TR201808280T4 - Pirazolo[1,5-a]pirimidin-bazlı bileşikler, bunları içeren bileşimler, ve bunların kullanım usulleri. - Google Patents

Pirazolo[1,5-a]pirimidin-bazlı bileşikler, bunları içeren bileşimler, ve bunların kullanım usulleri. Download PDF

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Publication number
TR201808280T4
TR201808280T4 TR2018/08280T TR201808280T TR201808280T4 TR 201808280 T4 TR201808280 T4 TR 201808280T4 TR 2018/08280 T TR2018/08280 T TR 2018/08280T TR 201808280 T TR201808280 T TR 201808280T TR 201808280 T4 TR201808280 T4 TR 201808280T4
Authority
TR
Turkey
Prior art keywords
pyrazolo
carboxylate
piperazine
pyrimidine
pyrimidin
Prior art date
Application number
TR2018/08280T
Other languages
English (en)
Turkish (tr)
Inventor
Bi Yingzhi
Gordon Carson Kenneth
Cianchetta Giovanni
Alan Green Michael
Kumi Godwin
Main Alan
Zhang Yulian
Gregory Zipp Glenn
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of TR201808280T4 publication Critical patent/TR201808280T4/tr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
TR2018/08280T 2012-03-09 2013-03-05 Pirazolo[1,5-a]pirimidin-bazlı bileşikler, bunları içeren bileşimler, ve bunların kullanım usulleri. TR201808280T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261608765P 2012-03-09 2012-03-09

Publications (1)

Publication Number Publication Date
TR201808280T4 true TR201808280T4 (tr) 2018-07-23

Family

ID=47892052

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/08280T TR201808280T4 (tr) 2012-03-09 2013-03-05 Pirazolo[1,5-a]pirimidin-bazlı bileşikler, bunları içeren bileşimler, ve bunların kullanım usulleri.

Country Status (25)

Country Link
US (3) US8946415B2 (2)
EP (1) EP2834243B1 (2)
JP (1) JP6418950B2 (2)
KR (1) KR101965025B1 (2)
CN (1) CN104302649B (2)
AR (1) AR090292A1 (2)
AU (1) AU2013230128B2 (2)
BR (1) BR112014022000A8 (2)
CA (1) CA2866143C (2)
DK (1) DK2834243T3 (2)
ES (1) ES2676224T3 (2)
HU (1) HUE038786T2 (2)
IL (1) IL234486A (2)
IN (1) IN2014DN07384A (2)
MX (2) MX381849B (2)
NZ (1) NZ630721A (2)
PL (1) PL2834243T3 (2)
PT (1) PT2834243T (2)
RU (1) RU2014140735A (2)
SG (1) SG11201405561RA (2)
TR (1) TR201808280T4 (2)
TW (1) TW201341386A (2)
UY (1) UY34668A (2)
WO (1) WO2013134228A1 (2)
ZA (1) ZA201406149B (2)

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EA202091475A1 (ru) * 2017-12-15 2020-09-09 Пирамид Байосайенсиз, Инк. ПРОИЗВОДНЫЕ 5-(2-(2,5-ДИФТОРФЕНИЛ)ПИРРОЛИДИН-1-ИЛ)-3-(1H-ПИРАЗОЛ-1-ИЛ)ПИРАЗОЛО[1,5-а]ПИРИМИДИНА И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ Trk КИНАЗЫ ДЛЯ ЛЕЧЕНИЯ РАКА
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Also Published As

Publication number Publication date
AR090292A1 (es) 2014-11-05
ES2676224T3 (es) 2018-07-17
DK2834243T3 (en) 2018-07-23
AU2013230128B2 (en) 2017-08-17
EP2834243B1 (en) 2018-04-25
MX2014010589A (es) 2014-09-18
KR20140138864A (ko) 2014-12-04
CA2866143A1 (en) 2013-09-12
BR112014022000A8 (pt) 2021-06-15
PL2834243T3 (pl) 2018-09-28
CN104302649A (zh) 2015-01-21
MX345830B (es) 2017-02-17
ZA201406149B (en) 2016-06-29
US9403832B2 (en) 2016-08-02
PT2834243T (pt) 2018-08-01
WO2013134228A1 (en) 2013-09-12
CA2866143C (en) 2020-08-04
MX381849B (es) 2025-03-13
IL234486A (en) 2016-10-31
HK1201257A1 (en) 2015-08-28
TW201341386A (zh) 2013-10-16
IN2014DN07384A (2) 2015-04-24
UY34668A (es) 2013-10-31
CN104302649B (zh) 2017-06-23
NZ630721A (en) 2016-12-23
BR112014022000A2 (pt) 2017-06-20
US20170129896A1 (en) 2017-05-11
EP2834243A1 (en) 2015-02-11
SG11201405561RA (en) 2014-10-30
HUE038786T2 (hu) 2018-11-28
US8946415B2 (en) 2015-02-03
JP2015509535A (ja) 2015-03-30
RU2014140735A (ru) 2016-04-27
US20130253194A1 (en) 2013-09-26
AU2013230128A1 (en) 2014-09-25
JP6418950B2 (ja) 2018-11-07
US20150183792A1 (en) 2015-07-02
KR101965025B1 (ko) 2019-04-02

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