SMT202000649T1 - Sistemi di additivi per l'uso nella pegilazione di proteine - Google Patents
Sistemi di additivi per l'uso nella pegilazione di proteineInfo
- Publication number
- SMT202000649T1 SMT202000649T1 SM20200649T SMT202000649T SMT202000649T1 SM T202000649 T1 SMT202000649 T1 SM T202000649T1 SM 20200649 T SM20200649 T SM 20200649T SM T202000649 T SMT202000649 T SM T202000649T SM T202000649 T1 SMT202000649 T1 SM T202000649T1
- Authority
- SM
- San Marino
- Prior art keywords
- additive systems
- protein pegylation
- pegylation
- protein
- additive
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562258644P | 2015-11-23 | 2015-11-23 | |
| EP16816042.2A EP3380487B1 (en) | 2015-11-23 | 2016-11-22 | Additive systems for use in protein pegylation |
| PCT/US2016/063313 WO2017091568A1 (en) | 2015-11-23 | 2016-11-22 | Additive systems for use in protein pegylation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT202000649T1 true SMT202000649T1 (it) | 2021-01-05 |
Family
ID=57589163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM20200649T SMT202000649T1 (it) | 2015-11-23 | 2016-11-22 | Sistemi di additivi per l'uso nella pegilazione di proteine |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10617765B2 (it) |
| EP (2) | EP3789395B1 (it) |
| JP (2) | JP6921821B2 (it) |
| KR (1) | KR102688003B1 (it) |
| CN (2) | CN108350025B (it) |
| CY (1) | CY1123699T1 (it) |
| DK (1) | DK3380487T3 (it) |
| ES (2) | ES2827776T3 (it) |
| HR (1) | HRP20201832T1 (it) |
| HU (1) | HUE052634T2 (it) |
| LT (1) | LT3380487T (it) |
| PL (1) | PL3380487T3 (it) |
| PT (1) | PT3380487T (it) |
| RS (1) | RS61072B1 (it) |
| SI (1) | SI3380487T1 (it) |
| SM (1) | SMT202000649T1 (it) |
| WO (1) | WO2017091568A1 (it) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT202000649T1 (it) * | 2015-11-23 | 2021-01-05 | Bristol Myers Squibb Co | Sistemi di additivi per l'uso nella pegilazione di proteine |
| KR20210057124A (ko) * | 2018-09-11 | 2021-05-20 | 암브룩스, 인코포레이티드 | 인터류킨-2 폴리펩타이드 접합체 및 그의 용도 |
| CN111484551B (zh) * | 2020-03-19 | 2022-02-11 | 北京翼方生物科技有限责任公司 | 一种聚乙二醇修饰的重组人碱性成纤维细胞生长因子 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19535571A1 (de) | 1995-09-14 | 1997-03-20 | Boehringer Mannheim Gmbh | Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten |
| TW518219B (en) | 1996-04-26 | 2003-01-21 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| EP0885613A1 (de) | 1997-06-21 | 1998-12-23 | Roche Diagnostics GmbH | Verwendung von modifizierten Hämoglobinen zur Behandlung von Anämien und Kombinationspräparate umfassend Erythropoietin und modifiziertes Hämoglobin |
| DE19734293A1 (de) | 1997-08-08 | 1999-02-11 | Boehringer Mannheim Gmbh | Verwendung von pharmazeutischen Kombinationspräparaten enthaltend Erythropoietin und Eisenpräparate zur Behandlung von rheumatischen Erkrankungen |
| DE602005025090D1 (de) * | 2004-03-17 | 2011-01-13 | Anticancer Inc | Methoden zur steigerung der protein polyethylenglykol (peg) konjugation |
| EP1885404A2 (en) * | 2005-06-01 | 2008-02-13 | Alza Corporation | Bioconjugation reactions for acylating polyethlene glycol reagents |
| HRP20110404T1 (hr) * | 2005-11-08 | 2011-08-31 | Ambrx | Ubrzivači za modifikaciju ne-prirodnih aminokiselina i polipeptida ne-prirodnih aminokiselina |
| CA2682147C (en) * | 2007-03-30 | 2017-08-08 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
| CN105102484B (zh) | 2013-01-30 | 2020-03-10 | 艾维拉斯生物科学公司 | 选择性递送分子及使用方法 |
| EP2988786A4 (en) | 2013-04-22 | 2016-12-21 | Avelas Biosciences Inc | COMPOSITIONS FOR SELECTIVE DRUG ADMINISTRATION AND METHOD OF USE |
| MX2017004947A (es) | 2014-10-24 | 2017-06-29 | Bristol Myers Squibb Co | Polipeptidos del factor de crecimiento de fibroblastos 2 (fgf-21) modificados y usos de los mismos. |
| SMT202000649T1 (it) * | 2015-11-23 | 2021-01-05 | Bristol Myers Squibb Co | Sistemi di additivi per l'uso nella pegilazione di proteine |
-
2016
- 2016-11-22 SM SM20200649T patent/SMT202000649T1/it unknown
- 2016-11-22 HU HUE16816042A patent/HUE052634T2/hu unknown
- 2016-11-22 CN CN201680067897.7A patent/CN108350025B/zh active Active
- 2016-11-22 SI SI201630957T patent/SI3380487T1/sl unknown
- 2016-11-22 ES ES16816042T patent/ES2827776T3/es active Active
- 2016-11-22 RS RS20201382A patent/RS61072B1/sr unknown
- 2016-11-22 JP JP2018526713A patent/JP6921821B2/ja active Active
- 2016-11-22 DK DK16816042.2T patent/DK3380487T3/da active
- 2016-11-22 US US15/776,923 patent/US10617765B2/en active Active
- 2016-11-22 HR HRP20201832TT patent/HRP20201832T1/hr unknown
- 2016-11-22 PL PL16816042T patent/PL3380487T3/pl unknown
- 2016-11-22 ES ES20189107T patent/ES3055983T3/es active Active
- 2016-11-22 LT LTEP16816042.2T patent/LT3380487T/lt unknown
- 2016-11-22 PT PT168160422T patent/PT3380487T/pt unknown
- 2016-11-22 EP EP20189107.4A patent/EP3789395B1/en active Active
- 2016-11-22 WO PCT/US2016/063313 patent/WO2017091568A1/en not_active Ceased
- 2016-11-22 EP EP16816042.2A patent/EP3380487B1/en active Active
- 2016-11-22 CN CN202211743414.4A patent/CN115819494A/zh active Pending
- 2016-11-22 KR KR1020187017508A patent/KR102688003B1/ko active Active
-
2020
- 2020-02-21 US US16/797,361 patent/US11213589B2/en active Active
- 2020-11-20 CY CY20201101102T patent/CY1123699T1/el unknown
-
2021
- 2021-07-28 JP JP2021123154A patent/JP7257457B2/ja active Active
- 2021-12-03 US US17/541,636 patent/US20220160883A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RS61072B1 (sr) | 2020-12-31 |
| ES3055983T3 (en) | 2026-02-17 |
| US20220160883A1 (en) | 2022-05-26 |
| JP2021176890A (ja) | 2021-11-11 |
| CN115819494A (zh) | 2023-03-21 |
| PT3380487T (pt) | 2020-10-29 |
| CN108350025A (zh) | 2018-07-31 |
| PL3380487T3 (pl) | 2020-12-28 |
| KR102688003B1 (ko) | 2024-07-23 |
| JP2019503994A (ja) | 2019-02-14 |
| DK3380487T3 (da) | 2020-12-07 |
| EP3789395B1 (en) | 2025-08-27 |
| KR20180081610A (ko) | 2018-07-16 |
| JP7257457B2 (ja) | 2023-04-13 |
| HUE052634T2 (hu) | 2021-05-28 |
| CY1123699T1 (el) | 2022-03-24 |
| US20190351065A1 (en) | 2019-11-21 |
| EP3380487A1 (en) | 2018-10-03 |
| HRP20201832T1 (hr) | 2021-01-08 |
| WO2017091568A8 (en) | 2018-01-04 |
| EP3789395A1 (en) | 2021-03-10 |
| CN108350025B (zh) | 2023-02-21 |
| ES2827776T3 (es) | 2021-05-24 |
| JP6921821B2 (ja) | 2021-08-18 |
| US11213589B2 (en) | 2022-01-04 |
| WO2017091568A1 (en) | 2017-06-01 |
| US20200276319A1 (en) | 2020-09-03 |
| US10617765B2 (en) | 2020-04-14 |
| EP3380487B1 (en) | 2020-09-02 |
| SI3380487T1 (sl) | 2020-11-30 |
| LT3380487T (lt) | 2020-12-28 |
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