SU624562A3 - Способ получени вещества, обладающего гормональным действием - Google Patents

Способ получени вещества, обладающего гормональным действием

Info

Publication number: SU624562A3
Authority: SU; USSR - Soviet Union
Prior art keywords: substance; solution; aqueous; powder; water
Prior art date: 1971-08-04

Application number

SU721818168A

Other languages

English (en)

Russian (ru)

Inventor

Фойер Ласло

Original Assignee

Хиноин Дьедьсер-Еш Ведьесети Термекек Дьяра Рт, (Инопредприятие)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-08-04

Filing date

1972-08-03

Publication date

1978-09-15

1972-08-03 Application filed by Хиноин Дьедьсер-Еш Ведьесети Термекек Дьяра Рт, (Инопредприятие) filed Critical Хиноин Дьедьсер-Еш Ведьесети Термекек Дьяра Рт, (Инопредприятие)

1978-09-15 Application granted granted Critical

1978-09-15 Publication of SU624562A3 publication Critical patent/SU624562A3/ru

Links

238000000034 method Methods 0.000 title claims description 9
239000000126 substance Substances 0.000 title description 17
230000003054 hormonal effect Effects 0.000 title description 3
230000001747 exhibiting effect Effects 0.000 title 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims description 10
102000004169 proteins and genes Human genes 0.000 claims description 8
108090000623 proteins and genes Proteins 0.000 claims description 8
239000000284 extract Substances 0.000 claims description 6
238000000605 extraction Methods 0.000 claims description 6
239000007787 solid Substances 0.000 claims description 4
229920001184 polypeptide Polymers 0.000 claims description 3
238000001556 precipitation Methods 0.000 claims description 3
102000004196 processed proteins & peptides Human genes 0.000 claims description 3
108090000765 processed proteins & peptides Proteins 0.000 claims description 3
239000002245 particle Substances 0.000 claims 1
238000000746 purification Methods 0.000 claims 1
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 20
239000000243 solution Substances 0.000 description 15
239000000843 powder Substances 0.000 description 13
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
210000004907 gland Anatomy 0.000 description 8
239000000203 mixture Substances 0.000 description 8
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
235000008504 concentrate Nutrition 0.000 description 6
239000012141 concentrate Substances 0.000 description 6
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
239000007864 aqueous solution Substances 0.000 description 5
238000000502 dialysis Methods 0.000 description 5
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
239000006286 aqueous extract Substances 0.000 description 4
239000008346 aqueous phase Substances 0.000 description 4
229940088623 biologically active substance Drugs 0.000 description 4
238000002523 gelfiltration Methods 0.000 description 4
239000002244 precipitate Substances 0.000 description 4
238000002360 preparation method Methods 0.000 description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
238000004108 freeze drying Methods 0.000 description 3
239000011521 glass Substances 0.000 description 3
210000002990 parathyroid gland Anatomy 0.000 description 3
239000012071 phase Substances 0.000 description 3
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
229920005654 Sephadex Polymers 0.000 description 2
239000012507 Sephadex™ Substances 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
229960000583 acetic acid Drugs 0.000 description 2
239000013543 active substance Substances 0.000 description 2
OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 2
239000004202 carbamide Substances 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
238000004587 chromatography analysis Methods 0.000 description 2
239000002537 cosmetic Substances 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
239000003480 eluent Substances 0.000 description 2
235000013861 fat-free Nutrition 0.000 description 2
239000000945 filler Substances 0.000 description 2
238000009472 formulation Methods 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
235000014666 liquid concentrate Nutrition 0.000 description 2
FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 2
239000002674 ointment Substances 0.000 description 2
238000000926 separation method Methods 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
239000003826 tablet Substances 0.000 description 2
WXHLLJAMBQLULT-UHFFFAOYSA-N 2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-n-(2-methyl-6-sulfanylphenyl)-1,3-thiazole-5-carboxamide;hydrate Chemical compound O.C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1S WXHLLJAMBQLULT-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
241000694440 Colpidium aqueous Species 0.000 description 1
206010015150 Erythema Diseases 0.000 description 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
241000233866 Fungi Species 0.000 description 1
IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 1
206010039710 Scleroderma Diseases 0.000 description 1
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
208000021386 Sjogren Syndrome Diseases 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000032683 aging Effects 0.000 description 1
238000013019 agitation Methods 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 description 1
229940106681 chloroacetic acid Drugs 0.000 description 1
238000011281 clinical therapy Methods 0.000 description 1
229940110456 cocoa butter Drugs 0.000 description 1
235000019868 cocoa butter Nutrition 0.000 description 1
239000006071 cream Substances 0.000 description 1
238000005238 degreasing Methods 0.000 description 1
230000008021 deposition Effects 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
231100000321 erythema Toxicity 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
239000012467 final product Substances 0.000 description 1
239000012634 fragment Substances 0.000 description 1
208000001130 gallstones Diseases 0.000 description 1
239000007789 gas Substances 0.000 description 1
239000012362 glacial acetic acid Substances 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
239000012299 nitrogen atmosphere Substances 0.000 description 1
239000003883 ointment base Substances 0.000 description 1
230000010494 opalescence Effects 0.000 description 1
230000000849 parathyroid Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
239000000047 product Substances 0.000 description 1
230000005855 radiation Effects 0.000 description 1
238000005185 salting out Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
SQGYOTSLMSWVJD-UHFFFAOYSA-N silver nitrate Substances [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 1
229910001961 silver nitrate Inorganic materials 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000005507 spraying Methods 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000011146 sterile filtration Methods 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
235000013619 trace mineral Nutrition 0.000 description 1
239000011573 trace mineral Substances 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Birds (AREA)
Zoology (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Developmental Biology & Embryology (AREA)
Oral & Maxillofacial Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Cosmetics (AREA)
Medicinal Preparation (AREA)

SU721818168A 1971-08-04 1972-08-03 Способ получени вещества, обладающего гормональным действием SU624562A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HUCI1146A HU169462B (2)	1971-08-04	1971-08-04

Publications (1)

Publication Number	Publication Date
SU624562A3 true SU624562A3 (ru)	1978-09-15

Family

ID=10994410

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SU721818168A SU624562A3 (ru)	1971-08-04	1972-08-03	Способ получени вещества, обладающего гормональным действием

Country Status (27)

Country	Link
JP (1)	JPS5416565B2 (2)
AR (1)	AR199086A1 (2)
AT (1)	AT318802B (2)
AU (1)	AU476825B2 (2)
BE (1)	BE786911A (2)
CA (1)	CA996026A (2)
CH (1)	CH609704A5 (2)
CS (1)	CS180062B1 (2)
DD (2)	DD99307A1 (2)
DE (1)	DE2234832C2 (2)
DK (1)	DK134509B (2)
EG (1)	EG10643A (2)
ES (1)	ES405274A1 (2)
FI (1)	FI51429C (2)
FR (1)	FR2150719B1 (2)
GB (1)	GB1404225A (2)
HU (1)	HU169462B (2)
IL (1)	IL39924A (2)
IN (1)	IN138815B (2)
NL (1)	NL173357C (2)
NO (1)	NO138852C (2)
PL (1)	PL82013B1 (2)
RO (1)	RO62452A (2)
SE (1)	SE416266B (2)
SU (1)	SU624562A3 (2)
YU (1)	YU35450B (2)
ZA (1)	ZA724904B (2)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2517028A1 (de) *	1971-08-04	1975-11-20	Chinoin Gyogyszer Es Vegyeszet	Verfahren zur isolierung von gamma- l-glutamyltaurin
JPS5076516A (2) *	1973-11-12	1975-06-23
JPS543205B2 (2) *	1973-12-28	1979-02-20
IL47149A (en) *	1974-04-29	1979-05-31	Chinoin Gyogyszer Es Vegyeszet	Amino acid derivatives,their preparation and pharmaceutical compositions containing them
JPS5144219A (en) *	1974-10-14	1976-04-15	Japan Servo	Musatsushidendokino kaitenseigyosochi
JPS5750437B2 (2) *	1974-12-28	1982-10-27
JPS5238315U (2) *	1975-09-11	1977-03-18

1971
- 1971-08-04 HU HUCI1146A patent/HU169462B/hu unknown
1972
- 1972-07-15 DE DE2234832A patent/DE2234832C2/de not_active Expired
- 1972-07-17 ZA ZA724904A patent/ZA724904B/xx unknown
- 1972-07-17 IL IL39924A patent/IL39924A/en unknown
- 1972-07-21 AU AU44839/72A patent/AU476825B2/en not_active Expired
- 1972-07-28 ES ES405274A patent/ES405274A1/es not_active Expired
- 1972-07-28 BE BE786911A patent/BE786911A/xx not_active IP Right Cessation
- 1972-07-31 YU YU1978/72A patent/YU35450B/xx unknown
- 1972-08-01 DD DD164796A patent/DD99307A1/xx unknown
- 1972-08-01 CA CA148,391A patent/CA996026A/en not_active Expired
- 1972-08-01 DD DD168077*A patent/DD101814A1/xx unknown
- 1972-08-01 SE SE7210027A patent/SE416266B/sv unknown
- 1972-08-01 AT AT662272A patent/AT318802B/de not_active IP Right Cessation
- 1972-08-02 FR FR7227814A patent/FR2150719B1/fr not_active Expired
- 1972-08-02 FI FI722154A patent/FI51429C/fi active
- 1972-08-02 EG EG314/72A patent/EG10643A/xx active
- 1972-08-02 PL PL1972157074A patent/PL82013B1/pl unknown
- 1972-08-03 JP JP7798972A patent/JPS5416565B2/ja not_active Expired
- 1972-08-03 SU SU721818168A patent/SU624562A3/ru active
- 1972-08-03 NL NLAANVRAGE7210648,A patent/NL173357C/xx not_active IP Right Cessation
- 1972-08-03 NO NO722758A patent/NO138852C/no unknown
- 1972-08-03 DK DK382572AA patent/DK134509B/da not_active IP Right Cessation
- 1972-08-03 CH CH1149972A patent/CH609704A5/xx not_active IP Right Cessation
- 1972-08-03 AR AR243415A patent/AR199086A1/es active
- 1972-08-04 GB GB3660872A patent/GB1404225A/en not_active Expired
- 1972-08-04 CS CS7200005460A patent/CS180062B1/cs unknown
- 1972-08-04 RO RO7200071859A patent/RO62452A/ro unknown
1973
- 1973-05-22 IN IN1198/CAL/73A patent/IN138815B/en unknown

Also Published As

Publication number	Publication date
EG10643A (en)	1976-05-31
DK134509B (da)	1976-11-22
ZA724904B (en)	1973-06-27
SE416266B (sv)	1980-12-15
NO138852C (no)	1978-11-22
YU35450B (en)	1981-02-28
HU169462B (2)	1976-11-28
ES405274A1 (es)	1975-07-01
AT318802B (de)	1974-11-25
IN138815B (2)	1976-04-03
NL7210648A (2)	1973-02-06
FR2150719B1 (2)	1975-10-31
DE2234832A1 (de)	1973-04-05
FR2150719A1 (2)	1973-04-13
JPS4828607A (2)	1973-04-16
DD101814A1 (2)	1973-11-20
AU476825B2 (en)	1976-10-07
CH609704A5 (2)	1979-03-15
DE2234832C2 (de)	1986-02-13
AR199086A1 (es)	1974-08-08
DD99307A1 (2)	1973-08-13
IL39924A0 (en)	1972-09-28
FI51429B (2)	1976-09-30
NO138852B (no)	1977-08-14
NL173357B (nl)	1983-08-16
BE786911A (fr)	1972-11-16
JPS5416565B2 (2)	1979-06-23
RO62452A (fr)	1978-02-15
CS180062B1 (en)	1977-12-30
AU4483972A (en)	1974-02-21
IL39924A (en)	1976-09-30
CA996026A (en)	1976-08-31
FI51429C (fi)	1977-01-10
NL173357C (nl)	1984-01-16
GB1404225A (en)	1975-08-28
YU197872A (en)	1980-06-30
PL82013B1 (en)	1975-10-31
DK134509C (2)	1977-04-25

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US3973001A (en)	1976-08-03	Tissue cell stimulating blood extracts
EP0069232A2 (en)	1983-01-12	Pharmaceutical composition comprising phenyl acetyl glutamine,a combination of this compound with phenylacetic acid or 3-(phenylacetylamino)piperidine-2,6-dione,a process for isolating the latter from urine and a process for the synthesis of 3-(phenylacetylamino)piperidine-2,6-dione
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WO2006111060A1 (fr)	2006-10-26	Procede permettant d’isoler et de purifier un polypeptide immuno-modulant a partir du placenta de vache
SU638243A3 (ru)	1978-12-15	Способ очистки гамма- -глутамилтаурина
GOSS et al.	1940	Further studies on the purification of mare gonadotropic hormone
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RU2033796C1 (ru)	1995-04-30	Пептидсодержащая фракция из селезенки млекопитающих, обладающая иммуностимулирующей активностью и способ ее получения
US4169139A (en)	1979-09-25	Glyco/proteinaceous materials derivable from beef liver and other tissues useful for the treatment of toxic and allergic conditions
US4001396A (en)	1977-01-04	Hormonal product extracted from parathyroid gland and process for the preparation thereof
US4228068A (en)	1980-10-14	Peptide complexes of DNA-containing organisms
SU934589A1 (ru)	1985-06-30	Способ получени полипептидов
SU871721A3 (ru)	1981-10-07	Способ получени биологически активного вещества,обладающего способностью усиливать секрецию инсулина и улучшать глюкозную толерантность
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US4908206A (en)	1990-03-13	Extracts of embryonic organs, process for their preparation and pharmaceutical preparation containing them
US4226884A (en)	1980-10-07	L-gamma-glutamyl-taurine as extracted from parathyroid gland and method of treatment using same
IL39924A (en)	1976-09-30	Hormone isolated from the parathyroid gland,its preparation and compositions containing it
JPS6346760B2 (2)	1988-09-19
SU581842A3 (ru)	1977-11-25	Способ получени антигенов
JPH0347200A (ja)	1991-02-28	マカラスムギ由来の糖タンパク質、その製造法及びそれを含有する免疫調節剤
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US2892754A (en)	1959-06-30	Process of preparing vitamin b12-intrinsic factor