TR199800729T2 - Eritmeli ekstrüzyonla hazirlanan siklodekstrin kati karisimlari. - Google Patents

Eritmeli ekstrüzyonla hazirlanan siklodekstrin kati karisimlari.

Info

Publication number
TR199800729T2
TR199800729T2 TR1998/00729T TR9800729T TR199800729T2 TR 199800729 T2 TR199800729 T2 TR 199800729T2 TR 1998/00729 T TR1998/00729 T TR 1998/00729T TR 9800729 T TR9800729 T TR 9800729T TR 199800729 T2 TR199800729 T2 TR 199800729T2
Authority
TR
Turkey
Prior art keywords
melt extrusion
solid mixtures
cyclodextrin
cyclodextrin prepared
prepared
Prior art date
Application number
TR1998/00729T
Other languages
English (en)
Inventor
Elvire Colette Baert Lieven
Peeters Jozef
Verreck Geert
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26139823&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR199800729(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of TR199800729T2 publication Critical patent/TR199800729T2/tr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Bir veya daha çok siklodekstrin ile çözünmeyen bir aktif bilesen içeren kati bir karisim hazirlamak için yöntem olup özelligi, bu yöntemin, aktif bilesenin siklodekstrin tasiyicinin içine yerlestirildigi bir eritmeli ekstrüzyon basamagi içermesidir.
TR1998/00729T 1995-11-23 1996-11-20 Eritmeli ekstrüzyonla hazirlanan siklodekstrin kati karisimlari. TR199800729T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95203219 1995-11-23
US09/081,808 US6365188B1 (en) 1995-11-23 1998-05-20 Solid mixtures of cyclodextrins prepared via meltextrusion

Publications (1)

Publication Number Publication Date
TR199800729T2 true TR199800729T2 (tr) 1998-07-21

Family

ID=26139823

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/00729T TR199800729T2 (tr) 1995-11-23 1996-11-20 Eritmeli ekstrüzyonla hazirlanan siklodekstrin kati karisimlari.

Country Status (16)

Country Link
US (1) US6365188B1 (tr)
EP (1) EP0862463A1 (tr)
JP (1) JP3310299B2 (tr)
CN (1) CN1198655C (tr)
AU (1) AU725204B2 (tr)
BR (1) BR9611562A (tr)
CZ (1) CZ154398A3 (tr)
HU (1) HUP9900730A3 (tr)
IL (1) IL123654A (tr)
NO (1) NO981078L (tr)
NZ (1) NZ322907A (tr)
PL (1) PL189122B1 (tr)
SK (1) SK67298A3 (tr)
TR (1) TR199800729T2 (tr)
WO (1) WO1997018839A1 (tr)
ZA (1) ZA969831B (tr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9900730A3 (en) * 1995-11-23 2001-04-28 Janssen Pharmaceutica Nv Solid mixtures of cyclodextrins prepared via melt-extrusion
KR19990001564A (ko) * 1997-06-16 1999-01-15 유충식 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제
CA2310847C (en) 1997-11-28 2007-03-13 Knoll Aktiengesellschaft Method for producing solvent-free non-crystalline biologically active substances
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
JP3635238B2 (ja) 1998-11-10 2005-04-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｈｉｖの複製を阻害するピリミジン類
US6194395B1 (en) 1999-02-25 2001-02-27 Orthro-Mcneil Pharmaceutical, Inc. Cyclodextrin cladribine formulations
DE19911097A1 (de) * 1999-03-12 2000-09-14 Basf Ag Verfahren zur Herstellung von festen cyclodextrinhaltigen Dosierungsformen
ATE307808T1 (de) 1999-03-24 2005-11-15 Scherer Technologies Inc R P Pharmazeutische formulierungen mit verbesserter löslichkeit in wasser
ES2194723T3 (es) 1999-05-04 2003-12-01 Janssen Pharmaceutica Nv Eteres antifungicos.
FR2803748A1 (fr) * 2000-01-14 2001-07-20 Ethypharm Lab Prod Ethiques Composition d'itraconazole et procede de preparation
ATE414079T1 (de) 2000-03-01 2008-11-15 Janssen Pharmaceutica Nv 2,4-disubstituierte thiazolyl derivate
US6835717B2 (en) * 2000-03-08 2004-12-28 The Johns Hopkins University School Of Medicine β-cyclodextrin compositions, and use to prevent transmission of sexually transmitted diseases
US7276510B2 (en) 2000-05-08 2007-10-02 Janssen Pharmaceutica, Inc. HIV replication inhibitors
US6932861B2 (en) 2000-11-28 2005-08-23 Fmc Corporation Edible PGA coating composition
ITRN20000051A1 (it) 2000-12-22 2002-06-22 Ascor Chimici Srl Metodo e apparecchiatura per formare sferule composite contenenti principi attivi del tipo farmaceutico e/o integratori alimentari o cosmeti
GB0113841D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
EA007717B1 (ru) 2001-08-13 2006-12-29 Янссен Фармацевтика Н.В. 2-амино-4,5-тризамещенные производные тиазолила
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
AU2003218737B2 (en) 2002-03-13 2008-04-10 Janssen Pharmaceutica N.V. Inhibitors of histone deacetylase
ES2306880T3 (es) 2002-03-13 2008-11-16 Janssen Pharmaceutica Nv Derivados de sulfonilamino como inhibidores novedosos de la histona desacetilasa.
CN102702111B (zh) 2002-08-09 2014-12-17 詹森药业有限公司 制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法
PL227577B1 (pl) 2003-02-07 2017-12-29 Janssen Pharmaceutica Nv Zastosowanie pochodnych pirymidyny do wytwarzania leku do zapobiegania zakażeniu wirusem HIV oraz kompozycja farmaceutyczna
CN102503903A (zh) 2003-02-07 2012-06-20 詹森药业有限公司 抑制hiv的1,2,4-三嗪
CL2004000303A1 (es) 2003-02-20 2005-04-08 Tibotec Pharm Ltd Compuestos derivados de pirimidinas y triazinas; proceso de preparacion; composicion farmaceutica; y su uso para inhibir la replicacion del vih.
ES2584183T3 (es) * 2003-03-28 2016-09-26 Ares Trading S.A. Formulaciones de cladribina para suministro mejorado oral y transmucosa
HRP20050925A2 (en) * 2003-03-28 2006-08-31 Ivax Corporation Oral formulations of cladribine
AP2006003517A0 (en) 2003-09-25 2006-02-28 Janssen Pharmaceutica Nv Hiv replication purine derivatives.
US20050118265A1 (en) * 2003-11-28 2005-06-02 Anandi Krishnan Antifungal oral dosage forms and the methods for preparation
PL1781639T3 (pl) 2004-07-28 2012-07-31 Janssen Pharmaceutica Nv Podstawione pochodne indolilo-alkiloaminowe jako nowe inhibitory deacetylazy histonowej
RU2401833C2 (ru) 2004-08-10 2010-10-20 Янссен Фармацевтика Н.В. Производные 1, 2, 4-триазин-6-она, ингибирующие вич
CA2577467C (en) 2004-09-30 2013-05-28 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 5-heterocyclyl pyrimidines
RU2410379C2 (ru) 2004-09-30 2011-01-27 Тиботек Фармасьютикалз Лтд. 5-замещенные пиримидины, ингибирующие вич
US8153640B2 (en) 2004-10-29 2012-04-10 Tibotec Pharmaceuticals Ltd. HIV inhibiting bicyclic pyrimdine derivatives
ES2373820T3 (es) 2005-01-27 2012-02-09 Tibotec Pharmaceuticals Derivados de 2-(4-cianofenilamino)pirimidina que inhiben el vih.
PT1858861E (pt) 2005-03-04 2010-09-16 Tibotec Pharm Ltd 2-(4-cianofenil)-6-hidroxilaminopirimidinas inibidoras do hiv
EP1912626B1 (en) * 2005-08-08 2016-04-13 AbbVie Deutschland GmbH & Co KG Dosage forms with improved bioavailability
US20070082870A1 (en) * 2005-10-11 2007-04-12 Buchanan Charles M Pharmaceutical formulations of cyclodextrins and antifungal azole compounds
JP5247470B2 (ja) 2006-01-19 2013-07-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体
EP1832281A1 (en) * 2006-03-10 2007-09-12 Abbott GmbH & Co. KG Process for producing a solid dispersion of an active ingredient
CA2645959C (en) 2006-03-30 2016-05-17 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 5-(hydroxymethylene and aminomethylene) substituted pyrimidines
EP2004632B1 (en) 2006-03-30 2014-03-12 Janssen R&D Ireland Hiv inhibiting 5-amido substituted pyrimidines
US9006243B2 (en) 2006-12-29 2015-04-14 Janssen R&D Ireland HIV inhibiting 6-substituted pyrimidines
CN106045965A (zh) 2006-12-29 2016-10-26 爱尔兰詹森科学公司 抑制hiv的5,6‑取代的嘧啶类化合物
MX2010011962A (es) * 2008-04-30 2010-11-30 Novartis Ag Proceso continuo para hacer composiciones farmaceuticas.
HRP20131155T1 (hr) 2009-05-07 2014-02-28 Gea Pharma Systems Limited Modul za proizvodnju tableta i postupak kontinuirane proizvodnje tableta
US20120148678A1 (en) 2010-12-08 2012-06-14 Advanced Technologies And Regenerative Medicine, Llc. Sustained release of poorly water soluble active compounds
US10532102B2 (en) 2016-08-19 2020-01-14 Foresee Pharmaceuticals Co., Ltd. Pharmaceutical composition and methods of uses
CN107441504A (zh) * 2017-09-06 2017-12-08 广州中医药大学 番茄红素包合物及其制备方法及番茄红素包合物片剂、胶囊和颗粒
WO2021108022A1 (en) * 2019-11-30 2021-06-03 Dispersol Technologies, Llc Inclusion complexes of pharmaceuticals and cyclic oligomers
CN110898015A (zh) * 2019-12-31 2020-03-24 上海汉维生物医药科技有限公司 一种伊曲康唑制剂的制备方法
CN115317369A (zh) * 2022-08-12 2022-11-11 江苏集萃新型药物制剂技术研究所有限公司 制备固体分散体的装置和方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61152765A (ja) * 1984-12-27 1986-07-11 Nippon Ekishiyou Kk シクロデキストリン類で包接された化合物を含有した合成樹脂製品及びその製造方法
US5009900A (en) * 1989-10-02 1991-04-23 Nabisco Brands, Inc. Glassy matrices containing volatile and/or labile components, and processes for preparation and use thereof
KR100291361B1 (ko) * 1992-10-14 2001-09-17 니뽄 신야쿠 가부시키가이샤 결정상태의전이방법
WO1994011031A1 (fr) 1992-11-10 1994-05-26 Nippon Shinyaku Co., Ltd. Procede de production d'un compose d'encapsulation
FR2705677B1 (fr) * 1993-05-28 1995-08-11 Roquette Freres Micro-granules obtenus par extrusion-sphéronisation contenant une cyclodextrine.
HUP9900730A3 (en) * 1995-11-23 2001-04-28 Janssen Pharmaceutica Nv Solid mixtures of cyclodextrins prepared via melt-extrusion
KR100331529B1 (ko) 1999-06-16 2002-04-06 민경윤 난용성 항진균제의 경구투여용 조성물 및 그의 제조 방법

Also Published As

Publication number Publication date
CZ154398A3 (cs) 1998-08-12
IL123654A0 (en) 1998-10-30
JP3310299B2 (ja) 2002-08-05
AU7694396A (en) 1997-06-11
CN1198655C (zh) 2005-04-27
HUP9900730A2 (hu) 1999-07-28
NO981078L (no) 1998-05-22
ZA969831B (en) 1998-05-22
CN1200677A (zh) 1998-12-02
US6365188B1 (en) 2002-04-02
NO981078D0 (no) 1998-03-11
IL123654A (en) 2001-08-08
BR9611562A (pt) 1999-03-02
JPH11501050A (ja) 1999-01-26
EP0862463A1 (en) 1998-09-09
PL189122B1 (pl) 2005-06-30
NZ322907A (en) 1998-12-23
WO1997018839A1 (en) 1997-05-29
PL326161A1 (en) 1998-08-31
HUP9900730A3 (en) 2001-04-28
SK67298A3 (en) 1998-11-04
AU725204B2 (en) 2000-10-05

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