TR199801846T2 - �ntegrinlere �zg� aktiviteye sahip trisiklik bile�ikler. - Google Patents

�ntegrinlere �zg� aktiviteye sahip trisiklik bile�ikler.

Info

Publication number: TR199801846T2
Authority: TR; Turkey
Prior art keywords: integrin; specific activity; tricyclic compounds; formula; intermediates
Prior art date: 1996-03-20

Application number

TR1998/01846T

Other languages

English (en)

Turkish (tr)

Inventor

Bernard Serge

Carniato Denis

Gourvest Jean-Fran�ois

Teutsch Jean-Georges

Knolle Jochen

Stilz Hans-Ulrich

Wehner Volkmar

C. Bodary Sarah

R.Gadek Thomas

S. Mcdowell Robert

M. Pitti Robert

Original Assignee

Hoechst Marion Roussel

Genentech Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-20

Filing date

1997-03-20

Publication date

1998-12-21

1997-03-20 Application filed by Hoechst Marion Roussel, Genentech Inc. filed Critical Hoechst Marion Roussel

1998-12-21 Publication of TR199801846T2 publication Critical patent/TR199801846T2/xx

Links

150000001875 compounds Chemical class 0.000 title 1
102000006495 integrins Human genes 0.000 title 1
108010044426 integrins Proteins 0.000 title 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/18—Nitrogen atoms not forming part of a nitro radical with hetero atoms attached to said nitrogen atoms, except nitro radicals, e.g. hydrazine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
- C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
- C07C281/12—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being part of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/02—Thiocyanates
- C07C331/04—Thiocyanates having sulfur atoms of thiocyanate groups bound to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/02—Thiocyanates
- C07C331/10—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/02—Thiocyanates
- C07C331/12—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/02—Thiocyanates
- C07C331/14—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
- C07C337/08—Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/516—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of nitrogen-containing compounds to >C = O groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
- C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Physical Education & Sports Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

TR1998/01846T 1996-03-20 1997-03-20 �ntegrinlere �zg� aktiviteye sahip trisiklik bile�ikler. TR199801846T2 (xx)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9603437A FR2746394B1 (fr)	1996-03-20	1996-03-20	Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number	Publication Date
TR199801846T2 true TR199801846T2 (xx)	1998-12-21

Family

ID=9490337

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TR1998/01846T TR199801846T2 (xx)	1996-03-20	1997-03-20	�ntegrinlere �zg� aktiviteye sahip trisiklik bile�ikler.

Country Status (16)

Country	Link
CN (2)	CN1090178C (lt)
AR (1)	AR006317A1 (lt)
CZ (1)	CZ288898A3 (lt)
ES (1)	ES2164337T3 (lt)
FR (1)	FR2746394B1 (lt)
HR (1)	HRP970163A2 (lt)
HU (1)	HUP9902495A3 (lt)
IL (1)	IL126106A0 (lt)
LT (1)	LT4535B (lt)
OA (1)	OA11603A (lt)
PL (1)	PL329034A1 (lt)
PT (1)	PT888292E (lt)
TR (1)	TR199801846T2 (lt)
TW (1)	TW458963B (lt)
YU (1)	YU40898A (lt)
ZA (1)	ZA972393B (lt)

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3044236A1 (de)	1980-11-25	1982-06-16	Hoechst Ag, 6000 Frankfurt	Aminosaeurederivate und verfahren zu ihrer herstellung
DE2937779A1 (de)	1979-09-19	1981-04-09	Hoechst Ag, 6000 Frankfurt	Aminosaeurederivate und verfahren zu ihrer herstellung
FR2487829A2 (fr)	1979-12-07	1982-02-05	Science Union & Cie	Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2503155A2 (fr)	1980-10-02	1982-10-08	Science Union & Cie	Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4350704A (en)	1980-10-06	1982-09-21	Warner-Lambert Company	Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
DE3177130D1 (de)	1980-08-30	1990-01-11	Hoechst Ag	Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung.
US4344949A (en)	1980-10-03	1982-08-17	Warner-Lambert Company	Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
FR2492381A1 (fr)	1980-10-21	1982-04-23	Science Union & Cie	Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
LU88621I2 (fr)	1980-10-23	1995-09-01	Schering Corp	Sandopril
US4374847A (en)	1980-10-27	1983-02-22	Ciba-Geigy Corporation	1-Carboxyalkanoylindoline-2-carboxylic acids
DE3226768A1 (de)	1981-11-05	1983-05-26	Hoechst Ag, 6230 Frankfurt	Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
IE55867B1 (en)	1981-12-29	1991-02-14	Hoechst Ag	New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
DE3210496A1 (de)	1982-03-23	1983-10-06	Hoechst Ag	Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3211397A1 (de)	1982-03-27	1983-11-10	Hoechst Ag, 6230 Frankfurt	Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3211676A1 (de)	1982-03-30	1983-10-06	Hoechst Ag	Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
DE3227055A1 (de)	1982-07-20	1984-01-26	Hoechst Ag, 6230 Frankfurt	Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung
DE3242151A1 (de)	1982-11-13	1984-05-17	Hoechst Ag, 6230 Frankfurt	Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3246503A1 (de)	1982-12-16	1984-06-20	Hoechst Ag, 6230 Frankfurt	Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3643012A1 (de)	1986-12-17	1988-06-30	Hoechst Ag	2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3818850A1 (de)	1988-06-03	1989-12-07	Hoechst Ag	Oligopeptide mit zyklischen prolin-analogen aminosaeuren
JPH10504825A (ja) *	1994-08-22	1998-05-12	スミスクライン・ビーチャム・コーポレイション	二環式化合物
FR2731217B1 (fr)	1995-03-03	1997-06-13	Roussel Uclaf	Nouveaux derives tricycliques, leur preparation, leur application a la preparation de la colchicine et de la thiocolchicine optiquement actives ou racemiques et d'analogues ou derives et intermediaires

1996
- 1996-03-20 FR FR9603437A patent/FR2746394B1/fr not_active Expired - Lifetime
1997
- 1997-03-19 AR ARP970101095A patent/AR006317A1/es unknown
- 1997-03-19 ZA ZA9702393A patent/ZA972393B/xx unknown
- 1997-03-19 HR HR9603437A patent/HRP970163A2/hr not_active Application Discontinuation
- 1997-03-20 PL PL97329034A patent/PL329034A1/xx unknown
- 1997-03-20 CZ CZ982888A patent/CZ288898A3/cs unknown
- 1997-03-20 CN CN97194806A patent/CN1090178C/zh not_active Expired - Fee Related
- 1997-03-20 IL IL12610697A patent/IL126106A0/xx unknown
- 1997-03-20 ES ES97915519T patent/ES2164337T3/es not_active Expired - Lifetime
- 1997-03-20 PT PT97915519T patent/PT888292E/pt unknown
- 1997-03-20 TR TR1998/01846T patent/TR199801846T2/xx unknown
- 1997-03-20 HU HU9902495A patent/HUP9902495A3/hu unknown
- 1997-09-23 TW TW086113848A patent/TW458963B/zh not_active IP Right Cessation
1998
- 1998-09-18 YU YU40898A patent/YU40898A/sh unknown
- 1998-09-18 OA OA9800175A patent/OA11603A/fr unknown
- 1998-10-15 LT LT98-145A patent/LT4535B/lt not_active IP Right Cessation
2002
- 2002-06-27 CN CN02141265A patent/CN1401621A/zh active Pending

Also Published As

Publication number	Publication date
PT888292E (pt)	2002-04-29
OA11603A (fr)	2004-08-11
HUP9902495A3 (en)	2001-07-30
IL126106A0 (en)	1999-05-09
HUP9902495A2 (hu)	1999-11-29
LT4535B (lt)	1999-08-25
AR006317A1 (es)	1999-08-25
YU40898A (sh)	1999-09-27
HRP970163A2 (en)	1998-08-31
TW458963B (en)	2001-10-11
CN1090178C (zh)	2002-09-04
ZA972393B (en)	1998-03-19
CN1219165A (zh)	1999-06-09
CN1401621A (zh)	2003-03-12
FR2746394B1 (fr)	1998-05-29
CZ288898A3 (cs)	1999-03-17
ES2164337T3 (es)	2002-02-16
LT98145A (lt)	1999-03-25
PL329034A1 (en)	1999-03-01
FR2746394A1 (fr)	1997-09-26

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AR018175A1 (es)	2001-10-31	Compuestos de indol-3-glioxilamidas sustituidas, utiles como medicamentos antitumorales, composiciones farmaceuticas formuladas con dichos derivados,utilizacion de dichos derivados para la preparacion de medicamentos antitumorales y los medicamentos asi preparados.
NZ236589A (en)	1993-02-25	A-nor-steroid-3-carboxylic acid derivatives and pharmaceutical compositions
FI980033A7 (fi)	1998-03-05	Solujen kiinnittymisen inhibiittoreita
EA200400944A1 (ru)	2005-04-28	Замещенные производные тетрациклина, фармацевтическая композиция и способ лечения субъекта с их использованием
TR200001282T2 (tr)	2000-09-21	Mikron-altı 9-hidroksirisperidon yağlı asit esterlerinin sulu süspansiyonları.
AR053232A1 (es)	2007-04-25	Derivados de piridina condensadas, composiciones farmaceuticas que los contienen y su empleo en la fabricacion de agentes terapeuticos antiinflamatorios y para el tratamiento de enfermedades relacionadas con el sistema inmunologico.
EA199800484A1 (ru)	1999-02-25	Лактоновые производные 17.бета.-карбокси, карботио и амид андростанов
ATE250602T1 (de)	2003-10-15	Pyrimido(6,1-a)isochinolinonderivate
HUP0003309A2 (hu)	2002-01-28	Imidazolilcsoportot tartalmazó gyűrűs acetálok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények
DE59807405D1 (de)	2003-04-10	Acylsulfamoylbenzoesäureamide, diese enthaltende nutzpflanzenschützende mittel und verfahren zu ihrer herstellung
RU94029662A (ru)	1996-07-10	Фосфонооксиметиловые эфиры производных таксана, фармацевтическая композиция, способы лечения
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TR199902383T2 (xx)	2000-06-21	Yeni pirimidin t�revleri ve bunlar�n haz�rlanmas� i�in proses.
ES2059789T3 (es)	1994-11-16	Esteroides sustituidos con acido fosfinico como inhibidores de la esteroide-5 alfa-reductasa.
TR199901765T2 (xx)	1999-10-21	S�lfomid-metalloproteaz inhibit�rleri
TR199802344A2 (xx)	1999-06-21	�kame edilmi� imidazolidin t�revleri
HUT76511A (en)	1997-09-29	Benzoyl derivatives, preparation and use thereot
EA200100774A1 (ru)	2002-02-28	Гетероциклические производные с функциональными группами (варианты), фармацевтическая композиция и комбинация, способ модулирования активности рецептора хемокина (варианты), способ профилактики инфицирования вич и лечения инфекции вич, замедления проявления спид и лечения спид, способ лечения воспалительных процессов
ES2135429T3 (es)	1999-11-01	Derivados de ciclohexano sustituidos para el tratamiento de enfermedades.
EA199800837A1 (ru)	1999-06-24	ТРИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ, ОБЛАДАЮЩИЕ АКТИВНОСТЬЮ В ОТНОШЕНИИ ИНТЕГРИНОВ, В ЧАСТНОСТИ, В ОТНОШЕНИИ ИНТЕГРИНА АЛЬФАvБЕТА 3, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ, ИСПОЛЬЗУЕМЫЕ В ЭТОМ СПОСОБЕ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ МЕДИКАМЕНТОВ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, КОТОРЫЕ ИХ СОДЕРЖАТ
KR970702042A (ko)	1997-05-13	약물로서 사용되는 피리미딘 또는 트리아진 카르복실산 유도체(Pyrimidine or Triazine Carboxylic Acid Derivatives to be Used as Medicaments)
AR016480A1 (es)	2001-07-04	Azoles hidrosolubles como antifungicos de amplio espectro, un proceso para su preparacion, un intermediario y una composicion farmaceutica que los comprende y el uso d elos mismos en la elaboracion de un medicamento
AR009137A1 (es)	2000-03-08	Derivados de acidos 4-bifenil-4-hidroxibutirico sustituidos como inhibidores de metaloproteasas de matriz, composicion farmaceutica y uso dedichos derivados para preparar dedicametos.
TR199801846T2 (xx)	1998-12-21	�ntegrinlere �zg� aktiviteye sahip trisiklik bile�ikler.