SMT201400064B - Procedimento per la produzione di acido 2-[(3,5-difluoro-3'-metossi-1,1'-bifenil-4-il) amino] nicotinico - Google Patents
Procedimento per la produzione di acido 2-[(3,5-difluoro-3'-metossi-1,1'-bifenil-4-il) amino] nicotinicoInfo
- Publication number
- SMT201400064B SMT201400064B SM201400064T SM201400064T SMT201400064B SM T201400064 B SMT201400064 B SM T201400064B SM 201400064 T SM201400064 T SM 201400064T SM 201400064 T SM201400064 T SM 201400064T SM T201400064 B SMT201400064 B SM T201400064B
- Authority
- SM
- San Marino
- Prior art keywords
- difluoro
- biphenyl
- methoxy
- amino
- production
- Prior art date
Links
- OMPATGZMNFWVOH-UHFFFAOYSA-N 2-[2,6-difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid Chemical compound COC1=CC=CC(C=2C=C(F)C(NC=3C(=CC=CN=3)C(O)=O)=C(F)C=2)=C1 OMPATGZMNFWVOH-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09382212A EP2314577A1 (fr) | 2009-10-16 | 2009-10-16 | Procédé de fabrication de l'acide 2-[(3,5-difluoro-3'-méthoxy-1,1'-biphényl-4-yl)amino]nicotinique |
| PCT/EP2010/006283 WO2011045059A1 (fr) | 2009-10-16 | 2010-10-14 | Procédé de fabrication d'acide 2-[(3,5-difluoro-3'-méthoxy-1,1'-biphényl-4-yl)amino]nicotinique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201400064B true SMT201400064B (it) | 2014-07-07 |
Family
ID=41402565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201400064T SMT201400064B (it) | 2009-10-16 | 2014-06-03 | Procedimento per la produzione di acido 2-[(3,5-difluoro-3'-metossi-1,1'-bifenil-4-il) amino] nicotinico |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US8598363B2 (fr) |
| EP (2) | EP2314577A1 (fr) |
| JP (1) | JP5809630B2 (fr) |
| KR (1) | KR101699999B1 (fr) |
| CN (2) | CN103936668A (fr) |
| AU (1) | AU2010306098B2 (fr) |
| BR (1) | BR112012008464B1 (fr) |
| CA (1) | CA2776328C (fr) |
| CL (1) | CL2012000739A1 (fr) |
| CO (1) | CO6430508A2 (fr) |
| CR (1) | CR20120185A (fr) |
| CY (1) | CY1115161T1 (fr) |
| DK (1) | DK2488497T3 (fr) |
| EA (1) | EA022805B1 (fr) |
| ES (1) | ES2467165T3 (fr) |
| HR (1) | HRP20140523T1 (fr) |
| IL (1) | IL218446A (fr) |
| IN (1) | IN2012DN01938A (fr) |
| ME (1) | ME01812B (fr) |
| MX (1) | MX2012004033A (fr) |
| MY (1) | MY160308A (fr) |
| NZ (1) | NZ598429A (fr) |
| PE (1) | PE20121173A1 (fr) |
| PH (1) | PH12012500548A1 (fr) |
| PL (1) | PL2488497T3 (fr) |
| PT (1) | PT2488497E (fr) |
| RS (1) | RS53319B (fr) |
| SI (1) | SI2488497T1 (fr) |
| SM (1) | SMT201400064B (fr) |
| UA (1) | UA107811C2 (fr) |
| WO (1) | WO2011045059A1 (fr) |
| ZA (1) | ZA201201563B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
| UY31272A1 (es) * | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
| EP2135610A1 (fr) * | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combinaison comportant des inhibiteurs DHODH et de la méthotrexate |
| EP2239256A1 (fr) | 2009-03-13 | 2010-10-13 | Almirall, S.A. | Sel de sodium de l'acide 5-cyclopropyl-2-{[2-(2,6-difluorophényl)pyrimidin-5-yl]amino}benzoïque en tant qu'inhibiteurs de la DHOD |
| JP7343373B2 (ja) * | 2019-12-02 | 2023-09-12 | 花王株式会社 | 香料組成物 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT837710E (pt) | 1995-06-21 | 2002-05-31 | Sofotec Gmbh & Co Kg | Cartucho de po farmaceutico com dispositivo de doseamento integrado e inalador para medicamentos em po |
| DE19547648A1 (de) | 1995-12-20 | 1997-06-26 | Hoechst Ag | Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate |
| DE19610955A1 (de) | 1996-03-20 | 1997-09-25 | Hoechst Ag | Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid |
| GB9804343D0 (en) | 1998-02-27 | 1998-04-22 | Univ Cardiff | Chemical compounds |
| PL352430A1 (en) | 1999-06-10 | 2003-08-25 | Warner Lambert Co | Method of inhibiting agreggation of amyloid proteins and visualising amyloid deposits |
| EP1381356B1 (fr) | 2001-04-05 | 2008-05-28 | Aventis Pharmaceuticals Inc. | Utilisation de l'acide (z)-2-cyano-3-hydroxy-but-2-enoique-(4'-trifluoromethylphenyl)-amide pour le traitement de la sclerose en plaques |
| PE20030120A1 (es) | 2001-06-19 | 2003-02-12 | Merck & Co Inc | Sal amina de un antagonista de receptor de integrin |
| DE10129703A1 (de) | 2001-06-22 | 2003-01-02 | Sofotec Gmbh & Co Kg | Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren |
| MXPA04000224A (es) | 2001-07-10 | 2005-07-25 | 4Sc Ag | Novedosos compuestos como agentes antiinflamatorios, inmunomoduladores y antiproliferativos. |
| US7258118B2 (en) | 2002-01-24 | 2007-08-21 | Sofotec Gmbh & Co, Kg | Pharmaceutical powder cartridge, and inhaler equipped with same |
| DE10202940A1 (de) | 2002-01-24 | 2003-07-31 | Sofotec Gmbh & Co Kg | Patrone für einen Pulverinhalator |
| KR20040081201A (ko) * | 2002-02-13 | 2004-09-20 | 글락소 그룹 리미티드 | 항정신병제로서 벤젠술폰아미드 유도체 |
| US20070135488A1 (en) * | 2002-04-13 | 2007-06-14 | Chung You S | Amlodipine nicotinate and process for the preparation thereof |
| PE20040844A1 (es) * | 2002-11-26 | 2004-12-30 | Novartis Ag | Acidos fenilaceticos y derivados como inhibidores de la cox-2 |
| EP1581478A1 (fr) | 2002-12-23 | 2005-10-05 | 4Sc Ag | Inhibiteurs de l'enzyme dhodh et leur procede d'identification |
| US7071355B2 (en) | 2002-12-23 | 2006-07-04 | 4 Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| SE0400234D0 (sv) | 2004-02-06 | 2004-02-06 | Active Biotech Ab | New compounds, methods for their preparation and use thereof |
| EP1763346A4 (fr) | 2004-05-21 | 2009-03-04 | Uab Research Foundation | Composition et methodes se rapportant aux inhibiteurs de la synthese de la pyrimidine |
| WO2006022442A1 (fr) | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | Nouveaux derives d’amides heterocycliques ayant une activite d’inhibition de la dihydroorotate deshydrogenase |
| CA2584655A1 (fr) | 2004-10-19 | 2006-04-27 | Aventis Pharmaceuticals Inc. | Emploi du (4'-trifluoromethylphenyl)amide de l'acide (z)-2-cyano-3-hydroxy-but-2-enoique dans le traitement d'affections abdominales inflammatoires |
| ES2265276B1 (es) | 2005-05-20 | 2008-02-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
| CN1696100B (zh) * | 2005-06-01 | 2010-11-24 | 黑龙江福和华星制药集团股份有限公司 | 痤疮治疗药阿达帕林的新型简捷合成方法 |
| ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
| JP5349332B2 (ja) | 2007-02-06 | 2013-11-20 | チェルシー・セラピューティクス，インコーポレイテッド | 新規化合物、その調製方法、およびその使用 |
| UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
| EP2135610A1 (fr) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combinaison comportant des inhibiteurs DHODH et de la méthotrexate |
| EP2210615A1 (fr) | 2009-01-21 | 2010-07-28 | Almirall, S.A. | Combinaisons comportant des inhibiteurs DHODH et de la méthotrexate |
| EP2239256A1 (fr) | 2009-03-13 | 2010-10-13 | Almirall, S.A. | Sel de sodium de l'acide 5-cyclopropyl-2-{[2-(2,6-difluorophényl)pyrimidin-5-yl]amino}benzoïque en tant qu'inhibiteurs de la DHOD |
| EP2230232A1 (fr) | 2009-03-13 | 2010-09-22 | Almirall, S.A. | Sels adjuvants de trométhamine dotés de dérivés d'acide azabiphénylaminobenzoïque en tant qu'inhibiteurs de la DHOD |
| EP2228367A1 (fr) | 2009-03-13 | 2010-09-15 | Almirall, S.A. | Sels adjuvants d'amines contenant des groupes hydroxyle et/ou carbonyle avec des dérivés d'acides aminonicotiques en tant qu'inhibiteurs de la DHODH |
-
2009
- 2009-10-16 EP EP09382212A patent/EP2314577A1/fr not_active Withdrawn
-
2010
- 2010-10-14 PL PL10765586T patent/PL2488497T3/pl unknown
- 2010-10-14 SI SI201030632T patent/SI2488497T1/sl unknown
- 2010-10-14 PT PT107655862T patent/PT2488497E/pt unknown
- 2010-10-14 JP JP2012533527A patent/JP5809630B2/ja active Active
- 2010-10-14 RS RS20140253A patent/RS53319B/sr unknown
- 2010-10-14 ES ES10765586.2T patent/ES2467165T3/es active Active
- 2010-10-14 CN CN201410085756.0A patent/CN103936668A/zh active Pending
- 2010-10-14 BR BR112012008464-0A patent/BR112012008464B1/pt active IP Right Grant
- 2010-10-14 AU AU2010306098A patent/AU2010306098B2/en not_active Ceased
- 2010-10-14 NZ NZ598429A patent/NZ598429A/en unknown
- 2010-10-14 ME MEP-2014-50A patent/ME01812B/me unknown
- 2010-10-14 WO PCT/EP2010/006283 patent/WO2011045059A1/fr not_active Ceased
- 2010-10-14 CN CN201080046816.8A patent/CN102574800B/zh active Active
- 2010-10-14 MX MX2012004033A patent/MX2012004033A/es active IP Right Grant
- 2010-10-14 UA UAA201205649A patent/UA107811C2/ru unknown
- 2010-10-14 HR HRP20140523AT patent/HRP20140523T1/hr unknown
- 2010-10-14 MY MYPI2012001685A patent/MY160308A/en unknown
- 2010-10-14 PE PE2012000491A patent/PE20121173A1/es active IP Right Grant
- 2010-10-14 US US13/501,847 patent/US8598363B2/en active Active
- 2010-10-14 CA CA2776328A patent/CA2776328C/fr active Active
- 2010-10-14 DK DK10765586.2T patent/DK2488497T3/da active
- 2010-10-14 EA EA201200594A patent/EA022805B1/ru unknown
- 2010-10-14 EP EP10765586.2A patent/EP2488497B1/fr active Active
- 2010-10-14 KR KR1020127009609A patent/KR101699999B1/ko active Active
- 2010-10-14 PH PH1/2012/500548A patent/PH12012500548A1/en unknown
-
2012
- 2012-03-01 IL IL218446A patent/IL218446A/en active IP Right Grant
- 2012-03-01 ZA ZA2012/01563A patent/ZA201201563B/en unknown
- 2012-03-05 IN IN1938DEN2012 patent/IN2012DN01938A/en unknown
- 2012-03-23 CL CL2012000739A patent/CL2012000739A1/es unknown
- 2012-04-16 CO CO12061780A patent/CO6430508A2/es active IP Right Grant
- 2012-04-16 CR CR20120185A patent/CR20120185A/es unknown
-
2014
- 2014-06-03 SM SM201400064T patent/SMT201400064B/xx unknown
- 2014-06-06 CY CY20141100405T patent/CY1115161T1/el unknown
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