SMT201300045B - Processi per la preparazione di composti di amminosolfone - Google Patents
Processi per la preparazione di composti di amminosolfoneInfo
- Publication number
- SMT201300045B SMT201300045B SM201300045T SM201300045T SMT201300045B SM T201300045 B SMT201300045 B SM T201300045B SM 201300045 T SM201300045 T SM 201300045T SM 201300045 T SM201300045 T SM 201300045T SM T201300045 B SMT201300045 B SM T201300045B
- Authority
- SM
- San Marino
- Prior art keywords
- processes
- preparation
- aminosulfone compounds
- aminosulfone
- compounds
- Prior art date
Links
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical class NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9590208P | 2008-09-10 | 2008-09-10 | |
| PCT/US2009/005055 WO2010030345A2 (fr) | 2008-09-10 | 2009-09-09 | Procédés pour la préparation de composés d’aminosulfone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201300045B true SMT201300045B (it) | 2013-07-09 |
Family
ID=41565187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201300045T SMT201300045B (it) | 2008-09-10 | 2013-04-19 | Processi per la preparazione di composti di amminosolfone |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8242310B2 (fr) |
| EP (1) | EP2334639B1 (fr) |
| JP (1) | JP5513508B2 (fr) |
| CN (1) | CN102209709B (fr) |
| CA (1) | CA2736171A1 (fr) |
| DK (1) | DK2334639T3 (fr) |
| ES (1) | ES2404336T3 (fr) |
| HR (1) | HRP20130356T1 (fr) |
| MX (1) | MX2011002589A (fr) |
| MY (1) | MY155424A (fr) |
| PL (1) | PL2334639T3 (fr) |
| PT (1) | PT2334639E (fr) |
| SI (1) | SI2334639T1 (fr) |
| SM (1) | SMT201300045B (fr) |
| WO (1) | WO2010030345A2 (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
| US9532977B2 (en) | 2010-12-16 | 2017-01-03 | Celgene Corporation | Controlled release oral dosage forms of poorly soluble drugs and uses thereof |
| JP6143675B2 (ja) | 2010-12-16 | 2017-06-07 | セルジーン コーポレイション | 難溶性薬物の制御放出経口剤形及びその使用 |
| WO2012097116A2 (fr) | 2011-01-14 | 2012-07-19 | Celgene Corporation | Isotopologues de dérivés d'isoindole |
| JP6022548B2 (ja) | 2011-04-28 | 2016-11-09 | セルジーン コーポレイション | Ｐｄｅ４阻害剤を自己免疫疾患及び炎症性疾患の治療及び管理に使用する方法及び組成物 |
| RU2627471C2 (ru) | 2011-09-14 | 2017-08-08 | Селджин Корпорейшн | Препараты { 2-[(1s)-1-(3-этокси-4-метоксифенил)-2-метансульфонилэтил]-3-оксо-2,3-дигидро-1h-изоиндол-4-ил} амида циклопропанкарбоновой кислоты |
| AR090100A1 (es) * | 2012-02-21 | 2014-10-22 | Celgene Corp | Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina |
| US9126906B2 (en) * | 2012-02-21 | 2015-09-08 | Celgene Corporation | Asymmetric synthetic processes for the preparation of aminosulfone compounds |
| EP2764866A1 (fr) | 2013-02-07 | 2014-08-13 | IP Gesellschaft für Management mbH | Inhibiteurs de l'enzyme activant nedd8 |
| WO2014151180A1 (fr) | 2013-03-14 | 2014-09-25 | Celgene Corporation | Traitement de la polyarthrite psoriasique à l'aide d'apremilast |
| EP3539539B1 (fr) | 2013-06-17 | 2025-11-05 | Amgen (Europe) GmbH | Formulations de comprimés de (+)-2-[1+3-ethoxy-4-méthoxyphényl)-(-2-méthylsulfonyléthyl]-4-acétylaminoisoindoline-1,3-dione |
| ES2751773T3 (es) | 2014-05-15 | 2020-04-01 | Amgen Europe Gmbh | Uso de inhibidores pde4 y combinaciones de los mismos para el tratamiento de la fibrosis quística |
| WO2015175956A1 (fr) | 2014-05-16 | 2015-11-19 | Celgene Corporation | Compositions et procédés de traitement de maladies cardiovasculaires athérosclérotiques à l'aide de modulateurs de pde4 |
| EP2949645A1 (fr) | 2014-05-28 | 2015-12-02 | LEK Pharmaceuticals d.d. | Procédés de préparation de composés ß-aminosulfone |
| MX2016014384A (es) | 2014-06-23 | 2017-01-20 | Celgene Corp | Apremilast para el tratamiento de una enfermedad del higado o una anormalidad en la funcion del higado. |
| US10092541B2 (en) | 2014-08-15 | 2018-10-09 | Celgene Corporation | Methods for the treatment of diseases ameliorated by PDE4 inhibition using dosage titration of apremilast |
| JP2018516912A (ja) * | 2015-05-26 | 2018-06-28 | ルピン・リミテッド | アプレミラストおよびその新規な多形の改善された製造方法 |
| EP3307711A1 (fr) * | 2015-06-09 | 2018-04-18 | Dr. Reddy's Laboratories Ltd. | Procédé de préparation de l'aprémilast et de ses intermédiaires |
| EP3106457A1 (fr) | 2015-06-15 | 2016-12-21 | LEK Pharmaceuticals d.d. | Nouvelle voie synthetique vers l'apremilast |
| EP3144393A1 (fr) | 2015-09-18 | 2017-03-22 | LEK Pharmaceuticals d.d. | Voie synthétique vers l'apremilast |
| EP3356327A1 (fr) | 2015-09-29 | 2018-08-08 | Pliva Hrvatska D.O.O. | Procédés de préparation d'aprémilast, et ses intermédiaires |
| WO2017070291A1 (fr) | 2015-10-21 | 2017-04-27 | Celgene Corporation | Modulateurs de pde4 pour le traitement et la prévention du syndrome inflammatoire de reconstitution immunitaire (iris) |
| EP3373916A1 (fr) | 2015-11-11 | 2018-09-19 | Celgene Corporation | Formes pharmaceutiques orales à libération contrôlée de médicaments faiblement solubles et leurs utilisations |
| US10774041B2 (en) | 2016-04-15 | 2020-09-15 | Davuluri Ramamohan Rao | Process for the preparation of apremilast |
| CN106543050B (zh) * | 2016-09-28 | 2018-04-10 | 中南大学湘雅医院 | 一种阿普斯特中间体的合成工艺 |
| EP3606907B1 (fr) | 2017-04-04 | 2021-01-20 | Quimica Sintetica, S.A. | Composés de bêta-aminosulfone racémiques |
| SI3606908T1 (sl) | 2017-04-04 | 2020-10-30 | Quimica Sintetica, S.A. | Delitev racemičnih beta-aminosulfonskih spojin |
| CN107011209A (zh) * | 2017-05-11 | 2017-08-04 | 蚌埠中实化学技术有限公司 | 一种3‑甲氧基‑4‑乙氧基苯腈的合成新工艺 |
| CN115572248B (zh) * | 2022-11-08 | 2024-04-26 | 中山大学 | 一种制备β-氨基砜类化合物的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8501192D0 (en) * | 1985-01-17 | 1985-02-20 | Boots Co Plc | Therapeutic agents |
| JPH02289584A (ja) * | 1989-02-17 | 1990-11-29 | Takeda Chem Ind Ltd | セファロスポリンγ―ラクトン化合物 |
| EP0731086B1 (fr) * | 1995-03-09 | 1999-04-28 | Ciba SC Holding AG | Procédé de préparation de nitriles aromatiques |
| JPH1087547A (ja) * | 1996-09-13 | 1998-04-07 | Nippon Soda Co Ltd | 光学活性合成中間体の製造法 |
| GB9711650D0 (en) * | 1997-06-05 | 1997-07-30 | Pfizer Ltd | Compounds useful in therapy |
| US6020358A (en) * | 1998-10-30 | 2000-02-01 | Celgene Corporation | Substituted phenethylsulfones and method of reducing TNFα levels |
| BR0317885A (pt) * | 2002-12-30 | 2005-12-06 | Celgene Corp | Composto, isÈmeros s e r enantiomericamente puros do mesmo, composição farmacêutica e métodos de inibir pde4 e mmp, de modular a produção de tnf-alfa, de tratar ou prevenir mds, de tratar doença mieloproliferativa, angiogênese indesejada, câncer, uma doença, inflamação dos pulmões, depressão, distúrbio pulmonar obstrutivo crÈnico, doença inflamatória do intestino, dermatite atópica, psorìase, doença de crohn, artrite reumatóide, asma, eslcerose múltipla e doença cardìaca em um mamìfero e de tratar, prevenir ou controlar a sìndrome de dor regional complexa |
-
2009
- 2009-09-09 EP EP09789280A patent/EP2334639B1/fr active Active
- 2009-09-09 HR HRP20130356AT patent/HRP20130356T1/hr unknown
- 2009-09-09 WO PCT/US2009/005055 patent/WO2010030345A2/fr not_active Ceased
- 2009-09-09 JP JP2011526855A patent/JP5513508B2/ja active Active
- 2009-09-09 PL PL09789280T patent/PL2334639T3/pl unknown
- 2009-09-09 ES ES09789280T patent/ES2404336T3/es active Active
- 2009-09-09 MX MX2011002589A patent/MX2011002589A/es active IP Right Grant
- 2009-09-09 SI SI200930584T patent/SI2334639T1/sl unknown
- 2009-09-09 CN CN200980144555.0A patent/CN102209709B/zh active Active
- 2009-09-09 DK DK09789280.6T patent/DK2334639T3/da active
- 2009-09-09 US US12/556,479 patent/US8242310B2/en active Active
- 2009-09-09 PT PT97892806T patent/PT2334639E/pt unknown
- 2009-09-09 MY MYPI2011001053A patent/MY155424A/en unknown
- 2009-09-09 CA CA2736171A patent/CA2736171A1/fr not_active Abandoned
-
2013
- 2013-04-19 SM SM201300045T patent/SMT201300045B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5513508B2 (ja) | 2014-06-04 |
| MX2011002589A (es) | 2011-04-07 |
| US20100168475A1 (en) | 2010-07-01 |
| EP2334639B1 (fr) | 2013-01-23 |
| HRP20130356T1 (en) | 2013-05-31 |
| SI2334639T1 (sl) | 2013-06-28 |
| CN102209709A (zh) | 2011-10-05 |
| ES2404336T3 (es) | 2013-05-27 |
| CN102209709B (zh) | 2014-08-13 |
| PT2334639E (pt) | 2013-04-26 |
| PL2334639T3 (pl) | 2013-08-30 |
| MY155424A (en) | 2015-10-15 |
| WO2010030345A2 (fr) | 2010-03-18 |
| US8242310B2 (en) | 2012-08-14 |
| HK1159064A1 (en) | 2012-07-27 |
| CA2736171A1 (fr) | 2010-03-18 |
| DK2334639T3 (da) | 2013-05-06 |
| JP2012502097A (ja) | 2012-01-26 |
| WO2010030345A3 (fr) | 2010-05-06 |
| EP2334639A2 (fr) | 2011-06-22 |
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