TR200301898T4 - 4-piridil-ve 2,4-pirimidinil-ikameli pirrol türevleri ve eczacılıkta kullanımları - Google Patents

4-piridil-ve 2,4-pirimidinil-ikameli pirrol türevleri ve eczacılıkta kullanımları

Info

Publication number
TR200301898T4
TR200301898T4 TR2003/01898T TR200301898T TR200301898T4 TR 200301898 T4 TR200301898 T4 TR 200301898T4 TR 2003/01898 T TR2003/01898 T TR 2003/01898T TR 200301898 T TR200301898 T TR 200301898T TR 200301898 T4 TR200301898 T4 TR 200301898T4
Authority
TR
Turkey
Prior art keywords
pyrimidyl
pyridyl
alkyl
inhibitor
1beta
Prior art date
Application number
TR2003/01898T
Other languages
English (en)
Inventor
Striegel Hans-G�nter
Laufer Stefan
Tollmann Karola
Tries Susanne
Original Assignee
Merckle Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merckle Gmbh filed Critical Merckle Gmbh
Publication of TR200301898T4 publication Critical patent/TR200301898T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Iste bulus formül (1) içlerindeki degiskenlerin tanimda belirtildigi anlamlara sahip oldugu 4-piridil- ve 2,4-pirimidinil ikameli pirrol türevleri ve eczacilikta kulanimlari. Bulusa uygun bilesikler imün modülasyonu saglayan ve/veya sitokin açiga birakilmasini önleyen bir etkiye sahiptir ve bu nedenle de imün sistemine bagli ortaya çikan bir bozukluktan kaynaklanan hastaliklarin tedavisinde kullanilabilir. Formül (I)
TR2003/01898T 2000-02-01 2001-01-31 4-piridil-ve 2,4-pirimidinil-ikameli pirrol türevleri ve eczacılıkta kullanımları TR200301898T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10004157A DE10004157A1 (de) 2000-02-01 2000-02-01 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie

Publications (1)

Publication Number Publication Date
TR200301898T4 true TR200301898T4 (tr) 2004-01-21

Family

ID=7629335

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2003/01898T TR200301898T4 (tr) 2000-02-01 2001-01-31 4-piridil-ve 2,4-pirimidinil-ikameli pirrol türevleri ve eczacılıkta kullanımları

Country Status (16)

Country Link
US (1) US6867211B2 (tr)
EP (1) EP1252163B1 (tr)
JP (1) JP2003525227A (tr)
KR (1) KR20030005176A (tr)
CN (1) CN1206230C (tr)
AT (1) ATE250608T1 (tr)
AU (1) AU2001230219A1 (tr)
CA (1) CA2398111C (tr)
DE (2) DE10004157A1 (tr)
DK (1) DK1252163T3 (tr)
ES (1) ES2208548T3 (tr)
MX (1) MXPA02007403A (tr)
NO (1) NO323246B1 (tr)
PT (1) PT1252163E (tr)
TR (1) TR200301898T4 (tr)
WO (1) WO2001057042A2 (tr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10001166A1 (de) 2000-01-13 2001-07-19 Merckle Gmbh Anellierte Pyrrolverbindungen, diese enthaltende pharmazeutische Mittel und deren Verwendung
CN1549711A (zh) * 2001-08-30 2004-11-24 ��Ĭ���� 稠合的吡咯化合物在治疗关节软骨或软骨下骨组织退化中的用途
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US6849627B2 (en) 2001-09-20 2005-02-01 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7087615B2 (en) 2001-09-20 2006-08-08 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia
US20050043331A1 (en) * 2002-09-27 2005-02-24 Bullington James L. Substituted 3-(2,5-disubstituted)pyridyl-4-aryl pyrroles for treating inflammatory diseases
ATE426605T1 (de) * 2003-06-12 2009-04-15 Merck & Co Inc Inhibitoren von mitotischem kinesin
GB0520958D0 (en) * 2005-10-14 2005-11-23 Cyclacel Ltd Compound
EP1884239A1 (en) * 2006-07-28 2008-02-06 Merckle Gmbh Annellated pyrrole compounds for cancer management
GB0816759D0 (en) * 2008-09-12 2008-10-22 Selcia Ltd Compounds
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods

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JPS56100784A (en) 1980-01-16 1981-08-12 Yoshitomi Pharmaceut Ind Ltd Indolizine derivative
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FR2539417A1 (fr) 1983-01-13 1984-07-20 Rhone Poulenc Sante Nouveaux pyrrolo-1, 2 heterocycles, leur preparation et les medicaments qui les contiennent
AU562833B2 (en) * 1983-01-13 1987-06-18 Rhone-Poulenc Sante Ortho-fused pyrrole derivatives
US4560699A (en) 1983-01-17 1985-12-24 Syntex (U.S.A.) Inc. 5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories
FR2557111B1 (fr) 1983-12-21 1986-04-11 Rhone Poulenc Sante Nouveaux derives ortho-condenses du pyrrole, leur preparation et les medicaments qui les contiennent
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Also Published As

Publication number Publication date
CA2398111A1 (en) 2001-08-09
JP2003525227A (ja) 2003-08-26
CA2398111C (en) 2008-08-12
DK1252163T3 (da) 2004-01-19
PT1252163E (pt) 2004-02-27
ATE250608T1 (de) 2003-10-15
US20030153558A1 (en) 2003-08-14
CN1206230C (zh) 2005-06-15
AU2001230219A1 (en) 2001-08-14
EP1252163B1 (de) 2003-09-24
KR20030005176A (ko) 2003-01-17
NO20023634D0 (no) 2002-07-31
NO20023634L (no) 2002-09-25
US6867211B2 (en) 2005-03-15
WO2001057042A3 (de) 2001-12-27
CN1396923A (zh) 2003-02-12
ES2208548T3 (es) 2004-06-16
DE50100678D1 (de) 2003-10-30
EP1252163A2 (de) 2002-10-30
DE10004157A1 (de) 2001-08-02
MXPA02007403A (es) 2004-04-05
WO2001057042A2 (de) 2001-08-09
NO323246B1 (no) 2007-02-12

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