TR200100854T2 - Çeşitli kinazlarda inhibitör etkisi olan yeni ikameli indolinonlar. - Google Patents

Çeşitli kinazlarda inhibitör etkisi olan yeni ikameli indolinonlar.

Info

Publication number
TR200100854T2
TR200100854T2 TR2001/00854T TR200100854T TR200100854T2 TR 200100854 T2 TR200100854 T2 TR 200100854T2 TR 2001/00854 T TR2001/00854 T TR 2001/00854T TR 200100854 T TR200100854 T TR 200100854T TR 200100854 T2 TR200100854 T2 TR 200100854T2
Authority
TR
Turkey
Prior art keywords
general formula
compounds
inhibitory effects
various kinases
new substituted
Prior art date
Application number
TR2001/00854T
Other languages
English (en)
Inventor
Walter Rainer
Grell Wolfgang
Heckel Armin
Himmelsbach Frank
Eberlein Wolfgang
Roth Gerald
C.A. Van Meel Jacobus
Redemann Norbert
Spevak Walter
Tontsch-Grunt Ulrike
von R�den Thomas
Original Assignee
Boehringer Ingelheim Pharma Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19844003A external-priority patent/DE19844003A1/de
Priority claimed from DE19937496A external-priority patent/DE19937496A1/de
Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of TR200100854T2 publication Critical patent/TR200100854T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Eldeki bulus içinde X ve R1 ile R5 arasindakilerin istem 1'deki gibi tanimlanmis oldugu genel formül I'in ikame edilmis yeni indolinonlarini, bunun degerli özelliklere sahip olan izomerlerini ve tuzlarini kapsamaktadir. Içinde R1'in bir hidrojen atomu, bir C1-3-alkil grubu veya bir ön ilaç oldugu yukarida belirtilen genel formül I'in bilesiklerinin özellikle degisik kinazlar, viral siklin ve reseptör-tirosin kinazlari üzerinde inhibe edici bir etki basta olmak üzere degerli farmakolojik özelliklere sahiplerdir, ve içinde R1'in bir hidrojen atomu olmadigi, bir C1-3-alkil grubunu ve bir ön ilaci teskil etmedigi genel formül I'in diger bilesikleri de yukarida belirtilen bilesiklerin üretiminde degerli ara ürünleri teskil ederler. (FORMÜL VAR)
TR2001/00854T 1998-09-25 1999-09-22 Çeşitli kinazlarda inhibitör etkisi olan yeni ikameli indolinonlar. TR200100854T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19844003A DE19844003A1 (de) 1998-09-25 1998-09-25 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19937496A DE19937496A1 (de) 1999-08-07 1999-08-07 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
TR200100854T2 true TR200100854T2 (tr) 2001-12-21

Family

ID=26049076

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00854T TR200100854T2 (tr) 1998-09-25 1999-09-22 Çeşitli kinazlarda inhibitör etkisi olan yeni ikameli indolinonlar.

Country Status (28)

Country Link
US (1) US6855710B2 (tr)
EP (1) EP1115704B1 (tr)
JP (1) JP2002525356A (tr)
KR (1) KR20010085841A (tr)
CN (1) CN1319090A (tr)
AT (1) ATE243195T1 (tr)
AU (1) AU763361B2 (tr)
BG (1) BG105327A (tr)
BR (1) BR9914065A (tr)
CA (1) CA2342622A1 (tr)
DE (1) DE59906030D1 (tr)
DK (1) DK1115704T3 (tr)
EA (1) EA200100320A1 (tr)
EE (1) EE200100184A (tr)
ES (1) ES2196860T3 (tr)
HR (1) HRP20010216A2 (tr)
HU (1) HUP0104973A3 (tr)
ID (1) ID27757A (tr)
IL (1) IL141622A0 (tr)
NO (1) NO20011477L (tr)
NZ (1) NZ510845A (tr)
PL (1) PL346898A1 (tr)
PT (1) PT1115704E (tr)
SI (1) SI1115704T1 (tr)
SK (1) SK4032001A3 (tr)
TR (1) TR200100854T2 (tr)
WO (1) WO2000018734A1 (tr)
YU (1) YU21301A (tr)

Families Citing this family (36)

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GB9904933D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US20030225152A1 (en) * 2001-09-27 2003-12-04 Andrews Steven W. 3-(Arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
US6797825B2 (en) 2001-12-13 2004-09-28 Abbott Laboratories Protein kinase inhibitors
JP4324480B2 (ja) 2002-03-26 2009-09-02 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド グルココルチコイドミメティクス、その製法、医薬組成物、及び使用
US7514468B2 (en) 2002-07-23 2009-04-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions
PE20040701A1 (es) * 2002-07-23 2004-11-30 Boehringer Ingelheim Pharma Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
DE10233366A1 (de) * 2002-07-23 2004-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel
DE10237423A1 (de) * 2002-08-16 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen
US20040204458A1 (en) 2002-08-16 2004-10-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of Lck inhibitors for treatment of immunologic diseases
NZ538932A (en) * 2002-08-29 2007-04-27 Boehringer Ingelheim Pharma 3-(sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative disease
US7148249B2 (en) * 2002-09-12 2006-12-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7125996B2 (en) * 2003-10-03 2006-10-24 Boehringer Ingelheim Pharmaceuticals, Inc. Fluorescent probes for use in protein kinase inhibitor binding assay
RU2376286C2 (ru) 2004-03-11 2009-12-20 Актелион Фармасьютиклз Лтд Производные индол-1-илуксусной кислоты
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
PE20061155A1 (es) * 2004-12-24 2006-12-16 Boehringer Ingelheim Int Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas
PE20060776A1 (es) 2004-12-27 2006-09-26 Boehringer Ingelheim Pharma Mimeticos de glucocorticoides, metodos para prepararlos y composiciones farmaceuticas
KR20080007645A (ko) * 2005-04-28 2008-01-22 베링거 인겔하임 인터내셔날 게엠베하 염증성 질환 치료용 신규 화합물
MX2009005264A (es) 2006-12-06 2009-05-28 Boehringer Ingelheim Int Mimeticos de glucocorticoides, metodos para su fabricacion, composiciones farmaceuticas y usos de los mismos.
JP2010512407A (ja) * 2006-12-11 2010-04-22 ジェネンテック インコーポレイテッド 新生物を処置するための組成物および方法
CN101273991B (zh) * 2007-03-28 2010-05-26 广东同德药业有限公司 四氢吲哚酮/四氢吲唑酮/四氢咔唑衍生物及其盐在制备抗病毒药物中的应用
PE20091445A1 (es) * 2007-12-03 2009-10-19 Boehringer Ingelheim Int Derivados de indolinona y procedimiento para su fabricacion
TR201802086T4 (tr) * 2007-12-03 2018-03-21 Boehringer Ingelheim Int Bir indolinon türevinin imalatı için proses.
PL2238108T3 (pl) * 2008-01-25 2013-01-31 Boehringer Ingelheim Int Postacie soli pochodnej 6-fluoro-1,2-dihydro-2-okso-3H-indol-3-ilidenu, sposób ich wytwarzania oraz kompozycje farmaceutyczne je zawierające
DK2300472T3 (da) 2008-06-06 2012-04-10 Boehringer Ingelheim Int Glucocorticoidmimetika, fremgangsmåder til disses fremstilling, farmaceutiske sammensætninger samt anvendelser deraf
AU2009275964A1 (en) 2008-07-29 2010-02-04 Boehringer Ingelheim International Gmbh New compounds
WO2013137371A1 (ja) * 2012-03-15 2013-09-19 興和株式会社 新規ピリミジン化合物及びそれらを含有する医薬
CN103664737A (zh) * 2012-09-25 2014-03-26 杨子娇 一类治疗房角狭窄的化合物及其用途
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂
CN114957084B (zh) * 2022-01-21 2023-05-09 九江学院 一种吲哚酮类化合物及其制备方法和应用
WO2025155711A1 (en) * 2024-01-17 2025-07-24 The Board Of Trustees Of The Leland Stanford Junior University Lrrk2 inhibitors and compositions and uses thereof

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GB9501567D0 (en) * 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease

Also Published As

Publication number Publication date
CN1319090A (zh) 2001-10-24
BG105327A (bg) 2001-12-29
PT1115704E (pt) 2003-11-28
ID27757A (id) 2001-04-26
EA200100320A1 (ru) 2001-10-22
SK4032001A3 (en) 2001-11-06
NO20011477D0 (no) 2001-03-22
WO2000018734A1 (de) 2000-04-06
HRP20010216A2 (en) 2002-04-30
ATE243195T1 (de) 2003-07-15
CA2342622A1 (en) 2000-04-06
DE59906030D1 (de) 2003-07-24
DK1115704T3 (da) 2003-09-29
EE200100184A (et) 2002-08-15
HUP0104973A2 (hu) 2002-04-29
ES2196860T3 (es) 2003-12-16
EP1115704A1 (de) 2001-07-18
KR20010085841A (ko) 2001-09-07
US6855710B2 (en) 2005-02-15
IL141622A0 (en) 2002-03-10
AU763361B2 (en) 2003-07-17
NZ510845A (en) 2003-10-31
AU6086399A (en) 2000-04-17
US20040058978A1 (en) 2004-03-25
YU21301A (sh) 2003-04-30
SI1115704T1 (sl) 2003-12-31
EP1115704B1 (de) 2003-06-18
BR9914065A (pt) 2001-06-19
JP2002525356A (ja) 2002-08-13
HUP0104973A3 (en) 2002-06-28
NO20011477L (no) 2001-03-22
PL346898A1 (en) 2002-03-11

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