SK92898A3 - Novel substituted imidazole compounds - Google Patents

Novel substituted imidazole compounds Download PDF

Info

Publication number: SK92898A3
Authority: SK; Slovakia
Prior art keywords: alkyl; formula; compound; substituted; aryl
Prior art date: 1996-01-11

Application number

SK928-98A

Other languages

English (en)

Slovak (sk)

Inventor

Jerry L Adams

Jeffrey C Boehm

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-11

Filing date

1997-01-10

Publication date

1999-05-07

1997-01-10 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1999-05-07 Publication of SK92898A3 publication Critical patent/SK92898A3/sk

Links

150000002460 imidazoles Chemical class 0.000 title claims abstract description 14
150000001875 compounds Chemical class 0.000 claims description 181
125000000217 alkyl group Chemical group 0.000 claims description 136
-1 CH 2 OR 12 Chemical group 0.000 claims description 99
238000000034 method Methods 0.000 claims description 65
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 51
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 48
238000006243 chemical reaction Methods 0.000 claims description 44
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 40
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 38
229910052739 hydrogen Inorganic materials 0.000 claims description 38
239000001257 hydrogen Substances 0.000 claims description 36
125000001072 heteroaryl group Chemical group 0.000 claims description 35
239000002904 solvent Substances 0.000 claims description 35
125000000623 heterocyclic group Chemical group 0.000 claims description 33
229910052736 halogen Inorganic materials 0.000 claims description 32
238000011282 treatment Methods 0.000 claims description 32
150000003839 salts Chemical class 0.000 claims description 31
150000002367 halogens Chemical class 0.000 claims description 30
125000003118 aryl group Chemical group 0.000 claims description 29
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 27
238000004519 manufacturing process Methods 0.000 claims description 27
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 26
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 24
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 22
230000015572 biosynthetic process Effects 0.000 claims description 21
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238000002360 preparation method Methods 0.000 claims description 16
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SK928-98A 1996-01-11 1997-01-10 Novel substituted imidazole compounds SK92898A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US990996P	1996-01-11	1996-01-11
PCT/US1997/000529 WO1997025046A1 (fr)	1996-01-11	1997-01-10	Nouveaux composes substitues de l'imidazole

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Publication Number	Publication Date
SK92898A3 true SK92898A3 (en)	1999-05-07

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SK927-98A SK92798A3 (en)	1996-01-11	1997-01-10	Novel substituted imidazole compounds
SK928-98A SK92898A3 (en)	1996-01-11	1997-01-10	Novel substituted imidazole compounds

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Application Number	Title	Priority Date	Filing Date
SK927-98A SK92798A3 (en)	1996-01-11	1997-01-10	Novel substituted imidazole compounds

Country Status (26)

Country	Link
US (3)	US6214844B1 (fr)
EP (1)	EP0935465B1 (fr)
JP (2)	JP2000503303A (fr)
KR (1)	KR19990077165A (fr)
CN (1)	CN1213307A (fr)
AR (1)	AR006307A1 (fr)
AT (1)	ATE264105T1 (fr)
AU (1)	AU726084C (fr)
BR (1)	BR9706934A (fr)
DE (1)	DE69728685T2 (fr)
DK (1)	DK0935465T3 (fr)
EA (1)	EA001430B1 (fr)
ES (1)	ES2219750T3 (fr)
HU (1)	HUP9900645A3 (fr)
IL (1)	IL125282A (fr)
MX (1)	MX9805634A (fr)
NO (1)	NO316625B1 (fr)
NZ (1)	NZ327052A (fr)
OA (1)	OA11514A (fr)
PL (1)	PL187616B1 (fr)
PT (1)	PT935465E (fr)
SK (2)	SK92798A3 (fr)
TR (1)	TR199801360T2 (fr)
TW (1)	TW523512B (fr)
WO (1)	WO1997025046A1 (fr)
ZA (1)	ZA97175B (fr)

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1997
- 1997-01-09 ZA ZA9700175A patent/ZA97175B/xx unknown
- 1997-01-10 IL IL12528297A patent/IL125282A/xx not_active IP Right Cessation
- 1997-01-10 US US09/101,550 patent/US6214844B1/en not_active Expired - Fee Related
- 1997-01-10 KR KR1019980705303A patent/KR19990077165A/ko not_active Ceased
- 1997-01-10 PL PL97327934A patent/PL187616B1/pl not_active IP Right Cessation
- 1997-01-10 EA EA199800633A patent/EA001430B1/ru not_active IP Right Cessation
- 1997-01-10 US US08/781,466 patent/US5716955A/en not_active Expired - Fee Related
- 1997-01-10 TR TR1998/01360T patent/TR199801360T2/xx unknown
- 1997-01-10 DK DK97902013T patent/DK0935465T3/da active
- 1997-01-10 WO PCT/US1997/000529 patent/WO1997025046A1/fr not_active Ceased
- 1997-01-10 AT AT97902013T patent/ATE264105T1/de not_active IP Right Cessation
- 1997-01-10 DE DE69728685T patent/DE69728685T2/de not_active Expired - Fee Related
- 1997-01-10 ES ES97902013T patent/ES2219750T3/es not_active Expired - Lifetime
- 1997-01-10 PT PT97902013T patent/PT935465E/pt unknown
- 1997-01-10 JP JP9525459A patent/JP2000503303A/ja not_active Ceased
- 1997-01-10 HU HU9900645A patent/HUP9900645A3/hu not_active Application Discontinuation
- 1997-01-10 NZ NZ327052A patent/NZ327052A/xx unknown
- 1997-01-10 SK SK927-98A patent/SK92798A3/sk unknown
- 1997-01-10 EP EP97902013A patent/EP0935465B1/fr not_active Expired - Lifetime
- 1997-01-10 SK SK928-98A patent/SK92898A3/sk unknown
- 1997-01-10 AU AU15782/97A patent/AU726084C/en not_active Ceased
- 1997-01-10 AR ARP970100104A patent/AR006307A1/es not_active Application Discontinuation
- 1997-01-10 CN CN97193002A patent/CN1213307A/zh active Pending
- 1997-01-10 BR BR9706934-5A patent/BR9706934A/pt not_active Application Discontinuation
- 1997-08-22 TW TW086112052A patent/TW523512B/zh not_active IP Right Cessation
- 1997-11-21 US US08/976,522 patent/US5811549A/en not_active Expired - Fee Related
1998
- 1998-07-10 MX MX9805634A patent/MX9805634A/es not_active IP Right Cessation
- 1998-07-10 NO NO19983181A patent/NO316625B1/no not_active IP Right Cessation
- 1998-07-10 OA OA9800113A patent/OA11514A/en unknown
2004
- 2004-01-08 JP JP2004003158A patent/JP2004107358A/ja active Pending

Also Published As

Publication number	Publication date
ES2219750T3 (es)	2004-12-01
EA001430B1 (ru)	2001-02-26
NZ327052A (en)	2000-01-28
US6214844B1 (en)	2001-04-10
MX9805634A (es)	1998-11-30
HUP9900645A2 (hu)	1999-06-28
EP0935465A1 (fr)	1999-08-18
OA11514A (en)	2004-02-04
ATE264105T1 (de)	2004-04-15
PL327934A1 (en)	1999-01-04
AU726084B2 (en)	2000-11-02
DE69728685T2 (de)	2005-04-14
EP0935465B1 (fr)	2004-04-14
US5811549A (en)	1998-09-22
US5716955A (en)	1998-02-10
EP0935465A4 (fr)	1999-08-18
PL187616B1 (pl)	2004-08-31
SK92798A3 (en)	1999-05-07
WO1997025046A1 (fr)	1997-07-17
DE69728685D1 (de)	2004-05-19
AR006307A1 (es)	1999-08-25
NO316625B1 (no)	2004-03-15
IL125282A (en)	2003-06-24
AU726084C (en)	2001-08-30
NO983181L (no)	1998-09-10
JP2000503303A (ja)	2000-03-21
CN1213307A (zh)	1999-04-07
HK1022624A1 (en)	2000-08-18
IL125282A0 (en)	1999-03-12
PT935465E (pt)	2004-08-31
TW523512B (en)	2003-03-11
ZA97175B (en)	1997-11-04
EA199800633A1 (ru)	1999-02-25
JP2004107358A (ja)	2004-04-08
TR199801360T2 (xx)	1998-10-21
DK0935465T3 (da)	2004-08-09
HUP9900645A3 (en)	2000-03-28
KR19990077165A (ko)	1999-10-25
BR9706934A (pt)	2000-10-24
AU1578297A (en)	1997-08-01

Publication	Publication Date	Title
SK92798A3 (en)	1999-05-07	Novel substituted imidazole compounds
US5739143A (en)	1998-04-14	Imidazole compounds and compositions
EP0831830B1 (fr)	2003-03-05	Composes d'imidazole
RU2196139C2 (ru)	2003-01-10	1,4,5-тризамещенные производные имидазола, способы их получения и фармацевтическая композиция на их основе
US5977103A (en)	1999-11-02	Substituted imidazole compounds
CZ218198A3 (cs)	1999-09-15	Nové cykloalkylem substituované imidazoly, způsob jejich přípravy, farmaceutické prostředky s jejich obsahem a způsob inhibice
HUP0102677A2 (hu)	2002-04-29	Triszubsztituált imidazolszármazékok, eljárás az előállításukra és a vegyületeket tartalmazó gyógyászati készítmények
JP2001526230A (ja)	2001-12-18	ヘテロアリール置換イミダゾール化合物、その医薬組成物および使用
AP999A (en)	2001-08-11	Novel substituted imidazole compounds.
BG63362B1 (bg)	2001-11-30	Нови заместени имидазоли
CZ219698A3 (cs)	2000-02-16	Nová substituovaná imidazolová sloučenina, způsob její přípravy, farmaceutický prostředek s jejím obsahem a způsob léčení
KR19990077166A (ko)	1999-10-25	신규한 시클로알킬 치환 이미다졸
HK1022624B (en)	2004-12-10	Novel substituted imidazole compounds
AU1827101A (en)	2001-04-26	Novel substituted imidazole compounds
HK1057540A (en)	2004-04-08	Pyridyl and pyrimidinyl imines as intermediates for imidazole derivatives
HK1052690A (en)	2003-09-26	Process for the preparation of tosylbenzylformamides