SU1131469A3 - Способ получени 4-замещенных производных амино-3-карбэтокси-или 3-циано-1,2-дигидро-2-оксо-1,8-нафтиридина или их солей - Google Patents

Способ получени 4-замещенных производных амино-3-карбэтокси-или 3-циано-1,2-дигидро-2-оксо-1,8-нафтиридина или их солей Download PDF

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Publication number
SU1131469A3
SU1131469A3 SU803220198A SU3220198A SU1131469A3 SU 1131469 A3 SU1131469 A3 SU 1131469A3 SU 803220198 A SU803220198 A SU 803220198A SU 3220198 A SU3220198 A SU 3220198A SU 1131469 A3 SU1131469 A3 SU 1131469A3
Authority
SU
USSR - Soviet Union
Prior art keywords
methyl
oxo
dihydro
piperazinyl
naphthyridine
Prior art date
Application number
SU803220198A
Other languages
English (en)
Russian (ru)
Inventor
К.Скотес Энтони
А.Сантилли Артур
Original Assignee
Американ Хоум Продактс Корпорейшн (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Американ Хоум Продактс Корпорейшн (Фирма) filed Critical Американ Хоум Продактс Корпорейшн (Фирма)
Application granted granted Critical
Publication of SU1131469A3 publication Critical patent/SU1131469A3/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SU803220198A 1979-04-18 1980-12-17 Способ получени 4-замещенных производных амино-3-карбэтокси-или 3-циано-1,2-дигидро-2-оксо-1,8-нафтиридина или их солей SU1131469A3 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3125579A 1979-04-18 1979-04-18
US06/125,600 US4324893A (en) 1979-04-18 1980-02-28 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives

Publications (1)

Publication Number Publication Date
SU1131469A3 true SU1131469A3 (ru) 1984-12-23

Family

ID=26707004

Family Applications (1)

Application Number Title Priority Date Filing Date
SU803220198A SU1131469A3 (ru) 1979-04-18 1980-12-17 Способ получени 4-замещенных производных амино-3-карбэтокси-или 3-циано-1,2-дигидро-2-оксо-1,8-нафтиридина или их солей

Country Status (22)

Country Link
US (1) US4324893A (2)
EP (2) EP0060012B1 (2)
JP (1) JPS56500373A (2)
KR (1) KR840000076B1 (2)
AR (2) AR225437A1 (2)
AU (1) AU531348B2 (2)
CA (1) CA1115272A (2)
DK (1) DK537780A (2)
ES (1) ES490645A0 (2)
FI (1) FI801229A7 (2)
GB (1) GB2053198B (2)
GR (1) GR67253B (2)
HU (1) HU183125B (2)
IE (1) IE49696B1 (2)
IL (1) IL59667A (2)
IN (1) IN150969B (2)
NZ (1) NZ193445A (2)
PH (1) PH16524A (2)
PT (1) PT71081A (2)
SU (1) SU1131469A3 (2)
WO (1) WO1980002287A1 (2)
YU (1) YU105680A (2)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11434248B2 (en) 2017-09-28 2022-09-06 Nanjing Transthera Biosciences Co. Ltd. PDE9 inhibitor and use thereof
RU2793732C2 (ru) * 2017-09-28 2023-04-05 Транстера Сайенсиз (Наньцзин), Инк. Ингибитор pde9 и его применение

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US4420615A (en) * 1981-08-24 1983-12-13 Merck & Co., Inc. Substituted pyridopyrimidines as gastric secretion inhibitors
FR2567520B1 (fr) * 1984-07-11 1987-01-02 Carpibem Nouvelles phenyl-naphthyridines, leur procede de preparation, medicaments les contenant, notamment anti-ulceres
FR2592651B1 (fr) * 1986-01-06 1988-05-13 Carpibem Nouvelles phenyl naphtyridines comportant un substituant methyle en position 3, et les medicaments qui en contiennent.
NZ218773A (en) * 1986-01-06 1990-05-28 Carpibem 3-methyl-2-oxo-1-(substituted phenyl)-naphthyridines and pharmaceutical compositions
FR2592652B1 (fr) * 1986-01-06 1988-04-29 Carpibem Nouvelles phenyl-naphtyridines, leur procede de preparation et les medicaments en contenant.
FR2592649B1 (fr) * 1986-01-06 1988-04-29 Carpibem Cyano et amido phenyl-naphtyridines, leur procede de preparation, medicaments les contenant, notamment anti-ulceres.
FR2592650B1 (fr) * 1986-01-06 1988-04-29 Carpibem Nouvelles phenyl-naphtyridines fonctionnalisees en position-3, leur procede de preparation, medicaments les contenant, notamment anti-ulceres.
NZ218774A (en) * 1986-01-06 1990-06-26 Carpibem 3-substituted phenylnaphthyridines and pharmaceutical compositions
US5037826A (en) * 1986-10-15 1991-08-06 Schering Corporation 1-substituted naphthyridine and pyridopyrazine derivatives
EP0267691A3 (en) * 1986-10-15 1989-08-23 Schering Corporation Use of 1-substituted naphthyridine and pyridopyrazine derivatives for the preparation of medicaments with immunosuppressor activity.
US4916131A (en) * 1986-10-15 1990-04-10 Schering Corporation Naphthyridine derivatives and method for treating allergic reactions
FR2632861B1 (fr) * 1988-06-15 1990-11-09 Sanofi Sa Derives d'amino-4 carboxy-3 quinoleines et naphtyridines, leur procede de preparation et leur application comme medicaments
DK273689A (da) * 1988-06-06 1989-12-07 Sanofi Sa 4-amino-3-carboxyquinoliner og -naphthyridiner, fremgangsmaade til deres fremstilling og anvendelse deraf i laegemidler
FR2632639B1 (fr) * 1988-06-09 1990-10-05 Sanofi Sa Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent
FR2637890B1 (fr) * 1988-09-14 1991-02-01 Europ Propulsion Materiau composite a matrice zircone
GB9318931D0 (en) * 1993-09-14 1993-10-27 Boots Co Plc Therapeutic agents
GB9420168D0 (en) * 1994-10-06 1994-11-23 Boots Co Plc Therapeutic agents
AR029185A1 (es) 1999-10-25 2003-06-18 Yamanouchi Pharma Co Ltd Derivado de naftiridina
MY140679A (en) 2001-05-24 2010-01-15 Avanir Pharmaceuticals Inhibitors of macrohage migration inhibitory factor and methods for identifying the same
KR20020092756A (ko) * 2001-06-05 2002-12-12 이종완 젓갈과 그 제조 방법
TW200418829A (en) 2003-02-14 2004-10-01 Avanir Pharmaceutics Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
EP1610795A4 (en) * 2003-04-07 2007-10-24 Cylene Pharmaceuticals Inc HETEROCYCLIC SUBSTITUTED 1,4-DIHYDRO-4-OXO-1,8-NAPHTHPYRIDINE ANALOGUE
EP1656376A1 (en) * 2003-08-22 2006-05-17 Avanir Pharmaceuticals Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases
EP1861407A1 (en) 2005-03-24 2007-12-05 Avanir Pharmaceuticals Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors
GB0605689D0 (en) * 2006-03-21 2006-05-03 Novartis Ag Organic compounds
PT3814347T (pt) 2018-06-27 2023-07-18 Bristol Myers Squibb Co Compostos de naftiridinona úteis como ativadores de células t
CN112654621B (zh) 2018-06-27 2024-05-14 百时美施贵宝公司 可作为t细胞活化剂的经取代萘啶酮化合物
AR119821A1 (es) 2019-08-28 2022-01-12 Bristol Myers Squibb Co Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t
CN114846007B (zh) 2019-12-23 2024-11-22 百时美施贵宝公司 可用作t细胞激活剂的经取代的喹唑啉基化合物
AR120823A1 (es) 2019-12-23 2022-03-23 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos útiles como activadores de células t
EP4081522A1 (en) 2019-12-23 2022-11-02 Bristol-Myers Squibb Company Substituted piperazine derivatives useful as t cell activators

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* Cited by examiner, † Cited by third party
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CA947301A (en) * 1970-01-28 1974-05-14 Sumitomo Chemical Company Process for the preparation of compound having antibacterial action
CA988522A (en) * 1972-05-05 1976-05-04 Haydn W.R. Williams 1,8-naphthyridine compounds
US3993656A (en) * 1974-11-19 1976-11-23 Merck & Co., Inc. 1,8-Naphthyridine compounds
US4103257A (en) * 1976-05-25 1978-07-25 The United States Of America As Represented By The United States Department Of Energy Azaquinolone dye lasers
US4133885A (en) * 1977-07-18 1979-01-09 Merck & Co., Inc. Substituted naphthyridinones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
1 . Гетероциклические соединени . Под ред. Р. Эльдерфильда. М., Мир, 1965, с. 179. *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11434248B2 (en) 2017-09-28 2022-09-06 Nanjing Transthera Biosciences Co. Ltd. PDE9 inhibitor and use thereof
RU2793732C2 (ru) * 2017-09-28 2023-04-05 Транстера Сайенсиз (Наньцзин), Инк. Ингибитор pde9 и его применение
RU2814498C2 (ru) * 2019-03-15 2024-02-29 Транстера Сайенсиз (Наньцзин), Инк. Кристаллическая форма ингибитора фосфодиэстеразы, способ ее получения и ее применение
RU2852028C2 (ru) * 2019-03-15 2025-12-02 Транстера Сайенсиз (Наньцзин), Инк. Кристаллическая форма ингибитора фосфодиэстеразы, способ ее получения и ее применение
RU2856097C2 (ru) * 2021-04-01 2026-02-11 Транстера Сайенсиз (Наньцзин), Инк. Способ получения ингибитора фосфодиэстеразы

Also Published As

Publication number Publication date
PT71081A (en) 1980-05-01
NZ193445A (en) 1982-09-07
EP0018735B1 (en) 1983-07-27
ES8104286A1 (es) 1981-04-16
GB2053198B (en) 1983-04-07
FI801229A7 (fi) 1981-01-01
KR830002759A (ko) 1983-05-30
GR67253B (2) 1981-06-26
AR227427A1 (es) 1982-10-29
EP0060012B1 (en) 1984-08-29
IE49696B1 (en) 1985-11-27
IL59667A (en) 1983-11-30
KR840000076B1 (ko) 1984-02-08
US4324893A (en) 1982-04-13
HU183125B (en) 1984-04-28
AR225437A1 (es) 1982-03-31
IE800761L (en) 1980-10-18
YU105680A (en) 1983-09-30
DK537780A (da) 1980-12-17
JPS56500373A (2) 1981-03-26
GB2053198A (en) 1981-02-04
AU5751980A (en) 1980-10-23
IN150969B (2) 1983-02-05
PH16524A (en) 1983-11-10
AU531348B2 (en) 1983-08-18
CA1115272A (en) 1981-12-29
WO1980002287A1 (en) 1980-10-30
ES490645A0 (es) 1981-04-16
EP0018735A1 (en) 1980-11-12
EP0060012A1 (en) 1982-09-15

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