SK91395A3 - Lysine salt of 6-chloro-5-fluoro-3-(2-tenoyl)-2-oxindole-1- -carboxamide and pharmaceutical composition on their base - Google Patents

Lysine salt of 6-chloro-5-fluoro-3-(2-tenoyl)-2-oxindole-1- -carboxamide and pharmaceutical composition on their base Download PDF

Info

Publication number
SK91395A3
SK91395A3 SK913-95A SK91395A SK91395A3 SK 91395 A3 SK91395 A3 SK 91395A3 SK 91395 A SK91395 A SK 91395A SK 91395 A3 SK91395 A3 SK 91395A3
Authority
SK
Slovakia
Prior art keywords
oxindole
chloro
carboxamide
fluoro
tenoyl
Prior art date
Application number
SK913-95A
Other languages
English (en)
Slovak (sk)
Inventor
Kelvin Cooper
Thomas C Crawford
Bruce H Littman
Christopher J Pazoles
Sally G Ruggeri
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/007,217 external-priority patent/US5298522A/en
Application filed by Pfizer filed Critical Pfizer
Publication of SK91395A3 publication Critical patent/SK91395A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK913-95A 1993-01-22 1994-01-06 Lysine salt of 6-chloro-5-fluoro-3-(2-tenoyl)-2-oxindole-1- -carboxamide and pharmaceutical composition on their base SK91395A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/007,217 US5298522A (en) 1993-01-22 1993-01-22 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
US13827793A 1993-10-18 1993-10-18
PCT/US1994/000096 WO1994016694A1 (en) 1993-01-22 1994-01-06 Lysine salt of 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide

Publications (1)

Publication Number Publication Date
SK91395A3 true SK91395A3 (en) 1996-12-04

Family

ID=26676677

Family Applications (1)

Application Number Title Priority Date Filing Date
SK913-95A SK91395A3 (en) 1993-01-22 1994-01-06 Lysine salt of 6-chloro-5-fluoro-3-(2-tenoyl)-2-oxindole-1- -carboxamide and pharmaceutical composition on their base

Country Status (27)

Country Link
EP (1) EP0680321B1 (da)
JP (1) JP2711939B2 (da)
CN (1) CN1116822A (da)
AP (1) AP468A (da)
AT (1) ATE171373T1 (da)
AU (1) AU671533B2 (da)
BG (1) BG61966B1 (da)
BR (1) BR9405661A (da)
CA (1) CA2153050C (da)
CZ (1) CZ182895A3 (da)
DE (1) DE69413518T2 (da)
DK (1) DK0680321T3 (da)
DZ (1) DZ1748A1 (da)
ES (1) ES2122236T3 (da)
FI (1) FI940309A7 (da)
HU (1) HUT69687A (da)
IL (1) IL108326A0 (da)
LV (1) LV10920B (da)
MA (1) MA23095A1 (da)
NO (1) NO952904L (da)
NZ (1) NZ261449A (da)
OA (1) OA10173A (da)
PL (1) PL309957A1 (da)
SK (1) SK91395A3 (da)
UY (1) UY23723A1 (da)
WO (1) WO1994016694A1 (da)
YU (1) YU48719B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7503496A (en) * 1995-12-19 1997-07-14 Pfizer Inc. Stable, long acting salts of indole derivatives for the treatment of joint diseases
EP0826685A1 (en) * 1996-08-21 1998-03-04 Pfizer Inc. Stable, long acting salts of carboxamides for the treatment of joint disease
DE10106852A1 (de) * 2001-02-14 2002-09-05 T Luger Entzündungshemmende Verbindungen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4853409A (en) * 1988-04-13 1989-08-01 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
DE4111305C2 (de) * 1991-04-08 1994-12-01 Mack Chem Pharm Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält
DE4111306C2 (de) * 1991-04-08 1994-06-01 Mack Chem Pharm Pharmazeutische Zubereitungen, die ein 2-Oxindol-l-carboxamid-derivat enthalten und zur Injektion bestimmt sind
US5298522A (en) * 1993-01-22 1994-03-29 Pfizer Inc. 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio

Also Published As

Publication number Publication date
FI940309A0 (fi) 1994-01-21
UY23723A1 (es) 1994-06-28
BR9405661A (pt) 1995-11-21
JPH08501109A (ja) 1996-02-06
WO1994016694A1 (en) 1994-08-04
AU671533B2 (en) 1996-08-29
EP0680321B1 (en) 1998-09-23
CA2153050C (en) 1998-12-29
DZ1748A1 (fr) 2002-02-17
DE69413518T2 (de) 1999-02-11
AU6019894A (en) 1994-08-15
DE69413518D1 (en) 1998-10-29
FI940309L (fi) 1994-07-23
LV10920A (lv) 1995-12-20
CZ182895A3 (en) 1996-01-17
EP0680321A1 (en) 1995-11-08
DK0680321T3 (da) 1999-06-14
PL309957A1 (en) 1995-11-13
OA10173A (en) 1996-12-18
AP9400609A0 (en) 1994-01-31
YU2394A (sh) 1996-10-18
NO952904D0 (no) 1995-07-21
NO952904L (no) 1995-07-21
HUT69687A (en) 1995-09-28
NZ261449A (en) 1996-08-27
BG99767A (bg) 1996-02-28
AP468A (en) 1996-03-05
ATE171373T1 (de) 1998-10-15
CN1116822A (zh) 1996-02-14
MA23095A1 (fr) 1994-10-01
LV10920B (en) 1996-04-20
IL108326A0 (en) 1994-04-12
BG61966B1 (bg) 1998-11-30
HU9400176D0 (en) 1994-05-30
CA2153050A1 (en) 1994-08-04
ES2122236T3 (es) 1998-12-16
FI940309A7 (fi) 1994-07-23
YU48719B (sh) 1999-07-28
JP2711939B2 (ja) 1998-02-10

Similar Documents

Publication Publication Date Title
KR100424124B1 (ko) 동맥경화및황색종의치료
US4336397A (en) 2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis
RU2109293C1 (ru) Способ аналгезии и снятия воспалительной реакции у человека
US4337258A (en) 2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis
US4423063A (en) 2,4-Dioxo-4-substituted-1-butaoic acid derivatives useful in treating urinary track calcium oxalate lithiasis
KR900006724B1 (ko) 벤조티아진 디옥사이드 유도체
JPH0611739B2 (ja) Ｎ―［６―メトキシ―５―（パーフルオロアルキル）―１―ナフトイル―ｎ―メチルグリシンおよびチオナフトイル類似体
JP2002053557A (ja) アポリポ蛋白ａ−ｉ産生促進薬
CA2153050C (en) Lysine salt of 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide
EP0718290B1 (en) Carboxyalkyl heterocyclic derivatives
SK695188A3 (en) Enolether amide 1,1-dioxo-6-chloro-4-hydroxy-2-methyl-n-(2- -pyridyl)-2h-thieno (2,3-e)-1,2-thiazine-3-carboxylic acid, method of its production and pharmaceutical agent
JP2010159293A (ja) ５−アミノサリチル酸のアゾ誘導体のナトリウム塩
EP1163217B1 (en) New salt of (2r,3r,4r)-3,4-dihydroxy-2-hydroxymethylpyrrolidine
US6316489B1 (en) Salt of (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine
KR100556559B1 (ko) 2-(4-(4-(4,5-디클로로-2-메틸이미다졸-1-일)부틸)-1-피페라지닐)-5-플루오로피리미딘, 이것의 제조 방법 및 이것의치료적 용도
JP4397875B2 (ja) 糖尿病合併症予防薬又は治療薬
CA1306464C (en) 2-(3, 5-dimethyl-4-hydroxyphenyl)indole derivatives
US4910216A (en) 2-(3,5-dimethyl-4-hydroxyphenyl)indole derivatives
SI9400099A (sl) Lizinova sol 6-kloro-5-fluoro-3-{2-tenoil)-2-oksindol-1-karboksiamida
IE51324B1 (en) Esters of substituted benzoic acid
CZ12566U1 (cs) Amlodipinhemimaleát a farmaceutický prostředek
MXPA05001011A (es) Derivado de acidos indolalcanoicos substituidos y formulaciones que lo contienen para uso en tratamiento de complicaciones diabeticas.