SU427513A3 - Способ получения производных пиримидина - Google Patents

Способ получения производных пиримидина

Info

Publication number: SU427513A3
Authority: SU; USSR - Soviet Union
Prior art keywords: amino; methyl; piperazine; pyrimidine derivatives; methanol
Prior art date: 1965-10-22

Application number

SU1335465A

Other languages

English (en)

Russian (ru)

Original Assignee

Иност аиец

Эрнст Швайцер

Иностранна фирма Циба Гейги

Ь. ,

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1965-10-22

Filing date

1966-10-07

Publication date

1974-05-05

1966-10-07 Application filed by Иност аиец, Эрнст Швайцер, Иностранна фирма Циба Гейги, Ь. , filed Critical Иност аиец

1974-05-05 Application granted granted Critical

1974-05-05 Publication of SU427513A3 publication Critical patent/SU427513A3/ru

Links

238000000034 method Methods 0.000 title description 5
229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title description 2
150000003230 pyrimidines Chemical class 0.000 title description 2
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 12
229910052757 nitrogen Inorganic materials 0.000 description 12
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
125000000217 alkyl group Chemical group 0.000 description 5
229910052739 hydrogen Inorganic materials 0.000 description 5
239000001257 hydrogen Substances 0.000 description 5
125000004435 hydrogen atom Chemical group [H]* 0.000 description 5
PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 description 4
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 4
229910052736 halogen Inorganic materials 0.000 description 4
150000002367 halogens Chemical class 0.000 description 4
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
239000000047 product Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
FIMUTBLUWQGTIJ-UHFFFAOYSA-N 4,6-dichloro-2-methylpyrimidine Chemical compound CC1=NC(Cl)=CC(Cl)=N1 FIMUTBLUWQGTIJ-UHFFFAOYSA-N 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
125000003710 aryl alkyl group Chemical group 0.000 description 2
GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 2
239000000203 mixture Substances 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
238000010992 reflux Methods 0.000 description 2
235000011121 sodium hydroxide Nutrition 0.000 description 2
125000001302 tertiary amino group Chemical group 0.000 description 2
125000003396 thiol group Chemical group [H]S* 0.000 description 2
VNFVKWMKVDOSKT-LREBCSMRSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;piperazine Chemical compound C1CNCCN1.OC(=O)[C@H](O)[C@@H](O)C(O)=O VNFVKWMKVDOSKT-LREBCSMRSA-N 0.000 description 1
GVBHCMNXRKOJRH-UHFFFAOYSA-N 2,4,5,6-tetrachloropyrimidine Chemical compound ClC1=NC(Cl)=C(Cl)C(Cl)=N1 GVBHCMNXRKOJRH-UHFFFAOYSA-N 0.000 description 1
-1 6-chloropyrimidyl-4-amino-piperazine Chemical compound 0.000 description 1
241001024304 Mino Species 0.000 description 1
125000003342 alkenyl group Chemical group 0.000 description 1
125000003302 alkenyloxy group Chemical group 0.000 description 1
125000004183 alkoxy alkyl group Chemical group 0.000 description 1
125000003545 alkoxy group Chemical group 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
238000001816 cooling Methods 0.000 description 1
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
238000002955 isolation Methods 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
150000003335 secondary amines Chemical class 0.000 description 1
125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 description 1
239000007858 starting material Substances 0.000 description 1
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

SU1335465A 1965-10-22 1966-10-07 Способ получения производных пиримидина SU427513A3 (ru)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
CH1751468A CH499528A (de)	1965-10-22	1965-10-22	Verfahren zur Herstellung neuer Pyrimidine
CH1463065A CH478816A (de)	1965-10-22	1965-10-22	Verfahren zur Herstellung neuer N,N'-Di-(pyrimidyl-(4)-aminoalkyl)-diazacycloalkanen
CH506368A CH478817A (de)	1965-10-22	1965-10-22	Verfahren zur Herstellung neuer N,N'-Di-(pyrimidyl-(4)-aminoalkyl)-diazacycloalkanen
CH506568A CH478819A (de)	1965-10-22	1965-10-22	Verfahren zur Herstellung neuer N,N'-Di-(pyrimidyl-(4)-aminoalkyl)-diazacycloalkanen
CH506468A CH478818A (de)	1965-10-22	1965-10-22	Verfahren zur Herstellung neuer N,N'-Di-(pyrimidyl-(4)-aminoalkyl)-diazacycloalkanen
CH1133066		1966-08-05

Publications (1)

Publication Number	Publication Date
SU427513A3 true SU427513A3 (ru)	1974-05-05

Family

ID=27543760

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SU1335465A SU427513A3 (ru)	1965-10-22	1966-10-07	Способ получения производных пиримидина
SU1106159A SU436494A3 (ru)	1965-10-22	1966-10-07	Способ получения n,n'-ди[пиpиmидил-

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SU1106159A SU436494A3 (ru)	1965-10-22	1966-10-07	Способ получения n,n'-ди[пиpиmидил-

Country Status (11)

Country	Link
US (1)	US3503963A (2)
BE (1)	BE688660A (2)
BR (1)	BR6683919D0 (2)
CH (5)	CH478819A (2)
DE (1)	DE1670392A1 (2)
FR (3)	FR1500479A (2)
GB (1)	GB1135259A (2)
IL (1)	IL26473A (2)
NL (1)	NL6614961A (2)
SE (1)	SE345273B (2)
SU (2)	SU427513A3 (2)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH485754A (de) *	1966-07-28	1970-02-15	Ciba Geigy	Verfahren zur Herstellung neuer Aminopyrimidine
CN102558155A (zh)	2003-01-14	2012-07-11	阿伦纳药品公司	作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗
WO2004076413A2 (en) *	2003-02-24	2004-09-10	Arena Pharmaceuticals, Inc.	Phenyl- and pyridylpiperidine-derivatives as modulators of glucose metabolism
AR045047A1 (es)	2003-07-11	2005-10-12	Arena Pharm Inc	Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
HRP20090093T3 (en) *	2004-06-04	2009-03-31	Arena Pharmaceuticals Inc.	Substituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
GT200500284A (es) *	2004-10-15	2006-03-27	Aventis Pharma Inc	Pirimidinas como antagonistas del receptor de prostaglandina d2
DOP2006000010A (es)	2005-01-10	2006-07-31	Arena Pharm Inc	Procedimiento para preparar eteres aromáticos
MY148521A (en)	2005-01-10	2013-04-30	Arena Pharm Inc	Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
GEP20104966B (en) *	2005-09-16	2010-04-26	Arena Pharm Inc	Modulators of metabolism and the treatment of disorders related thereto
TW200811147A (en) *	2006-07-06	2008-03-01	Arena Pharm Inc	Modulators of metabolism and the treatment of disorders related thereto
TW200811140A (en) *	2006-07-06	2008-03-01	Arena Pharm Inc	Modulators of metabolism and the treatment of disorders related thereto
CA2786994C (en)	2010-01-27	2018-01-16	Arena Pharmaceuticals, Inc.	Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
MX2013003184A (es)	2010-09-22	2013-06-07	Arena Pharm Inc	Moduladores del receptor gpr119 y el tratamiento de transtornos relacionados con el mismo.
AU2016205361C1 (en)	2015-01-06	2021-04-08	Arena Pharmaceuticals, Inc.	Methods of treating conditions related to the S1P1 receptor
PL3310760T3 (pl)	2015-06-22	2023-03-06	Arena Pharmaceuticals, Inc.	Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
KR20190116416A (ko)	2017-02-16	2019-10-14	아레나 파마슈티칼스, 인크.	원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
AU2019280822A1 (en)	2018-06-06	2021-01-07	Arena Pharmaceuticals, Inc.	Methods of treating conditions related to the S1P1 receptor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB944443A (2) *	1959-09-25	1900-01-01

1965
- 1965-10-22 CH CH506568A patent/CH478819A/de not_active IP Right Cessation
- 1965-10-22 CH CH1751468A patent/CH499528A/de not_active IP Right Cessation
- 1965-10-22 CH CH506368A patent/CH478817A/de not_active IP Right Cessation
- 1965-10-22 CH CH506468A patent/CH478818A/de not_active IP Right Cessation
- 1965-10-22 CH CH1463065A patent/CH478816A/de not_active IP Right Cessation
1966
- 1966-09-07 IL IL26473A patent/IL26473A/en unknown
- 1966-10-07 SU SU1335465A patent/SU427513A3/ru active
- 1966-10-07 SU SU1106159A patent/SU436494A3/ru active
- 1966-10-14 DE DE19661670392 patent/DE1670392A1/de active Pending
- 1966-10-14 FR FR80113A patent/FR1500479A/fr not_active Expired
- 1966-10-17 GB GB46245/66A patent/GB1135259A/en not_active Expired
- 1966-10-21 NL NL6614961A patent/NL6614961A/xx unknown
- 1966-10-21 BE BE688660D patent/BE688660A/xx unknown
- 1966-10-21 BR BR183919/66A patent/BR6683919D0/pt unknown
- 1966-10-21 SE SE14418/66A patent/SE345273B/xx unknown
- 1966-11-30 US US597870A patent/US3503963A/en not_active Expired - Lifetime
1967
- 1967-01-05 FR FR90061A patent/FR6083M/fr not_active Expired
- 1967-01-05 FR FR90062A patent/FR6084M/fr not_active Expired

Also Published As

Publication number	Publication date
FR6084M (2)	1968-06-04
CH478816A (de)	1969-09-30
NL6614961A (2)	1967-04-24
DE1670392A1 (de)	1970-07-16
SU436494A3 (ru)	1974-07-15
CH478817A (de)	1969-09-30
CH478819A (de)	1969-09-30
SE345273B (2)	1972-05-23
IL26473A (en)	1971-08-25
US3503963A (en)	1970-03-31
BE688660A (2)	1967-04-21
FR6083M (2)	1968-06-04
BR6683919D0 (pt)	1973-12-04
FR1500479A (fr)	1967-11-03
CH478818A (de)	1969-09-30
CH499528A (de)	1970-11-30
GB1135259A (en)	1968-12-04

Publication	Publication Date	Title
NO115800B (2)	1968-12-09
SU436494A3 (ru)	1974-07-15	Способ получения n,n'-ди[пиpиmидил-
SU450398A3 (ru)	1974-11-15	Способ получени -арил-2аминоалкоксистиролов
US4792557A (en)	1988-12-20	2,4-diamino-5[4-amino (or dimethylamino)-3,5-dimethoxybenzyl]pyrimidine and antibacterial composition thereof
SU509231A3 (ru)	1976-03-30	Способ получени производныхморфолина
SU826955A3 (ru)	1981-04-30	Способ получения производных аминопропанола или их солей 1
SU772484A3 (ru)	1980-10-15	Способ получени производных бензодиазепинона или их солей
NO313196B1 (no)	2002-08-26	Pyrimidinylpyrazol-derivat, og antitumormiddel inneholdende dette
US3748327A (en)	1973-07-24	Basically substituted 4(3h)-quinazolinone derivatives
IE48979B1 (en)	1985-06-26	Carbazoles
US4122264A (en)	1978-10-24	Pyridine containing morpholines
US2688019A (en)	1954-08-31	6-aryl-2,4-diamino pyrimidines and process of preparing same
US2621182A (en)	1952-12-09	Office
FI61029C (fi)	1982-05-10	Nytt foerfarande foer framstaellning av terapeutiskt anvaendbara dibentso(b e)(1,4)diazepiner
US3940394A (en)	1976-02-24	2-pyrimidinylthio)alkanoic acids, esters, amides and hydrazides
SU428602A3 (ru)	1974-05-15	Способ получения основпозамещенных производных 1
SU609465A3 (ru)	1978-05-30	Способ получени проивзодных бензилпиримидина или их солей
FR2522000A1 (fr)	1983-08-26	Nouvelles thiopyrannopyrimidines, utiles notamment comme agents hypoglycemiants, et leur fabrication
SU1364623A1 (ru)	1988-01-07	Замещенные в 5-положении 5,10-дигидро-11н-дибензо( @ , @ ) (1,4)-диазепин-11-оны или их физиологически совместимые соли с неорганическими или органическими кислотами,про вл ющие противо звенную и подавл ющую секрецию активность
SU504490A3 (ru)	1976-02-25	Способ получени производных теофиллина
US3901887A (en)	1975-08-26	(2-pyrimidinylthio) alkanoic acids, esters, amides and hydrazides
SU549080A3 (ru)	1977-02-28	Способ получени "-(аминоациламинофенил)-ацетамидинов или их солей
SU583742A3 (ru)	1977-12-05	Способ получени дифенилметоксиэтиламинов или их солей
FI80263B (fi)	1990-01-31	Foerfarande foer framstaellning av terapeutiskt anvaendbara aminoetylpyridin- och pyrazinderivat.
US3268533A (en)	1966-08-23	4-aminophenylcyclopropyl ketones