TR201802659T4 - Folr1 kanser terapisinin etkinliğini arttırmak için yöntemler. - Google Patents

Folr1 kanser terapisinin etkinliğini arttırmak için yöntemler. Download PDF

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TR201802659T4
TR201802659T4 TR2018/02659T TR201802659T TR201802659T4 TR 201802659 T4 TR201802659 T4 TR 201802659T4 TR 2018/02659 T TR2018/02659 T TR 2018/02659T TR 201802659 T TR201802659 T TR 201802659T TR 201802659 T4 TR201802659 T4 TR 201802659T4
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folr1
methods
cancer therapy
expression
cancer
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TR2018/02659T
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N Carrigan Christina
R Whiteman Kathleen
Payne Gillian
Ladd Sharron
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Immunogen Inc
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Abstract

İnsan folat reseptörü 1'i hedef alan kanser terapilerinin başarısını iyileştirmek için yöntemler sağlanır. İlaveten, yöntemlerde yararlı olan reaktifleri içeren kitler sağlanır.

Description

TARIFNAME FOLR1 KANSER TERAPISININ ETKINLIGINI ARTTIRMAK içiN YÖNTEMLER ILGILI BASVURULARA ÇAPRAZ-REFERANS Bu basvuru, 1 Nisan 2011'de dosyalanan, U.S. Provizyonel Basvuru No. 61/471,007'nin yararhüalep etmektedir. BULUSUN ALT-YAPISI Bulusun Sahasi Bulusun alani genel olarak, insan folat reseptörü 1'in (FOLR1'in) asirii-iekspresyonu ile karakterize edilen kanserlerin tedavisinin etkinligini arttlrlma ile ilgilidir. Daha spesifik olarak, bulus kansere yatkn olan veya kanser tansîalmüs olan hastalarin daha etkili tedavisi ile ilgilidir, burada tümör hücreleri bir FOLR1 antagonisti, örnegin, bir FOLR1 immünokonjugat] ile bir gen ekspresyon analiz ile belirlendigi üzere FOLR1'i asEEeksprese eder. Teknigin AIt-YapLsLI Kanser, yalnizca Amerika Birlesik Devletleri'nde her ym kanser tanLsLlalms bir milyonun üstünde insan ve 500.000 ölüm ile, gelismis dünyada ölümün önde gelen nedenlerinden biridir. Toplamda, her 3 insanda 1'inden fazlasnini yasamlar l boyunca kanserin bir kaç formunu gelistirecegi tahmin edilir. -Meme, akciger, kolorektal ve prostat- olan dördünün tüm yeni olgularm yarßmdan fazlaslia sebebiyet verdigi 200'den fazla farklEkanser tipi vardE (Jemal et al., 2003, Cancer Ayri [zamanda Folat Reseptörü-alfa veya Folat Baglama Proteini olarak da bilinen Folat Reseptörü 1 (FOLR1), hücrelerin plazma membran: üzerinde eksprese edilen bir N-glikosile edilmis proteindir. FOLR1, folik asit için ve bir kaç indirgenmis folik asit türevi için yüksek bir afiniteye sahiptir. FOLR1, fizyolojik folat n, 5- methitetrahidrofolatin, hücrelerin iç kISmlnia aktar m na arac Ilk eder. FOLR1, ovaryan kanserlerin büyük çogunlugunda ve çok sayida uterin, endometriyal, pankreatik, renal, akciger ve meme kanserinde asnîeksprese edilirken, normal dokularda FOLR1 ekspresyonu böbrek proksimal tübüllerindeki, akcigerin alveoler pnömositlerindeki, idrar kesesindeki, testislerdeki, koroid pleksustaki ve tiroitteki epitelyal hücrelerin apikal membranEile shllandmii bu ekspresyon paterni, bunu FOLR1'e yönlendirilmis kanser terapisi için arzu edilebilir bir hedef haline getirir. Ovaryan kanser ilerlemis evreye kadar tipik olarak asemptomatik olugundan, buna sikllkla geç bir evrede tani koyulur ve güncel olarak mevcut prosedürler, tipik olarak cerrahi tümör ç karma ameliyat nidan sonra kemoterapötik ilaçlar, ile tedavi edildiginde bu kötü prognoza sahiptir (von Gruenigen V et al., Cancer 112: 2221- için daha etkili terapötiklere yönelik karslanmamg asikar bir ihtiyaç vard I. BULUSUN KISA AÇIKLAMASI Mevcut bulus, tümör dokusunda FOLR1'in dinamik bir ekspresyon aralLgLnim kesfine ve arttirilmis FOLR1 ekspresyon düzeyleri olan tümörlerin anti-FOLR1 antikorlari iveya anti-FOLR1 immünokonjugatlari ile tedaviye daha çok yanit verdigi kesfine dayanir. Mevcut bulus avantajlîbir sekilde, terapötik ajanlar] yani, anti- FOLR1 antikorlarnjveya anti-FOLR1 immünokonjugatlari] bir arttîlttmß FOLR1 ekspresyon düzeyine sahip oldugu bulunan hastalara uygulama ile tedaviye yarim vermenin daha büyük bir olasmgma sahip olan hastalarh tedavisine izin verir. Mevcut bulus, bir süjede kanser terapisinde kullanJInasj için bir anti-Folat reseptörü 1 (FOLR1) antikoru veya anti-FOLR1 immünokonjugatEolup, burada söz konusu süjeden aanian bir kanser örneginde FOLR1 geninin veya proteininin bir arttiriilmis ekspresyonu, bir veya birden fazla referans örnekte boyama yogunluguna veya boyama tekdüzeligine k yasla bir FOLR1 eksprese eden kanser örneginde boyama yogunlugunu veya boyama tekdüzeligini ayint eden bir saptama yöntemi kullanilarak saptanmistin, burada bir anti-FOLR1 antikoru veya anti- FOLR1 immünokonjugatîle kanser terapisinin etkinligi bu yolla arttnirnistm; burada, kanser terapisinde kullantlmasEiçin anti-FOLR1 antikoru asagîilakileri (i) SEO lD NO: 3 amino asit dizisini içeren bir ag& zincir degisken alan: (huM ve SEO ID NO: 4 amino asit dizisini içeren bir hafif zincir degisken alan JhuMov veya (ii) SEQ ID NO: 3 amino asit dizisini içeren bir agn zincir degisken alani (huMov19 vHC) ve SEO ID NO: 5 amino asit dizisini içeren bir hafif zincir degisken alan (huMov19 vLCv1.60); ve burada kanser terapisinde kullanilmas iiçin anti-FOLR1 immünokonjugati ibir anti- FOLR1 antikoru, bir baglayÜFi ve bir sitotoksin içerir, burada anti-FOLR1 immünokonjugatnn anti-FOLR1 antikoru asag Illakileri içerir: (i) SEQ lD NO: 3 amino asit dizisini içeren bir ag& zincir degisken alan: (huM ve SEO ID NO: 4 amino asit dizisini içeren bir hafif zincir degisken alan 1huMov veya (ii) SEQ ID NO: 3 amino asit dizisini içeren bir ag] zincir degisken alan: (huMov19 vHC) ve SEO ID NO: 5 amino asit dizisini içeren bir hafif zincir degisken alan (huMov19 vLCv1.60). Bulusun ilave uygulamalarTlZ ila 17 arasmidaki istemler ile tanlîtnlanm Mevcut bulus, bir Folat Reseptörü 1'i (FOLR1) hedef alan anti-kanser terapötigine olumlu bir sekilde yantt verme egiliminde olan bir süjeyi tanmnlamak için bir yöntemi tarif eder, yöntem süjeden elde edilen bir doku örneginde FOLR1 ekspresyonunu saptamayjçerir. Mevcut bulus aerca, bir kanser terapisinin etkililiginin olasiLgJJiJarttLrmak için bir yöntemi de tarif eder, yöntem bir FOLRi'i hedef alan anti-kanser terapötiginin bir terapötik olarak etkili dozunu bir süjeye uygulamayi içerir, burada süjeden elde edilen bir doku örneginde FOLR1 ekspresyonunun arttiii Id gi bulunmustur. Mevcut bulus ayrßa, bir düsük-dozlu kanser tedavisinin etkililigini tahmin etmek için bir yöntem de tarif eder, yöntem bir FOLR1'i hedef alan anti-kanser terapötiginin bir terapötik olarak etkili dozunu bir süjeye uygulamayüiçerir, burada söz konusu süjenin bir örnek içinde arttltlîmß FOLR1 ekspresyonuna sahip oldugu bulunmustur. Bir uygulamada, yöntemler ovaryan karsinoma, küçük hücreli-olmayan akciger adenokarsinomuna (bronsiyoloalveoler karsinom dahil), renal karsinomlara ve endometriyal karsinomlara yöneliktir. Bir uygulamada, FOLR1 ekspresyonunun kapsam i ve tekdüzeligi immünohistokimya (IHC), akis sitometrisi veya nükleik asit hibridizasyonu ile saptanl. Bir baska uygulamada, FOLR1 ekspresyonunun düzeyi immünohistokimya ile saptanE. IHC'nin sîlayEE olmayan örnekleri, FOLR1'in çesitlilik gösteren düzeylerini ayît eden IHC yöntemlerini ve kalibre edilmis IHC yöntemlerini, örnegin, burada tarif edilenleri, içerir. FOLR1 ekspresyonu, bunlarla smmltkalmamak kaydg/Ia, burada tarif edilen skorlama yöntemlerini içeren, uygun bir skorlama sistemi kullanilarak skorlanabilir. Örnegin, FOLR1 ekspresyonu, boyama yogunlugu için O'Lni en düsük boyama yogunlugu düzeyi oldugu ve 3+'nm en yüksek boyama yogunlugu düzeyi oldugu 0, 1, 2, 3 ve 3+ olan bir araligi iiçeren bir kalibre edilmis IHC yöntemi kullanilarak skorlanabilir. Alternatif veya ilave olarak, FOLR1 ekspresyonu fokal (boyanmis hücrelerin TR TR TR TR TR TR TR TR TR TR TR TR

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Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110166319A1 (en) * 2005-02-11 2011-07-07 Immunogen, Inc. Process for preparing purified drug conjugates
EP3539572A1 (en) 2005-08-24 2019-09-18 ImmunoGen, Inc. Process for preparing maytansinoid antibody conjugates
BRPI1010620B8 (pt) 2009-06-03 2021-05-25 Immunogen Inc métodos de conjugação
CN103037900B (zh) 2010-02-24 2016-04-06 伊缪诺金公司 叶酸受体1抗体与免疫缀合物以及其用途
RS58367B1 (sr) 2011-03-29 2019-03-29 Immunogen Inc Priprema konjugata antitela i majtanzinoida jednostepenim postupkom
IL281714B2 (en) 2011-04-01 2023-11-01 Immunogen Inc Methods for increasing the effectiveness of FOLR1 cancer therapy
HUE049693T2 (hu) 2012-08-31 2020-10-28 Immunogen Inc Diagnosztikai ASSAY-k és készletek a folát receptor 1 kimutatására
WO2014055877A1 (en) 2012-10-04 2014-04-10 Immunogen, Inc. Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
JP6224619B2 (ja) * 2012-12-07 2017-11-01 協和発酵キリン株式会社 抗ｆｏｌｒ１抗体
RU2015129800A (ru) 2012-12-21 2017-01-30 Биоэллаенс К. В. Гидрофильные саморазрушающиеся линкеры и их конъюгаты
US20140302037A1 (en) * 2013-03-15 2014-10-09 Amgen Inc. BISPECIFIC-Fc MOLECULES
CA2911499A1 (en) * 2013-05-14 2014-11-20 Immunogen, Inc. Anti-folr1 immunoconjugate dosing regimens
AU2014312086B2 (en) * 2013-08-30 2020-03-12 Immunogen, Inc. Antibodies and assays for detection of folate receptor 1
IL298044B2 (en) 2013-10-08 2024-11-01 Immunogen Inc Dosing regimens of anti-FOLR1 immunoconjugate
US20150297744A1 (en) * 2014-03-28 2015-10-22 Immunogen, Inc. Anti-FOLR1 Immunoconjugate Dosing Regimens
SG11201610620UA (en) * 2014-06-20 2017-01-27 Bioalliance Cv Anti-folate receptor aplha (fra) antibody-drug conjugates and methods of using thereof
CN106999604B (zh) 2014-09-02 2021-08-03 伊缪诺金公司 用于配制抗体药物缀合物组合物的方法
ES2815353T3 (es) 2014-09-03 2021-03-29 Immunogen Inc Derivados de benzodiazepina citotóxicos
EP3189057A1 (en) 2014-09-03 2017-07-12 ImmunoGen, Inc. Cytotoxic benzodiazepine derivatives
RS61010B1 (sr) 2014-11-20 2020-11-30 Hoffmann La Roche Bispecifični antigen vezujući molekuli koji aktiviraju t ćelije protiv folr1 i cd3
DK3221355T3 (da) 2014-11-20 2020-12-07 Hoffmann La Roche Kombinationsbehandling med T-celleaktiverende bispecifikke antigenbindende molekyler CD3 og folatreceptor 1 (FolR1) samt PD-1-aksebindende antagonister
SI3221357T1 (sl) 2014-11-20 2020-09-30 F. Hoffmann-La Roche Ag Pogoste lahke verige in načini uporabe
WO2017020048A1 (en) * 2015-07-30 2017-02-02 Expression Pathology, Inc. QUANTIFYING FR-α AND GART PROTEINS FOR OPTIMAL CANCER THERAPY
AU2016323968B2 (en) 2015-09-17 2023-07-06 Immunogen, Inc. Therapeutic combinations comprising anti-FOLR1 immunoconjugates
PT3380525T (pt) 2015-11-25 2024-02-05 Immunogen Inc Formulações farmacêuticas e métodos que as utilizam
SG11201805557SA (en) 2016-01-08 2018-07-30 Bioalliance Cv Tetravalent anti-psgl-1 antibodies and uses thereof
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
EP4353319A3 (en) 2016-09-28 2024-06-05 Atossa Therapeutics, Inc. Methods of adoptive cell therapy
KR20250171447A (ko) 2017-02-28 2025-12-08 이뮤노젠 아이엔씨 자기희생적 펩티드 링커 및 이들의 접합체를 갖는 메이탄시노이드 유도체
WO2018195243A1 (en) 2017-04-20 2018-10-25 Immunogen, Inc. Cytotoxic benzodiazepine derivatives and conjugates thereof
IT201700087291A1 (it) * 2017-07-28 2019-01-28 Fondazione St Italiano Tecnologia Metodo di imaging di un campione biologico e relativa sonda
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
TW202413360A (zh) 2017-12-28 2024-04-01 美商伊繆諾金公司 苯二氮平衍生物
CN115925952A (zh) * 2018-03-13 2023-04-07 东莞凡恩世生物医药有限公司 抗叶酸受体1抗体及其用途
US11833214B2 (en) 2019-03-21 2023-12-05 Immunogen, Inc. Methods of preparing cell-binding agent-drug conjugates
EP3947395A1 (en) 2019-03-29 2022-02-09 ImmunoGen, Inc. Cytotoxic bis-benzodiazepine derivatives and conjugates thereof with cell-binding agents for inhibiting abnormal cell growth or for treating proliferative diseases
JP7561141B2 (ja) 2019-04-26 2024-10-03 イミュノジェン・インコーポレーテッド カンプトテシン誘導体
WO2020223221A1 (en) 2019-04-29 2020-11-05 Immunogen, Inc. Biparatopic fr-alpha antibodies and immunoconjugates
EP3980127A1 (en) * 2019-06-06 2022-04-13 Mythic Therapeutics, Inc. Antigen-binding protein constructs and uses thereof
CN111579798A (zh) * 2020-05-29 2020-08-25 深圳市锦欣医疗科技创新中心有限公司 一种评估子宫内膜容受性的试剂盒及其使用方法
CA3194182A1 (en) * 2020-09-12 2022-03-17 Medimmune Limited A scoring method for an anti-b7h4 antibody-drug conjugate therapy
WO2022256507A1 (en) * 2021-06-04 2022-12-08 Immunogen, Inc. Treatment of cancer in patients with soluble fr-alpha
IL314452A (en) * 2022-03-11 2024-09-01 Astrazeneca Ab Scoring method for anti-frα antibody-drug treatment
WO2025094146A1 (en) 2023-11-02 2025-05-08 Immunogen Switzerland Gmbh Vasconstrictors for reducing ocular toxicity of antibody-maytansinoid conjugates
US12600795B2 (en) 2023-12-26 2026-04-14 Medicovestor, Inc. Oligomeric IgG for immunotherapeutics and diagnostics
US12258396B1 (en) * 2024-02-02 2025-03-25 Medicovestor, Inc. Methods of using immunotherapeutics that bind folate receptor alpha
CN117741149A (zh) * 2024-02-19 2024-03-22 卡秋(江苏)生物科技有限公司 一种用于卵巢癌细胞叶酸受体α的检测试剂盒及其应用
WO2025195447A1 (zh) * 2024-03-22 2025-09-25 北京桦冠生物技术有限公司 结合folr1蛋白的抗体、抗体药物偶联物及其用途

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4563304A (en) 1981-02-27 1986-01-07 Pharmacia Fine Chemicals Ab Pyridine compounds modifying proteins, polypeptides or polysaccharides
US4957939A (en) 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4472509A (en) 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4938948A (en) 1985-10-07 1990-07-03 Cetus Corporation Method for imaging breast tumors using labeled monoclonal anti-human breast cancer antibodies
WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
US20040049014A1 (en) 1988-12-28 2004-03-11 Protein Design Labs, Inc. Humanized immunoglobulins
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
JPH049249A (ja) 1990-04-27 1992-01-14 Kusuda:Kk 塗型剤吹き付け機
US6916605B1 (en) 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
EP1306095A3 (en) 1992-03-05 2003-06-25 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US20030148406A1 (en) 1992-03-17 2003-08-07 David John King Multivalent antigen-binding proteins
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
AU7378096A (en) 1995-09-28 1997-04-17 Alexion Pharmaceuticals, Inc. Porcine cell interaction proteins
US6596850B1 (en) 1998-01-30 2003-07-22 Ixsys, Incorporated Anti-αv3β3 recombinant human antibodies, nucleic acids encoding same
WO2000023082A1 (en) 1998-10-19 2000-04-27 Yeda Research And Development Co. Ltd. Treatment of systemic lupus erythematosus by down-regulating the autoimmune response to autoantigens
US20040031072A1 (en) 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
IT1307309B1 (it) 1999-12-30 2001-10-30 Enea Ente Nuove Tec Peptidi stabilizzanti, polipeptidi ed anticorpi che li comprendono.
PL211872B1 (pl) 2000-03-31 2012-07-31 Purdue Research Foundation Kompozycja farmaceutyczna
DE10037759A1 (de) 2000-08-03 2002-07-04 Gruenenthal Gmbh Screeningverfahren
MXPA03007316A (es) 2001-02-19 2003-12-04 Merck Patent Gmbh Metodo para la identificacion de epitopes de celulas t y el uso para la preparacion de moleculas con inmunogenicidad reducida.
AU2002258518A1 (en) 2001-03-14 2002-09-24 Millennium Pharmaceuticals, Inc. Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
CA2445826C (en) 2001-05-02 2014-03-25 Purdue Research Foundation Treatment and diagnosis of macrophage mediated disease
US7314974B2 (en) 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
WO2003074704A1 (fr) 2002-03-01 2003-09-12 Japan Envirochemicals, Ltd. Proteines capables de se lier aux hormones sexuelles feminines et procede de preparation
AU2003224073C1 (en) 2002-04-22 2010-03-11 AgroProtect GmbH Antibodies, recombinant antibodies, recombinant antibody fragments and fusions mediated plant disease resistance against fungi
WO2004043989A2 (en) 2002-11-07 2004-05-27 Medarex, Inc. Human monoclonal antibodies to heparanase
EP1481993A1 (en) 2003-05-28 2004-12-01 Xerion Pharmaceuticals AG Modulation of the poliovirus receptor function
US20050255114A1 (en) 2003-04-07 2005-11-17 Nuvelo, Inc. Methods and diagnosis for the treatment of preeclampsia
US20050025763A1 (en) 2003-05-08 2005-02-03 Protein Design Laboratories, Inc. Therapeutic use of anti-CS1 antibodies
CA2525251C (en) 2003-05-09 2015-10-27 Duke University Cd20-specific antibodies and methods employing same
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
KR101424624B1 (ko) 2003-05-14 2014-07-31 이뮤노젠 아이엔씨 약물 콘쥬게이트 조성물
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
ZA200510282B (en) 2003-07-02 2007-03-28 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor
CA2548942C (en) 2003-12-05 2013-10-15 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health Anti-sars monoclonal antibodies
CA2556027C (en) * 2004-02-12 2015-11-24 Morphotek, Inc. Monoclonal antibodies that specifically block biological activity of a tumor antigen
CA2562833A1 (en) 2004-04-27 2005-11-03 Galapagos N.V. Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts
US7241598B2 (en) 2004-06-29 2007-07-10 The Chinese University Of Hong Kong Frame-shifting PCR for germline immunoglobulin genes retrieval and antibody engineering
US7780963B2 (en) 2004-10-25 2010-08-24 Merck & Co., Inc. Anti-ADDL antibodies and uses thereof
AU2005337132B2 (en) 2004-12-21 2011-01-20 Monsanto Technology, Llc Transgenic plants with enhanced agronomic traits
BRPI0518994A2 (pt) 2004-12-31 2008-12-02 Biogen Idec Inc anticorpos ou polipeptÍdeos que se ligam a br3, seus usos e formulaÇÕes lÍquidas
US7700738B2 (en) 2005-01-27 2010-04-20 The Regents Of The University Of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
US7608413B1 (en) 2005-03-25 2009-10-27 Celera Corporation Kidney disease targets and uses thereof
AU2006230099B2 (en) 2005-03-25 2012-04-19 Gitr, Inc. GITR binding molecules and uses therefor
ATE460668T1 (de) 2005-03-30 2010-03-15 Purdue Research Foundation Verfahren zur prognose von brustkrebs mittels quantifizierung von zellulären folat vitamin rezeptoren
EP2172487A1 (en) * 2005-04-22 2010-04-07 Morphotek Inc. Antibodies with Immune Effector Activity that Internalize in Folate Receptor Alpha-Positive Cells
US7786266B2 (en) 2005-05-12 2010-08-31 Oncotherapy Science, Inc. Methods for damaging cells using effector function of anti-DSC2 antibody
WO2006122822A2 (en) 2005-05-20 2006-11-23 Lonza Biologics Plc. High-level expression of recombinant antibody in a mammalian host cell
MX2007014673A (es) 2005-05-24 2008-04-08 Avestha Gengraine Tech Pvt Ltd Metodo para la produccion de un anticuerpo monoclonal para cd20 para el tratamiento de linfoma de celular b.
US20070009434A1 (en) 2005-07-05 2007-01-11 Low Philip S Imaging and therapeutic method using monocytes
US7521195B1 (en) 2005-07-21 2009-04-21 Celera Corporation Lung disease targets and uses thereof
CA2619725C (en) 2005-08-18 2016-06-07 Ramot At Tel Aviv University Ltd. Single chain antibodies against beta-amyloid peptide
AU2006291990B2 (en) 2005-09-13 2012-05-31 National Research Council Of Canada Methods and compositions for modulating tumor cell activity
CA2625403A1 (en) 2005-10-17 2007-04-26 Institute For System Biology Tissue-and serum-derived glycoproteins and methods of their use
EP1790664A1 (en) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
HRP20130494T1 (en) 2005-12-20 2013-08-31 Sbi Biotech Co., Ltd. Anti-ilt7 antibody
US8486412B2 (en) 2006-06-01 2013-07-16 Mayo Foundation For Medical Education And Research Immunity to folate receptors
CA2655933C (en) 2006-06-23 2014-09-09 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in cancer
US7910702B2 (en) 2006-07-28 2011-03-22 The Governors Of The University Of Alberta Recombinant antibodies to sclerotinia antigens
EP2520935A3 (en) 2006-08-09 2013-02-13 Homestead Clinical Corporation Organ-specific proteins and methods of their use
EP1900752A1 (en) 2006-09-15 2008-03-19 DOMPE' pha.r.ma s.p.a. Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma
EP1900533A1 (de) 2006-09-16 2008-03-19 J. Zimmer Maschinenbau Gesellschaft m.b.H. Vorrichtung zum Auftragen von Substanz auf flächige Substrate
MY162056A (en) 2006-10-12 2017-05-31 Univ Tokyo Diagnosis and treatment of cancer using anti -ereg antibody
JP5632582B2 (ja) 2006-12-14 2014-11-26 中外製薬株式会社 抗Ｃｌａｕｄｉｎ３モノクローナル抗体およびそれを用いる癌の治療および診断
BRPI0720565A2 (pt) 2006-12-20 2013-09-17 Mmr Information Systems Inc anticorpos e mÉtodos para a sua preparaÇço e seu uso
US20080227704A1 (en) 2006-12-21 2008-09-18 Kamens Joanne S CXCL13 binding proteins
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
EP2604284A1 (en) 2007-02-16 2013-06-19 KTB Tumorforschungsgesellschaft mbH Receptor And Antigen Targeted Prodrug
WO2008145136A1 (en) 2007-05-30 2008-12-04 Aarhus Universitet Stat3 inactivation by inhibition of the folate receptor pathway
BRPI0812970A2 (pt) 2007-06-25 2019-09-24 Endocyte Inc conjugados contendo espaçadores hidrofílicos
WO2009017679A2 (en) 2007-07-31 2009-02-05 Merck & Co., Inc. Igf-1r specific antibodies useful in the detection and diagnosis of cellular proliferative disorders
CN101139613B (zh) 2007-08-01 2011-06-08 姜荣锡 抗肿瘤二元多肽及其应用与制备方法
WO2009032974A2 (en) 2007-09-06 2009-03-12 Tripath Imaging, Inc. Nucleic acid-based methods for the detection of ovarian cancer
JP5660900B2 (ja) 2007-12-21 2015-01-28 ノバルティス アーゲー 有機化合物
CN101918450A (zh) 2008-01-11 2010-12-15 国立大学法人东京大学 抗cldn6抗体
WO2009132081A2 (en) 2008-04-24 2009-10-29 The Research Foundation Of State University Of New York Monoclonal antibody-based targeting of folate receptors
KR20200058590A (ko) 2008-04-30 2020-05-27 이뮤노젠 아이엔씨 가교제 및 그 용도
EP2276506A4 (en) 2008-04-30 2014-05-07 Immunogen Inc EFFICIENT CONJUGATES AND HYDROPHILIC BINDER
US8383351B2 (en) 2008-06-11 2013-02-26 Oxford Brookes University Antibody to inhibin/ activin β-B subunit
AU2009293140A1 (en) 2008-09-17 2010-03-25 Endocyte, Inc. Folate receptor binding conjugates of antifolates
US20100092470A1 (en) 2008-09-22 2010-04-15 Icb International, Inc. Antibodies, analogs and uses thereof
EP2367939A4 (en) 2008-11-20 2012-07-04 Oncotherapy Science Inc METHOD FOR DIAGNOSIS OR TREATMENT OF PROSTATE CANCER
CN101440130B (zh) 2008-11-21 2011-07-27 中国人民解放军第四军医大学 一种抗人IL-13Rα2单克隆抗体的重链和轻链的可变区
AU2010229924B2 (en) 2009-03-24 2016-07-21 Plus Therapeutics Inc. Devices and methods of cell capture and analysis
ES2624835T3 (es) * 2009-08-06 2017-07-17 Immunas Pharma, Inc. Anticuerpos que se unen específicamente a los oligómeros A beta y uso de los mismos
AU2010295172B2 (en) 2009-09-21 2016-08-04 Ranju Ralhan Methods and compositions for the diagnosis and treatment of thyroid cancer
TW201129383A (en) 2010-02-10 2011-09-01 Immunogen Inc CD20 antibodies and uses thereof
CN103037900B (zh) 2010-02-24 2016-04-06 伊缪诺金公司 叶酸受体1抗体与免疫缀合物以及其用途
AU2011323124C1 (en) * 2010-11-05 2016-09-22 Eisai Inc. Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers
RS58367B1 (sr) * 2011-03-29 2019-03-29 Immunogen Inc Priprema konjugata antitela i majtanzinoida jednostepenim postupkom
MX2013011201A (es) * 2011-03-29 2013-12-16 Immunogen Inc Proceso para la elaboracion de conjugados de mejor homogeneidad.
WO2012135517A2 (en) * 2011-03-29 2012-10-04 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
IL281714B2 (en) 2011-04-01 2023-11-01 Immunogen Inc Methods for increasing the effectiveness of FOLR1 cancer therapy
US20120282282A1 (en) 2011-04-04 2012-11-08 Immunogen, Inc. Methods for Decreasing Ocular Toxicity of Antibody Drug Conjugates
WO2012145112A2 (en) 2011-04-18 2012-10-26 Immunogen, Inc. Novel maytansinoid derivatives with sulfoxide linker
PL2731972T3 (pl) 2011-07-15 2018-06-29 Eisai R&D Management Co., Ltd. Przeciwciała skierowane przeciwko receptorowi folianowemu alfa i ich zastosowania
HUE049693T2 (hu) 2012-08-31 2020-10-28 Immunogen Inc Diagnosztikai ASSAY-k és készletek a folát receptor 1 kimutatására
WO2014055842A1 (en) 2012-10-04 2014-04-10 Immunogen, Inc. Process for preparing stable antibody maytansinoid conjugates
CA2911499A1 (en) 2013-05-14 2014-11-20 Immunogen, Inc. Anti-folr1 immunoconjugate dosing regimens
AU2014312086B2 (en) 2013-08-30 2020-03-12 Immunogen, Inc. Antibodies and assays for detection of folate receptor 1
IL298044B2 (en) * 2013-10-08 2024-11-01 Immunogen Inc Dosing regimens of anti-FOLR1 immunoconjugate
US20150297744A1 (en) * 2014-03-28 2015-10-22 Immunogen, Inc. Anti-FOLR1 Immunoconjugate Dosing Regimens
CN107110840A (zh) 2014-07-01 2017-08-29 爱科谱迅病理研究公司 针对化疗靶标的srm测定
CN106999604B (zh) 2014-09-02 2021-08-03 伊缪诺金公司 用于配制抗体药物缀合物组合物的方法
AU2016323968B2 (en) 2015-09-17 2023-07-06 Immunogen, Inc. Therapeutic combinations comprising anti-FOLR1 immunoconjugates
KR20250171447A (ko) 2017-02-28 2025-12-08 이뮤노젠 아이엔씨 자기희생적 펩티드 링커 및 이들의 접합체를 갖는 메이탄시노이드 유도체
RU2019141270A (ru) 2017-05-16 2021-06-16 Иммуноджен, Инк. Комбинации анти-folr1 иммуноконъюгатов и анти-pd-1 антител

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