SMT202000649T1 - Sistemi di additivi per l'uso nella pegilazione di proteine - Google Patents

Sistemi di additivi per l'uso nella pegilazione di proteine

Info

Publication number
SMT202000649T1
SMT202000649T1 SM20200649T SMT202000649T SMT202000649T1 SM T202000649 T1 SMT202000649 T1 SM T202000649T1 SM 20200649 T SM20200649 T SM 20200649T SM T202000649 T SMT202000649 T SM T202000649T SM T202000649 T1 SMT202000649 T1 SM T202000649T1
Authority
SM
San Marino
Prior art keywords
additive systems
protein pegylation
pegylation
protein
additive
Prior art date
Application number
SM20200649T
Other languages
English (en)
Inventor
Matthew R Hickey
Antonio Ramirez
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SMT202000649T1 publication Critical patent/SMT202000649T1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SM20200649T 2015-11-23 2016-11-22 Sistemi di additivi per l'uso nella pegilazione di proteine SMT202000649T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562258644P 2015-11-23 2015-11-23
EP16816042.2A EP3380487B1 (en) 2015-11-23 2016-11-22 Additive systems for use in protein pegylation
PCT/US2016/063313 WO2017091568A1 (en) 2015-11-23 2016-11-22 Additive systems for use in protein pegylation

Publications (1)

Publication Number Publication Date
SMT202000649T1 true SMT202000649T1 (it) 2021-01-05

Family

ID=57589163

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20200649T SMT202000649T1 (it) 2015-11-23 2016-11-22 Sistemi di additivi per l'uso nella pegilazione di proteine

Country Status (17)

Country Link
US (3) US10617765B2 (it)
EP (2) EP3789395B1 (it)
JP (2) JP6921821B2 (it)
KR (1) KR102688003B1 (it)
CN (2) CN108350025B (it)
CY (1) CY1123699T1 (it)
DK (1) DK3380487T3 (it)
ES (2) ES2827776T3 (it)
HR (1) HRP20201832T1 (it)
HU (1) HUE052634T2 (it)
LT (1) LT3380487T (it)
PL (1) PL3380487T3 (it)
PT (1) PT3380487T (it)
RS (1) RS61072B1 (it)
SI (1) SI3380487T1 (it)
SM (1) SMT202000649T1 (it)
WO (1) WO2017091568A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT202000649T1 (it) * 2015-11-23 2021-01-05 Bristol Myers Squibb Co Sistemi di additivi per l'uso nella pegilazione di proteine
KR20210057124A (ko) * 2018-09-11 2021-05-20 암브룩스, 인코포레이티드 인터류킨-2 폴리펩타이드 접합체 및 그의 용도
CN111484551B (zh) * 2020-03-19 2022-02-11 北京翼方生物科技有限责任公司 一种聚乙二醇修饰的重组人碱性成纤维细胞生长因子

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19535571A1 (de) 1995-09-14 1997-03-20 Boehringer Mannheim Gmbh Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten
TW518219B (en) 1996-04-26 2003-01-21 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
EP0885613A1 (de) 1997-06-21 1998-12-23 Roche Diagnostics GmbH Verwendung von modifizierten Hämoglobinen zur Behandlung von Anämien und Kombinationspräparate umfassend Erythropoietin und modifiziertes Hämoglobin
DE19734293A1 (de) 1997-08-08 1999-02-11 Boehringer Mannheim Gmbh Verwendung von pharmazeutischen Kombinationspräparaten enthaltend Erythropoietin und Eisenpräparate zur Behandlung von rheumatischen Erkrankungen
DE602005025090D1 (de) * 2004-03-17 2011-01-13 Anticancer Inc Methoden zur steigerung der protein polyethylenglykol (peg) konjugation
EP1885404A2 (en) * 2005-06-01 2008-02-13 Alza Corporation Bioconjugation reactions for acylating polyethlene glycol reagents
HRP20110404T1 (hr) * 2005-11-08 2011-08-31 Ambrx Ubrzivači za modifikaciju ne-prirodnih aminokiselina i polipeptida ne-prirodnih aminokiselina
CA2682147C (en) * 2007-03-30 2017-08-08 Ambrx, Inc. Modified fgf-21 polypeptides and their uses
CN105102484B (zh) 2013-01-30 2020-03-10 艾维拉斯生物科学公司 选择性递送分子及使用方法
EP2988786A4 (en) 2013-04-22 2016-12-21 Avelas Biosciences Inc COMPOSITIONS FOR SELECTIVE DRUG ADMINISTRATION AND METHOD OF USE
MX2017004947A (es) 2014-10-24 2017-06-29 Bristol Myers Squibb Co Polipeptidos del factor de crecimiento de fibroblastos 2 (fgf-21) modificados y usos de los mismos.
SMT202000649T1 (it) * 2015-11-23 2021-01-05 Bristol Myers Squibb Co Sistemi di additivi per l'uso nella pegilazione di proteine

Also Published As

Publication number Publication date
RS61072B1 (sr) 2020-12-31
ES3055983T3 (en) 2026-02-17
US20220160883A1 (en) 2022-05-26
JP2021176890A (ja) 2021-11-11
CN115819494A (zh) 2023-03-21
PT3380487T (pt) 2020-10-29
CN108350025A (zh) 2018-07-31
PL3380487T3 (pl) 2020-12-28
KR102688003B1 (ko) 2024-07-23
JP2019503994A (ja) 2019-02-14
DK3380487T3 (da) 2020-12-07
EP3789395B1 (en) 2025-08-27
KR20180081610A (ko) 2018-07-16
JP7257457B2 (ja) 2023-04-13
HUE052634T2 (hu) 2021-05-28
CY1123699T1 (el) 2022-03-24
US20190351065A1 (en) 2019-11-21
EP3380487A1 (en) 2018-10-03
HRP20201832T1 (hr) 2021-01-08
WO2017091568A8 (en) 2018-01-04
EP3789395A1 (en) 2021-03-10
CN108350025B (zh) 2023-02-21
ES2827776T3 (es) 2021-05-24
JP6921821B2 (ja) 2021-08-18
US11213589B2 (en) 2022-01-04
WO2017091568A1 (en) 2017-06-01
US20200276319A1 (en) 2020-09-03
US10617765B2 (en) 2020-04-14
EP3380487B1 (en) 2020-09-02
SI3380487T1 (sl) 2020-11-30
LT3380487T (lt) 2020-12-28

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