ID29578A - Turunan-turunan indeno-, nafto- dan benzosikloheptadihidrotiazol serta pembuatan dan penggunaannya sebagai obat-obatan anorektik - Google Patents

Turunan-turunan indeno-, nafto- dan benzosikloheptadihidrotiazol serta pembuatan dan penggunaannya sebagai obat-obatan anorektik

Info

Publication number
ID29578A
ID29578A IDW20010719A ID20010719A ID29578A ID 29578 A ID29578 A ID 29578A ID W20010719 A IDW20010719 A ID W20010719A ID 20010719 A ID20010719 A ID 20010719A ID 29578 A ID29578 A ID 29578A
Authority
ID
Indonesia
Prior art keywords
benzosicloheptihihidrotiazol
nafto
indeno
derives
manufacturing
Prior art date
Application number
IDW20010719A
Other languages
English (en)
Inventor
Gerhard Dr Jaehne
Heiner Dr Glombik
Karl Dr Geisen
Martin Dr Bickel
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of ID29578A publication Critical patent/ID29578A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IDW20010719A 1998-09-29 1999-09-16 Turunan-turunan indeno-, nafto- dan benzosikloheptadihidrotiazol serta pembuatan dan penggunaannya sebagai obat-obatan anorektik ID29578A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19844547A DE19844547C2 (de) 1998-09-29 1998-09-29 Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
ID29578A true ID29578A (id) 2001-09-06

Family

ID=7882588

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20010719A ID29578A (id) 1998-09-29 1999-09-16 Turunan-turunan indeno-, nafto- dan benzosikloheptadihidrotiazol serta pembuatan dan penggunaannya sebagai obat-obatan anorektik

Country Status (25)

Country Link
US (2) US6090833A (id)
EP (1) EP1119557B1 (id)
JP (1) JP3542078B2 (id)
KR (1) KR20010079952A (id)
CN (1) CN1143852C (id)
AR (1) AR020662A1 (id)
AT (1) ATE255569T1 (id)
AU (1) AU755158B2 (id)
BR (1) BR9915014A (id)
CA (1) CA2345359A1 (id)
DE (2) DE19844547C2 (id)
DK (1) DK1119557T3 (id)
ES (1) ES2212673T3 (id)
HK (1) HK1040080B (id)
HU (1) HUP0103504A3 (id)
ID (1) ID29578A (id)
IL (1) IL142096A0 (id)
NO (1) NO318388B1 (id)
NZ (1) NZ510399A (id)
PL (1) PL347072A1 (id)
PT (1) PT1119557E (id)
RU (1) RU2217427C2 (id)
TR (1) TR200100868T2 (id)
WO (1) WO2000018749A1 (id)
ZA (1) ZA200102446B (id)

Families Citing this family (32)

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DE19908539A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA2389703A1 (en) 1999-11-05 2001-05-10 Aventis Pharma Deutschland Gmbh Indeno-, naphtho-, and benzocyclohepta-dihydrothiazole derivatives, the production thereof and their use as anorectic medicaments
DE10008274A1 (de) 2000-02-23 2001-08-30 Aventis Pharma Gmbh Substituierte 8,8a-Dihydro-3aH-indeno[1,2-d]thiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
NZ520926A (en) * 2000-02-23 2004-08-27 Aventis Pharma Gmbh 8,8a-dihydro-indeno[1,2-d]thiazole derivatives, substituted in position 8a, a method for their production and their use as medicaments, e.g. anorectic agents
SK285571B6 (sk) * 2000-02-26 2007-04-05 Sanofi-Aventis Deutschland Gmbh 8,8a-Dihydroindeno[1,2-d]tiazolové deriváty nesúce v polohe 2 substituent so sulfónamidovou štruktúrou, spôsob ich prípravy a farmaceutické prostriedky, ktoré ich obsahujú
DE10142663B4 (de) 2001-08-31 2004-08-19 Aventis Pharma Deutschland Gmbh C2-Disubstituierte Indan-1-ol-Systeme
DE10142665B4 (de) * 2001-08-31 2004-05-06 Aventis Pharma Deutschland Gmbh C2-Disubstituierte Indan-1-one und ihre Derivate
DE10142722A1 (de) 2001-08-31 2003-03-27 Aventis Pharma Deutschland GmbH, 65929 Frankfurt C2-substituierte Indan-1-one und ihre Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
CA2662084A1 (en) 2006-09-07 2008-03-13 Nycomed Gmbh Combination treatment for diabetes mellitus
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2008259342B2 (en) 2007-06-04 2014-07-10 Ben-Gurion University Of The Negev Research And Development Authority Tri-aryl compounds and compositions comprising the same
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US8410284B2 (en) 2008-10-22 2013-04-02 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
CA2741672A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
AU2011218830B2 (en) 2010-02-25 2014-07-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2826649C (en) 2011-02-25 2016-07-26 Merck Sharp & Dohme Corp. Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
EA201391254A1 (ru) 2011-03-01 2014-02-28 Синерджи Фармасьютикалз Инк. Способ получения агонистов гуанилатциклазы c
RU2015106909A (ru) 2012-08-02 2016-09-27 Мерк Шарп И Доум Корп. Антидиабетические трициклические соединения
BR112015019836A2 (pt) 2013-02-22 2017-07-18 Merck Sharp & Dohme composto, composição farmacêutica, e, uso de um composto
EP2970119B1 (en) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2015068156A1 (en) 2013-11-05 2015-05-14 Ben-Gurion University Of The Negev Research And Development Authority Compounds for the treatment of diabetes and disease complications arising from same
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
WO2018118670A1 (en) 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2942003A (en) * 1957-06-06 1960-06-21 Gen Aniline & Film Corp Process for preparing naphtho [1, 2-d]-thiazoles
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
CA1292226C (en) * 1986-01-16 1991-11-19 Terumi Hachiya Indenothiazole derivative and process for preparing the same
JPH0514068A (ja) * 1991-07-03 1993-01-22 Shimada Phys & Chem Ind Co Ltd 並列増幅部切換型高周波低雑音増幅装置
JP3197602B2 (ja) * 1992-02-17 2001-08-13 久光製薬株式会社 チアゾール類縁化合物及び皮膚外用剤
EP0749966A4 (en) * 1994-03-11 1997-07-02 Yamanouchi Pharma Co Ltd 5-HT 3 RECEPTOR AGONIST, NEW THIAZOLE DERIVATIVE AND INTERMEDIATE FOR OBTAINING IT
GB9517381D0 (en) * 1995-08-24 1995-10-25 Pharmacia Spa Aryl and heteroaryl piperazine derivatives
TW416953B (en) * 1996-09-25 2001-01-01 Takeda Chemical Industries Ltd Tricyclic compounds for eliciting a prostaglandin I2 receptor agonistic effect, their production and use

Also Published As

Publication number Publication date
WO2000018749A1 (de) 2000-04-06
HK1040080B (zh) 2004-08-20
NO20011503D0 (no) 2001-03-23
EP1119557A1 (de) 2001-08-01
PT1119557E (pt) 2004-04-30
CA2345359A1 (en) 2000-04-06
EP1119557B1 (de) 2003-12-03
NZ510399A (en) 2003-10-31
DE19844547A1 (de) 2000-03-30
NO318388B1 (no) 2005-03-14
HK1040080A1 (en) 2002-05-24
JP3542078B2 (ja) 2004-07-14
AU755158B2 (en) 2002-12-05
HUP0103504A2 (hu) 2002-07-29
RU2217427C2 (ru) 2003-11-27
PL347072A1 (en) 2002-03-11
BR9915014A (pt) 2001-08-07
CN1143852C (zh) 2004-03-31
ATE255569T1 (de) 2003-12-15
AU5978799A (en) 2000-04-17
KR20010079952A (ko) 2001-08-22
US6090833A (en) 2000-07-18
DK1119557T3 (da) 2004-04-13
AR020662A1 (es) 2002-05-22
ZA200102446B (en) 2001-09-28
DE59907961D1 (de) 2004-01-15
DE19844547C2 (de) 2002-11-07
IL142096A0 (en) 2002-03-10
NO20011503L (no) 2001-03-23
HUP0103504A3 (en) 2002-10-28
CN1320120A (zh) 2001-10-31
ES2212673T3 (es) 2004-07-16
US6291486B1 (en) 2001-09-18
TR200100868T2 (tr) 2001-09-21
JP2002525363A (ja) 2002-08-13

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