TR200003438T2 - Lokal analjezi için trisiklik antidepresanların kullanımı - Google Patents

Lokal analjezi için trisiklik antidepresanların kullanımı

Info

Publication number
TR200003438T2
TR200003438T2 TR2000/03438T TR200003438T TR200003438T2 TR 200003438 T2 TR200003438 T2 TR 200003438T2 TR 2000/03438 T TR2000/03438 T TR 2000/03438T TR 200003438 T TR200003438 T TR 200003438T TR 200003438 T2 TR200003438 T2 TR 200003438T2
Authority
TR
Turkey
Prior art keywords
generation
antidepressants
tricyclic
analgesia
tricyclic antidepressants
Prior art date
Application number
TR2000/03438T
Other languages
English (en)
Inventor
Sawynok Jana
Esser Mike
Reid Allison
Original Assignee
Dalhousie University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dalhousie University filed Critical Dalhousie University
Publication of TR200003438T2 publication Critical patent/TR200003438T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Lokal olarak uygulandiginda amitriptilin ve desipramin gibi trisiklik, ikinci jenerasyon ve üçüncü jenerasyon antidepresanlarin, lokal bir rahatsizlik sahasina bir subjede analjezi ürettikleri gösterilmistir lokal olarak uygulandiklarinda bu antidepresanlarin analjezik etkisi, sistemik uygulamayla elde edilene esittir ve daha uzun süre kalicidir. Bulus, topik uygulama için veya yavas saliveren uygulama araçlariyla enjeksiyon için formül edilenler gibi lokal uygulamaya yönelik trisiklik, ikici jenerasyon ve üçüncü jenerasyon antidepresanlar ihtiva eden kompozisyonlar ve bunlarin, lokal analjezi üretyiminde kullanildiklari metotlar saglar.
TR2000/03438T 1998-05-19 1999-05-19 Lokal analjezi için trisiklik antidepresanların kullanımı TR200003438T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/081,709 US6211171B1 (en) 1998-05-19 1998-05-19 Use of antidepressants for local analgesia

Publications (1)

Publication Number Publication Date
TR200003438T2 true TR200003438T2 (tr) 2001-03-21

Family

ID=22165886

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03438T TR200003438T2 (tr) 1998-05-19 1999-05-19 Lokal analjezi için trisiklik antidepresanların kullanımı

Country Status (12)

Country Link
US (1) US6211171B1 (tr)
EP (1) EP1094818A1 (tr)
JP (1) JP2002515438A (tr)
KR (1) KR20010071301A (tr)
CN (1) CN1308530A (tr)
AU (1) AU3807799A (tr)
BR (1) BR9911046A (tr)
CA (1) CA2333310A1 (tr)
NO (1) NO20005835L (tr)
NZ (1) NZ508991A (tr)
TR (1) TR200003438T2 (tr)
WO (1) WO1999059598A1 (tr)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6572880B2 (en) * 1996-10-24 2003-06-03 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
WO1999059593A1 (en) * 1998-05-21 1999-11-25 Eli Lilly And Company Combination therapy for treatment of depression
AU3422800A (en) * 1999-02-18 2000-09-04 Novartis Ag Use of 5-ht3 receptor antagonists
GB9904163D0 (en) * 1999-02-23 1999-04-14 Bioglan Lab Ltd Pharmaceutical compositions
US6383511B1 (en) * 1999-10-25 2002-05-07 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
GB9930077D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
US7074961B2 (en) 2000-09-26 2006-07-11 The Brigham And Women's Hospital, Inc. Antidepressants and their analogues as long-acting local anesthetics and analgesics
WO2002026020A2 (en) * 2000-09-26 2002-04-04 The Brigham And Women's Hospital, Inc. Tricyclic antidepressants and their analogues as long-acting local anesthetics and analgesics
IL139975A0 (en) * 2000-11-29 2002-02-10 Univ Ramot Anti proliferative drugs
US20050013853A1 (en) * 2000-11-29 2005-01-20 Irit Gil-Ad Anti-proliferative drugs
US6906046B2 (en) 2000-12-22 2005-06-14 Celltech R & D Inc. Pharmaceutical uses and synthesis of benzobicyclooctanes
GB0216027D0 (en) * 2002-07-10 2002-08-21 Arachnova Therapeutics Ltd New therapeutic use
US20040048874A1 (en) * 2001-05-22 2004-03-11 Bardsley Hazel Judith New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
HRP20040102A2 (en) 2001-07-09 2004-10-31 Combinatorx Combinations for the treatment of inflammatory disorders
US6638981B2 (en) * 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
US20030082225A1 (en) * 2001-10-19 2003-05-01 Mason Paul Arthur Sterile, breathable patch for treating wound pain
US20030124174A1 (en) * 2001-10-25 2003-07-03 Endo Pharmaceuticals, Inc Method for treating non-neuropathic pain
US20040220153A1 (en) * 2002-09-24 2004-11-04 Jost-Price Edward Roydon Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
MXPA05005609A (es) * 2002-11-26 2005-07-26 Alexza Pharmaceuticals Inc Tratamiento de dolor de cabeza con antipsicoticos suministrados por inhalacion.
JP2006514934A (ja) * 2002-11-26 2006-05-18 アレックザ ファーマシューティカルズ， インコーポレイテッド 疼痛治療用薬剤製造のためのロキサピンまたはアモキサピンの使用
US20040161481A1 (en) * 2002-12-18 2004-08-19 Algorx Administration of capsaicinoids
MXPA05007381A (es) * 2003-01-13 2006-02-10 Dynogen Pharmaceuticals Inc Metodo para el tratamiento de transtornos funcionales del intestino.
US20050085652A1 (en) * 2003-04-08 2005-04-21 Algorx Pharmaceuticals, Inc. Preparation and purification of synthetic capsaicin
EP1613324A2 (en) * 2003-04-14 2006-01-11 Pain Therapeutics, Inc. Methods for the treatment of pain comprising opioid antagonists
US20040234916A1 (en) 2003-05-21 2004-11-25 Alexza Molecular Delivery Corporation Optically ignited or electrically ignited self-contained heating unit and drug-supply unit employing same
US7838029B1 (en) * 2003-07-31 2010-11-23 Watson Laboratories, Inc. Mirtazapine solid dosage forms
US20050089559A1 (en) 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
US20050176809A1 (en) * 2004-02-05 2005-08-11 Rodlen Laboratories, Inc. Method and compositions for treatment of painful disorders
US20050209319A1 (en) * 2004-03-18 2005-09-22 Xenoport, Inc. Treatment of local pain
US7585627B2 (en) * 2004-05-21 2009-09-08 Duke University Polymorphism in tryptophan hydroxylase-2 controls brain serotonin synthesis
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP1781360A1 (en) 2004-08-12 2007-05-09 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
US20060039866A1 (en) * 2004-08-20 2006-02-23 Cypress Bioscience, Inc. Method for treating sleep-related breathing disorders
EP1827450A4 (en) * 2004-11-17 2009-04-22 Cypress Bioscience Inc METHOD FOR REDUCING THE SIDE EFFECTS OF TREATMENT WITH MIRTAZAPINE
WO2006105117A2 (en) * 2005-03-28 2006-10-05 Dynogen Pharmaceuticals, Inc. Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors
US20070270413A1 (en) * 2006-05-22 2007-11-22 N.V. Organon Mirtazapine for the treatment of neuropathic pain
TW200808804A (en) * 2006-05-22 2008-02-16 Organon Nv Mirtazapine for the treatment of neuropathic pain
US7960436B2 (en) 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
US7763603B2 (en) * 2006-08-10 2010-07-27 Tyeryar Kimberly R Manipulation of brain CDP-diacylglycerol and uses thereof
US9593360B2 (en) * 2006-08-10 2017-03-14 Ashiwel S Undieh Measurement of brain CDP-diacylglycerol synthase 1 enzyme and uses thereof
SG174095A1 (en) * 2006-08-23 2011-09-29 Valeant Pharmaceuticals Int Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
US20080081067A1 (en) * 2006-10-03 2008-04-03 Gupta Manishkumar Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
CN101578259A (zh) * 2006-11-28 2009-11-11 威朗国际制药公司 作为钾通道调节剂的1,4-二氨基双环瑞替加滨类似物
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
EP2167096A4 (en) * 2007-06-13 2010-07-14 Cypress Bioscience Inc IMPROVING TOLERANCE TO MIRTAZAPINE AND A SECOND ACTIVE INGREDIENT BY THE COMBINED USE OF THEM
US8563566B2 (en) * 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
CA2716080C (en) 2008-02-20 2016-12-13 Targia Pharmaceuticals Cns pharmaceutical compositions and methods of use
CN101966151B (zh) * 2010-09-06 2011-11-09 海南美大制药有限公司 马来酸曲米帕明脂质体固体制剂
EP2629615B1 (en) 2010-10-22 2018-10-10 Duke University Slow-release formulations of 5-hydroxytryptophan as an adjunct to pro-serotonergic therapies
US20130217673A1 (en) * 2012-02-22 2013-08-22 Warsaw Orthopedic, Inc Mixed monoamine reuptake inhibitor in a biodegradable polymer carrier
ES2961655T3 (es) 2013-01-18 2024-03-13 Kemphys Ltd Medicamento para tratamiento de enfermedad neuropática
WO2016138357A1 (en) 2015-02-27 2016-09-01 Kindred Biosciences, Inc. Stimulation of appetite, management of weight loss, and treatment of anorexia in dogs and cats
FR3065371B1 (fr) * 2017-04-25 2021-05-21 Laboratoires Mayoly Spindler Composition pharmaceutique topique comprenant au moins de l'amitriptyline pour le traitement de douleurs neuropathiques peripheriques
US12214118B2 (en) 2018-02-02 2025-02-04 Alexza Pharmaceuticals, Inc. Electrical condensation aerosol device
TWI886158B (zh) 2019-10-10 2025-06-11 加拿大商再諾製藥公司 選擇性鉀通道調節劑之固態晶型
MX2022005490A (es) 2019-11-08 2022-08-10 Xenon Pharmaceuticals Inc Metodos para el tratamiento de trastornos depresivos.
US11957675B2 (en) 2021-02-09 2024-04-16 Xenon Pharmaceuticals Inc. Methods and uses for treating anhedonia

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3491188A (en) 1967-10-02 1970-01-20 Geigy Chem Corp Pharmaceutical compositions and methods for the treatment of pain with combinations of thioridazine and imipramine,desipramine or pharmaceutically acceptable acid addition salts thereof
US4594358A (en) 1985-02-25 1986-06-10 Eli Lilly And Company Analgesic method
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
EP0489108B1 (en) 1989-08-21 1996-03-13 Beth Israel Hospital Association Use of spiperone derivatives for immunosuppression
DK0431663T3 (da) 1989-12-06 1994-03-07 Akzo Nobel Nv Stabiliserende opløsninger af psykotrope midler
US5589511A (en) 1990-08-13 1996-12-31 Sepracor Inc. Method for treating migraine headaches using optically pure S(+) fluoxetine
CA2104873C (en) 1991-02-26 2000-05-23 James N. Campbell Compositions and methods of treatment of sympathetically maintained pain
CA2115792C (en) 1993-03-05 2005-11-01 David J. Mayer Method for the treatment of pain
US6197830B1 (en) 1995-09-22 2001-03-06 Bruce M. Frome Method for achieving relief from sympathetically mediated pain
EP0942751B1 (en) * 1996-07-05 2002-09-25 The WWK Trust Compositions for the treatment of peripheral neuropathies containing antidepressants and/or monoamine oxidase inhibitors and/or vitamin b12 and/or precursors or inducers of a neurotransmitter

Also Published As

Publication number Publication date
WO1999059598A1 (en) 1999-11-25
NO20005835D0 (no) 2000-11-17
BR9911046A (pt) 2001-04-24
US6211171B1 (en) 2001-04-03
CN1308530A (zh) 2001-08-15
JP2002515438A (ja) 2002-05-28
AU3807799A (en) 1999-12-06
EP1094818A1 (en) 2001-05-02
NZ508991A (en) 2003-09-26
CA2333310A1 (en) 1999-11-25
KR20010071301A (ko) 2001-07-28
NO20005835L (no) 2001-01-18

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