TR199901679T2 - Glikopeptid antibiyotiklerin indirgenerek alkil ile birlestirilmesi. - Google Patents
Glikopeptid antibiyotiklerin indirgenerek alkil ile birlestirilmesi.Info
- Publication number
- TR199901679T2 TR199901679T2 TR1999/01679T TR9901679T TR199901679T2 TR 199901679 T2 TR199901679 T2 TR 199901679T2 TR 1999/01679 T TR1999/01679 T TR 1999/01679T TR 9901679 T TR9901679 T TR 9901679T TR 199901679 T2 TR199901679 T2 TR 199901679T2
- Authority
- TR
- Turkey
- Prior art keywords
- virgin
- alkyl
- glycopeptide antibiotics
- glycopeptide
- compounds
- Prior art date
Links
- 239000003910 polypeptide antibiotic agent Substances 0.000 title abstract 4
- 230000029936 alkylation Effects 0.000 title 1
- 238000005804 alkylation reaction Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 abstract 2
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Bu bulus, glikopeptid antibiyotiklerin indirgenerek alkil ile birlestirilmesi için gelistirilmis islemlere iliskindir. Gelisme, glikopeptid antibiyotigin bakir birlesiginin üretimiyle sonuçlanan bir bakir kaynagi temin edilmesindedir. Bu bilesigin indirgenerek alkil ile birlestirilmesi, bölge seçici alkil ile birlesme ve daha fazla ürün hasadi saglar. Glikopeptid antibiyotik baslangiç malzemelerinin bakir bilesikleri ve alkil ile birlestirilmis ürünlerin bakir bilesikleri de bulusun parçasidir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3159696P | 1996-11-21 | 1996-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199901679T2 true TR199901679T2 (tr) | 1999-09-21 |
Family
ID=21860369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1999/01679T TR199901679T2 (tr) | 1996-11-21 | 1997-11-20 | Glikopeptid antibiyotiklerin indirgenerek alkil ile birlestirilmesi. |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0845478B1 (tr) |
| JP (1) | JP4308912B2 (tr) |
| KR (1) | KR100514276B1 (tr) |
| CN (1) | CN100463917C (tr) |
| AR (1) | AR010621A1 (tr) |
| AT (1) | ATE286910T1 (tr) |
| AU (1) | AU723941B2 (tr) |
| BR (1) | BR9713523B1 (tr) |
| CA (1) | CA2272240C (tr) |
| CO (1) | CO4650045A1 (tr) |
| CZ (1) | CZ300528B6 (tr) |
| DE (1) | DE69732215T2 (tr) |
| EA (1) | EA002925B1 (tr) |
| EG (1) | EG23855A (tr) |
| HU (1) | HU227641B1 (tr) |
| ID (1) | ID18900A (tr) |
| IL (1) | IL129991A0 (tr) |
| MY (1) | MY117383A (tr) |
| NO (1) | NO325365B1 (tr) |
| NZ (1) | NZ335840A (tr) |
| PE (1) | PE17499A1 (tr) |
| PL (1) | PL190780B1 (tr) |
| TR (1) | TR199901679T2 (tr) |
| TW (1) | TW585868B (tr) |
| UA (1) | UA58526C2 (tr) |
| WO (1) | WO1998022121A1 (tr) |
| ZA (1) | ZA9710428B (tr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1276759T1 (sl) * | 2000-05-02 | 2008-12-31 | Theravance Inc | Postopek reduktivnega alkiliranja na glikopeptidih |
| CA2904387C (en) | 2013-03-15 | 2021-12-07 | Melinta Therapeutics, Inc. | Methods of treating infections in overweight and obese patients using antibiotics |
| HUE070928T2 (hu) * | 2014-07-17 | 2025-07-28 | Melinta Therapeutics Llc | Nagy tisztaságú oritavancin és eljárás annak elõállítására |
| CN106188243B (zh) * | 2015-05-05 | 2020-06-26 | 博瑞生物医药（苏州）股份有限公司 | 一种奥利万星的制备方法 |
| CN106467570B (zh) * | 2015-08-14 | 2020-04-07 | 正大天晴药业集团股份有限公司 | 糖肽类抗生素的还原烷基化方法 |
| CN108409837B (zh) * | 2018-03-06 | 2021-09-24 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4051237A (en) * | 1975-08-28 | 1977-09-27 | Bristol-Myers Company | Glycopeptide antibiotics bu-2231 a and b and process for producing same |
| JPS58116497A (ja) * | 1981-12-29 | 1983-07-11 | Microbial Chem Res Found | アミノプロピルアミノブレオマイシン誘導体及びその製造法 |
| US4698327A (en) * | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
| CA2031803C (en) * | 1989-12-13 | 2001-05-29 | Ramakrishnan Nagarajan | Improvements in or relating to glycopeptide deriveratives |
| AU703106B2 (en) * | 1994-01-28 | 1999-03-18 | Eli Lilly And Company | Glycopeptide antibiotic derivatives |
-
1997
- 1997-11-13 ID IDP973669A patent/ID18900A/id unknown
- 1997-11-19 CO CO97067572A patent/CO4650045A1/es unknown
- 1997-11-19 AT AT97309305T patent/ATE286910T1/de not_active IP Right Cessation
- 1997-11-19 EG EG123597A patent/EG23855A/xx active
- 1997-11-19 PE PE1997001054A patent/PE17499A1/es not_active Application Discontinuation
- 1997-11-19 AR ARP970105411A patent/AR010621A1/es active IP Right Grant
- 1997-11-19 MY MYPI97005545A patent/MY117383A/en unknown
- 1997-11-19 EP EP97309305A patent/EP0845478B1/en not_active Expired - Lifetime
- 1997-11-19 ZA ZA9710428A patent/ZA9710428B/xx unknown
- 1997-11-19 DE DE69732215T patent/DE69732215T2/de not_active Expired - Lifetime
- 1997-11-20 AU AU54497/98A patent/AU723941B2/en not_active Ceased
- 1997-11-20 CN CNB971813701A patent/CN100463917C/zh not_active Expired - Fee Related
- 1997-11-20 TR TR1999/01679T patent/TR199901679T2/tr unknown
- 1997-11-20 PL PL333778A patent/PL190780B1/pl unknown
- 1997-11-20 UA UA99052810A patent/UA58526C2/uk unknown
- 1997-11-20 JP JP52387898A patent/JP4308912B2/ja not_active Expired - Fee Related
- 1997-11-20 BR BRPI9713523-2A patent/BR9713523B1/pt not_active IP Right Cessation
- 1997-11-20 NZ NZ335840A patent/NZ335840A/xx not_active IP Right Cessation
- 1997-11-20 IL IL12999197A patent/IL129991A0/xx not_active IP Right Cessation
- 1997-11-20 HU HU0000268A patent/HU227641B1/hu not_active IP Right Cessation
- 1997-11-20 WO PCT/US1997/021238 patent/WO1998022121A1/en not_active Ceased
- 1997-11-20 KR KR10-1999-7004441A patent/KR100514276B1/ko not_active Expired - Lifetime
- 1997-11-20 EA EA199900480A patent/EA002925B1/ru not_active IP Right Cessation
- 1997-11-20 CA CA2272240A patent/CA2272240C/en not_active Expired - Fee Related
- 1997-11-20 CZ CZ0179499A patent/CZ300528B6/cs not_active IP Right Cessation
- 1997-11-22 TW TW086117372A patent/TW585868B/zh not_active IP Right Cessation
-
1999
- 1999-05-20 NO NO19992415A patent/NO325365B1/no not_active IP Right Cessation
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