BR9910058A - Compostos azapolicìclicos aril-condensados - Google Patents

Compostos azapolicìclicos aril-condensados

Info

Publication number
BR9910058A
BR9910058A BR9910058-4A BR9910058A BR9910058A BR 9910058 A BR9910058 A BR 9910058A BR 9910058 A BR9910058 A BR 9910058A BR 9910058 A BR9910058 A BR 9910058A
Authority
BR
Brazil
Prior art keywords
compounds
aryl
condensed
azapolycyclic compounds
condensed azapolycyclic
Prior art date
Application number
BR9910058-4A
Other languages
English (en)
Inventor
Jotham Wadsworth Coe
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR9910058A publication Critical patent/BR9910058A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: <B>"COMPOSTOS AZAPOLICìCLICOS ARIL CONDENSADOS"<D>. São reivindicados compostos de fórmula e os seus sais farmaceuticamente aceitáveis, em que R¹, R², R³ e Z são definidos como na especificação, intermediários na síntese de tais compostos, composições farmacêuticas contendo tais composto e métodos para o uso de tais compostos no tratamento de distúrbios neurológicos e psicológicos.
BR9910058-4A 1998-04-29 1999-04-08 Compostos azapolicìclicos aril-condensados BR9910058A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8355698P 1998-04-29 1998-04-29
PCT/IB1999/000617 WO1999055680A1 (en) 1998-04-29 1999-04-08 Aryl fused azapolycyclic compounds

Publications (1)

Publication Number Publication Date
BR9910058A true BR9910058A (pt) 2000-12-26

Family

ID=22179102

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910058-4A BR9910058A (pt) 1998-04-29 1999-04-08 Compostos azapolicìclicos aril-condensados

Country Status (41)

Country Link
US (3) US6462035B1 (pt)
EP (1) EP1076650B1 (pt)
JP (1) JP2002513007A (pt)
KR (1) KR100420423B1 (pt)
CN (1) CN1144787C (pt)
AP (1) AP1154A (pt)
AR (1) AR018596A1 (pt)
AT (1) ATE258921T1 (pt)
AU (1) AU749831B2 (pt)
BG (1) BG64556B1 (pt)
BR (1) BR9910058A (pt)
CA (1) CA2330576A1 (pt)
CO (1) CO5021124A1 (pt)
DE (1) DE69914594T2 (pt)
DK (1) DK1076650T3 (pt)
DZ (1) DZ2778A1 (pt)
EA (1) EA003669B1 (pt)
ES (1) ES2213354T3 (pt)
GT (1) GT199900059A (pt)
HR (1) HRP20000731A2 (pt)
HU (1) HUP0103340A3 (pt)
ID (1) ID26700A (pt)
IL (1) IL138917A0 (pt)
IS (1) IS5649A (pt)
MA (1) MA26623A1 (pt)
MY (1) MY133474A (pt)
NO (1) NO317300B1 (pt)
NZ (1) NZ507035A (pt)
OA (1) OA11506A (pt)
PA (1) PA8471301A1 (pt)
PE (1) PE20000435A1 (pt)
PL (1) PL344010A1 (pt)
PT (1) PT1076650E (pt)
SK (1) SK15952000A3 (pt)
TN (1) TNSN99080A1 (pt)
TR (1) TR200003122T2 (pt)
UA (1) UA61991C2 (pt)
UY (1) UY25636A1 (pt)
WO (1) WO1999055680A1 (pt)
YU (1) YU64400A (pt)
ZA (1) ZA992971B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE386024T1 (de) 1997-12-31 2008-03-15 Pfizer Prod Inc Arylkondensierte azapolycyclische derivate
US6605610B1 (en) * 1997-12-31 2003-08-12 Pfizer Inc Aryl fused azapolycyclic compounds
US20010036943A1 (en) * 2000-04-07 2001-11-01 Coe Jotham W. Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines
CZ20032814A3 (cs) * 2001-04-20 2004-08-18 Pfizeráproductsáinc Způsob přípravy �Ź@@substituovaných indenů a aryl@kondezovaných azapolycyklických sloučenin
BR0213696A (pt) * 2001-10-31 2004-10-26 Pfizer Prod Inc Agonistas do receptor de acetilcolina nicotìnicos no tratamento da sìndrome de pernas inquietas
ATE405574T1 (de) 2001-11-30 2008-09-15 Pfizer Prod Inc Aryl-annellierte azapolyzyklische verbindungen
US20060089400A1 (en) * 2002-05-03 2006-04-27 The Vernalis Group Of Companies Novel spiro ketone and carboxylic acid derivatives as specific inhibitors for (po3h2) ser/(po3h2)thr-pro-specific peptidyl-prolylcis/trans-isomerases
US20040224962A1 (en) * 2003-05-09 2004-11-11 Pfizer Inc Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss
US20040224963A1 (en) * 2003-05-09 2004-11-11 Pfizer Inc Pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal
MXPA06000892A (es) * 2003-07-21 2006-03-30 Pfizer Prod Inc Compuestos azapoliciclicos arilo fusionados.
ES2331245T3 (es) * 2003-07-21 2009-12-28 Pfizer Products Inc. Compuestos azapoliciclicos condensados con heteroarilo que reducen la adiccion a la nicotina.
US20050043407A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
ATE395348T1 (de) * 2004-12-07 2008-05-15 Pfizer Prod Inc 1,2,3,3a;8,8a-hexahydro-2,7a- diazacyclopenta(a)inden-7-onderivate, die sich an neuronale nikotinische acetylcholinspezifische rezeptorstellen binden und zur modulation der cholinergen funktion und zur behandlung von suchterkrankungen eignen
US20060210498A1 (en) * 2005-03-18 2006-09-21 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Novel resorcinol derivatives for skin
US20060210497A1 (en) * 2005-03-18 2006-09-21 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Novel resorcinol derivatives
DE102005061426A1 (de) * 2005-12-22 2007-07-05 Grünenthal GmbH Substituierte tricyclische Piperidon-Derivate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687937A (en) * 1970-06-23 1972-08-29 Us Of America The 1,5-methano-3-benzazocine derivatives
JPS4914473A (pt) * 1972-06-09 1974-02-07
JPS4924968A (pt) * 1972-07-01 1974-03-05

Also Published As

Publication number Publication date
EA003669B1 (ru) 2003-08-28
NZ507035A (en) 2003-05-30
CO5021124A1 (es) 2001-03-27
PT1076650E (pt) 2004-05-31
KR20010043143A (ko) 2001-05-25
OA11506A (en) 2004-05-14
IL138917A0 (en) 2001-11-25
WO1999055680A1 (en) 1999-11-04
MY133474A (en) 2007-11-30
ES2213354T3 (es) 2004-08-16
SK15952000A3 (sk) 2002-06-04
ATE258921T1 (de) 2004-02-15
US7122534B2 (en) 2006-10-17
US20030008890A1 (en) 2003-01-09
HK1036453A1 (en) 2002-01-04
CA2330576A1 (en) 1999-11-04
ID26700A (id) 2001-02-01
DE69914594T2 (de) 2004-12-09
TR200003122T2 (tr) 2001-03-21
PE20000435A1 (es) 2000-05-26
HUP0103340A3 (en) 2002-10-28
DK1076650T3 (da) 2004-05-24
EP1076650A1 (en) 2001-02-21
CN1144787C (zh) 2004-04-07
NO20005397L (no) 2000-10-26
UY25636A1 (es) 2000-02-23
AP9901524A0 (en) 1999-06-30
US6706702B2 (en) 2004-03-16
HRP20000731A2 (en) 2001-06-30
PA8471301A1 (es) 2000-09-29
NO317300B1 (no) 2004-10-04
AP1154A (en) 2003-03-27
US20040167149A1 (en) 2004-08-26
BG64556B1 (bg) 2005-07-29
UA61991C2 (en) 2003-12-15
BG104983A (en) 2001-09-28
NO20005397D0 (no) 2000-10-26
YU64400A (sh) 2003-01-31
DE69914594D1 (de) 2004-03-11
DZ2778A1 (fr) 2005-04-23
CN1298394A (zh) 2001-06-06
AU2951699A (en) 1999-11-16
EA200000996A1 (ru) 2001-06-25
AR018596A1 (es) 2001-11-28
IS5649A (is) 2000-09-29
GT199900059A (es) 2000-10-11
MA26623A1 (fr) 2004-12-20
KR100420423B1 (ko) 2004-03-04
ZA992971B (en) 2000-10-30
TNSN99080A1 (fr) 2005-11-10
JP2002513007A (ja) 2002-05-08
US6462035B1 (en) 2002-10-08
HUP0103340A2 (hu) 2002-02-28
EP1076650B1 (en) 2004-02-04
AU749831B2 (en) 2002-07-04
PL344010A1 (en) 2001-09-24

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL: C07D 221/22, A61K 31/439, A61P 25/00

Ipc: C07D 221/22 (2008.04), A61K 31/439 (2008.04), A61P

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.