TR200200034T2 - Büyüme hormonu formülasyonları. - Google Patents

Büyüme hormonu formülasyonları.

Info

Publication number
TR200200034T2
TR200200034T2 TR2002/00034T TR200200034T TR200200034T2 TR 200200034 T2 TR200200034 T2 TR 200200034T2 TR 2002/00034 T TR2002/00034 T TR 2002/00034T TR 200200034 T TR200200034 T TR 200200034T TR 200200034 T2 TR200200034 T2 TR 200200034T2
Authority
TR
Turkey
Prior art keywords
growth hormone
temperatures
aggregation
level
formulations
Prior art date
Application number
TR2002/00034T
Other languages
English (en)
Inventor
Siebold Bernhard
Stevens John
Original Assignee
Grandis Biotech Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26315757&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200200034(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9916252.1A external-priority patent/GB9916252D0/en
Priority claimed from GBGB9918902.9A external-priority patent/GB9918902D0/en
Application filed by Grandis Biotech Gmbh filed Critical Grandis Biotech Gmbh
Publication of TR200200034T2 publication Critical patent/TR200200034T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Büyüme hormonlarinin baska katki maddeleri olmaksizin sadece yaklasik fizyolojik pH seviyesindeki fosfat tamponu içerisinde formüle edilmesiyle, likit büyüme hormonu formülasyonlarinin 2-8 C araligindaki sicakliklarda 6 aydan daha uzun süreler sabit olarak saklanabilmesi mümkün olur. pH seviyesinin 6.2 ya da daha üzerinde temin edilmesiyle, buzdolabi sicakliklari ya da üzerindeki sicakliklarda saklama esnasinda büyüme hormonu kristallesmesi engellenir ya da azaltilir. Iyonik harici sürfaktana ait düsük konsantrasyonlarin kullanilmasi, dökme formülasyonun dozaj haznelerine otomatize olarak nakledilmesi esnasinda karsilasilan fiziksel kuvvetlerin bir sonucu olarak büyüme hormonu kümelenmesini (agregasyon) azaltmaya yardimci olabilir. Izotonik formülasyonlarin saglanmasi amaciyla mannitol dahil edilir. Bakteri kirlenmesini azaltmak ve böylece 2-8 C sicakliklarda saklanmasi mümkün çoklu dozaj birimlerine olanak vermek amaciyla koruma maddeleri (prezervatifler) dahi edilir.
TR2002/00034T 1999-07-12 2000-07-11 Büyüme hormonu formülasyonları. TR200200034T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9916252.1A GB9916252D0 (en) 1999-07-12 1999-07-12 Growth hormone formulation
GBGB9918902.9A GB9918902D0 (en) 1999-08-12 1999-08-12 Growth hormone formulation

Publications (1)

Publication Number Publication Date
TR200200034T2 true TR200200034T2 (tr) 2002-05-21

Family

ID=26315757

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/00034T TR200200034T2 (tr) 1999-07-12 2000-07-11 Büyüme hormonu formülasyonları.

Country Status (25)

Country Link
US (1) US20060029635A1 (tr)
EP (1) EP1194170B1 (tr)
JP (3) JP2003504346A (tr)
KR (1) KR20020031388A (tr)
CN (1) CN1360506A (tr)
AR (1) AR024728A1 (tr)
AT (1) ATE386501T1 (tr)
AU (1) AU775107C (tr)
BR (1) BR0013162A (tr)
CA (1) CA2378949C (tr)
CZ (1) CZ200260A3 (tr)
DE (1) DE60038118T2 (tr)
ES (1) ES2300268T3 (tr)
HK (1) HK1046358A1 (tr)
HU (1) HUP0202189A3 (tr)
IL (2) IL147253A0 (tr)
MX (1) MXPA02000404A (tr)
NO (1) NO20020151L (tr)
NZ (1) NZ516507A (tr)
PL (1) PL353238A1 (tr)
SI (1) SI1194170T1 (tr)
SK (1) SK252002A3 (tr)
TR (1) TR200200034T2 (tr)
TW (1) TWI247608B (tr)
WO (1) WO2001003741A1 (tr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030162711A1 (en) * 1996-04-24 2003-08-28 Soren Bjorn Pharmaceutical formulation
US20070179096A1 (en) * 1996-04-24 2007-08-02 Novo Nordisk A/S Pharmaceutical Formulation
GB2371227A (en) * 2001-01-10 2002-07-24 Grandis Biotech Gmbh Crystallisation - resistant aqueous growth hormone formulations
AU2003249992A1 (en) * 2002-07-09 2004-01-23 Sandoz Ag Liquid formulations with high concentration of human growth hormone (hgh) comprising phenol
JP4949828B2 (ja) * 2003-03-18 2012-06-13 アレス トレーディング ソシエテ アノニム 溶液中での成長ホルモンの安定化
JP2007506683A (ja) * 2003-09-25 2007-03-22 カンジェーン コーポレイション ヒト成長ホルモン剤およびその調整方法と使用方法
US8338374B2 (en) 2003-12-23 2012-12-25 Pharmacia Corporation Stable growth hormone liquid formulation
UA89781C2 (uk) * 2004-04-07 2010-03-10 Арес Трейдінг С.А. Рідкий склад гормона росту
US8293532B2 (en) 2009-03-26 2012-10-23 Dow AgroSciences, L.L.C. Method and apparatus for tissue transfer
EP2501367B1 (en) * 2009-11-17 2015-01-21 Ipsen Pharma S.A.S. Formulation for HGH and RHIGF-1 combination
US20140194356A1 (en) 2011-07-25 2014-07-10 Sandoz Ag Aqueous formulation comprising at least a neutral salt and a biopharmaceutical protein
US20130288968A1 (en) * 2012-04-30 2013-10-31 Sun Pharmaceutical Industries Ltd. Leuprolide injection
JP6001401B2 (ja) * 2012-09-28 2016-10-05 ユニ・チャーム株式会社 ウェットティッシュ用薬液及びウェットティッシュ
JP6179690B1 (ja) 2015-12-10 2017-08-16 三菱瓦斯化学株式会社 光硬化性組成物及び光学材料
JP6172880B1 (ja) * 2017-02-01 2017-08-02 協和発酵キリン株式会社 ダルベポエチンを含む液体医薬組成物
US11738068B2 (en) 2018-06-25 2023-08-29 Jcr Pharmaceuticals Co., Ltd. Protein-containing aqueous liquid formulation
AU2021379990A1 (en) * 2020-11-16 2023-06-29 W. L. Gore & Associates, Inc. Formulations, methods, and pre-filled multi-dose injection devices without cloud point
CN112494638B (zh) * 2020-12-22 2023-12-19 深圳科兴药业有限公司 一种人生长激素注射剂组合物及其制备方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783441A (en) * 1979-04-30 1988-11-08 Hoechst Aktiengesellschaft Aqueous protein solutions stable to denaturation
DE3325223A1 (de) * 1983-07-13 1985-01-24 Hoechst Ag, 6230 Frankfurt Gegen denaturierung bestaendige, waessrige proteinloesungen, verfahren zu ihrer herstellung und ihre verwendung
BR8603586A (pt) * 1985-07-30 1987-03-10 Int Minerals & Chem Corp Processo para manter a fluidez de um homonio;processo para efetuar a promocao de crescimento em animais e formulacao promotora de crescimento
US4857505A (en) * 1987-03-09 1989-08-15 American Cyanamid Company Sustained release compositions for parenteral administration and their use
IL86799A (en) * 1987-07-02 1993-03-15 Kabi Pharmacia Ab Method and device for injection
US5151265A (en) * 1987-11-03 1992-09-29 Genentech, Inc. Gamma interferon formulation
CA1331133C (en) * 1988-03-01 1994-08-02 Michael Jon Pikal Pharmaceutical growth hormone formulations
US5763394A (en) * 1988-04-15 1998-06-09 Genentech, Inc. Human growth hormone aqueous formulation
US5096885A (en) * 1988-04-15 1992-03-17 Genentech, Inc. Human growth hormone formulation
JPH0383931A (ja) * 1989-08-29 1991-04-09 Sumitomo Pharmaceut Co Ltd 低刺激性ｇｒｆ経鼻投与製剤
US5681814A (en) * 1990-06-07 1997-10-28 Genentech, Inc. Formulated IGF-I Composition
US5126324A (en) * 1990-06-07 1992-06-30 Genentech, Inc. Method of enhancing growth in patients using combination therapy
DE69110290T2 (de) * 1990-09-21 1995-10-19 Novonordisk As Adaptor.
SE9201073D0 (sv) * 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
MD1699F2 (ro) * 1992-07-31 2001-07-31 Genentech, Inc. Compoziţie apoasă a hormonului somatotrop uman şi procedeu de prevenire a denaturării ei
US5334162A (en) * 1993-03-15 1994-08-02 Eli Lilly And Company Cartridge assembly for a lyophilized compound forming a disposable portion of an injector pen and method for same
US5496801A (en) * 1993-12-23 1996-03-05 Allelix Biopharmaceuticals Inc. Parathyroid hormone formulation
US5610134A (en) * 1994-04-15 1997-03-11 Genentech, Inc. Treatment of congestive heart failure
JPH0892125A (ja) * 1994-09-21 1996-04-09 Nippon Chem Res Kk 水性医薬組成物
SE9502927D0 (sv) * 1995-08-24 1995-08-24 Pharmacia Ab Solution containing IGF-I
AUPN801296A0 (en) * 1996-02-12 1996-03-07 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
DE69709069T2 (de) * 1996-02-13 2002-07-04 G.D. Searle & Co., Chicago Zusammensetzungen mit immunosuppressiven wirkungen, welche 5-lipoxygenase-inhibitoren und cyclooxygenase-2-inhibitoren enthalten
ZA9711731B (en) * 1996-12-31 1998-07-01 Monsanto Co Aqueous glycerol formulations of somatotropin
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
JP3723857B2 (ja) * 1998-02-04 2005-12-07 日本ケミカルリサーチ株式会社 ヒト成長ホルモン含有水性医薬組成物

Also Published As

Publication number Publication date
BR0013162A (pt) 2002-05-28
SK252002A3 (en) 2002-06-04
CN1360506A (zh) 2002-07-24
CA2378949A1 (en) 2001-01-18
KR20020031388A (ko) 2002-05-01
IL147253A (en) 2007-07-24
MXPA02000404A (es) 2004-05-21
NZ516507A (en) 2004-02-27
CZ200260A3 (cs) 2002-04-17
HUP0202189A2 (en) 2002-10-28
DE60038118D1 (de) 2008-04-03
CA2378949C (en) 2015-03-31
AU775107B2 (en) 2004-07-15
IL147253A0 (en) 2002-08-14
JP2012051891A (ja) 2012-03-15
AU775107C (en) 2005-02-24
TWI247608B (en) 2006-01-21
JP2003504346A (ja) 2003-02-04
JP5941496B2 (ja) 2016-06-29
ATE386501T1 (de) 2008-03-15
JP2014208656A (ja) 2014-11-06
WO2001003741B1 (en) 2001-04-19
SI1194170T1 (sl) 2008-10-31
NO20020151L (no) 2002-03-12
DE60038118T2 (de) 2009-03-05
EP1194170A1 (en) 2002-04-10
HK1046358A1 (zh) 2003-01-10
AU5997500A (en) 2001-01-30
ES2300268T3 (es) 2008-06-16
WO2001003741A1 (en) 2001-01-18
HUP0202189A3 (en) 2003-07-28
NO20020151D0 (no) 2002-01-11
AR024728A1 (es) 2002-10-23
EP1194170B1 (en) 2008-02-20
US20060029635A1 (en) 2006-02-09
PL353238A1 (en) 2003-11-03

Similar Documents

Publication Publication Date Title
MXPA02000404A (es) Formulaciones de hormona de crecimiento.
US12138248B2 (en) Formulations of bendamustine
AR040527A1 (es) Formulaciones de hgh en alta concentracion que contienen glicina
CA2204263C (en) Germicidal detergent-iodine compositions including polyvinyl pyrrolidone and compatible nonionic surfactant complexors
EP0662836B1 (en) Germicidal detergent-iodine compositions having reduced detergent content
AR040881A1 (es) Formulacion de anticuerpos humanos para el tratamiento de trastornos asociados con tnf-alfa
JPH07509719A (ja) ヒト成長ホルモン水性製剤
CZ307715B6 (cs) Způsob lyofilizace vodné farmaceutické formulace faktoru VIII prosté albuminu
CA2361392C (en) Premixed formulation of piperacillin sodium and tazobactam sodium injection
ATE554792T1 (de) Stabiles wachstumshormon-flüssigformulierung
CN102014920B (zh) 滴眼剂制剂及其应用
MX2022008949A (es) Formulacion de anticuerpos estable.
JP2012051891A5 (tr)
AU2004262501B2 (en) Veterinary aqueous injectable suspensions containing Florfenicol
CZ20022654A3 (cs) Farmaceutická kompozice, obsahující Pemetrexed společně s monothioglycerolem, L-cysteinem nebo kyselinou thioglykolovou
ES2258062T3 (es) Composicion antihelmintica.
EP1625791A1 (en) Insecticidal composition
EP2916818B1 (en) Enema composition for treatment of ulcerative colitis having long term stability
EP3178927B1 (en) Protein-stabilizing agent and protein-stabilizing method
JP2006508139A (ja) 冬の環境の間に乳房を消毒するための組成物および方法
JP4610154B2 (ja) 注射用製剤
EP0049731B1 (en) Anthelmintic imidazo(2,1-b)thiazole gel compositions
ZA200509284B (en) Insecticidal composition
JPH0621060B2 (ja) 非経口投与用組成物
RU1427644C (ru) Антибактериальный комплекс дл санации спермы сельскохоз йственных животных