SMAP200900002A - Sali di n-idrossi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]ammino]metil]fenil]-2e-2-propenammide - Google Patents

Sali di n-idrossi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]ammino]metil]fenil]-2e-2-propenammide

Info

Publication number
SMAP200900002A
SMAP200900002A SM200900002T SM200900002T SMAP200900002A SM AP200900002 A SMAP200900002 A SM AP200900002A SM 200900002 T SM200900002 T SM 200900002T SM 200900002 T SM200900002 T SM 200900002T SM AP200900002 A SMAP200900002 A SM AP200900002A
Authority
SM
San Marino
Prior art keywords
methyl
propenamide
indol
hydroxy
phenyl
Prior art date
Application number
SM200900002T
Other languages
English (en)
Other versions
SMP200900002B (it
Inventor
Murat Acemoglu
Joginder S Bajwa
Piotr Karpinski
Dimitris Papoutsakis
Joel Slade
Frank Stowasser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38564366&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMAP200900002(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SMAP200900002A publication Critical patent/SMAP200900002A/it
Publication of SMP200900002B publication Critical patent/SMP200900002B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SM200900002T 2006-06-12 2007-06-07 Sali di n-idrossi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]ammino]metil]fenil]-2e-2-propenammide SMP200900002B (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80452306P 2006-06-12 2006-06-12
US86999306P 2006-12-14 2006-12-14
PCT/US2007/070558 WO2007146715A1 (en) 2006-06-12 2007-06-07 Salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide

Publications (2)

Publication Number Publication Date
SMAP200900002A true SMAP200900002A (it) 2009-01-14
SMP200900002B SMP200900002B (it) 2010-01-19

Family

ID=38564366

Family Applications (1)

Application Number Title Priority Date Filing Date
SM200900002T SMP200900002B (it) 2006-06-12 2007-06-07 Sali di n-idrossi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]ammino]metil]fenil]-2e-2-propenammide

Country Status (37)

Country Link
US (3) US20090197936A1 (it)
EP (1) EP2032531B1 (it)
JP (2) JP2009540005A (it)
KR (2) KR20090026281A (it)
AR (1) AR061298A1 (it)
AU (1) AU2007257962B2 (it)
BR (1) BRPI0712771A2 (it)
CA (1) CA2654439C (it)
CL (1) CL2007001692A1 (it)
CR (1) CR10439A (it)
DK (1) DK2032531T3 (it)
EA (1) EA015212B1 (it)
EC (1) ECSP088979A (it)
ES (1) ES2570934T3 (it)
GE (1) GEP20105125B (it)
GT (1) GT200800279A (it)
HN (1) HN2008001859A (it)
HR (1) HRP20160291T1 (it)
HU (1) HUE027126T2 (it)
IL (1) IL195087A (it)
JO (1) JO3138B1 (it)
MA (1) MA30563B1 (it)
ME (1) ME00531B (it)
MX (1) MX2008015901A (it)
MY (1) MY147345A (it)
NO (1) NO341871B1 (it)
NZ (1) NZ572547A (it)
PE (1) PE20080937A1 (it)
PL (1) PL2032531T3 (it)
RS (1) RS54640B1 (it)
SI (1) SI2032531T1 (it)
SM (1) SMP200900002B (it)
SV (1) SV2008003126A (it)
TN (1) TNSN08501A1 (it)
TW (1) TWI409254B (it)
UY (1) UY30403A1 (it)
WO (1) WO2007146715A1 (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY149337A (en) 2006-06-12 2013-08-30 Novartis Ag Polymorphs of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
AU2008204928B2 (en) * 2007-01-10 2011-03-31 Novartis Ag Formulations of deacetylase inhibitors
US8519002B2 (en) 2008-04-07 2013-08-27 Takeda Pharmaceuticals U.S.A., Inc. Colchicine solid complex; methods of making; and methods of use thereof
US8003700B2 (en) * 2008-04-07 2011-08-23 Mutual Pharamaceutical Company, Inc. Colchicine solid complex; methods of making; and methods of use thereof
UY32297A (es) * 2008-12-22 2010-05-31 Almirall Sa Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
JP5263211B2 (ja) 2010-03-30 2013-08-14 ブラザー工業株式会社 サーバ、プリンタ、及び、サーバのためのコンピュータプログラム
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
MA41544A (fr) 2015-02-19 2017-12-26 Novartis Ag Dosages de panobinostat pour le traitement du myélome multiple
WO2017221163A1 (en) * 2016-06-21 2017-12-28 Alembic Pharmaceuticals Limited Novel salts and polymorphic forms of panobinostat
US12220569B2 (en) 2020-03-25 2025-02-11 Boston Scientific Scimed, Inc. Medical device for treating decompensated heart failure
FI4143169T3 (fi) 2020-04-30 2026-06-08 Exelixis Inc Kinaasi-inhibiittorin valmistusmenetelmät
CN116648449A (zh) * 2020-10-28 2023-08-25 维拉克塔附属公司 Hdac抑制剂固态形式

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
US20060270730A1 (en) * 2003-08-07 2006-11-30 Andreas Katopodis Histone deacetylase inhibitors as immunosuppressants
US20050228300A1 (en) * 2004-04-07 2005-10-13 Triage Data Networks Cuffless blood-pressure monitor and accompanying wireless mobile device
MY149337A (en) * 2006-06-12 2013-08-30 Novartis Ag Polymorphs of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
AU2007257882B2 (en) * 2006-06-12 2011-09-08 Secura Bio Inc. Process for making salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide

Also Published As

Publication number Publication date
AU2007257962A1 (en) 2007-12-21
JO3138B1 (ar) 2017-09-20
PL2032531T3 (pl) 2016-07-29
SV2008003126A (es) 2011-07-05
UY30403A1 (es) 2008-01-31
JP2013256542A (ja) 2013-12-26
NO20090128L (no) 2009-03-11
SI2032531T1 (sl) 2016-05-31
RS54640B1 (sr) 2016-08-31
GEP20105125B (en) 2010-11-25
PE20080937A1 (es) 2008-08-29
KR101629352B1 (ko) 2016-06-13
IL195087A0 (en) 2009-08-03
WO2007146715A1 (en) 2007-12-21
GT200800279A (es) 2010-06-16
ES2570934T3 (es) 2016-05-23
DK2032531T3 (en) 2016-04-11
HRP20160291T1 (hr) 2016-04-22
EA200802382A1 (ru) 2009-06-30
EA015212B1 (ru) 2011-06-30
MY147345A (en) 2012-11-30
SMP200900002B (it) 2010-01-19
AR061298A1 (es) 2008-08-20
ECSP088979A (es) 2009-01-30
KR20090026281A (ko) 2009-03-12
IL195087A (en) 2012-10-31
MX2008015901A (es) 2009-01-12
TWI409254B (zh) 2013-09-21
US20110112308A1 (en) 2011-05-12
CL2007001692A1 (es) 2008-05-09
CA2654439C (en) 2014-08-05
US20090197936A1 (en) 2009-08-06
NZ572547A (en) 2011-06-30
HUE027126T2 (en) 2016-08-29
CA2654439A1 (en) 2007-12-21
HK1126496A1 (zh) 2009-09-04
EP2032531B1 (en) 2016-02-10
BRPI0712771A2 (pt) 2012-09-25
KR20150029765A (ko) 2015-03-18
HN2008001859A (es) 2011-07-19
ME00531B (me) 2011-10-10
JP5771257B2 (ja) 2015-08-26
AU2007257962B2 (en) 2011-06-23
US20100286409A1 (en) 2010-11-11
NO341871B1 (no) 2018-02-12
TNSN08501A1 (en) 2010-04-14
TW200815343A (en) 2008-04-01
MA30563B1 (fr) 2009-07-01
JP2009540005A (ja) 2009-11-19
CR10439A (es) 2009-01-15
EP2032531A1 (en) 2009-03-11

Similar Documents

Publication Publication Date Title
SMP200900002B (it) Sali di n-idrossi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]ammino]metil]fenil]-2e-2-propenammide
SMAP200900001A (it) Polimorfi di n-idrossi-3[4-[[[2-(2-metil-1h-indol-3-il)etil]ammino]metil]fenil]-2e-2-propenammide
IL195344A0 (en) Process for making salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
ZA200809383B (en) Salts of n-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl] amino]methyl]phenyl]-2E-2propenamide
ZA200809651B (en) Process for making salts of N-hydroxy-3[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide
IL233836A0 (en) Method for preparing n-hydroxy-3-[4-[[[2-(2-methyl-h1-indol-3-yl)ethyl]amino]methyl]phenyl]-e2-2-propanamide
UA97243C2 (en) Crystalline anhydrous form of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
HK1132509A (en) Polymorphs of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
CY1117493T1 (el) Αλατα του ν-υδροξυ-3-[4-[[[2-(2-μεθυλ-1η-ινδολ-3-υλ)αιθυλ]αμινο]μεθυλο]φαινυλο]-2ε-2-προπεναμιδιου
DOP2008000069A (es) Sales de n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]amino]metil]]fenil]-2e-2-propenamida.
DOP2008000068A (es) Polimorfos de n-hidroxi-3[4-[[[2-(2-metil-1h-indol-3-il)etil]amino]metil]fenil]-2e-2-propenamida