TNSN99080A1 - Composes azapolycycliques condenses a noyau aryle, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Composes azapolycycliques condenses a noyau aryle, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
TNSN99080A1
TNSN99080A1 TNTNSN99080A TNSN99080A TNSN99080A1 TN SN99080 A1 TNSN99080 A1 TN SN99080A1 TN TNSN99080 A TNTNSN99080 A TN TNSN99080A TN SN99080 A TNSN99080 A TN SN99080A TN SN99080 A1 TNSN99080 A1 TN SN99080A1
Authority
TN
Tunisia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
compounds
azapolycyclic compounds
Prior art date
Application number
TNTNSN99080A
Other languages
English (en)
Inventor
Wadsworth Coe Jotham
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN99080A1 publication Critical patent/TNSN99080A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSES DE FORMULE I : DANS LAQUELLE Z REPRESENTE UN GROUPE CH2, C(=0) OU CF2, ET R1, R2 ET R3 REPRESENTENT L'HYDROGENE OU DIVERS RADICAUX. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LEUR PREPARATION, DES INTERMEDIAIRES UTILISES DANS LEUR SYNTHESE, ET DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS DANS LE TRAITEMENT DE TROUBLES NEUROLOGIQUES ET PSYCHOLOGIQUES. DANS LAQUELLE Z REPRESENTE UN GROUPE CH2, C(=0) OU CF2, ET R1, R2 ET R3 REPRESENTENT L'HYDROGENE OU DIVERS RADICAUX. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LEUR PREPARATION, DES INTERMEDIAIRES UTILISES DANS LEUR SYNTHESE, ET DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS DANS LE TRAITEMENT DE TROUBLES NEUROLOGIQUES ET PSYCHOLOGIQUES.
TNTNSN99080A 1998-04-29 1999-04-28 Composes azapolycycliques condenses a noyau aryle, procede pour leur preparation et compositions pharmaceutiques les contenant TNSN99080A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8355698P 1998-04-29 1998-04-29

Publications (1)

Publication Number Publication Date
TNSN99080A1 true TNSN99080A1 (fr) 2005-11-10

Family

ID=22179102

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN99080A TNSN99080A1 (fr) 1998-04-29 1999-04-28 Composes azapolycycliques condenses a noyau aryle, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (41)

Country Link
US (3) US6462035B1 (fr)
EP (1) EP1076650B1 (fr)
JP (1) JP2002513007A (fr)
KR (1) KR100420423B1 (fr)
CN (1) CN1144787C (fr)
AP (1) AP1154A (fr)
AR (1) AR018596A1 (fr)
AT (1) ATE258921T1 (fr)
AU (1) AU749831B2 (fr)
BG (1) BG64556B1 (fr)
BR (1) BR9910058A (fr)
CA (1) CA2330576A1 (fr)
CO (1) CO5021124A1 (fr)
DE (1) DE69914594T2 (fr)
DK (1) DK1076650T3 (fr)
DZ (1) DZ2778A1 (fr)
EA (1) EA003669B1 (fr)
ES (1) ES2213354T3 (fr)
GT (1) GT199900059A (fr)
HR (1) HRP20000731A2 (fr)
HU (1) HUP0103340A3 (fr)
ID (1) ID26700A (fr)
IL (1) IL138917A0 (fr)
IS (1) IS5649A (fr)
MA (1) MA26623A1 (fr)
MY (1) MY133474A (fr)
NO (1) NO317300B1 (fr)
NZ (1) NZ507035A (fr)
OA (1) OA11506A (fr)
PA (1) PA8471301A1 (fr)
PE (1) PE20000435A1 (fr)
PL (1) PL344010A1 (fr)
PT (1) PT1076650E (fr)
SK (1) SK15952000A3 (fr)
TN (1) TNSN99080A1 (fr)
TR (1) TR200003122T2 (fr)
UA (1) UA61991C2 (fr)
UY (1) UY25636A1 (fr)
WO (1) WO1999055680A1 (fr)
YU (1) YU64400A (fr)
ZA (1) ZA992971B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS50069B (sr) * 1997-12-31 2009-01-22 Pfizer Products Inc., Aril kondenzovana azapoliciklična jedinjenja
US6605610B1 (en) 1997-12-31 2003-08-12 Pfizer Inc Aryl fused azapolycyclic compounds
US20010036943A1 (en) * 2000-04-07 2001-11-01 Coe Jotham W. Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines
WO2002085843A2 (fr) 2001-04-20 2002-10-31 Pfizer Products Inc. Procede de preparation d'indenes 1,3-substitues et composes azapolycycliques d'aryle fondus
CA2460118A1 (fr) * 2001-10-31 2003-05-08 Pfizer Products Inc. Agonistes du recepteur d'acetylcholine nicotinique pour traiter les impatiences des membres inferieurs
CN1596263A (zh) 2001-11-30 2005-03-16 辉瑞产品公司 芳基－稠合的氮杂多环化合物
US20060089400A1 (en) * 2002-05-03 2006-04-27 The Vernalis Group Of Companies Novel spiro ketone and carboxylic acid derivatives as specific inhibitors for (po3h2) ser/(po3h2)thr-pro-specific peptidyl-prolylcis/trans-isomerases
US20040224963A1 (en) * 2003-05-09 2004-11-11 Pfizer Inc Pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal
US20040224962A1 (en) * 2003-05-09 2004-11-11 Pfizer Inc Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss
CA2533100A1 (fr) * 2003-07-21 2005-01-27 Pfizer Products Inc. Composes azapolycycliques fusionnes avec aryle
ES2331245T3 (es) * 2003-07-21 2009-12-28 Pfizer Products Inc. Compuestos azapoliciclicos condensados con heteroarilo que reducen la adiccion a la nicotina.
US20050043407A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
EP1824852B1 (fr) * 2004-12-07 2008-05-14 Pfizer Products Incorporated Derives de 1,2,3,3a,8,8a-hexahydro-2,7a-diaza-cyclopenta[a]inden-7-one se liant a des sites de recepteurs nicotiniques neuronaux specifiques de l'acetylcholine, utiles dans la modulation de la fonction cholinergique et dans le traitement de troubles de dependance
US20060210497A1 (en) * 2005-03-18 2006-09-21 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Novel resorcinol derivatives
US20060210498A1 (en) * 2005-03-18 2006-09-21 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Novel resorcinol derivatives for skin
DE102005061426A1 (de) * 2005-12-22 2007-07-05 Grünenthal GmbH Substituierte tricyclische Piperidon-Derivate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687937A (en) * 1970-06-23 1972-08-29 Us Of America The 1,5-methano-3-benzazocine derivatives
JPS4914473A (fr) * 1972-06-09 1974-02-07
JPS4924968A (fr) * 1972-07-01 1974-03-05

Also Published As

Publication number Publication date
OA11506A (en) 2004-05-14
TR200003122T2 (tr) 2001-03-21
JP2002513007A (ja) 2002-05-08
AP1154A (en) 2003-03-27
CA2330576A1 (fr) 1999-11-04
US7122534B2 (en) 2006-10-17
HUP0103340A3 (en) 2002-10-28
KR100420423B1 (ko) 2004-03-04
DE69914594T2 (de) 2004-12-09
GT199900059A (es) 2000-10-11
DK1076650T3 (da) 2004-05-24
EP1076650A1 (fr) 2001-02-21
DE69914594D1 (de) 2004-03-11
US20030008890A1 (en) 2003-01-09
AU749831B2 (en) 2002-07-04
CO5021124A1 (es) 2001-03-27
ZA992971B (en) 2000-10-30
US6706702B2 (en) 2004-03-16
BG64556B1 (bg) 2005-07-29
IL138917A0 (en) 2001-11-25
WO1999055680A1 (fr) 1999-11-04
HRP20000731A2 (en) 2001-06-30
AR018596A1 (es) 2001-11-28
IS5649A (is) 2000-09-29
EA200000996A1 (ru) 2001-06-25
ID26700A (id) 2001-02-01
SK15952000A3 (sk) 2002-06-04
UA61991C2 (en) 2003-12-15
NO317300B1 (no) 2004-10-04
BR9910058A (pt) 2000-12-26
NZ507035A (en) 2003-05-30
HK1036453A1 (en) 2002-01-04
ATE258921T1 (de) 2004-02-15
UY25636A1 (es) 2000-02-23
BG104983A (en) 2001-09-28
PA8471301A1 (es) 2000-09-29
NO20005397D0 (no) 2000-10-26
EP1076650B1 (fr) 2004-02-04
CN1298394A (zh) 2001-06-06
MY133474A (en) 2007-11-30
AP9901524A0 (en) 1999-06-30
PT1076650E (pt) 2004-05-31
CN1144787C (zh) 2004-04-07
KR20010043143A (ko) 2001-05-25
AU2951699A (en) 1999-11-16
NO20005397L (no) 2000-10-26
US20040167149A1 (en) 2004-08-26
ES2213354T3 (es) 2004-08-16
DZ2778A1 (fr) 2005-04-23
YU64400A (sh) 2003-01-31
EA003669B1 (ru) 2003-08-28
HUP0103340A2 (hu) 2002-02-28
MA26623A1 (fr) 2004-12-20
PE20000435A1 (es) 2000-05-26
US6462035B1 (en) 2002-10-08
PL344010A1 (en) 2001-09-24

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