TR200000254A3 - Antitümör ve antimetastaz maddeleri olarak O-ikameli hidroksikumaranon türevleri - Google Patents

Antitümör ve antimetastaz maddeleri olarak O-ikameli hidroksikumaranon türevleri

Info

Publication number
TR200000254A3
TR200000254A3 TR2000/00254A TR200000254A TR200000254A3 TR 200000254 A3 TR200000254 A3 TR 200000254A3 TR 2000/00254 A TR2000/00254 A TR 2000/00254A TR 200000254 A TR200000254 A TR 200000254A TR 200000254 A3 TR200000254 A3 TR 200000254A3
Authority
TR
Turkey
Prior art keywords
hydroxyumaranone
antimetastasis
antitumor
derivatives
substituted
Prior art date
Application number
TR2000/00254A
Other languages
English (en)
Other versions
TR200000254A2 (tr
Inventor
Friebe Walter-Gunar
Koenig Bernhard
Krell Hans-Willi
Woelle Sabine
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of TR200000254A3 publication Critical patent/TR200000254A3/tr
Publication of TR200000254A2 publication Critical patent/TR200000254A2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
TR2000/00254A 1999-01-30 2000-01-27 Antitümör ve antimetastaz maddeleri olarak O-ikameli hidroksikumaranon türevleri TR200000254A2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99101956 1999-01-30

Publications (2)

Publication Number Publication Date
TR200000254A3 true TR200000254A3 (tr) 2000-09-21
TR200000254A2 TR200000254A2 (tr) 2000-09-21

Family

ID=8237485

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00254A TR200000254A2 (tr) 1999-01-30 2000-01-27 Antitümör ve antimetastaz maddeleri olarak O-ikameli hidroksikumaranon türevleri

Country Status (10)

Country Link
US (1) US6307051B1 (tr)
JP (1) JP3165421B2 (tr)
KR (1) KR100387275B1 (tr)
CN (1) CN1132828C (tr)
AR (1) AR029330A1 (tr)
AU (1) AU736869B2 (tr)
BR (1) BR0000226A (tr)
CA (1) CA2297225A1 (tr)
TR (1) TR200000254A2 (tr)
ZA (1) ZA200000392B (tr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088986A2 (de) * 1982-03-13 1983-09-21 Roche Diagnostics GmbH Bicyclische Phenolether, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Arzneimittel
JPH01246271A (ja) * 1988-03-28 1989-10-02 Kissei Pharmaceut Co Ltd ジヒドロベンゾフラノン誘導体
US5354861A (en) * 1992-11-04 1994-10-11 National University Of Singapore 2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolemic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU76760A1 (tr) * 1977-02-11 1978-10-18
JPH02215779A (ja) * 1989-02-14 1990-08-28 Kuraray Co Ltd カルボン酸アミド誘導体類及びその医薬用途
FR2725989B1 (fr) * 1994-10-20 1997-01-10 Pf Medicament Nouvelles 2-(1-(omega-phenoxyalcoylpiperidin-4-yl) aminomethylene)-2h-benzofuran-3-ones substituees, leur preparation et leur application en therapeutique
ID24525A (id) * 1997-07-31 2000-07-20 Hoffmann La Roche Turunan-turunan hidroksikumaranon tersubstitusi-0 sebagai zat anti tumor dan zat antimetastatik
US5886191A (en) * 1997-08-18 1999-03-23 Dupont Pharmaceuticals Company Amidinoindoles, amidinoazoles, and analogs thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088986A2 (de) * 1982-03-13 1983-09-21 Roche Diagnostics GmbH Bicyclische Phenolether, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Arzneimittel
JPH01246271A (ja) * 1988-03-28 1989-10-02 Kissei Pharmaceut Co Ltd ジヒドロベンゾフラノン誘導体
US5354861A (en) * 1992-11-04 1994-10-11 National University Of Singapore 2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolemic agents

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
C. C. TEO ET AL.: "Synthesis of 2-(p-Chlorobenzyl)-3-aryl-6-methoxybenzofurans as Selective Ligands for Antiestrogen-Binding Sites. Effects on Cell Proliferation and Cholesterol Synthesis", J. MED. CHEM., vol. 35, no. 8, 1992, pages 1330 - 1339, XP002136807 *
M. YAMATO ET AL.: "Synthesis and Antitumor Activity of Tropolone Derivatives. 4", J. MED. CHEM., vol. 30, no. 1, 1987, pages 117 - 120, XP002136806 *
PATENT ABSTRACTS OF JAPAN vol. 013, no. 589 25 December 1989 (1989-12-25) *

Also Published As

Publication number Publication date
AU1352600A (en) 2000-08-17
ZA200000392B (en) 2001-07-30
US6307051B1 (en) 2001-10-23
CN1132828C (zh) 2003-12-31
JP3165421B2 (ja) 2001-05-14
TR200000254A2 (tr) 2000-09-21
CN1266850A (zh) 2000-09-20
KR20000071317A (ko) 2000-11-25
CA2297225A1 (en) 2000-07-30
KR100387275B1 (ko) 2003-06-11
AR029330A1 (es) 2003-06-25
AU736869B2 (en) 2001-08-02
BR0000226A (pt) 2001-08-21
JP2000226381A (ja) 2000-08-15

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