TR200200034T2 - Büyüme hormonu formülasyonları. - Google Patents

Büyüme hormonu formülasyonları.

Info

Publication number
TR200200034T2
TR200200034T2 TR2002/00034T TR200200034T TR200200034T2 TR 200200034 T2 TR200200034 T2 TR 200200034T2 TR 2002/00034 T TR2002/00034 T TR 2002/00034T TR 200200034 T TR200200034 T TR 200200034T TR 200200034 T2 TR200200034 T2 TR 200200034T2
Authority
TR
Turkey
Prior art keywords
growth hormone
temperatures
aggregation
level
formulations
Prior art date
Application number
TR2002/00034T
Other languages
English (en)
Inventor
Siebold Bernhard
Stevens John
Original Assignee
Grandis Biotech Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26315757&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200200034(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9916252.1A external-priority patent/GB9916252D0/en
Priority claimed from GBGB9918902.9A external-priority patent/GB9918902D0/en
Application filed by Grandis Biotech Gmbh filed Critical Grandis Biotech Gmbh
Publication of TR200200034T2 publication Critical patent/TR200200034T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Büyüme hormonlarinin baska katki maddeleri olmaksizin sadece yaklasik fizyolojik pH seviyesindeki fosfat tamponu içerisinde formüle edilmesiyle, likit büyüme hormonu formülasyonlarinin 2-8 C araligindaki sicakliklarda 6 aydan daha uzun süreler sabit olarak saklanabilmesi mümkün olur. pH seviyesinin 6.2 ya da daha üzerinde temin edilmesiyle, buzdolabi sicakliklari ya da üzerindeki sicakliklarda saklama esnasinda büyüme hormonu kristallesmesi engellenir ya da azaltilir. Iyonik harici sürfaktana ait düsük konsantrasyonlarin kullanilmasi, dökme formülasyonun dozaj haznelerine otomatize olarak nakledilmesi esnasinda karsilasilan fiziksel kuvvetlerin bir sonucu olarak büyüme hormonu kümelenmesini (agregasyon) azaltmaya yardimci olabilir. Izotonik formülasyonlarin saglanmasi amaciyla mannitol dahil edilir. Bakteri kirlenmesini azaltmak ve böylece 2-8 C sicakliklarda saklanmasi mümkün çoklu dozaj birimlerine olanak vermek amaciyla koruma maddeleri (prezervatifler) dahi edilir.
TR2002/00034T 1999-07-12 2000-07-11 Büyüme hormonu formülasyonları. TR200200034T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9916252.1A GB9916252D0 (en) 1999-07-12 1999-07-12 Growth hormone formulation
GBGB9918902.9A GB9918902D0 (en) 1999-08-12 1999-08-12 Growth hormone formulation

Publications (1)

Publication Number Publication Date
TR200200034T2 true TR200200034T2 (tr) 2002-05-21

Family

ID=26315757

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/00034T TR200200034T2 (tr) 1999-07-12 2000-07-11 Büyüme hormonu formülasyonları.

Country Status (25)

Country Link
US (1) US20060029635A1 (tr)
EP (1) EP1194170B1 (tr)
JP (3) JP2003504346A (tr)
KR (1) KR20020031388A (tr)
CN (1) CN1360506A (tr)
AR (1) AR024728A1 (tr)
AT (1) ATE386501T1 (tr)
AU (1) AU775107C (tr)
BR (1) BR0013162A (tr)
CA (1) CA2378949C (tr)
CZ (1) CZ200260A3 (tr)
DE (1) DE60038118T2 (tr)
ES (1) ES2300268T3 (tr)
HK (1) HK1046358A1 (tr)
HU (1) HUP0202189A3 (tr)
IL (2) IL147253A0 (tr)
MX (1) MXPA02000404A (tr)
NO (1) NO20020151L (tr)
NZ (1) NZ516507A (tr)
PL (1) PL353238A1 (tr)
SI (1) SI1194170T1 (tr)
SK (1) SK252002A3 (tr)
TR (1) TR200200034T2 (tr)
TW (1) TWI247608B (tr)
WO (1) WO2001003741A1 (tr)

Families Citing this family (18)

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US20030162711A1 (en) * 1996-04-24 2003-08-28 Soren Bjorn Pharmaceutical formulation
US20070179096A1 (en) * 1996-04-24 2007-08-02 Novo Nordisk A/S Pharmaceutical Formulation
GB2371227A (en) * 2001-01-10 2002-07-24 Grandis Biotech Gmbh Crystallisation - resistant aqueous growth hormone formulations
EP1521596A1 (en) * 2002-07-09 2005-04-13 Sandoz AG Liquid formulations with a high concentration of human growth hormone (hgh) comprising glycine
JP4949828B2 (ja) * 2003-03-18 2012-06-13 アレス トレーディング ソシエテ アノニム 溶液中での成長ホルモンの安定化
WO2005027960A1 (en) * 2003-09-25 2005-03-31 Cangene Corporation Liquid human growth hormone formulation containing polyethylene glycol
WO2005063298A1 (en) * 2003-12-23 2005-07-14 Pharmacia Corporation Stable growth hormone liquid formulation
US7662393B2 (en) * 2004-04-07 2010-02-16 Ares Trading S.A. Liquid growth hormone formulation and method of use
US8293532B2 (en) 2009-03-26 2012-10-23 Dow AgroSciences, L.L.C. Method and apparatus for tissue transfer
KR101614983B1 (ko) * 2009-11-17 2016-04-22 입센 파마 에스.에이.에스 Ｈｇｈ 및 ｒｈｉｇｆ―１의 조합물을 위한 제제
BR112014001921B1 (pt) 2011-07-25 2022-05-10 Sandoz Ag Formulação aquosa farmaceuticamente aceitável, método para aumentar a estabilidade de uma formulação aquosa farmaceuticamente aceitável e embalagem principal
JP2013231030A (ja) * 2012-04-30 2013-11-14 Sun Pharmaceutical Industries Ltd リュープロリド注射剤
JP6001401B2 (ja) * 2012-09-28 2016-10-05 ユニ・チャーム株式会社 ウェットティッシュ用薬液及びウェットティッシュ
CN107735429B (zh) 2015-12-10 2021-05-07 三菱瓦斯化学株式会社 光固化性组合物和光学材料
JP6172880B1 (ja) * 2017-02-01 2017-08-02 協和発酵キリン株式会社 ダルベポエチンを含む液体医薬組成物
KR20210024082A (ko) 2018-06-25 2021-03-04 제이씨알 파마 가부시키가이샤 단백질 함유 수성 액제
WO2022104389A1 (en) * 2020-11-16 2022-05-19 W. L. Gore & Associates, Inc. Formulations, methods, and pre-filled multi-dose injection devices without cloud point
CN112494638B (zh) * 2020-12-22 2023-12-19 深圳科兴药业有限公司 一种人生长激素注射剂组合物及其制备方法

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US4783441A (en) * 1979-04-30 1988-11-08 Hoechst Aktiengesellschaft Aqueous protein solutions stable to denaturation
DE3325223A1 (de) * 1983-07-13 1985-01-24 Hoechst Ag, 6230 Frankfurt Gegen denaturierung bestaendige, waessrige proteinloesungen, verfahren zu ihrer herstellung und ihre verwendung
AU6073386A (en) * 1985-07-30 1987-02-05 International Minerals & Chemical Corporation Stabilization of growth promoting hormones
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IL86799A (en) * 1987-07-02 1993-03-15 Kabi Pharmacia Ab Method and device for injection
US5151265A (en) * 1987-11-03 1992-09-29 Genentech, Inc. Gamma interferon formulation
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US5126324A (en) * 1990-06-07 1992-06-30 Genentech, Inc. Method of enhancing growth in patients using combination therapy
RU2068273C1 (ru) * 1990-09-21 1996-10-27 Ново Нордиск А/С Переходная головка
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EP0652766B2 (en) * 1992-07-31 2008-03-19 Genentech, Inc. Human growth hormone aqueous formulation
US5334162A (en) * 1993-03-15 1994-08-02 Eli Lilly And Company Cartridge assembly for a lyophilized compound forming a disposable portion of an injector pen and method for same
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US5610134A (en) * 1994-04-15 1997-03-11 Genentech, Inc. Treatment of congestive heart failure
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AUPN801296A0 (en) * 1996-02-12 1996-03-07 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
CA2246265A1 (en) * 1996-02-13 1997-08-21 G.D. Searle & Co. Combinations having immunosuppressive effects, containing cyclooxygenase-2-inhibitors and 5-lipoxygenase inhibitors
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JP3723857B2 (ja) * 1998-02-04 2005-12-07 日本ケミカルリサーチ株式会社 ヒト成長ホルモン含有水性医薬組成物

Also Published As

Publication number Publication date
AU775107C (en) 2005-02-24
SK252002A3 (en) 2002-06-04
BR0013162A (pt) 2002-05-28
WO2001003741B1 (en) 2001-04-19
NO20020151D0 (no) 2002-01-11
CA2378949C (en) 2015-03-31
JP5941496B2 (ja) 2016-06-29
IL147253A (en) 2007-07-24
TWI247608B (en) 2006-01-21
DE60038118T2 (de) 2009-03-05
JP2014208656A (ja) 2014-11-06
CA2378949A1 (en) 2001-01-18
HUP0202189A3 (en) 2003-07-28
KR20020031388A (ko) 2002-05-01
DE60038118D1 (de) 2008-04-03
ES2300268T3 (es) 2008-06-16
AU775107B2 (en) 2004-07-15
NO20020151L (no) 2002-03-12
CZ200260A3 (cs) 2002-04-17
IL147253A0 (en) 2002-08-14
SI1194170T1 (sl) 2008-10-31
AU5997500A (en) 2001-01-30
JP2003504346A (ja) 2003-02-04
HUP0202189A2 (en) 2002-10-28
ATE386501T1 (de) 2008-03-15
EP1194170B1 (en) 2008-02-20
EP1194170A1 (en) 2002-04-10
JP2012051891A (ja) 2012-03-15
HK1046358A1 (zh) 2003-01-10
PL353238A1 (en) 2003-11-03
CN1360506A (zh) 2002-07-24
AR024728A1 (es) 2002-10-23
WO2001003741A1 (en) 2001-01-18
US20060029635A1 (en) 2006-02-09
MXPA02000404A (es) 2004-05-21
NZ516507A (en) 2004-02-27

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