TR200001799T2 - Müstahzar olarak 5-(4-(2-(n-metil-n-(2-pirildil) mino)etoksi)benzil) tiyazolidin,-2,4-diyon, maleik asit tuzu, hidratı. - Google Patents

Müstahzar olarak 5-(4-(2-(n-metil-n-(2-pirildil) mino)etoksi)benzil) tiyazolidin,-2,4-diyon, maleik asit tuzu, hidratı.

Info

Publication number: TR200001799T2
Authority: TR; Turkey
Prior art keywords: thiazolidine; dione; pyridyl; ethoxy; benzyl
Prior art date: 1997-12-16

Application number

TR2000/01799T

Other languages

English (en)

Turkish (tr)

Inventor

David James Blackler Paul

C. Lee David

John Sasse Michael

Original Assignee

Smithkline Beecham P.L.C.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-16

Filing date

1998-12-14

Publication date

2001-01-22

1998-12-14 Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.

2001-01-22 Publication of TR200001799T2 publication Critical patent/TR200001799T2/xx

Links

OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical compound C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 title abstract 2
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 title 1
241001024304 Mino Species 0.000 title 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 title 1
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 title 1
150000002688 maleic acid derivatives Chemical class 0.000 title 1
HAFWELDDNUXLCK-ODZAUARKSA-N (z)-but-2-enedioic acid;hydrate Chemical compound O.OC(=O)\C=C/C(O)=O HAFWELDDNUXLCK-ODZAUARKSA-N 0.000 abstract 1
AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 abstract 1
-1 4- (2- (N-methyl-N- (2-pyridyl) amino) ethoxy) benzyl Chemical group 0.000 abstract 1
238000001237 Raman spectrum Methods 0.000 abstract 1
230000004927 fusion Effects 0.000 abstract 1
238000002329 infrared spectrum Methods 0.000 abstract 1
239000000843 powder Substances 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1
238000001228 spectrum Methods 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

TR2000/01799T 1997-12-16 1998-12-14 Müstahzar olarak 5-(4-(2-(n-metil-n-(2-pirildil) mino)etoksi)benzil) tiyazolidin,-2,4-diyon, maleik asit tuzu, hidratı. TR200001799T2 (tr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9726566.4A GB9726566D0 (en)	1997-12-16	1997-12-16	Novel pharmaceutical

Publications (1)

Publication Number	Publication Date
TR200001799T2 true TR200001799T2 (tr)	2001-01-22

Family

ID=10823692

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
TR2000/01799T TR200001799T2 (tr)	1997-12-16	1998-12-14	Müstahzar olarak 5-(4-(2-(n-metil-n-(2-pirildil) mino)etoksi)benzil) tiyazolidin,-2,4-diyon, maleik asit tuzu, hidratı.
TR1998/02625A TR199802625A3 (tr)	1997-12-16	1998-12-16	Yeni farmasötikler

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
TR1998/02625A TR199802625A3 (tr)	1997-12-16	1998-12-16	Yeni farmasötikler

Country Status (35)

Country	Link
EP (2)	EP1661895A1 (2)
JP (1)	JP2002508373A (2)
KR (1)	KR100549142B1 (2)
CN (3)	CN1281453A (2)
AP (1)	AP1365A (2)
AR (1)	AR017214A1 (2)
AU (1)	AU1967999A (2)
BG (1)	BG64988B1 (2)
BR (1)	BR9813600A (2)
CA (1)	CA2314107A1 (2)
CO (1)	CO4980880A1 (2)
CZ (1)	CZ299965B6 (2)
DZ (1)	DZ2681A1 (2)
EA (1)	EA004260B1 (2)
EG (1)	EG22337A (2)
GB (1)	GB9726566D0 (2)
HR (1)	HRP20000408B1 (2)
HU (1)	HUP0100509A3 (2)
IL (1)	IL136424A (2)
IN (1)	IN192487B (2)
MA (1)	MA26580A1 (2)
MY (1)	MY135612A (2)
NO (1)	NO317254B1 (2)
OA (1)	OA11766A (2)
PE (1)	PE20000058A1 (2)
PL (1)	PL341146A1 (2)
RS (1)	RS50126B (2)
SA (1)	SA99191115B1 (2)
SK (1)	SK286618B6 (2)
TR (2)	TR200001799T2 (2)
TW (1)	TW509690B (2)
UA (1)	UA72198C2 (2)
UY (2)	UY25308A1 (2)
WO (1)	WO1999031095A1 (2)
ZA (1)	ZA9811506B (2)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9726568D0 (en)	1997-12-16	1998-02-11	Smithkline Beecham Plc	Novel pharmaceutical
US6664278B2 (en)	1997-12-16	2003-12-16	Smithkline Beecham P.L.C.	Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
GB9909041D0 (en) *	1999-04-20	1999-06-16	Smithkline Beecham Plc	Novel pharmaceutical
PL351684A1 (en) *	1999-04-23	2003-06-02	Smithkline Beecham Plc	Polymorph of 5−[4−[2− (n−methyl−n−( 2−pyridyl)amino) ethoxy]benzyl] thiazolidine−2,4−dione, maleic acid salt
AU765498B2 (en) *	1999-04-23	2003-09-18	Smithkline Beecham Plc	Novel pharmaceutical
HK1045152A1 (zh) *	1999-04-23	2002-11-15	Smithkline Beecham Plc	噻唑烷二酮衍生物及其用作抗糖尿病藥的應用
HUP0300475A3 (en) *	2000-04-25	2004-10-28	Kyorin Seiyaku Kk	Novel stable crystal of thiazolidinedione derivative and process for producing the same
GB0014005D0 (en) *	2000-06-08	2000-08-02	Smithkline Beecham Plc	Novel pharmaceutical
GB0021784D0 (en) *	2000-09-05	2000-10-18	Smithkline Beecham Plc	Novel pharmaceutical
GB0021978D0 (en) *	2000-09-07	2000-10-25	Smithkline Beecham Plc	Novel pharmaceutical
AU2001291232B8 (en) *	2000-09-26	2006-12-21	Dr. Reddy's Laboratories Limited	Novel polymorphic forms of 5-[4-[2-[N-methyl-N-(2-pyridyl)amino]ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation
MXPA03002580A (es) *	2000-09-26	2003-10-15	Cord Janet I	Nuevas formas polimorficas de maleato de 5-(4-(2-(n-metil-n-(2-piridil) amino)etoxi)bencil) tiazolidin-2, 4-diona y proceso para su preparacion.
GB0129876D0 (en) *	2001-12-13	2002-02-06	Smithkline Beecham Plc	Novel pharmaceutical
GB0129872D0 (en) *	2001-12-13	2002-02-06	Smithkline Beecham Plc	Novel pharmaceutical
AU2002350965A1 (en) *	2001-12-13	2003-06-23	Smithkline Beecham Plc	Toluenesulfonate hydrates of a thiazolidinedione derivative
GB2405403A (en) *	2003-08-29	2005-03-02	Cipla Ltd	Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
ITMI20041537A1 (it) *	2004-07-28	2004-10-28	Chemi Spa	Nuova forma polimorfa del rosiglitazone maleato
CZ298424B6 (cs) *	2005-05-24	2007-09-26	Zentiva, A. S.	Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
EP2184055A1 (en)	2008-11-07	2010-05-12	LEK Pharmaceuticals d.d.	Process for preparing solid dosage forms of rosiglitazone maleate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE186724T1 (de) *	1987-09-04	1999-12-15	Beecham Group Plc	Substituierte thiazolidindionderivate
GB8820389D0 (en) *	1988-08-26	1988-09-28	Beecham Group Plc	Novel compounds
GB9218830D0 (en) *	1992-09-05	1992-10-21	Smithkline Beecham Plc	Novel compounds
JPH09512249A (ja) *	1994-02-10	1997-12-09	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	腎臓疾患を治療するためのインスリンセンシタイザーの使用

1997
- 1997-12-16 GB GBGB9726566.4A patent/GB9726566D0/en not_active Ceased
1998
- 1998-12-14 CN CN98812089A patent/CN1281453A/zh active Pending
- 1998-12-14 MA MA25389A patent/MA26580A1/fr unknown
- 1998-12-14 CN CNA200810087031XA patent/CN101381367A/zh active Pending
- 1998-12-14 BR BR9813600-3A patent/BR9813600A/pt not_active Application Discontinuation
- 1998-12-14 TR TR2000/01799T patent/TR200001799T2/xx unknown
- 1998-12-14 UA UA2000063485A patent/UA72198C2/uk unknown
- 1998-12-14 CA CA002314107A patent/CA2314107A1/en not_active Abandoned
- 1998-12-14 JP JP2000539019A patent/JP2002508373A/ja not_active Withdrawn
- 1998-12-14 AU AU19679/99A patent/AU1967999A/en not_active Abandoned
- 1998-12-14 EP EP05077331A patent/EP1661895A1/en not_active Withdrawn
- 1998-12-14 EA EA200000654A patent/EA004260B1/ru not_active IP Right Cessation
- 1998-12-14 KR KR1020007006515A patent/KR100549142B1/ko not_active Expired - Fee Related
- 1998-12-14 PL PL98341146A patent/PL341146A1/xx not_active Application Discontinuation
- 1998-12-14 OA OA1200000178A patent/OA11766A/en unknown
- 1998-12-14 EP EP98964510A patent/EP1040110A1/en not_active Withdrawn
- 1998-12-14 CZ CZ20002204A patent/CZ299965B6/cs not_active IP Right Cessation
- 1998-12-14 HR HR20000408A patent/HRP20000408B1/xx not_active IP Right Cessation
- 1998-12-14 WO PCT/EP1998/008155 patent/WO1999031095A1/en not_active Ceased
- 1998-12-14 AP APAP/P/2000/001831A patent/AP1365A/en active
- 1998-12-14 SK SK917-2000A patent/SK286618B6/sk not_active IP Right Cessation
- 1998-12-14 CN CNA2008100870305A patent/CN101302215A/zh active Pending
- 1998-12-14 HU HU0100509A patent/HUP0100509A3/hu unknown
- 1998-12-14 IL IL13642498A patent/IL136424A/xx unknown
- 1998-12-14 RS YUP-363/00A patent/RS50126B/sr unknown
- 1998-12-15 EG EG155698A patent/EG22337A/xx active
- 1998-12-15 DZ DZ980291A patent/DZ2681A1/xx active
- 1998-12-15 ZA ZA9811506A patent/ZA9811506B/xx unknown
- 1998-12-15 UY UY25308A patent/UY25308A1/es not_active IP Right Cessation
- 1998-12-15 AR ARP980106370A patent/AR017214A1/es unknown
- 1998-12-15 MY MYPI98005674A patent/MY135612A/en unknown
- 1998-12-15 UY UY25304A patent/UY25304A1/es unknown
- 1998-12-16 PE PE1998001233A patent/PE20000058A1/es not_active Application Discontinuation
- 1998-12-16 CO CO98074834A patent/CO4980880A1/es unknown
- 1998-12-16 TR TR1998/02625A patent/TR199802625A3/tr unknown
- 1998-12-16 TW TW087121121A patent/TW509690B/zh not_active IP Right Cessation
- 1998-12-16 IN IN3772DE1998 patent/IN192487B/en unknown
1999
- 1999-02-27 SA SA99191115A patent/SA99191115B1/ar unknown
2000
- 2000-06-15 NO NO20003069A patent/NO317254B1/no not_active IP Right Cessation
- 2000-07-13 BG BG104603A patent/BG64988B1/bg unknown

Also Published As

Publication number	Publication date
AP2000001831A0 (en)	2000-06-30
ZA9811506B (en)	2000-11-06
RS50126B (sr)	2009-03-25
CN101302215A (zh)	2008-11-12
CZ299965B6 (cs)	2009-01-07
CZ20002204A3 (cs)	2000-11-15
SK286618B6 (sk)	2009-02-05
BG104603A (en)	2001-03-30
HRP20000408B1 (hr)	2008-04-30
AU1967999A (en)	1999-07-05
GB9726566D0 (en)	1998-02-11
IN192487B (2)	2004-04-24
BR9813600A (pt)	2000-10-10
SA99191115B1 (ar)	2006-10-11
IL136424A0 (en)	2001-06-14
UY25308A1 (es)	1999-07-19
HUP0100509A3 (en)	2002-06-28
EG22337A (en)	2002-12-31
SK9172000A3 (en)	2001-01-18
CN1281453A (zh)	2001-01-24
PE20000058A1 (es)	2000-02-26
YU36300A (sh)	2004-03-12
MY135612A (en)	2008-05-30
TW509690B (en)	2002-11-11
TR199802625A2 (xx)	1999-10-21
CA2314107A1 (en)	1999-06-24
OA11766A (en)	2005-07-19
NO317254B1 (no)	2004-09-27
AR017214A1 (es)	2001-08-22
EA004260B1 (ru)	2004-02-26
MA26580A1 (fr)	2004-12-20
UA72198C2 (en)	2005-02-15
NO20003069D0 (no)	2000-06-15
KR20010033141A (ko)	2001-04-25
IL136424A (en)	2003-12-10
CO4980880A1 (es)	2000-11-27
KR100549142B1 (ko)	2006-02-03
EP1661895A1 (en)	2006-05-31
AP1365A (en)	2005-01-26
HUP0100509A2 (hu)	2002-05-29
BG64988B1 (bg)	2006-11-30
NO20003069L (no)	2000-06-15
PL341146A1 (en)	2001-03-26
CN101381367A (zh)	2009-03-11
TR199802625A3 (tr)	1999-10-21
JP2002508373A (ja)	2002-03-19
WO1999031095A1 (en)	1999-06-24
HRP20000408A2 (en)	2000-08-31
EP1040110A1 (en)	2000-10-04
EA200000654A1 (ru)	2000-12-25
DZ2681A1 (fr)	2004-06-20
UY25304A1 (es)	2000-12-29

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TR200001793T2 (tr)	2000-10-23	Yapısında değişiklik yapılmış tiyazolidinediyon türevi, bunun hazırlanması için işlem ve eczacılık alanında kullanımı
ES2133543T3 (es)	1999-09-16	Derivados de pirrolidina y oxazolidina, su preparacion y su uso como inhibidores de la agregacion de trombocitos.
TR199901667T2 (xx)	1999-10-21	3-Heterosiklil-ikame edilmi� benzoil t�revleri
TR200001798T2 (tr)	2000-11-21	5-(4-(2-(N-metil-N-(2-piridil) amino)oksi)benzil) tiyazolidin-2'nin hidratı, 4-diyon maleik asit tuzu.
CA2297911A1 (en)	1999-02-04	Substituted 6-phenylphenanthridines
ATE330955T1 (de)	2006-07-15	Indolderivate und deren verwendung als inhibitoren der phosphodiesterase 4.
BG103590A (en)	2000-11-30	Pesticide 1-arylpyrazols
NL350045I1 (nl)	2010-04-01	N-(5,7-dimethoxy\[1,2,4\]triazolo\[1,5-a\]pyrimidin-2-yl)arylsulfonamideverbindingen en het gebruik ervan als herbiciden.
BG104670A (en)	2001-05-31	4-(2-keto-1-benzimidazolinyl)piperidinne compounds as orl1-receptor agonists
ATE260899T1 (de)	2004-03-15	Neue tetrazolderivate
GR3015313T3 (en)	1995-06-30	Indole derivatives as antiallergy and antiinflammatory agents.
CA2250569A1 (en)	1997-10-02	Novel phenanthridines substituted in the 6 position
ATE429450T1 (de)	2009-05-15	Chimärische dr4 antikörper und ihre verwendung
BR9711134A (pt)	1999-08-17	Composto e uso de um composto
MY124487A (en)	2006-06-30	Dolastatin derivatives, their preparation and use
DE50301941D1 (de)	2006-01-19	Derivate-1h-pyrazolo (3, 4-b) -5-(4-pyridinyl)-4-pyrimidinamins und ihre verwendung als guanylatcyclase-stimulatoren
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WO2001055066A3 (en)	2002-01-31	3-phenoxy-1-phenyl acetylene derivatives and their use as herbicides
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DE69821530D1 (de)	2004-03-11	Dihydrobenzifurane
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ES2002352A6 (es)	1988-08-01	Procedimiento para la preparacion de 3,4,5,6-tetrahidroftalimidas substituidas en n.
TR199901416T2 (xx)	1999-08-23	Heterosiklik karbonikasit t�revleri.
CA2423357A1 (en)	2002-02-07	Fused heterocyclic derivatives as phosphodiesterase inhibitors