TR201819812T4 - Kanserin Tedavisi Ve/Veya Önlenmesi Amacına Yönelik Farmasötik Bileşim - Google Patents

Kanserin Tedavisi Ve/Veya Önlenmesi Amacına Yönelik Farmasötik Bileşim Download PDF

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TR201819812T4
TR201819812T4 TR2018/19812T TR201819812T TR201819812T4 TR 201819812 T4 TR201819812 T4 TR 201819812T4 TR 2018/19812 T TR2018/19812 T TR 2018/19812T TR 201819812 T TR201819812 T TR 201819812T TR 201819812 T4 TR201819812 T4 TR 201819812T4
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antibody
caprin
pharmaceutical composition
cancer disease
seq
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TR2018/19812T
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English (en)
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Okano Fumiyoshi
Saito Takanori
Minamida Yoshitaka
Ido Takayoshi
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Toray Industries
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Abstract

Geleneksel antikorlara kıyasla antitümör aktivitesi açısından daha üstün nitelikte olan bir CAPRIN-1-hedefleyici antikor sunulması ve bunun bir kanser hastalığı için terapötik ve/veya önleyici ajan olarak kullanımının sağlanması hedeflenmektedir. Bu buluş, kanser hücrelerinin yüzeyi üzerinde spesifik olarak eksprese edilen bir CAPRIN-1 polipeptidini hedef alan bir antikor ve bu antikorun bir kanser hastalığı için terapötik ve/veya önleyici ajan olarak kullanımını sunmaktadır. Bu buluş, SEKANS KOD NO.: 1, 2 ve 3 ile temsil edilen tamamlayıcılık belirleme bölgeleri içeren bir ağır zincir değişken bölgesi ve SEKANS KOD NO.: 4, 5 ve 6 ile temsil edilen tamamlayıcılık belirleme bölgeleri içeren bir hafif zincir değişken bölgesi bulunan ve bir CAPRIN-1 proteiniyle immünolojik reaktiviteye sahip olan bir antikor ya da onun bir fragmanını ve bir kanser hastalığının tedavisi ve/veya önlenmesi amacına yönelik olan ve bu antikoru ya da fragmanını bir etkin madde olarak içeren bir farmasötik bileşim sunmaktadır.
TR2018/19812T 2013-08-09 2014-08-08 Kanserin Tedavisi Ve/Veya Önlenmesi Amacına Yönelik Farmasötik Bileşim TR201819812T4 (tr)

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US (1) US9862774B2 (tr)
EP (1) EP3031826B1 (tr)
JP (1) JP6447130B2 (tr)
KR (1) KR102255616B1 (tr)
CN (1) CN105452294B (tr)
AU (1) AU2014303375B2 (tr)
BR (1) BR112016001753B1 (tr)
CA (1) CA2918989C (tr)
DK (1) DK3031826T3 (tr)
ES (1) ES2704909T3 (tr)
HU (1) HUE042081T2 (tr)
MX (1) MX360671B (tr)
PL (1) PL3031826T3 (tr)
PT (1) PT3031826T (tr)
RU (1) RU2678138C2 (tr)
TR (1) TR201819812T4 (tr)
WO (1) WO2015020212A1 (tr)

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