-05-28 US US10/311,730 patent/US20040047922A1/en not_active Abandoned
- 2001-05-28 PL PL01364992A patent/PL364992A1/xx not_active Application Discontinuation
- 2001-05-28 MX MXPA03000718A patent/MXPA03000718A/es not_active Application Discontinuation
- 2001-05-28 SK SK87-2003A patent/SK872003A3/sk not_active Application Discontinuation
- 2001-05-28 RU RU2003105695/15A patent/RU2003105695A/ru not_active Application Discontinuation
- 2001-05-28 NZ NZ523185A patent/NZ523185A/en unknown
- 2001-05-28 WO PCT/DE2001/002082 patent/WO2002009685A1/de not_active Ceased
- 2001-05-28 EP EP01944968A patent/EP1305013A1/de not_active Withdrawn
- 2001-05-28 AU AU2001267324A patent/AU2001267324A1/en not_active Abandoned
- 2001-05-28 CA CA002411907A patent/CA2411907A1/en not_active Abandoned
- 2001-05-28 BR BR0112663-6A patent/BR0112663A/pt not_active Application Discontinuation
- 2001-05-28 JP JP2002515238A patent/JP2004513077A/ja active Pending
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2002
- 2002-12-13 ZA ZA200210123A patent/ZA200210123B/xx unknown
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2003
- 2003-01-27 NO NO20030412A patent/NO20030412L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03000718A (es) | 2003-06-04 |
| NO20030412L (no) | 2003-02-11 |
| ZA200210123B (en) | 2003-05-27 |
| BR0112663A (pt) | 2003-06-24 |
| NO20030412D0 (no) | 2003-01-27 |
| AU2001267324A1 (en) | 2002-02-13 |
| CA2411907A1 (en) | 2002-12-05 |
| DE10038640A1 (de) | 2002-02-14 |
| WO2002009685A1 (de) | 2002-02-07 |
| US20040047922A1 (en) | 2004-03-11 |
| JP2004513077A (ja) | 2004-04-30 |
| CN1444475A (zh) | 2003-09-24 |
| NZ523185A (en) | 2005-07-29 |
| EP1305013A1 (de) | 2003-05-02 |
| CZ2003194A3 (cs) | 2003-05-14 |
| RU2003105695A (ru) | 2004-06-27 |
| EE200300044A (et) | 2004-10-15 |
| PL364992A1 (en) | 2004-12-27 |
| DE10192998D2 (de) | 2003-01-16 |
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