TR200401848T4 - Uzun süreli levodopa ve karbidopa bırakılması içeren kompozisyon. - Google Patents
Uzun süreli levodopa ve karbidopa bırakılması içeren kompozisyon.Info
- Publication number
- TR200401848T4 TR200401848T4 TR2004/01848T TR200401848T TR200401848T4 TR 200401848 T4 TR200401848 T4 TR 200401848T4 TR 2004/01848 T TR2004/01848 T TR 2004/01848T TR 200401848 T TR200401848 T TR 200401848T TR 200401848 T4 TR200401848 T4 TR 200401848T4
- Authority
- TR
- Turkey
- Prior art keywords
- carbidopa
- levodopa
- composition containing
- term release
- containing long
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- IVTMXOXVAHXCHI-YXLMWLKOSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid;(2s)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1.NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 IVTMXOXVAHXCHI-YXLMWLKOSA-N 0.000 title 1
- 230000007774 longterm Effects 0.000 title 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 abstract 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 abstract 1
- 229960004205 carbidopa Drugs 0.000 abstract 1
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 230000006835 compression Effects 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 229960004502 levodopa Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Bulus, terapötik olarak etkili miktarda levodopa ve karbidopa içeren, hidrofilik bir matris içinde dagilmis bir farmasötik kompozisyonla ilgilidir, sözü edilen kompozisyon bir organik asit içerir. Bulus ayrica kompozisyonu hazirlamak için bir islemle ilgilidir, islem; özellikle sivilastirilmis bir yatakta çesitli bilesenlerin granülasyonu ve elde edilen taneciklerin sikistirilmasini içerir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/866,857 US6531153B2 (en) | 2001-05-29 | 2001-05-29 | Composition with sustained release of levodopa and carbidopa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200401848T4 true TR200401848T4 (tr) | 2004-09-21 |
Family
ID=25348578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2004/01848T TR200401848T4 (tr) | 2001-05-29 | 2002-05-17 | Uzun süreli levodopa ve karbidopa bırakılması içeren kompozisyon. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6531153B2 (tr) |
| EP (1) | EP1262198B1 (tr) |
| AT (1) | ATE265231T1 (tr) |
| DE (1) | DE60200416T2 (tr) |
| DK (1) | DK1262198T3 (tr) |
| ES (1) | ES2222436T3 (tr) |
| PT (1) | PT1262198E (tr) |
| TR (1) | TR200401848T4 (tr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030091634A1 (en) * | 2001-09-14 | 2003-05-15 | Pawan Seth | Delayed release tablet of venlafaxin |
| US20060159751A1 (en) * | 2002-04-11 | 2006-07-20 | Mona Gogia | Controlled release pharmaceutical compositions of carbidopa and levodopa |
| WO2004022745A2 (en) * | 2002-09-03 | 2004-03-18 | Universite Libre De Bruxelles | Reversible, parallel and multitask cloning method and kit |
| ATE339192T1 (de) * | 2003-05-14 | 2006-10-15 | Eurand Pharmaceuticals Ltd | Kontrollierte medikamentfreigabe zusammensetzung mit in vivo mechanikstresswiderstand |
| DE602004031134D1 (de) * | 2003-08-29 | 2011-03-03 | Transform Pharmaceuticals Inc | Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa |
| US8815950B2 (en) | 2003-08-29 | 2014-08-26 | Janssen Biotech, Inc. | Pharmaceutical compositions and method of using levodopa and carbidopa |
| US20060024362A1 (en) * | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
| MX2007011976A (es) * | 2005-03-28 | 2007-12-07 | Orexo Ab | Composiciones farmaceuticas novedosas utiles en el tratamiento de la enfermedad de parkinson. |
| CA2613631A1 (en) * | 2005-06-23 | 2007-01-04 | Spherics, Inc. | Improved dosage forms for movement disorder treatment |
| AR055106A1 (es) * | 2005-08-05 | 2007-08-08 | Osmotica Pharmaceutical Argent | Composicion farmaceutica solida de liberacion extendida que contiene carbidopa y levodopa |
| WO2007056570A2 (en) * | 2005-11-07 | 2007-05-18 | Teva Pharmaceutical Industries Ltd. | Levodopa compositions |
| US20080131492A1 (en) * | 2006-06-23 | 2008-06-05 | Spherics, Inc. | Dosage forms for movement disorder treatment |
| PE20080669A1 (es) * | 2006-09-08 | 2008-07-18 | Drugtech Corp | Composicion de liberacion sostenida que comprende levodopa |
| AU2007338631A1 (en) * | 2006-12-22 | 2008-07-03 | Combinatorx, Incorporated | Pharmaceutical compositions for treatment of parkinson's disease and related disorders |
| EP2128308B1 (en) * | 2007-01-10 | 2012-03-14 | Crystal Systems Corporation | Floating zone melting apparatus |
| US20090155369A1 (en) * | 2007-12-13 | 2009-06-18 | Laboratorios Lesvi, S.L. | Pharmaceutical composition containing levodopa, entacapone and carbidopa |
| CN101910113A (zh) | 2007-12-28 | 2010-12-08 | 怡百克制药公司 | 左旋多巴控释制剂及其用途 |
| AU2014202306B2 (en) * | 2007-12-28 | 2016-09-08 | Impax Laboratories, Llc | Controlled release formulations of levodopa and uses thereof |
| DE102008004893A1 (de) * | 2008-01-17 | 2009-07-23 | Add Technologies Ltd. | Trägerpellets, Verfahren zu deren Herstellung und deren Verwendung |
| CN102202656A (zh) * | 2008-08-15 | 2011-09-28 | 蒂宝制药公司 | 治疗和预防cns障碍的胃滞留药用组合物 |
| TR201204839A2 (tr) | 2012-04-25 | 2012-12-21 | Ali̇ Rai̇f İlaç Sanayi̇ A.Ş. | Uzatılmış salım sağlayan levodopa karbıdopa entakapon içeren tablet formülasyonu. |
| BR112015010601B1 (pt) | 2012-11-09 | 2022-07-19 | Civitas Therapeutics, Inc. | Composição farmacêutica e uso da composição |
| US8545878B1 (en) * | 2012-11-09 | 2013-10-01 | Civitas Therapeutics, Inc. | Capsules containing high doses of levodopa for pulmonary use |
| CN105658211A (zh) | 2013-10-07 | 2016-06-08 | 怡百克制药公司 | 左旋多巴和/或左旋多巴的酯的粘膜粘附性、控制释放调配物和其用途 |
| US10987313B2 (en) | 2013-10-07 | 2021-04-27 | Impax Laboratories, Llc | Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof |
| US10918597B2 (en) | 2017-06-16 | 2021-02-16 | Kashiv Specialty Pharmaceuticals, Llc | Gastroretentive dosage forms for sustained drug delivery |
| US10588863B2 (en) | 2017-06-16 | 2020-03-17 | Kashiv Biosciences, Llc | Extended release compositions comprising pyridostigmine |
| US10987311B2 (en) | 2017-06-16 | 2021-04-27 | Kashiv Specialty Pharmaceuticals, Llc | Extended release compositions comprising pyridostigmine |
| JP7066351B2 (ja) * | 2017-08-18 | 2022-05-13 | 大原薬品工業株式会社 | 良好な徐放性を有する、レボドパ含有小型化錠剤 |
| EP3824881B1 (en) | 2018-06-18 | 2022-02-16 | Amneal Complex Products Research LLC | Extended release compositions comprising pyridostigmine |
| US11986449B2 (en) | 2020-12-22 | 2024-05-21 | Amneal Pharmaceuticals Llc | Levodopa dosing regimen |
| KR20230124622A (ko) | 2020-12-22 | 2023-08-25 | 암닐 파마슈티컬스 엘엘씨 | 레보도파 투여 요법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4424235A (en) | 1981-09-14 | 1984-01-03 | Hoffmann-La Roche Inc. | Hydrodynamically balanced controlled release compositions containing L-dopa and a decarboxylase inhibitor |
| NZ220599A (en) * | 1986-06-16 | 1990-10-26 | Merck & Co Inc | Controlled release oral dosage formulation of carbidopa and levodopa |
| US5190763A (en) * | 1990-05-07 | 1993-03-02 | Alza Corporation | Dosage form indicated for the management of abnormal posture, tremor and involuntary movement |
| DE4101873C2 (de) | 1991-01-23 | 1993-12-09 | Isis Pharma Gmbh | Peroral applizierbare Arzneiform zur Behandlung zentraler Dopaminmangelzustände |
| US5354885A (en) * | 1992-12-24 | 1994-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Process for preparing ethyl ester of L-DOPA |
| IT1293764B1 (it) | 1997-07-23 | 1999-03-10 | Chiesi Farma Spa | Composizioni farmaceutiche sotto forma di compresse effervescenti contenenti un principio attivo instabile in presenza di acqua |
-
2001
- 2001-05-29 US US09/866,857 patent/US6531153B2/en not_active Expired - Lifetime
-
2002
- 2002-05-17 PT PT02291229T patent/PT1262198E/pt unknown
- 2002-05-17 AT AT02291229T patent/ATE265231T1/de active
- 2002-05-17 EP EP02291229A patent/EP1262198B1/en not_active Expired - Lifetime
- 2002-05-17 DK DK02291229T patent/DK1262198T3/da active
- 2002-05-17 DE DE60200416T patent/DE60200416T2/de not_active Expired - Lifetime
- 2002-05-17 ES ES02291229T patent/ES2222436T3/es not_active Expired - Lifetime
- 2002-05-17 TR TR2004/01848T patent/TR200401848T4/tr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2222436T3 (es) | 2005-02-01 |
| US6531153B2 (en) | 2003-03-11 |
| PT1262198E (pt) | 2004-09-30 |
| ATE265231T1 (de) | 2004-05-15 |
| DE60200416T2 (de) | 2005-03-03 |
| EP1262198B1 (en) | 2004-04-28 |
| EP1262198A1 (en) | 2002-12-04 |
| DK1262198T3 (da) | 2004-08-16 |
| US20020192290A1 (en) | 2002-12-19 |
| DE60200416D1 (de) | 2004-06-03 |
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