TR200201169T2 - 2-(4,6-Dimetilpirimidinil-2-oksi)-3- [2-(3,4-dimetoksifenil)etoksi]-3,3-difenilpropiyonat ve endotelin antagonist olarak kullanılması - Google Patents

2-(4,6-Dimetilpirimidinil-2-oksi)-3- [2-(3,4-dimetoksifenil)etoksi]-3,3-difenilpropiyonat ve endotelin antagonist olarak kullanılması

Info

Publication number: TR200201169T2
Authority: TR; Turkey
Prior art keywords: dimethylpyrimidinyl; diphenylpropionate; endothelin; dimethoxyphenyl; antagonist
Prior art date: 1999-10-27

Application number

TR2002/01169T

Other languages

English (en)

Turkish (tr)

Inventor

Jansen Rolf

Original Assignee

Basf Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-27

Filing date

2000-10-17

Publication date

2002-09-23

2000-10-17 Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft

2002-09-23 Publication of TR200201169T2 publication Critical patent/TR200201169T2/xx

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
210000003038 endothelium Anatomy 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Oncology (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

TR2002/01169T 1999-10-27 2000-10-17 2-(4,6-Dimetilpirimidinil-2-oksi)-3- [2-(3,4-dimetoksifenil)etoksi]-3,3-difenilpropiyonat ve endotelin antagonist olarak kullanılması TR200201169T2 (tr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19951671A DE19951671A1 (de)	1999-10-27	1999-10-27	2-(4,6-Dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionssäure-Natriumsalz und seine Verwendung als Endothelinantagonist

Publications (1)

Publication Number	Publication Date
TR200201169T2 true TR200201169T2 (tr)	2002-09-23

Family

ID=7927001

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TR2002/01169T TR200201169T2 (tr)	1999-10-27	2000-10-17	2-(4,6-Dimetilpirimidinil-2-oksi)-3- [2-(3,4-dimetoksifenil)etoksi]-3,3-difenilpropiyonat ve endotelin antagonist olarak kullanılması

Country Status (17)

Country	Link
EP (1)	EP1228047A1 (cs)
JP (1)	JP2003512460A (cs)
KR (1)	KR20020047301A (cs)
CN (1)	CN1384822A (cs)
AU (1)	AU1272701A (cs)
BG (1)	BG106700A (cs)
BR (1)	BR0015112A (cs)
CA (1)	CA2389012A1 (cs)
CZ (1)	CZ20021485A3 (cs)
DE (1)	DE19951671A1 (cs)
HU (1)	HUP0203476A3 (cs)
IL (1)	IL149312A0 (cs)
MX (1)	MXPA02004071A (cs)
NO (1)	NO20021986L (cs)
SK (1)	SK5962002A3 (cs)
TR (1)	TR200201169T2 (cs)
WO (1)	WO2001030767A1 (cs)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2881078C (en)	2004-06-24	2018-10-02	Vertex Pharmaceuticals Incorporated	Modulators of atp-binding cassette transporters

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19636046A1 (de) *	1996-09-05	1998-03-12	Basf Ag	Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten

1999
- 1999-10-27 DE DE19951671A patent/DE19951671A1/de not_active Withdrawn
2000
- 2000-10-17 IL IL14931200A patent/IL149312A0/xx unknown
- 2000-10-17 SK SK596-2002A patent/SK5962002A3/sk unknown
- 2000-10-17 HU HU0203476A patent/HUP0203476A3/hu unknown
- 2000-10-17 MX MXPA02004071A patent/MXPA02004071A/es unknown
- 2000-10-17 JP JP2001533121A patent/JP2003512460A/ja not_active Abandoned
- 2000-10-17 CN CN00814871A patent/CN1384822A/zh active Pending
- 2000-10-17 TR TR2002/01169T patent/TR200201169T2/xx unknown
- 2000-10-17 WO PCT/EP2000/010202 patent/WO2001030767A1/de not_active Ceased
- 2000-10-17 CZ CZ20021485A patent/CZ20021485A3/cs unknown
- 2000-10-17 CA CA002389012A patent/CA2389012A1/en not_active Abandoned
- 2000-10-17 AU AU12727/01A patent/AU1272701A/en not_active Abandoned
- 2000-10-17 KR KR1020027005457A patent/KR20020047301A/ko not_active Ceased
- 2000-10-17 EP EP00974404A patent/EP1228047A1/de not_active Withdrawn
- 2000-10-17 BR BR0015112-2A patent/BR0015112A/pt not_active IP Right Cessation
2002
- 2002-04-26 NO NO20021986A patent/NO20021986L/no not_active Application Discontinuation
- 2002-05-14 BG BG106700A patent/BG106700A/xx unknown

Also Published As

Publication number	Publication date
AU1272701A (en)	2001-05-08
HUP0203476A2 (en)	2003-05-28
MXPA02004071A (es)	2002-10-11
WO2001030767A1 (de)	2001-05-03
IL149312A0 (en)	2002-11-10
CN1384822A (zh)	2002-12-11
KR20020047301A (ko)	2002-06-21
BG106700A (en)	2003-02-28
EP1228047A1 (de)	2002-08-07
BR0015112A (pt)	2002-10-29
NO20021986D0 (no)	2002-04-26
NO20021986L (no)	2002-04-26
CA2389012A1 (en)	2001-05-03
HUP0203476A3 (en)	2003-07-28
DE19951671A1 (de)	2001-05-03
JP2003512460A (ja)	2003-04-02
CZ20021485A3 (cs)	2003-06-18
SK5962002A3 (en)	2002-09-10

Publication	Publication Date	Title
IS6362A (is)	2002-04-26	Úrea (eða þvagefnis) efnasambönd sem hafa múskarín viðtaka mótlyfs virkni
AU2426602A (en)	2002-05-27	Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5ht-2 receptor
BRPI0606455A (pt)	2008-03-11	compostos farmacêuticos
MXPA04003795A (es)	2004-07-30	Compuestos de pirimidina y composiciones farmaceuticas que contienen los compuestos.
TR200101155T2 (tr)	2001-09-21	4-Aroil Piperidin CCR-3 Reseptör Antagonistleri III
CY1110243T1 (el)	2015-01-14	Ανταγωνιστες npyy5
DE60108420D1 (en)	2005-02-17	Morpholinderivate als antagonisten an orexinrezeptoren
HUP0302435A2 (hu)	2003-12-29	11-Béta-hidroxiszteroid dehidrogenáz 1 típusú enzimet gátló anyagok és ezeket tartalmazó gyógyszerkészítmények
DK1200426T3 (da)	2004-06-21	Substituerede thien-3-yl-sulfonylamino(thio)carbonyl-tiazolin(thi)oner
TR200102489T2 (tr)	2002-04-22	3-Fenilpiridin Türevleri ve bunların NK-1 alıcı antagonistler olarak kullanılması
AR018168A1 (es)	2001-10-31	Antagonista de nociceptina que comprende un derivado de amida, composicion farmaceutica y analgesica que lo incluye, uso de dicho derivado de amida yenvase comercial que comprende dicha composicion farmaceutica
TR200101893T2 (tr)	2001-11-21	Antiviral maddeler olarak 4-okso-1,4 dihidro -3- kuinolinkarboksamitler.
YU39803A (sh)	2006-05-25	Jedinjenja piperazinilpirazina kao agonisti ili antagonisti serotonin 5ht-2-receptora
TR200102540T2 (tr)	2002-01-21	Heterosiklik bileşimler, ara ürünleri ve elastaz inhibitörleri.
MXPA05009988A (es)	2005-11-04	Derivados de 6-sulfonamida quinolina y cromeno como antagonistas de los receptores de androgenos.
BRPI0412577A (pt)	2006-09-19	derivados de aminoquinolina e seu uso como ligantes de adenosina a3
TR200003652T2 (tr)	2001-04-20	Glisin antagonistleri olarak tetrahidrokuinolin türevleri.
TR200103855T2 (tr)	2002-04-22	Melagatranın büyük ölçüde kristalin bir formu.
HRP20010630B1 (hr)	2010-08-31	Derivati 4-heterociklil-sulfonamidil-6-metoksi-5-(2-metoksi-fenoksi)-2-piridil-pirimidina, njihova proizvodnja i upotreba kao endotelin receptor antagonista
TR200101654T2 (tr)	2002-03-21	Vitronektin reseptr antagonistleri
DE60036558D1 (de)	2007-11-08	Phthalazinon-derivate als pde 4 hemmer
BR9806875A (pt)	2000-04-18	Processo para a preparação de um composto.
NO20021986L (no)	2002-04-26	Natrium-2-(4,6-dimetyl-pyrimidin-2-yloksy)-3-(2-(3,4- dimetoksyfenyl)etoksy)-3,3-difenylpropionat og anvendelse deravsom endothelin-antagonist
DE60100811D1 (de)	2003-10-23	Crf rezeptor-antagonisten und darauf bezogene methoden
EA200300226A1 (ru)	2003-10-30	ГЕМ-ЗАМЕЩЕННЫЕ АНТАГОНИСТЫ ИНТЕГРИНА αvβ3