IS6362A - Úrea (eða þvagefnis) efnasambönd sem hafa múskarín viðtaka mótlyfs virkni - Google Patents

Úrea (eða þvagefnis) efnasambönd sem hafa múskarín viðtaka mótlyfs virkni

Info

Publication number: IS6362A
Authority: IS; Iceland
Prior art keywords: urea; compounds; receptor antagonist; antagonist activity; muscarinic receptor
Prior art date: 1999-12-07

Application number

IS6362A

Other languages

English (en)

Other versions

IS2191B (is

Inventor

Mammen Mathai

Oare David

Original Assignee

Theravance, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-07

Filing date

2002-04-26

Publication date

2002-04-26

2002-04-26 Application filed by Theravance, Inc. filed Critical Theravance, Inc.

2002-04-26 Publication of IS6362A publication Critical patent/IS6362A/is

2007-01-15 Publication of IS2191B publication Critical patent/IS2191B/is

Links

229940121948 Muscarinic receptor antagonist Drugs 0.000 title abstract 2
230000000694 effects Effects 0.000 title abstract 2
239000003149 muscarinic antagonist Substances 0.000 title abstract 2
150000003672 ureas Chemical class 0.000 title abstract 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
239000004202 carbamide Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IS6362A 1999-12-07 2002-04-26 Þvagefnisefnasambönd sem hafa múskarínviðtaka mótlyfsvirkni IS2191B (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US45617099A	1999-12-07	1999-12-07
PCT/US2000/033155 WO2001042213A1 (en)	1999-12-07	2000-12-07	Urea compounds having muscarinic receptor antagonist activity

Publications (2)

Publication Number	Publication Date
IS6362A true IS6362A (is)	2002-04-26
IS2191B IS2191B (is)	2007-01-15

Family

ID=23811737

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS6362A IS2191B (is)	1999-12-07	2002-04-26	Þvagefnisefnasambönd sem hafa múskarínviðtaka mótlyfsvirkni

Country Status (27)

Country	Link
US (3)	US6635764B2 (is)
EP (2)	EP1457488B1 (is)
JP (1)	JP2003516391A (is)
KR (1)	KR100748150B1 (is)
CN (1)	CN1271054C (is)
AT (2)	ATE439345T1 (is)
AU (1)	AU782232B2 (is)
BR (1)	BR0015963A (is)
CA (1)	CA2392030C (is)
CZ (1)	CZ20021830A3 (is)
DE (2)	DE60042762D1 (is)
EA (1)	EA006437B1 (is)
ES (3)	ES2329785T3 (is)
HK (1)	HK1049483B (is)
HR (1)	HRP20020574B1 (is)
HU (1)	HUP0203677A2 (is)
IL (2)	IL149289A0 (is)
IS (1)	IS2191B (is)
MX (1)	MXPA02005602A (is)
NO (1)	NO323544B1 (is)
NZ (1)	NZ518722A (is)
PL (1)	PL364922A1 (is)
SK (1)	SK7982002A3 (is)
UA (1)	UA73543C2 (is)
WO (1)	WO2001042213A1 (is)
YU (1)	YU42402A (is)
ZA (2)	ZA200204553B (is)

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JP2008517072A (ja) *	2004-10-20	2008-05-22	ザレジェンツオブザユニバーシティーオブカリフォルニア	可溶性エポキシド加水分解酵素の改良された阻害剤
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2000
- 2000-07-12 UA UA2002075566A patent/UA73543C2/uk unknown
- 2000-12-07 CN CNB008167028A patent/CN1271054C/zh not_active Expired - Lifetime
- 2000-12-07 BR BR0015963-8A patent/BR0015963A/pt not_active Application Discontinuation
- 2000-12-07 EP EP04012859A patent/EP1457488B1/en not_active Expired - Lifetime
- 2000-12-07 JP JP2001543514A patent/JP2003516391A/ja active Pending
- 2000-12-07 DE DE60042762T patent/DE60042762D1/de not_active Expired - Lifetime
- 2000-12-07 ES ES04012859T patent/ES2329785T3/es not_active Expired - Lifetime
- 2000-12-07 ES ES00983991T patent/ES2243333T3/es not_active Expired - Lifetime
- 2000-12-07 US US09/732,514 patent/US6635764B2/en not_active Expired - Lifetime
- 2000-12-07 SK SK798-2002A patent/SK7982002A3/sk unknown
- 2000-12-07 AU AU19518/01A patent/AU782232B2/en not_active Expired
- 2000-12-07 AT AT04012859T patent/ATE439345T1/de not_active IP Right Cessation
- 2000-12-07 HU HU0203677A patent/HUP0203677A2/hu unknown
- 2000-12-07 AT AT00982493T patent/ATE271039T1/de not_active IP Right Cessation
- 2000-12-07 CZ CZ20021830A patent/CZ20021830A3/cs unknown
- 2000-12-07 MX MXPA02005602A patent/MXPA02005602A/es active IP Right Grant
- 2000-12-07 WO PCT/US2000/033155 patent/WO2001042213A1/en not_active Ceased
- 2000-12-07 KR KR1020027007147A patent/KR100748150B1/ko not_active Expired - Lifetime
- 2000-12-07 NZ NZ518722A patent/NZ518722A/en not_active IP Right Cessation
- 2000-12-07 EP EP00982493A patent/EP1235803B1/en not_active Expired - Lifetime
- 2000-12-07 PL PL00364922A patent/PL364922A1/xx not_active Application Discontinuation
- 2000-12-07 DE DE60012223T patent/DE60012223T2/de not_active Expired - Lifetime
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- 2000-12-07 HK HK03101572.1A patent/HK1049483B/en not_active IP Right Cessation
- 2000-12-07 YU YU42402A patent/YU42402A/sh unknown
- 2000-12-07 EA EA200200646A patent/EA006437B1/ru not_active IP Right Cessation
2002
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- 2002-06-06 ZA ZA200204553A patent/ZA200204553B/en unknown
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- 2002-06-06 NO NO20022683A patent/NO323544B1/no not_active IP Right Cessation
2003
- 2003-04-30 US US10/426,364 patent/US20040054187A1/en not_active Abandoned
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Also Published As

Publication number	Publication date
DE60042762D1 (de)	2009-09-24
US20020049195A1 (en)	2002-04-25
NZ518722A (en)	2004-03-26
SK7982002A3 (en)	2002-12-03
NO20022683L (no)	2002-07-02
IS2191B (is)	2007-01-15
PL364922A1 (en)	2004-12-27
BR0015963A (pt)	2002-08-06
EP1457488B1 (en)	2009-08-12
ES2225275T3 (es)	2005-03-16
ZA200204557B (en)	2003-09-08
ES2243333T3 (es)	2005-12-01
DE60012223T2 (de)	2005-08-25
CN1271054C (zh)	2006-08-23
US6635764B2 (en)	2003-10-21
UA73543C2 (uk)	2005-08-15
ES2329785T3 (es)	2009-12-01
EP1235803B1 (en)	2004-07-14
HRP20020574A2 (en)	2005-08-31
HUP0203677A2 (hu)	2003-03-28
KR100748150B1 (ko)	2007-08-09
CN1407970A (zh)	2003-04-02
WO2001042213A1 (en)	2001-06-14
ATE439345T1 (de)	2009-08-15
US20040116706A1 (en)	2004-06-17
NO323544B1 (no)	2007-06-11
HK1049483A1 (en)	2003-05-16
EA200200646A1 (ru)	2002-12-26
NO20022683D0 (no)	2002-06-06
DE60012223D1 (de)	2004-08-19
YU42402A (sh)	2006-01-16
US20040054187A1 (en)	2004-03-18
JP2003516391A (ja)	2003-05-13
EP1235803A1 (en)	2002-09-04
CA2392030C (en)	2009-08-18
IL149289A (en)	2007-05-15
HK1049483B (en)	2005-02-18
EA006437B1 (ru)	2005-12-29
CA2392030A1 (en)	2001-06-14
IL149289A0 (en)	2002-11-10
KR20020058083A (ko)	2002-07-12
ATE271039T1 (de)	2004-07-15
AU782232B2 (en)	2005-07-14
MXPA02005602A (es)	2004-09-10
EP1457488A1 (en)	2004-09-15
HRP20020574B1 (hr)	2007-12-31
CZ20021830A3 (cs)	2002-10-16
AU1951801A (en)	2001-06-18
ZA200204553B (en)	2003-09-08

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