TR200103692T2 - Bisiklik heterosikilleri içeren ilaçlar ve üretimleri. - Google Patents

Bisiklik heterosikilleri içeren ilaçlar ve üretimleri.

Info

Publication number
TR200103692T2
TR200103692T2 TR2001/03692T TR200103692T TR200103692T2 TR 200103692 T2 TR200103692 T2 TR 200103692T2 TR 2001/03692 T TR2001/03692 T TR 2001/03692T TR 200103692 T TR200103692 T TR 200103692T TR 200103692 T2 TR200103692 T2 TR 200103692T2
Authority
TR
Turkey
Prior art keywords
bicyclic heterocycles
manufacture
drugs containing
containing bicyclic
diseases
Prior art date
Application number
TR2001/03692T
Other languages
English (en)
Inventor
Himmelsbach Frank
Langkopf Elke
Metz Thomas
Solca Flavio
Baum Anke
Jung Birgit
Original Assignee
Boehringer Ingelheim Pharma Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999128281 external-priority patent/DE19928281A1/de
Priority claimed from DE2000123085 external-priority patent/DE10023085A1/de
Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of TR200103692T2 publication Critical patent/TR200103692T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Eldeki bulus, içinde Ra ile Rc arasindakilerin, A ile E arasindakilerin ve X' in istem 1 deki gibi tanimlanmis oldugu genel formül (I)' in bisiklik heterosikillerini, bunun totomer, stereoizomer ve tuzlarini, özellikle de anorganik ve organik asit ve bazli fizyolojik olarak tolere edilebilen tuzlarini kapsamakta olup, basta tirosin kinazlarinin aracilik ettigi sinyal transdüksiyonu üzerinde olmak üzere degerli farmakolojik özelliklere sahip olup, ayrica bunlarin hastaliklarin, özellikle de tümör hastaliklarinin, akciger ve solunum yollarinin tedavisi için kullanimini ve üretimini kapsamaktadir.
TR2001/03692T 1999-06-21 2000-06-16 Bisiklik heterosikilleri içeren ilaçlar ve üretimleri. TR200103692T2 (tr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999128281 DE19928281A1 (de) 1999-06-21 1999-06-21 Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US14664499P 1999-07-30 1999-07-30
DE2000123085 DE10023085A1 (de) 2000-05-11 2000-05-11 Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
TR200103692T2 true TR200103692T2 (tr) 2002-10-21

Family

ID=27213849

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03692T TR200103692T2 (tr) 1999-06-21 2000-06-16 Bisiklik heterosikilleri içeren ilaçlar ve üretimleri.

Country Status (26)

Country Link
US (4) US7220750B2 (tr)
EP (2) EP1194418A1 (tr)
JP (1) JP3686610B2 (tr)
KR (1) KR100709909B1 (tr)
CN (1) CN1166645C (tr)
AU (1) AU775285B2 (tr)
BG (1) BG65890B1 (tr)
CA (1) CA2375259C (tr)
CZ (1) CZ302365B6 (tr)
DK (1) DK1731511T3 (tr)
EA (1) EA004981B1 (tr)
EE (1) EE04748B1 (tr)
ES (1) ES2552813T3 (tr)
HK (1) HK1044769B (tr)
HU (1) HUP0201900A3 (tr)
IL (2) IL147133A0 (tr)
ME (1) MEP45508A (tr)
MX (1) MXPA01012899A (tr)
NO (1) NO322094B1 (tr)
NZ (1) NZ516633A (tr)
PT (1) PT1731511E (tr)
SK (1) SK287010B6 (tr)
TR (1) TR200103692T2 (tr)
UA (1) UA71976C2 (tr)
WO (1) WO2000078735A1 (tr)
YU (1) YU90901A (tr)

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