SU618036A3 - Способ получени аминов или их солей - Google Patents

Способ получени аминов или их солей

Info

Publication number
SU618036A3
SU618036A3 SU752159067A SU2159067A SU618036A3 SU 618036 A3 SU618036 A3 SU 618036A3 SU 752159067 A SU752159067 A SU 752159067A SU 2159067 A SU2159067 A SU 2159067A SU 618036 A3 SU618036 A3 SU 618036A3
Authority
SU
USSR - Soviet Union
Prior art keywords
salts
amines
obtaining amines
obtaining
reaction
Prior art date
Application number
SU752159067A
Other languages
English (en)
Inventor
Харшаньи Кальман
Секереш Ласло
Хейа Гергель
Папп Дьюла
Корбонитш Деже
Киш Пал
Original Assignee
Хиноин Дьедьсер Еш Ведьесети Термекек Дьяра Рт (Инопредприятие)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хиноин Дьедьсер Еш Ведьесети Термекек Дьяра Рт (Инопредприятие) filed Critical Хиноин Дьедьсер Еш Ведьесети Термекек Дьяра Рт (Инопредприятие)
Application granted granted Critical
Publication of SU618036A3 publication Critical patent/SU618036A3/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Description

I
Изобретение относитс  к способу получени  новых, не описанных в литературе аминов итга их сопей, которые обладают биологической активностью и могут найти применение в медицине.
Известно получение простых эфиров из спиртов под действием минеральных кислот ij.
Целью предлагаемого изобретени   вл етс  синтез новых соединений, расшир ющих арсенал средств воздействи  на живой организм.
Поставленна  цепь достигаетс  способом , основанным на известной реакции
Согласно изобретению описьтаетс  способ получени  аминов общей формулы
Ас - О - СН2 - CHj-lIH - CII I
В
где Ас - бензоидгруппа, защищенна  двум  или трем  низщими алкоксигруппами;
А и В вместе образуют циклоалкил- группу с 3-7 атомами углерода.
или их солей, заключающийс  в том, что соединение общей формулы
АС-Т|Г-СН2-СН.,-ОН
5СН
/ А ВIT
где ACjA и В имеют вышеуказанные значени ,
10подвергают перегруппировке с помощью
газообразного хлористого водорода в органическом растворителе при температуре от комнатной до температуры, кипени  реакционной среды.
15В качестве органического растворител  используют преимущественно этип- ацетат. Процесс провод т так, что в реакционную смесь, котора  образовалась при реакции аминоспирта формулы
20А
CH-lfH-(CH2)n-OH
Б
и галогенида кислоты в присутствии средства дл  св зывани  кислоты (напри
SU752159067A 1972-04-28 1975-07-23 Способ получени аминов или их солей SU618036A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI1231A HU165022B (ru) 1972-04-28 1972-04-28

Publications (1)

Publication Number Publication Date
SU618036A3 true SU618036A3 (ru) 1978-07-30

Family

ID=10994439

Family Applications (4)

Application Number Title Priority Date Filing Date
SU1914706A SU539521A3 (ru) 1972-04-28 1973-04-27 Способ получени аминоэфиров или их солей
SU752159067A SU618036A3 (ru) 1972-04-28 1975-07-23 Способ получени аминов или их солей
SU752162230A SU621314A3 (ru) 1972-04-28 1975-07-25 Способ получени аминов или их солей
SU752162236A SU650499A3 (ru) 1972-04-28 1975-07-25 Способ получени аминоэфиров или их солей

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SU1914706A SU539521A3 (ru) 1972-04-28 1973-04-27 Способ получени аминоэфиров или их солей

Family Applications After (2)

Application Number Title Priority Date Filing Date
SU752162230A SU621314A3 (ru) 1972-04-28 1975-07-25 Способ получени аминов или их солей
SU752162236A SU650499A3 (ru) 1972-04-28 1975-07-25 Способ получени аминоэфиров или их солей

Country Status (21)

Country Link
US (1) US4010193A (ru)
JP (1) JPS4954342A (ru)
AR (2) AR203010A1 (ru)
AT (1) AT336586B (ru)
BE (1) BE798811A (ru)
BG (1) BG22808A3 (ru)
CA (1) CA985689A (ru)
CH (4) CH589603A5 (ru)
DD (1) DD107904A5 (ru)
DE (1) DE2320378A1 (ru)
EG (1) EG11264A (ru)
ES (4) ES414148A1 (ru)
FR (1) FR2183013B1 (ru)
GB (1) GB1426514A (ru)
HU (1) HU165022B (ru)
IL (1) IL42101A (ru)
IN (1) IN139005B (ru)
NL (1) NL7305829A (ru)
NO (1) NO137892C (ru)
PL (2) PL96117B1 (ru)
SU (4) SU539521A3 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5451244A (en) * 1977-09-30 1979-04-21 Sugiaki Kusatake Cover for colored earth surface portion buried frame
US4619938A (en) * 1984-03-21 1986-10-28 Terumo Kabushiki Kaisha Fatty acid derivatives of aminoalkyl nicotinic acid esters and platelet aggregation inhibitors
US5162344A (en) * 1987-05-04 1992-11-10 Robert Koch Procaine double salt complexes
US5254686A (en) * 1987-05-04 1993-10-19 Robert Koch Procaine double salt complexes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2339914A (en) * 1940-11-29 1944-01-25 Sharp & Dohme Inc Chemical compound
US2421129A (en) * 1944-06-22 1947-05-27 Oradent Chemical Co Inc Beta-isobutyl amino-beta, betadimethyl, ethyl benzoate
US2606205A (en) * 1946-07-09 1952-08-05 Wm S Merrell Co Dihalogen benzoic acid esters of amino alcohols
US2767207A (en) * 1953-10-30 1956-10-16 Mizzy Inc Beta (n-propylamino)beta, beta-dimethyl ethyl benzoate and its water-soluble salts
US2831016A (en) * 1954-05-27 1958-04-15 Univ Missouri beta-substituted aminoalkyl 2,6-dialkylsubstituted benzoates and method of making the same
NL216318A (ru) * 1957-04-13
US2971018A (en) * 1958-04-08 1961-02-07 Seymour L Shapiro Quaternary ammonium salts of (2-diethylamino-1-phenylethyl) benzoates

Also Published As

Publication number Publication date
ES441244A1 (es) 1977-04-01
SU539521A3 (ru) 1976-12-15
NO137892C (no) 1978-05-24
CH589603A5 (ru) 1977-07-15
GB1426514A (en) 1976-03-03
JPS4954342A (ru) 1974-05-27
ES441243A1 (es) 1977-03-16
PL96131B1 (pl) 1977-12-31
BG22808A3 (bg) 1977-04-20
FR2183013B1 (ru) 1976-07-02
IL42101A (en) 1977-07-31
DD107904A5 (ru) 1974-08-20
NL7305829A (ru) 1973-10-30
FR2183013A1 (ru) 1973-12-14
ES441242A1 (es) 1977-04-01
DE2320378A1 (de) 1973-11-08
ATA348973A (de) 1976-09-15
BE798811A (fr) 1973-08-16
PL96117B1 (pl) 1977-12-31
ES414148A1 (es) 1976-06-16
AR203010A1 (es) 1975-08-08
IN139005B (ru) 1976-04-24
CH589601A5 (ru) 1977-07-15
AT336586B (de) 1977-05-10
CA985689A (en) 1976-03-16
AR199361A1 (es) 1974-08-23
US4010193A (en) 1977-03-01
IL42101A0 (en) 1973-08-29
EG11264A (en) 1977-12-31
SU621314A3 (ru) 1978-08-25
SU650499A3 (ru) 1979-02-28
HU165022B (ru) 1974-06-28
CH590207A5 (ru) 1977-07-29
AU5490973A (en) 1974-10-31
CH589602A5 (ru) 1977-07-15
NO137892B (no) 1978-02-06

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