SU995700A3 - Способ получени терпенов,обладающих антипсориатическим действием - Google Patents
Способ получени терпенов,обладающих антипсориатическим действием Download PDFInfo
- Publication number
- SU995700A3 SU995700A3 SU792771805A SU2771805A SU995700A3 SU 995700 A3 SU995700 A3 SU 995700A3 SU 792771805 A SU792771805 A SU 792771805A SU 2771805 A SU2771805 A SU 2771805A SU 995700 A3 SU995700 A3 SU 995700A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- polypodium
- hexane
- ethanol
- evaporated
- zinn
- Prior art date
Links
- 150000003505 terpenes Chemical class 0.000 title claims abstract description 5
- 235000007586 terpenes Nutrition 0.000 title claims abstract description 5
- 230000000694 effects Effects 0.000 title description 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 241001518143 Polypodium <fern> Species 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims abstract description 5
- 230000002682 anti-psoriatic effect Effects 0.000 claims abstract description 4
- 241001624848 Phlebodium Species 0.000 claims abstract description 3
- 241001362840 Serpocaulon triseriale Species 0.000 claims abstract description 3
- 239000002904 solvent Substances 0.000 claims abstract description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 65
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 38
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 22
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000002244 precipitate Substances 0.000 claims description 8
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 229910052718 tin Inorganic materials 0.000 claims description 6
- 241000244324 Polypodium aureum Species 0.000 claims description 4
- 241000196133 Dryopteris Species 0.000 claims 1
- -1 sedimented Substances 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 abstract description 3
- 238000001704 evaporation Methods 0.000 abstract description 3
- 241000723185 Cyathea Species 0.000 abstract 1
- 241000393483 Dryopteris crassirhizoma Species 0.000 abstract 1
- 241001625037 Phlebodium aureum Species 0.000 abstract 1
- 241000487005 Phlebodium decumanum Species 0.000 abstract 1
- 229940075984 polypodium leucotomos Drugs 0.000 abstract 1
- 238000000638 solvent extraction Methods 0.000 abstract 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 18
- 201000004681 Psoriasis Diseases 0.000 description 15
- 239000000243 solution Substances 0.000 description 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 238000005406 washing Methods 0.000 description 5
- 230000003115 biocidal effect Effects 0.000 description 4
- 238000010828 elution Methods 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 241000191940 Staphylococcus Species 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 229940047766 co-trimoxazole Drugs 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000002178 crystalline material Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000001033 granulometry Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000401 methanolic extract Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 235000021400 peanut butter Nutrition 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES470204A ES470204A1 (es) | 1978-05-24 | 1978-05-24 | Procedimiento de obtencion de terpenos naturales con activi-dad antipsoriatica |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU995700A3 true SU995700A3 (ru) | 1983-02-07 |
Family
ID=8476164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU792771805A SU995700A3 (ru) | 1978-05-24 | 1979-05-23 | Способ получени терпенов,обладающих антипсориатическим действием |
Country Status (34)
| Country | Link |
|---|---|
| JP (1) | JPS59486B2 (pt) |
| AR (1) | AR226999A1 (pt) |
| AT (1) | AT366260B (pt) |
| AU (1) | AU529300B2 (pt) |
| BE (1) | BE872718A (pt) |
| BG (1) | BG34449A3 (pt) |
| CA (1) | CA1122589A (pt) |
| CH (1) | CH642039A5 (pt) |
| CS (1) | CS223879B2 (pt) |
| CU (1) | CU35086A (pt) |
| DE (1) | DE2847836C3 (pt) |
| DK (1) | DK211879A (pt) |
| EG (1) | EG14353A (pt) |
| ES (1) | ES470204A1 (pt) |
| FI (1) | FI64892C (pt) |
| FR (1) | FR2426471A1 (pt) |
| GB (1) | GB2022094B (pt) |
| GR (1) | GR65351B (pt) |
| HU (1) | HU180710B (pt) |
| IE (1) | IE48415B1 (pt) |
| IL (1) | IL57377A (pt) |
| IT (1) | IT7919644A0 (pt) |
| LU (1) | LU81315A1 (pt) |
| MA (1) | MA18443A1 (pt) |
| MX (1) | MX5537E (pt) |
| NL (1) | NL7904063A (pt) |
| NO (1) | NO791704L (pt) |
| NZ (1) | NZ190535A (pt) |
| PL (1) | PL126926B1 (pt) |
| PT (1) | PT68719A (pt) |
| SE (1) | SE7903761L (pt) |
| SU (1) | SU995700A3 (pt) |
| YU (1) | YU121579A (pt) |
| ZA (1) | ZA792540B (pt) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2124363C1 (ru) * | 1996-08-23 | 1999-01-10 | Общество с ограниченной ответственностью "Сибирский богатырь" | Способ лечения дерматологических заболеваний |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES490293A0 (es) * | 1980-04-02 | 1981-04-16 | Conrad Ltd | Un procedimiento de obtencion de un extracto de las fraccio-nes polares de los helechos de la familia polypodiaceae. |
| EP0503208A1 (en) * | 1991-03-08 | 1992-09-16 | Maracuyama International, S.A. | Procedure for obtaining a natural water-soluble extract from the leaves and/or rhizomes of various immunologically active ferns |
| EP0680762B1 (en) * | 1994-05-06 | 2002-08-14 | Especialidades Farmaceuticas Centrum, S.A. | Pharmaceutical composition comprising fern extract(s) for the treatment of neurodegenerative diseases. |
| ES2088770B1 (es) * | 1995-02-23 | 1997-03-16 | Esp Farmaceuticas Centrum Sa | Una composicion farmaceutica con actividad en el tratamiento de disfunciones cognitivas y/o neuroinmunes. |
| ES2068163B1 (es) * | 1994-05-06 | 1995-09-01 | Esp Farmaceuticas Centrum Sa | Procedimiento de obtencion de un extracto vegetal con actividad en el tratamiento de disfunciones cognitivas y/o neuroinmunes. |
| US6228366B1 (en) * | 1998-07-29 | 2001-05-08 | Helsint, S.A.L. | Water-soluble fractions of Phlebodium decumanum and its use as nutritional supplement in AIDS and cancer patients |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3395223A (en) * | 1965-05-13 | 1968-07-30 | Carter Wallace | Fern extract for treating gastric ulcers |
| JPS5464871A (en) * | 1977-10-31 | 1979-05-25 | Nippon Electric Co | Device for firing discharge lamp |
| ES471572A1 (es) * | 1978-07-07 | 1979-01-16 | Conrad Ltd | Procedimiento de obtencion de fraccion polar natural con ac-tividad antipsoriatica |
-
1978
- 1978-05-24 ES ES470204A patent/ES470204A1/es not_active Expired
- 1978-10-11 AR AR274039A patent/AR226999A1/es active
- 1978-10-12 GR GR57430A patent/GR65351B/el unknown
- 1978-10-25 CA CA314,254A patent/CA1122589A/en not_active Expired
- 1978-10-30 PT PT68719A patent/PT68719A/pt unknown
- 1978-11-03 DE DE2847836A patent/DE2847836C3/de not_active Expired
- 1978-12-13 BE BE192279A patent/BE872718A/xx not_active IP Right Cessation
-
1979
- 1979-01-26 IT IT7919644A patent/IT7919644A0/it unknown
- 1979-04-05 MX MX797853U patent/MX5537E/es unknown
- 1979-04-27 SE SE7903761A patent/SE7903761L/xx not_active Application Discontinuation
- 1979-05-21 MA MA18637A patent/MA18443A1/fr unknown
- 1979-05-22 EG EG309/79A patent/EG14353A/xx active
- 1979-05-22 FI FI791616A patent/FI64892C/fi not_active IP Right Cessation
- 1979-05-22 CH CH477679A patent/CH642039A5/de not_active IP Right Cessation
- 1979-05-22 AT AT0375279A patent/AT366260B/de not_active IP Right Cessation
- 1979-05-23 CU CU7935086A patent/CU35086A/es unknown
- 1979-05-23 PL PL1979215804A patent/PL126926B1/pl unknown
- 1979-05-23 HU HU79CO370A patent/HU180710B/hu unknown
- 1979-05-23 BG BG043706A patent/BG34449A3/xx unknown
- 1979-05-23 ZA ZA792540A patent/ZA792540B/xx unknown
- 1979-05-23 LU LU81315A patent/LU81315A1/xx unknown
- 1979-05-23 NO NO791704A patent/NO791704L/no unknown
- 1979-05-23 IL IL57377A patent/IL57377A/xx unknown
- 1979-05-23 SU SU792771805A patent/SU995700A3/ru active
- 1979-05-23 DK DK211879A patent/DK211879A/da not_active Application Discontinuation
- 1979-05-23 NZ NZ190535A patent/NZ190535A/xx unknown
- 1979-05-23 NL NL7904063A patent/NL7904063A/xx not_active Application Discontinuation
- 1979-05-23 CS CS793543A patent/CS223879B2/cs unknown
- 1979-05-23 YU YU01215/79A patent/YU121579A/xx unknown
- 1979-05-23 FR FR7913216A patent/FR2426471A1/fr active Granted
- 1979-05-24 GB GB7918175A patent/GB2022094B/en not_active Expired
- 1979-05-24 JP JP54064870A patent/JPS59486B2/ja not_active Expired
- 1979-05-24 AU AU47381/79A patent/AU529300B2/en not_active Ceased
- 1979-08-08 IE IE974/79A patent/IE48415B1/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2124363C1 (ru) * | 1996-08-23 | 1999-01-10 | Общество с ограниченной ответственностью "Сибирский богатырь" | Способ лечения дерматологических заболеваний |
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