TR200000254A2 - Antitümör ve antimetastaz maddeleri olarak O-ikameli hidroksikumaranon türevleri - Google Patents

Antitümör ve antimetastaz maddeleri olarak O-ikameli hidroksikumaranon türevleri

Info

Publication number
TR200000254A2
TR200000254A2 TR2000/00254A TR200000254A TR200000254A2 TR 200000254 A2 TR200000254 A2 TR 200000254A2 TR 2000/00254 A TR2000/00254 A TR 2000/00254A TR 200000254 A TR200000254 A TR 200000254A TR 200000254 A2 TR200000254 A2 TR 200000254A2
Authority
TR
Turkey
Prior art keywords
antimetastasis
antitumor
derivatives
substituted
agents
Prior art date
Application number
TR2000/00254A
Other languages
English (en)
Other versions
TR200000254A3 (tr
Inventor
Friebe Walter-Gunar
Koenig Bernhard
Krell Hans-Willi
Woelle Sabine
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of TR200000254A2 publication Critical patent/TR200000254A2/tr
Publication of TR200000254A3 publication Critical patent/TR200000254A3/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Mevcut bulus 2-alkiliden hidroksikumaranon türevlerine iliskin olup, burada hidroksi grubu azot ihtiva eden bir kalinti ile ikame edilmistir. Bu bilesiklerin uPA-uPAR antagonist etkinlige sahip olduklari ve antitümör ve/veya antimetastaz maddeleri olarak kullanilabildikleri bulunmustur.
TR2000/00254A 1999-01-30 2000-01-27 Antitümör ve antimetastaz maddeleri olarak O-ikameli hidroksikumaranon türevleri TR200000254A3 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99101956 1999-01-30

Publications (2)

Publication Number Publication Date
TR200000254A2 true TR200000254A2 (tr) 2000-09-21
TR200000254A3 TR200000254A3 (tr) 2000-09-21

Family

ID=8237485

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00254A TR200000254A3 (tr) 1999-01-30 2000-01-27 Antitümör ve antimetastaz maddeleri olarak O-ikameli hidroksikumaranon türevleri

Country Status (10)

Country Link
US (1) US6307051B1 (tr)
JP (1) JP3165421B2 (tr)
KR (1) KR100387275B1 (tr)
CN (1) CN1132828C (tr)
AR (1) AR029330A1 (tr)
AU (1) AU736869B2 (tr)
BR (1) BR0000226A (tr)
CA (1) CA2297225A1 (tr)
TR (1) TR200000254A3 (tr)
ZA (1) ZA200000392B (tr)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU76760A1 (tr) * 1977-02-11 1978-10-18
DE3209271A1 (de) 1982-03-13 1983-09-15 Boehringer Mannheim Gmbh, 6800 Mannheim Bicyclische phenolether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
JPH07121932B2 (ja) * 1988-03-28 1995-12-25 キッセイ薬品工業株式会社 ジヒドロベンゾフラノン誘導体
JPH02215779A (ja) * 1989-02-14 1990-08-28 Kuraray Co Ltd カルボン酸アミド誘導体類及びその医薬用途
US5354861A (en) * 1992-11-04 1994-10-11 National University Of Singapore 2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolemic agents
FR2725989B1 (fr) * 1994-10-20 1997-01-10 Pf Medicament Nouvelles 2-(1-(omega-phenoxyalcoylpiperidin-4-yl) aminomethylene)-2h-benzofuran-3-ones substituees, leur preparation et leur application en therapeutique
PL338614A1 (en) * 1997-07-31 2000-11-06 Hoffmann La Roche O-substituted derivatives of hydroxyenmarone as anticarcinogenic and antinetastic agents
US5886191A (en) * 1997-08-18 1999-03-23 Dupont Pharmaceuticals Company Amidinoindoles, amidinoazoles, and analogs thereof

Also Published As

Publication number Publication date
JP3165421B2 (ja) 2001-05-14
BR0000226A (pt) 2001-08-21
JP2000226381A (ja) 2000-08-15
AU736869B2 (en) 2001-08-02
US6307051B1 (en) 2001-10-23
CA2297225A1 (en) 2000-07-30
CN1266850A (zh) 2000-09-20
AU1352600A (en) 2000-08-17
KR20000071317A (ko) 2000-11-25
TR200000254A3 (tr) 2000-09-21
CN1132828C (zh) 2003-12-31
AR029330A1 (es) 2003-06-25
ZA200000392B (en) 2001-07-30
KR100387275B1 (ko) 2003-06-11

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