TR200601784T2 - 2'-deoksi-L-nükleositlerin sentezi - Google Patents

2'-deoksi-L-nükleositlerin sentezi

Info

Publication number
TR200601784T2
TR200601784T2 TR2006/01784T TR200601784T TR200601784T2 TR 200601784 T2 TR200601784 T2 TR 200601784T2 TR 2006/01784 T TR2006/01784 T TR 2006/01784T TR 200601784 T TR200601784 T TR 200601784T TR 200601784 T2 TR200601784 T2 TR 200601784T2
Authority
TR
Turkey
Prior art keywords
alkyl
nucleosides
deoxy
synthesis
chr
Prior art date
Application number
TR2006/01784T
Other languages
English (en)
Inventor
A Watanabe Kyoichi
Baeg Choi Woo
Original Assignee
Pharmasset Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmasset Ltd. filed Critical Pharmasset Ltd.
Publication of TR200601784T2 publication Critical patent/TR200601784T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Mevcut buluş;(A) yapısına sahip bileşiklerin hazırlanması için prosesler sağlamakta olup,söz konusuyapı içerisindeki X ve Y;aynı veya farklıdır ve H,OH,OR,SH,SR,NH2,NHR'veya NR'R'' dir. Z; H, F, CL,BR, I, CN veya NH2dir.R; hidrojen, halojen, C1-C6düşük alkil,aralkil, NO2,NH2,NHR',NR'R'',OH,OR,SH,SR, N,CONH2,CSNH2,CO2H,CO2R',CH2CO2H, CH2CO2R', CH=CHR, CH2CH=CHR veya C=CR'dir. R' ve R'', aynı veya farklıdır, ve C1-C6 düşük alkildir. R13, hidrojen, alkil, asil, fosfat (monofosfat difosfat,trifosfat, veya stabilize fosfat) veya silildir.
TR2006/01784T 1999-11-12 2000-11-13 2'-deoksi-L-nükleositlerin sentezi TR200601784T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16508799P 1999-11-12 1999-11-12

Publications (1)

Publication Number Publication Date
TR200601784T2 true TR200601784T2 (tr) 2007-01-22

Family

ID=22597367

Family Applications (3)

Application Number Title Priority Date Filing Date
TR2006/01784T TR200601784T2 (tr) 1999-11-12 2000-11-13 2'-deoksi-L-nükleositlerin sentezi
TR2006/01782T TR200601782T2 (tr) 1999-11-12 2000-11-13 2'-Deoksi-L-Nükleositlerin sentezi.
TR2006/01783T TR200601783T2 (tr) 1999-11-12 2000-11-13 2'-Deoksi-L-nükleositlerin sentezi

Family Applications After (2)

Application Number Title Priority Date Filing Date
TR2006/01782T TR200601782T2 (tr) 1999-11-12 2000-11-13 2'-Deoksi-L-Nükleositlerin sentezi.
TR2006/01783T TR200601783T2 (tr) 1999-11-12 2000-11-13 2'-Deoksi-L-nükleositlerin sentezi

Country Status (12)

Country Link
US (1) US20050090660A1 (tr)
EP (1) EP1232166A2 (tr)
JP (1) JP2003513984A (tr)
KR (1) KR100789162B1 (tr)
CN (4) CN1919860A (tr)
AU (3) AU784374C (tr)
BR (1) BR0015530A (tr)
CA (1) CA2391279A1 (tr)
IL (2) IL149592A0 (tr)
MX (1) MXPA02004779A (tr)
TR (3) TR200601784T2 (tr)
WO (1) WO2001034618A2 (tr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6822089B1 (en) 2000-03-29 2004-11-23 Isis Pharmaceuticals, Inc. Preparation of deoxynucleosides
KR20090089922A (ko) * 2000-10-18 2009-08-24 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
DE10216426A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin
TWI244393B (en) * 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
EP2345657A1 (en) * 2003-05-30 2011-07-20 Pharmasset, Inc. Modified fluorinated nucleoside analogues
EP1668023A1 (de) * 2003-09-12 2006-06-14 Max-Delbrück-Centrum Für Molekulare Medizin B-l-nucleoside und ihre verwendung als pharmazeutische mittel zur behandlung viraler erkrankungen
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
AU2005285045B2 (en) * 2004-09-14 2011-10-13 Gilead Sciences, Inc. Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
US7723340B2 (en) 2005-01-13 2010-05-25 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
US7759342B2 (en) 2005-01-13 2010-07-20 Signal Pharmaceuticals, Llc Methods of treatment and prevention using haloaryl substituted aminopurines
US7521446B2 (en) 2005-01-13 2009-04-21 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
EP1876965B1 (en) * 2005-04-29 2018-09-12 Cook Biotech, Inc. Volumetric grafts for treatment of fistulae and related systems
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2312993A4 (en) * 2008-07-21 2015-03-11 Arstasis Inc DEVICES, METHODS AND KITS FOR FORMING TISSUE TRAYS
CN102300464B (zh) 2008-11-17 2014-11-12 安那迪斯药品股份有限公司 制备脱氧呋喃核糖化合物的方法
SG194404A1 (en) 2008-12-23 2013-11-29 Gilead Pharmasset Llc Synthesis of purine nucleosides
KR20110098849A (ko) 2008-12-23 2011-09-01 파마셋 인코포레이티드 뉴클레오시드 유사체
PT2376088T (pt) 2008-12-23 2017-05-02 Gilead Pharmasset Llc Fosforamidatos de nucleósidos de 2-amino-purina 6-osubstituída
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
CN101555266B (zh) * 2009-05-25 2011-11-30 上海医药工业研究院 一种替比夫定的制备方法
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
PT2609923T (pt) 2010-03-31 2017-08-30 Gilead Pharmasset Llc Processo para a cristalização de 2-(((s)- (perfluorofenoxi)(fenoxi)fosforil)amino)propanoato de (s)-isopropilo
KR101198302B1 (ko) 2010-11-02 2012-11-07 서울대학교산학협력단 Ｃｄｋ를 저해하는 피롤로피리미디논 카복사미드 유도체 또는 이의 약학적으로 허용가능한 염, 이를 유효성분으로 함유하는 간세포암의 예방 또는 치료용 약학적 조성물
AU2011336632B2 (en) 2010-11-30 2015-09-03 Gilead Pharmasset Llc Compounds
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
WO2014031517A1 (en) * 2012-08-22 2014-02-27 Merck Sharp & Dohme Corp. Novel azabenzimidazole tetrahydrofuran derivatives
EA201690473A1 (ru) 2013-08-27 2017-03-31 ГАЙЛИД ФАРМАССЕТ ЭлЭлСи Комбинированный состав двух противовирусных соединений
CN112533607B (zh) * 2018-05-25 2025-01-07 普利缪尼治疗学股份有限公司 Tlr7激动剂
CN109111445B (zh) * 2018-11-02 2020-12-18 哈尔滨商业大学 5’-呋喃甲酰酯-3’-脱氧腺苷的合成方法及应用
CN109369758B (zh) * 2018-11-02 2021-04-13 哈尔滨商业大学 5′-(6-氯烟酰酯)-3′-脱氧腺苷的合成方法及其应用
CN109020974B (zh) * 2018-11-02 2021-01-05 哈尔滨商业大学 5′-噻吩甲酰酯-3′-脱氧腺苷的合成方法及其应用
CA3163093A1 (en) 2019-11-26 2021-06-03 Primmune Therapeutics, Inc. Tlr7 agonists

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5041449A (en) * 1988-04-11 1991-08-20 Iaf Biochem International, Inc. 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5200514A (en) * 1990-01-19 1993-04-06 University Of Georgia Research Foundation, Inc. Synthesis of 2'-deoxypyrimidine nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
IT1246983B (it) * 1990-11-13 1994-12-12 Consiglio Nazionale Ricerche L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
FR2709754B1 (fr) * 1993-09-10 1995-12-01 Centre Nat Rech Scient Composés 2' ou 3'-déoxy- et 2', 3'-didéoxy-beta-L-pentofuranonucléosides, procédé de préparation et application thérapeutique, notamment anti-virale.
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
US6025335A (en) * 1995-09-21 2000-02-15 Lipitek International, Inc. L-Nucleoside Dimer Compounds and therapeutic uses
US6444652B1 (en) * 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
ES2255295T3 (es) * 1998-08-10 2006-06-16 Idenix (Cayman) Limited 2'-deoxi-beta-l-nucleosidos para el tratamiento de la hepatitis b.
US6407077B1 (en) * 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection

Also Published As

Publication number Publication date
MXPA02004779A (es) 2004-07-01
AU2005204267A1 (en) 2005-09-22
IL149592A0 (en) 2002-11-10
AU1485801A (en) 2001-06-06
CN1919859A (zh) 2007-02-28
AU784374B2 (en) 2006-03-23
AU784374C (en) 2007-06-28
TR200601783T2 (tr) 2007-01-22
US20050090660A1 (en) 2005-04-28
CN1919860A (zh) 2007-02-28
AU2005204266B2 (en) 2008-11-06
WO2001034618A3 (en) 2002-01-03
IL149592A (en) 2008-11-26
EP1232166A2 (en) 2002-08-21
AU2005204266A1 (en) 2005-09-22
CN1919858A (zh) 2007-02-28
CN1423654A (zh) 2003-06-11
KR100789162B1 (ko) 2007-12-28
BR0015530A (pt) 2003-02-18
TR200601782T2 (tr) 2006-09-21
JP2003513984A (ja) 2003-04-15
CA2391279A1 (en) 2001-05-17
AU2005204267B2 (en) 2008-10-23
WO2001034618A2 (en) 2001-05-17
KR20030025220A (ko) 2003-03-28

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