SK99997A3 - Improved synthesis of cyclopropylacetylene - Google Patents

Improved synthesis of cyclopropylacetylene Download PDF

Info

Publication number
SK99997A3
SK99997A3 SK999-97A SK99997A SK99997A3 SK 99997 A3 SK99997 A3 SK 99997A3 SK 99997 A SK99997 A SK 99997A SK 99997 A3 SK99997 A3 SK 99997A3
Authority
SK
Slovakia
Prior art keywords
temperature
reaction mixture
butyllithium
cyclopropylacetylene
sodium
Prior art date
Application number
SK999-97A
Other languages
English (en)
Slovak (sk)
Inventor
Andrew S Thompson
Edward G Corley
Martha Huntington
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SK99997A3 publication Critical patent/SK99997A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/02—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/04—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C07C1/26—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms
    • C07C1/30—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms by splitting-off the elements of hydrogen halide from a single molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
SK999-97A 1995-01-23 1996-01-19 Improved synthesis of cyclopropylacetylene SK99997A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/376,611 US5663467A (en) 1995-01-23 1995-01-23 Synthesis of cyclopropylacetylene
PCT/US1996/000628 WO1996022955A1 (en) 1995-01-23 1996-01-19 Improved synthesis of cyclopropylacetylene

Publications (1)

Publication Number Publication Date
SK99997A3 true SK99997A3 (en) 1998-05-06

Family

ID=23485719

Family Applications (1)

Application Number Title Priority Date Filing Date
SK999-97A SK99997A3 (en) 1995-01-23 1996-01-19 Improved synthesis of cyclopropylacetylene

Country Status (23)

Country Link
US (1) US5663467A (da)
EP (1) EP0805790B1 (da)
JP (1) JP3107829B2 (da)
KR (1) KR19980701577A (da)
CN (1) CN1056824C (da)
AR (1) AR000771A1 (da)
AT (1) ATE186903T1 (da)
AU (1) AU692674B2 (da)
BR (1) BR9606782A (da)
CA (1) CA2210577A1 (da)
CZ (1) CZ234997A3 (da)
DE (1) DE69605282T2 (da)
DK (1) DK0805790T3 (da)
EA (1) EA000074B1 (da)
ES (1) ES2140062T3 (da)
FI (1) FI973086A0 (da)
GR (1) GR3032200T3 (da)
HR (1) HRP960029B1 (da)
HU (1) HUP9800849A3 (da)
NZ (1) NZ301206A (da)
SK (1) SK99997A3 (da)
WO (1) WO1996022955A1 (da)
YU (1) YU3696A (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3736197A (en) * 1996-07-26 1998-02-20 Du Pont Pharmaceuticals Company A practical synthesis of benzoxazinones useful as hiv reverse transcripta se inhibitors
US5932726A (en) * 1996-12-16 1999-08-03 Dupont Pharmaceuticals Company Asymmetric synthesis of benzoxazinones
ZA9711256B (en) 1996-12-16 1999-06-15 Du Pont Merck Pharma Asymmetric synthesis of benzoxazinones
US6028237A (en) * 1996-12-16 2000-02-22 Dupont Pharmaceuticals Company Synthesis of cyclopropylacetylene
US5955627A (en) * 1996-12-16 1999-09-21 Kuraray Co., Ltd. Process for the preparation of cyclopropylacetylene derivatives
US5965729A (en) * 1997-02-05 1999-10-12 Merck & Co., Inc. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
DE69841972D1 (de) * 1997-02-05 2010-12-09 Merck Sharp & Dohme Verfahren zur kristallisation eines reverstranskriptase-inhibitors, bei welchem ein anti-lösungsmittel benutzt wird
JP2001514636A (ja) 1997-03-07 2001-09-11 ビーエーエスエフ アクチェンゲゼルシャフト シクロプロピルアセチレンを製造するための改善法
CA2285000A1 (en) * 1997-04-07 1998-10-15 Dupont Pharmaceuticals Company Asymmetric synthesis of benzoxazinones via new intermediates
US6015926A (en) * 1997-05-16 2000-01-18 Merck & Co., Inc. Efficient enantioselective addition reaction using an organozinc reagent
BR9810842A (pt) * 1997-07-31 2000-07-25 Du Pont Pharm Co Processo para a sìntese de ciclopropilacetileno e composto
AU738790B2 (en) * 1997-08-06 2001-09-27 Merck & Co., Inc. Efficient synthesis of cyclopropylacetylene
US6072094A (en) * 1997-08-06 2000-06-06 Merck & Co., Inc. Efficient synthesis of cyclopropylacetylene
ES2170990T3 (es) * 1997-12-10 2002-08-16 Lonza Ag Procedimiento para la preparacion de etinil-ciclopropano.
KR100350752B1 (ko) * 1998-02-06 2002-08-28 가부시키가이샤 구라레 시클로프로필아세틸렌 유도체의 제조방법
US5952537A (en) * 1998-03-13 1999-09-14 Wiley Organics, Inc. Preparation of cycloalkylacetylene compounds using dialkylaminomagnesium halide or bis(dialkylamino)magnesium
UA72207C2 (uk) 1998-04-07 2005-02-15 Брістол- Майєрс Сквібб Фарма Компані Фармацевтична композиція ефавіренцу з добавкою дезінтегруючих агентів у вигляді швидкорозчинних капсул або таблеток та спосіб її виготовлення
US20010014352A1 (en) 1998-05-27 2001-08-16 Udit Batra Compressed tablet formulation
US6235957B1 (en) 1998-06-29 2001-05-22 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
US6288297B1 (en) 1998-10-01 2001-09-11 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
US6359164B1 (en) 1998-10-01 2002-03-19 Zhe Wang Process for the preparation of cyclopropylacetylene
GB2355988A (en) 1999-10-28 2001-05-09 Merck & Co Inc Synthesis of cyclopropylacetylene in a one-pot process using a diazo-keto-phos phonate
GB2355724A (en) * 1999-10-28 2001-05-02 Merck & Co Inc Synthesis of cyclopropylacetylene from propiolic acid (2-propynoic acid)
US8080655B2 (en) * 2009-07-20 2011-12-20 Apotex Pharmachem Inc. Methods of making efavirenz and intermediates thereof
EP2471783A1 (en) 2010-12-23 2012-07-04 Esteve Química, S.A. Novel polymorphic form of efavirenz
CN103254087B (zh) * 2013-06-07 2015-03-18 郑州大学 依非韦伦中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU578293A1 (ru) * 1972-02-04 1977-10-30 Институт Органической Химии Имени Н.Д.Зелинского Ан Ссср Способ получени циклопропилацетилена
SU555079A1 (ru) * 1976-01-30 1977-04-25 Институт органической химии им.Н.Д.Зелинского АН СССР Способ получени циклопропилацетилена
SU572445A1 (ru) * 1976-04-05 1977-09-15 Институт Органической Химии Имени Н.Д. Зелинского Ан Ссср Способ получени циклопропилацетилена

Also Published As

Publication number Publication date
DE69605282D1 (en) 1999-12-30
ES2140062T3 (es) 2000-02-16
WO1996022955A1 (en) 1996-08-01
HRP960029B1 (en) 2000-12-31
US5663467A (en) 1997-09-02
CN1056824C (zh) 2000-09-27
CA2210577A1 (en) 1996-08-01
BR9606782A (pt) 1997-12-30
NZ301206A (en) 1998-11-25
HRP960029A2 (en) 1997-08-31
JPH10512880A (ja) 1998-12-08
GR3032200T3 (en) 2000-04-27
CZ234997A3 (cs) 1998-02-18
EA199700139A1 (ru) 1997-12-30
FI973086L (fi) 1997-07-22
ATE186903T1 (de) 1999-12-15
AU4657496A (en) 1996-08-14
FI973086A7 (fi) 1997-07-22
EA000074B1 (ru) 1998-06-25
FI973086A0 (fi) 1997-07-22
DK0805790T3 (da) 2000-05-01
KR19980701577A (ko) 1998-05-15
JP3107829B2 (ja) 2000-11-13
HUP9800849A2 (hu) 1999-01-28
CN1169137A (zh) 1997-12-31
AU692674B2 (en) 1998-06-11
MX9705562A (es) 1997-10-31
YU3696A (sh) 1998-11-05
AR000771A1 (es) 1997-08-06
EP0805790A1 (en) 1997-11-12
EP0805790B1 (en) 1999-11-24
HUP9800849A3 (en) 2001-01-29
DE69605282T2 (de) 2000-07-13

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