SU385444A1 - - Google Patents
Info
- Publication number
- SU385444A1 SU385444A1 SU1680499A SU1680499A SU385444A1 SU 385444 A1 SU385444 A1 SU 385444A1 SU 1680499 A SU1680499 A SU 1680499A SU 1680499 A SU1680499 A SU 1680499A SU 385444 A1 SU385444 A1 SU 385444A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- amino
- imidazoline
- hydroxyalkyl
- substituted
- absolute ether
- Prior art date
Links
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 125000004433 nitrogen atom Chemical group N* 0.000 description 5
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical group C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- -1 2,6-dichlorophenyl Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- 125000002636 imidazolinyl group Chemical group 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000723347 Cinnamomum Species 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 241001024304 Mino Species 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 239000002026 chloroform extract Substances 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 239000012259 ether extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 150000002462 imidazolines Chemical class 0.000 description 1
- 229910052987 metal hydride Inorganic materials 0.000 description 1
- 150000004681 metal hydrides Chemical class 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 1
- 125000005429 oxyalkyl group Chemical group 0.000 description 1
- LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 235000011006 sodium potassium tartrate Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702016290 DE2016290A1 (de) | 1970-04-06 | 1970-04-06 | Substituierte N Hydroxylakyl 2 arylamine) imidazoline (2) und Verfahren zu deren Herstellung |
| SU1638555A SU399127A1 (ru) | 1971-04-01 | Способ получения |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SU385444A1 true SU385444A1 (2) | |
| SU385444A3 SU385444A3 (2) | 1973-05-29 |
Family
ID=25758923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU711680499A SU385444A3 (2) | 1970-04-06 | 1971-04-01 |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU385444A3 (2) |
-
1971
- 1971-04-01 SU SU711680499A patent/SU385444A3/ru active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SU1005655A3 (ru) | Способ получени 3-арилокси-3-фенилпропиламинов или их солей | |
| KR102773538B1 (ko) | 타피나로프의 제조 방법 | |
| JPS59193875A (ja) | イミダゾリン類および関連化合物類並びにそれらの合成 | |
| CZ281655B6 (cs) | Způsob přípravy derivátů 1-fenylimidazolin-2,5-dionu | |
| SU385444A1 (2) | ||
| US10053420B2 (en) | Processes for the preparation of compounds, such as 3-arylbutanals, useful in the synthesis of medetomidine | |
| US5190589A (en) | Compounds and process preparing a substituted or an unsubstituted 4(5)-(ω-aminoalkyl)imidazole | |
| SU645566A3 (ru) | Способ получени пиразолов | |
| SU497772A3 (ru) | Способ получени замещенных 2-фениламино-имидазолинов-(2) | |
| EP0005219B1 (en) | Arylimidazoles, their synthesis and pharmaceutical or veterinary preparations containing them | |
| EP0064820A1 (en) | Substituted imidazole and imidazoline derivatives and their preparation and use | |
| Feuer et al. | Alkyl nitrate nitration of active methylene compounds. VI. Synthesis of. alpha.-nitroalkyl heterocyclics | |
| Médebielle et al. | Tetrakis (dimethylamino) ethylene (TDAE) mediated addition of heterocyclic difluoromethyl anions to heteroaryl aldehydes. A facile synthetic method for new gem-difluorinated alcohols derived from 4-bromo-1-naphthylamine and 8-quinolylamine | |
| Katritzky et al. | The Synthesis and Reactions of 1‐(2‐Propynyl) pyidinium Salts | |
| SU378009A1 (ru) | ВСЕСОЮЗНАЯ ТЕ1ПпО-ТсХШ~.СШ *„Ян«отвка.-№БАМ. Кл. с 07d. 49/34УДК 547.781.3.07 | |
| Beart et al. | Hydroxamic acids. V. The alkylation of O-alkylarylhydroxamic acids | |
| JP5214096B2 (ja) | 新規なビピリジン誘導体 | |
| JPH0662577B2 (ja) | １−メチル−５−ヒドロキシピラゾ−ルの製造法 | |
| PL213564B1 (pl) | Sposób wytwarzania podstawionych pochodnych imidazolu i zwiazki posrednie stosowane w sposobie | |
| SU378010A1 (ru) | Способ получения замещенных n-okcиaлkил-2- ариламиноимидазолинов-(2) | |
| SU399127A1 (ru) | Способ получения | |
| JPS5944313B2 (ja) | インダゾ−ル誘導体の製法 | |
| Oberlander et al. | Synthesis and stereochemistry of benzamidines and acetamidines1 | |
| SU383294A1 (2) | ||
| Rodi et al. | NEW REARRANGEMENTS OF 1, 5-BENZODIAZEPINE-2, 4-DIONES INTO BENZIMIDAZOLONE DERIVATIVES |