TR200100868T2 - Indeno-,nafto-, benzosiklohepta-dihidrotiyazol türevleri, imalatları, anorektal ilaç olarak kullanılmaları. - Google Patents

Indeno-,nafto-, benzosiklohepta-dihidrotiyazol türevleri, imalatları, anorektal ilaç olarak kullanılmaları.

Info

Publication number
TR200100868T2
TR200100868T2 TR2001/00868T TR200100868T TR200100868T2 TR 200100868 T2 TR200100868 T2 TR 200100868T2 TR 2001/00868 T TR2001/00868 T TR 2001/00868T TR 200100868 T TR200100868 T TR 200100868T TR 200100868 T2 TR200100868 T2 TR 200100868T2
Authority
TR
Turkey
Prior art keywords
manufacture
benzocyclohepta
indeno
naphtho
derivatives
Prior art date
Application number
TR2001/00868T
Other languages
English (en)
Inventor
Jahne Gerhard
Glombik Heiner
Geisen Karl
Bickel Martin
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of TR200100868T2 publication Critical patent/TR200100868T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Polisiklik dihidrotiyazoller, imal edilmelerine yönelik yöntem ve ilaç maddesi olarak kullanimlari. Bulus polisiklik dihidrotiyazoller ve ayrica onlarin fizyolojik olarak hazmedilebilen tuzlari ve fizyolojik islevleri olan türevleri. Formül 1'in (FORMÜL VAR) içerisindeki artiklarin belirtilmis olan anlamlara geldigi, ve ayrica onlarin fizyolojik olarak hazmedilebilen tuzlari ve onlarin imal edilmesine yönelik yöntem tanimlanmaktadir. Bilesimler örnegin anorektikler olarak birebirdirler.
TR2001/00868T 1998-09-29 1999-09-16 Indeno-,nafto-, benzosiklohepta-dihidrotiyazol türevleri, imalatları, anorektal ilaç olarak kullanılmaları. TR200100868T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19844547A DE19844547C2 (de) 1998-09-29 1998-09-29 Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
TR200100868T2 true TR200100868T2 (tr) 2001-09-21

Family

ID=7882588

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00868T TR200100868T2 (tr) 1998-09-29 1999-09-16 Indeno-,nafto-, benzosiklohepta-dihidrotiyazol türevleri, imalatları, anorektal ilaç olarak kullanılmaları.

Country Status (25)

Country Link
US (2) US6090833A (tr)
EP (1) EP1119557B1 (tr)
JP (1) JP3542078B2 (tr)
KR (1) KR20010079952A (tr)
CN (1) CN1143852C (tr)
AR (1) AR020662A1 (tr)
AT (1) ATE255569T1 (tr)
AU (1) AU755158B2 (tr)
BR (1) BR9915014A (tr)
CA (1) CA2345359A1 (tr)
DE (2) DE19844547C2 (tr)
DK (1) DK1119557T3 (tr)
ES (1) ES2212673T3 (tr)
HK (1) HK1040080B (tr)
HU (1) HUP0103504A3 (tr)
ID (1) ID29578A (tr)
IL (1) IL142096A0 (tr)
NO (1) NO318388B1 (tr)
NZ (1) NZ510399A (tr)
PL (1) PL347072A1 (tr)
PT (1) PT1119557E (tr)
RU (1) RU2217427C2 (tr)
TR (1) TR200100868T2 (tr)
WO (1) WO2000018749A1 (tr)
ZA (1) ZA200102446B (tr)

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DE10008274A1 (de) * 2000-02-23 2001-08-30 Aventis Pharma Gmbh Substituierte 8,8a-Dihydro-3aH-indeno[1,2-d]thiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
KR100763214B1 (ko) * 2000-02-26 2007-10-08 사노피-아벤티스 도이칠란트 게엠베하 2 위치에서 설폰아미도 또는 설포노 치환체를 갖는 8,8ａ-디하이드로-인데노[1,2-ｄ]티아졸 유도체, 이의 제조방법 및 이를 포함하는 약제
DE10142722A1 (de) * 2001-08-31 2003-03-27 Aventis Pharma Deutschland GmbH, 65929 Frankfurt C2-substituierte Indan-1-one und ihre Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10142665B4 (de) * 2001-08-31 2004-05-06 Aventis Pharma Deutschland Gmbh C2-Disubstituierte Indan-1-one und ihre Derivate
DE10142663B4 (de) 2001-08-31 2004-08-19 Aventis Pharma Deutschland Gmbh C2-Disubstituierte Indan-1-ol-Systeme
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
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ES2465216T3 (es) 2007-06-04 2014-06-05 Ben Gurion University Of The Negev Research And Development Authority Compuestos de triarilo y composiciones que comprenden los mismos
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010047982A1 (en) 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
JP5557845B2 (ja) 2008-10-31 2014-07-23 メルク・シャープ・アンド・ドーム・コーポレーション 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体
US8895596B2 (en) 2010-02-25 2014-11-25 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
BR112013021236B1 (pt) 2011-02-25 2021-05-25 Merck Sharp & Dohme Corp composto derivado de benzimidazol, e, composição
ES2664873T3 (es) 2011-03-01 2018-04-23 Synergy Pharmaceuticals Inc. Proceso de preparación de agonistas de guanilato ciclasa C
US9527875B2 (en) 2012-08-02 2016-12-27 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
RU2015140066A (ru) 2013-02-22 2017-03-30 Мерк Шарп И Доум Корп. Противодиабетические бициклические соединения
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
CR20160207A (es) 2013-11-05 2016-08-10 Ben Gurion Univ Of The Negev Res And Dev Authority Compuestos para el tratamiento de la diabetes y las complicaciones que surgen de la misma enfermedad
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
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Also Published As

Publication number Publication date
ES2212673T3 (es) 2004-07-16
HUP0103504A3 (en) 2002-10-28
JP2002525363A (ja) 2002-08-13
DE19844547C2 (de) 2002-11-07
PT1119557E (pt) 2004-04-30
EP1119557A1 (de) 2001-08-01
JP3542078B2 (ja) 2004-07-14
HK1040080B (zh) 2004-08-20
DK1119557T3 (da) 2004-04-13
RU2217427C2 (ru) 2003-11-27
PL347072A1 (en) 2002-03-11
IL142096A0 (en) 2002-03-10
HK1040080A1 (en) 2002-05-24
NO20011503L (no) 2001-03-23
NO20011503D0 (no) 2001-03-23
DE19844547A1 (de) 2000-03-30
ID29578A (id) 2001-09-06
NO318388B1 (no) 2005-03-14
AR020662A1 (es) 2002-05-22
ATE255569T1 (de) 2003-12-15
NZ510399A (en) 2003-10-31
US6291486B1 (en) 2001-09-18
KR20010079952A (ko) 2001-08-22
HUP0103504A2 (hu) 2002-07-29
WO2000018749A1 (de) 2000-04-06
AU755158B2 (en) 2002-12-05
DE59907961D1 (de) 2004-01-15
ZA200102446B (en) 2001-09-28
CN1143852C (zh) 2004-03-31
AU5978799A (en) 2000-04-17
US6090833A (en) 2000-07-18
CA2345359A1 (en) 2000-04-06
BR9915014A (pt) 2001-08-07
EP1119557B1 (de) 2003-12-03
CN1320120A (zh) 2001-10-31

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