SK98793A3 - (s)-(+)-hydroxychloroquine - Google Patents
(s)-(+)-hydroxychloroquine Download PDFInfo
- Publication number
- SK98793A3 SK98793A3 SK987-93A SK98793A SK98793A3 SK 98793 A3 SK98793 A3 SK 98793A3 SK 98793 A SK98793 A SK 98793A SK 98793 A3 SK98793 A3 SK 98793A3
- Authority
- SK
- Slovakia
- Prior art keywords
- hydroxychloroquine
- substantially free
- rheumatoid arthritis
- pharmaceutically acceptable
- malaria
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Detergent Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/945,032 US5314894A (en) | 1992-09-15 | 1992-09-15 | (S)-(+)-hydroxychloroquine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK98793A3 true SK98793A3 (en) | 1994-09-07 |
Family
ID=25482508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK987-93A SK98793A3 (en) | 1992-09-15 | 1993-09-14 | (s)-(+)-hydroxychloroquine |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5314894A (de) |
| EP (1) | EP0588430B1 (de) |
| JP (1) | JPH06199801A (de) |
| KR (1) | KR940007002A (de) |
| AT (1) | ATE166646T1 (de) |
| AU (2) | AU4732693A (de) |
| CA (1) | CA2104903A1 (de) |
| CZ (1) | CZ192393A3 (de) |
| DE (1) | DE69318783D1 (de) |
| FI (1) | FI934051L (de) |
| HU (1) | HUT70025A (de) |
| IL (1) | IL107004A0 (de) |
| MX (1) | MX9305621A (de) |
| MY (1) | MY109822A (de) |
| NO (1) | NO180677C (de) |
| NZ (1) | NZ248671A (de) |
| PH (1) | PH30153A (de) |
| SK (1) | SK98793A3 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5453431A (en) * | 1993-10-29 | 1995-09-26 | Gilman; Andrew L. | Use of hydroxychloroquine for treatment of graft-versus-host disease |
| US6512010B1 (en) * | 1996-07-15 | 2003-01-28 | Alza Corporation | Formulations for the administration of fluoxetine |
| US20040229908A1 (en) * | 1999-07-13 | 2004-11-18 | Jodi Nelson | Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias |
| US20020198231A1 (en) * | 1999-07-13 | 2002-12-26 | Jodi Nelson | Compositions and methods for the treatment of Parkinson's disease |
| US7108992B2 (en) * | 2002-11-27 | 2006-09-19 | St. Jude Children's Research Hospital | ATM kinase compositions and methods |
| US6916627B2 (en) * | 2002-11-27 | 2005-07-12 | St. Jude Children's Research Hospital | ATM kinase compositions and methods |
| WO2005062723A2 (en) * | 2003-11-24 | 2005-07-14 | Ipca Laboratories Limited | An improved process for the preparation of 7-chloro-4-(5-n-ehtyl-n-2-hydroxyethylamine)-2-pentyl] aminoquinoline and its intermediates |
| KR101115412B1 (ko) * | 2008-09-08 | 2012-06-12 | 주식회사 대희화학 | 하이드록시클로로퀸의 신규 제조방법 |
| KR101208587B1 (ko) * | 2009-06-24 | 2012-12-06 | 여오영 | 하이드록시클로로퀸을 포함하는 항암 치료를 위한 국소 투여용 주사제 조성물 |
| JP2013529627A (ja) | 2010-06-24 | 2013-07-22 | パンメド リミテッド | ヒドロキシクロロキンまたはヒドロキシクロロキンおよび抗ウイルス剤の組合せを使用するｃ型肝炎ウイルス関連疾患の処置 |
| WO2012176149A1 (en) | 2011-06-23 | 2012-12-27 | Panmed Ltd. | Treatment of hepatitis c virus |
| EP2561868A1 (de) | 2011-08-24 | 2013-02-27 | Anton Bernhard Van Oosten | Pharmazeutische Zusammensetzungen mit Hydroxychlorocin (HCQ), Curcumin, Piperin/BioPerin und Verwendungen in der Medizin |
| WO2014122537A2 (en) | 2013-02-05 | 2014-08-14 | Genoscience Sa | Pharmaceutical compositions and methods of treating hepatitis c virus infection using a combination of hydroxychloroquine and ribavirin |
| CN105693606B (zh) * | 2016-03-09 | 2017-12-05 | 西安科技大学 | 一种光学纯(r)/(s)‑羟氯喹的不对称合成方法 |
| CN105693605B (zh) * | 2016-03-09 | 2017-12-22 | 西安科技大学 | 一种光学纯(r)/(s)‑氯喹的不对称合成方法 |
| CN110283121A (zh) * | 2019-08-06 | 2019-09-27 | 华东理工大学 | 羟氯喹的合成方法 |
| CN113350343A (zh) * | 2020-03-06 | 2021-09-07 | 华南理工大学 | 右旋手性磷酸氯喹在制备治疗冠状病毒药物中的应用 |
| CN113350344A (zh) * | 2020-03-06 | 2021-09-07 | 华南理工大学 | 左旋手性磷酸氯喹在制备治疗冠状病毒药物中的应用 |
| EP4135673A4 (de) * | 2020-04-14 | 2024-05-08 | Glanis Pharmaceuticals, Inc. | System zur transdermalen und/oder topischen verabreichung mit hydroxychlorquin und/oder chloroquin |
| US20230139565A1 (en) * | 2020-04-20 | 2023-05-04 | Glanis Pharmaceuticals, Inc. | Oral delivery system comprising hydroxychloroquine and/or chloroquine |
| TWI845802B (zh) * | 2020-04-21 | 2024-06-21 | 健亞生物科技股份有限公司 | 硫酸羥氯喹之晶體 |
| WO2021217574A1 (en) * | 2020-04-30 | 2021-11-04 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Treatment or prevention of coronaviridae infection |
| US20210369699A1 (en) | 2020-05-31 | 2021-12-02 | Genovate Biotechnology Co. Ltd. | Treatment of lupus erythematosus using s-hydroxychloroquine |
| CN111909087A (zh) * | 2020-06-15 | 2020-11-10 | 珠海润都制药股份有限公司 | 一种手性氨基氯喹啉的制备方法 |
| CN111803501B (zh) * | 2020-06-17 | 2022-10-18 | 南方科技大学 | 手性氯喹羟氯喹作为降低心脏毒性的用途 |
| CN111793026A (zh) * | 2020-07-23 | 2020-10-20 | 珠海润都制药股份有限公司 | 一种硫酸羟氯喹及其对映体的晶型和制备方法 |
| CN114057640A (zh) * | 2020-08-05 | 2022-02-18 | 凯特立斯（深圳）科技有限公司 | 一种光学纯(r)/(s)-羟氯喹侧链的不对称合成方法 |
| CN112505198A (zh) * | 2020-12-29 | 2021-03-16 | 珠海润都制药股份有限公司 | 一种s-硫酸羟氯喹异构体检验方法 |
| CN117396204A (zh) * | 2021-06-04 | 2024-01-12 | 健亚生物科技股份有限公司 | 使用s-羟氯喹治疗抗磷脂综合征 |
| CN114573464A (zh) * | 2022-03-02 | 2022-06-03 | 重庆南松凯博生物制药有限公司 | 一种羟氯喹侧链精制方法 |
| CN115089584A (zh) * | 2022-06-14 | 2022-09-23 | 广州惠善医疗技术有限公司 | 手性羟氯喹或其药学上可接受的盐在制备防诊治免疫疾病药物中的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2546658A (en) * | 1949-07-23 | 1951-03-27 | Sterling Drug Inc | 7-chloro-4-[5-(n-ethyl-n-2-hydroxyethylamino)-2-pentyl] aminoquinoline, its acid addition salts, and method of preparation |
| US5021426A (en) * | 1990-02-26 | 1991-06-04 | Merck & Co., Inc. | Method of traeting malaria with cyproheptadine derivatives |
-
1992
- 1992-09-15 US US07/945,032 patent/US5314894A/en not_active Expired - Fee Related
-
1993
- 1993-08-13 PH PH46684A patent/PH30153A/en unknown
- 1993-08-26 CA CA002104903A patent/CA2104903A1/en not_active Abandoned
- 1993-09-08 MY MYPI93001822A patent/MY109822A/en unknown
- 1993-09-11 EP EP93202641A patent/EP0588430B1/de not_active Expired - Lifetime
- 1993-09-11 AT AT93202641T patent/ATE166646T1/de not_active IP Right Cessation
- 1993-09-11 DE DE69318783T patent/DE69318783D1/de not_active Expired - Lifetime
- 1993-09-13 MX MX9305621A patent/MX9305621A/es not_active Application Discontinuation
- 1993-09-14 SK SK987-93A patent/SK98793A3/sk unknown
- 1993-09-14 JP JP5228485A patent/JPH06199801A/ja not_active Withdrawn
- 1993-09-14 IL IL107004A patent/IL107004A0/xx unknown
- 1993-09-14 AU AU47326/93A patent/AU4732693A/en not_active Abandoned
- 1993-09-15 HU HU9302613A patent/HUT70025A/hu unknown
- 1993-09-15 CZ CZ931923A patent/CZ192393A3/cs unknown
- 1993-09-15 FI FI934051A patent/FI934051L/fi not_active Application Discontinuation
- 1993-09-15 NO NO933293A patent/NO180677C/no unknown
- 1993-09-15 KR KR1019930018519A patent/KR940007002A/ko not_active Withdrawn
- 1993-09-15 NZ NZ248671A patent/NZ248671A/en unknown
-
1996
- 1996-12-20 AU AU75494/96A patent/AU7549496A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06199801A (ja) | 1994-07-19 |
| AU4732693A (en) | 1994-03-24 |
| NO180677B (no) | 1997-02-17 |
| EP0588430A1 (de) | 1994-03-23 |
| FI934051A7 (fi) | 1994-03-16 |
| MY109822A (en) | 1997-08-30 |
| PH30153A (en) | 1997-01-21 |
| NO933293L (no) | 1994-03-16 |
| HUT70025A (en) | 1995-09-28 |
| FI934051A0 (fi) | 1993-09-15 |
| NO180677C (no) | 1997-05-28 |
| KR940007002A (ko) | 1994-04-26 |
| HU9302613D0 (en) | 1993-12-28 |
| FI934051L (fi) | 1994-03-16 |
| US5314894A (en) | 1994-05-24 |
| NO933293D0 (no) | 1993-09-15 |
| CZ192393A3 (en) | 1994-03-16 |
| MX9305621A (es) | 1994-03-31 |
| ATE166646T1 (de) | 1998-06-15 |
| CA2104903A1 (en) | 1994-03-16 |
| IL107004A0 (en) | 1993-12-28 |
| NZ248671A (en) | 1995-04-27 |
| AU7549496A (en) | 1997-04-10 |
| EP0588430B1 (de) | 1998-05-27 |
| DE69318783D1 (de) | 1998-07-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SK98793A3 (en) | (s)-(+)-hydroxychloroquine | |
| DK172851B1 (da) | Phenylcarbamater | |
| US3466376A (en) | Ortho - alkenylphenoxy - hydroxyalkyl derivatives in the treatment of cardiac and vascular diseases | |
| DE69813896T2 (de) | Alpha-aminoamidderivate die als analgetische mittel nützlich sind | |
| JPH03294248A (ja) | Ｎ−プロパルギル−１−アミノインダン化合物のｒ（＋）−鏡像体、それらの製造法およびそれらを含有する薬剤組成物 | |
| SK167698A3 (en) | Polymorphs of donepezil hydrochloride and process for production | |
| JPH01500033A (ja) | 置換２‐アミノテトラリン類 | |
| EP1373207A1 (de) | Neues amlodipincamsylat und verfahren zu dessen herstellung | |
| IE59941B1 (en) | Piperidine derivative for treating pain | |
| US6169094B1 (en) | Compositions of (S) (-)-amisulpride | |
| US4743618A (en) | Substituted 2-aminotetralins | |
| DE68907566T2 (de) | Phenoxy- und phenylthio-, amino-substituierte Benzocyclo-alkan-Derivate bei der Behandlung und Verhütung von arzneimittelresistenten Protozoen-Infektionen. | |
| CA2100158A1 (en) | 3-hydroxypyridin-4-one derivatives as pharmaceutical compositions | |
| AU568704B2 (en) | Ether of n-propanolamine derivative | |
| CN105924382B (zh) | S-马尼地平盐酸盐i晶型及其制备方法 | |
| AU607437B2 (en) | Resolution of dl-methyl 3-(4-(2-hydroxy-3-isopropylamino) propoxy)phenylpropionate((dl-esmolol)) | |
| HU211699A9 (hu) | (S)-(+)-hidroxi-klorokvin Az átmeneti oltalom az 1-3. és 9-12. igénypontokra vonatkozik. | |
| DE69619156T2 (de) | Verwendung von alpha-Aminomethyl-3,4-dichlorbenzylthioaceamiden zur Herstellung eines dopaminwiederergreifungshemmenden Medikaments sowie Verbindungen zur Verwendung derselben | |
| US4831049A (en) | Pyrrolizidine compounds, and their use as antiarrhythmic agents | |
| US3629418A (en) | Process for producing an anti-depressant effect with piperazine quinolines | |
| US6979740B2 (en) | Process for preparation of ring-substituted 8-aminoquinoline analogs as antimalarial agents | |
| WO2013090319A2 (en) | Treatment of type i and type ii diabetes | |
| JP2004533418A (ja) | 抗マラリア化合物 | |
| JPS6245525A (ja) | 脂質低下剤 | |
| DE69621706T2 (de) | Verwendung von Piperazinverbindungen als narkotische Antagonisten |