SK88496A3 - Cyclic derivatives, manufacturing process thereof, pharmaceutical compositions containing them and their use antifungal sordaridin derivatives - Google Patents

Cyclic derivatives, manufacturing process thereof, pharmaceutical compositions containing them and their use antifungal sordaridin derivatives Download PDF

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Publication number
SK88496A3
SK88496A3 SK884-96A SK88496A SK88496A3 SK 88496 A3 SK88496 A3 SK 88496A3 SK 88496 A SK88496 A SK 88496A SK 88496 A3 SK88496 A3 SK 88496A3
Authority
SK
Slovakia
Prior art keywords
methyl
group
formula
solution
alkyl
Prior art date
Application number
SK884-96A
Other languages
English (en)
Slovak (sk)
Inventor
Jose R R Gomez
Jose M B Calderon
Dorado S Garcia-Ochoa
Gabaldon M T Fraile
Julia C Pichel
Roman J Fiandor
Viola D Gargallo
Zurita J C Cuevas
Diaz Jose L Lavandera
Sophie Huss
Original Assignee
Glaxo Wellcome Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP94500175A external-priority patent/EP0711784A1/en
Priority claimed from EP94500173A external-priority patent/EP0712859A1/en
Application filed by Glaxo Wellcome Sa filed Critical Glaxo Wellcome Sa
Publication of SK88496A3 publication Critical patent/SK88496A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK884-96A 1994-11-08 1995-11-06 Cyclic derivatives, manufacturing process thereof, pharmaceutical compositions containing them and their use antifungal sordaridin derivatives SK88496A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94500175A EP0711784A1 (en) 1994-11-08 1994-11-08 Antifungal Sordarin derivatives
EP94500173A EP0712859A1 (en) 1994-11-08 1994-11-08 Antifungal Sordarin derivatives
PCT/EP1995/004331 WO1996014326A1 (en) 1994-11-08 1995-11-06 Antifungal sordaridin derivatives

Publications (1)

Publication Number Publication Date
SK88496A3 true SK88496A3 (en) 1997-04-09

Family

ID=26137608

Family Applications (1)

Application Number Title Priority Date Filing Date
SK884-96A SK88496A3 (en) 1994-11-08 1995-11-06 Cyclic derivatives, manufacturing process thereof, pharmaceutical compositions containing them and their use antifungal sordaridin derivatives

Country Status (34)

Country Link
US (2) US5854280A (is)
EP (1) EP0753001B1 (is)
JP (1) JPH09508144A (is)
KR (1) KR100391401B1 (is)
CN (1) CN1056849C (is)
AP (1) AP614A (is)
AR (1) AR013815A1 (is)
AT (1) ATE184284T1 (is)
AU (1) AU704405B2 (is)
BG (1) BG62620B1 (is)
BR (1) BR9506473A (is)
CA (1) CA2179403A1 (is)
CO (1) CO4520226A1 (is)
CZ (1) CZ202796A3 (is)
DE (1) DE69512041T2 (is)
DK (1) DK0753001T3 (is)
EE (1) EE9600117A (is)
ES (1) ES2137549T3 (is)
FI (1) FI962773A7 (is)
GR (1) GR3031677T3 (is)
HU (1) HU218611B (is)
IL (1) IL115905A0 (is)
IS (1) IS4352A (is)
MX (1) MX9602563A (is)
NO (1) NO307092B1 (is)
NZ (1) NZ296091A (is)
OA (1) OA10303A (is)
PE (1) PE49696A1 (is)
RU (1) RU2152398C1 (is)
SI (1) SI0753001T1 (is)
SK (1) SK88496A3 (is)
TW (1) TW321644B (is)
WO (1) WO1996014326A1 (is)
ZA (1) ZA959362B (is)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2952197A (en) * 1996-05-08 1997-11-26 Glaxo Wellcome S.A. Process for the preparation of an indacene compound
US6436395B1 (en) * 1996-09-18 2002-08-20 Merck & Co., Inc. Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control
US6040463A (en) * 1996-10-07 2000-03-21 Merck & Co., Inc. Sordarin derivatives
US6096511A (en) * 1997-06-10 2000-08-01 Merck & Co., Inc. Protein elongation factor 2 as a target for antifungal and antiparasitic agents
AU740477B2 (en) * 1997-08-22 2001-11-08 Merck Sharp & Dohme Corp. 4-cyano-4-deformylsordarin derivatives
US5965612A (en) * 1997-08-22 1999-10-12 Merck & Co., Inc. 4-cyano-4-deformylsordaricin derivatives
US5972996A (en) * 1997-08-22 1999-10-26 Merck & Co., Inc. 4-cyano-4-deformylsordarin derivatives
US6136853A (en) * 1997-10-03 2000-10-24 Merck & Co., Inc. Sordarin derivatives
FI974385A0 (fi) 1997-12-01 1997-12-01 Xyrofin Oy Anvaendning av xylitol foer bekaempning av jaestinfektion och xylitolpreparat foer denna anvaendning
US7070965B1 (en) * 1998-04-14 2006-07-04 Zhenhua Yang Small molecule anticancer compounds and related production process
MA26628A1 (fr) * 1998-05-11 2004-12-20 Glaxo Wellcome Sa Morpholino ethers
CA2347803A1 (en) 1998-10-26 2000-05-04 Merck & Co., Inc. Microbial transformation product
WO2000076556A2 (en) 1999-06-11 2000-12-21 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6645960B1 (en) 1999-11-11 2003-11-11 Glaxo Wellcome S.A. Antifungal sordaricin derivatives
WO2002022567A1 (en) * 2000-09-15 2002-03-21 Bristol-Myers Squibb Company Novel thio derivatives of sordarin as antifungal agents
EP1390081A2 (en) 2001-01-08 2004-02-25 Neorx Corporation Therapeutic and diagnostic compounds, compositions, and methods
WO2003007878A2 (en) 2001-07-18 2003-01-30 Merck & Co., Inc. Antifungal agents of sordarin derivatives
RU2223093C2 (ru) * 2001-11-19 2004-02-10 Открытое акционерное общество "Биосинтез" Фармацевтическая композиция для лечения грибковых заболеваний
EP1458416A1 (en) 2001-12-13 2004-09-22 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
US20040242904A1 (en) * 2001-12-14 2004-12-02 Angelo Basilio Novel sordarin derivative isolated from culture fermentations and functions as an antifungal agent
RU2201230C1 (ru) * 2001-12-24 2003-03-27 Закрытое акционерное общество "Брынцалов-А" Лекарственное средство флузол, обладающее противогрибковым действием
RU2207842C1 (ru) * 2002-02-18 2003-07-10 Акционерное Курганское общество медицинских препаратов и изделий "Синтез" Противогрибковое средство в виде мази и способ его получения
MXPA05007156A (es) * 2002-12-31 2005-09-21 Nektar Therapeutics Formulacion farmaceuticas aerosolizable para terapia para infecciones fungicas.
US9314524B2 (en) 2007-12-31 2016-04-19 Calla Therapeutics Llc Topical formulations of Flucytosine
US8419948B2 (en) * 2009-11-22 2013-04-16 United Laboratories International, Llc Wastewater treatment
WO2012033427A1 (ru) * 2010-09-08 2012-03-15 Dalin Mikhail Viktorovich Способ лечения микотических инфекций и препарат для его осуществления
RU2630403C2 (ru) * 2016-02-25 2017-09-07 Жанна Владимировна Вараткова Абразивная масса для изготовления инструмента с высокими номерами структуры

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH465771A (de) * 1965-12-06 1968-11-30 Sandoz Ag Verfahren zur Herstellung eines neuen Antibioticums
JPH0615555B2 (ja) * 1985-08-14 1994-03-02 三共株式会社 抗生物質ゾフイマリン
JP3189443B2 (ja) * 1992-11-20 2001-07-16 萬有製薬株式会社 抗真菌性物質ｂｅ−３１４０５
SK29999A3 (en) * 1996-09-12 2000-02-14 Merck & Co Inc Antifungal combination therapy

Also Published As

Publication number Publication date
ATE184284T1 (de) 1999-09-15
AU704405B2 (en) 1999-04-22
FI962773L (fi) 1996-08-26
HUT76292A (en) 1997-07-28
FI962773A7 (fi) 1996-08-26
SI0753001T1 (en) 1999-12-31
KR100391401B1 (ko) 2003-12-31
HK1004222A1 (en) 1998-11-20
MX9602563A (es) 1997-05-31
BG62620B1 (bg) 2000-03-31
GR3031677T3 (en) 2000-02-29
DE69512041T2 (de) 2000-02-03
CA2179403A1 (en) 1996-05-17
EE9600117A (et) 1997-04-15
IS4352A (is) 1996-06-10
AP9600824A0 (en) 1996-07-31
NO307092B1 (no) 2000-02-07
BG100699A (bg) 1997-02-28
ZA959362B (en) 1996-05-08
JPH09508144A (ja) 1997-08-19
PE49696A1 (es) 1996-12-05
TW321644B (is) 1997-12-01
HU218611B (hu) 2000-10-28
NZ296091A (en) 1998-06-26
CN1143965A (zh) 1997-02-26
CZ202796A3 (en) 1997-02-12
EP0753001A1 (en) 1997-01-15
HU9601865D0 (en) 1996-11-28
DE69512041D1 (de) 1999-10-14
AU3980995A (en) 1996-05-31
WO1996014326A1 (en) 1996-05-17
US5952334A (en) 1999-09-14
AP614A (en) 1997-09-05
BR9506473A (pt) 1997-10-07
EP0753001B1 (en) 1999-09-08
FI962773A0 (fi) 1996-07-05
US5854280A (en) 1998-12-29
IL115905A0 (en) 1996-01-31
NO962856D0 (no) 1996-07-05
DK0753001T3 (da) 2000-05-08
CO4520226A1 (es) 1997-10-15
CN1056849C (zh) 2000-09-27
RU2152398C1 (ru) 2000-07-10
NO962856L (no) 1996-09-05
AR013815A1 (es) 2001-01-31
ES2137549T3 (es) 1999-12-16
OA10303A (en) 1997-10-07

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