TR201908638T4 - Ang2 bağlayıcı moleküller. - Google Patents

Ang2 bağlayıcı moleküller. Download PDF

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Publication number
TR201908638T4
TR201908638T4 TR2019/08638T TR201908638T TR201908638T4 TR 201908638 T4 TR201908638 T4 TR 201908638T4 TR 2019/08638 T TR2019/08638 T TR 2019/08638T TR 201908638 T TR201908638 T TR 201908638T TR 201908638 T4 TR201908638 T4 TR 201908638T4
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TR
Turkey
Prior art keywords
binding molecules
ang2 binding
ang2
vhhs
angiogenesis
Prior art date
Application number
TR2019/08638T
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English (en)
Inventor
Borges Eric
Gschwind Andreas
Georg Ott Rene
Buyse Marie-Ange
Boucneau Joachim
Merchiers Pascal
Depla Erik
Stevenaert Frederik
Original Assignee
Boehringer Ingelheim Int
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48190468&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR201908638(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of TR201908638T4 publication Critical patent/TR201908638T4/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3038—Kidney, bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Ang2 bağlayıcı moleküller, tercihen VHH'ler ve domen antikorları gibi Ang2 bağlayıcı immünoglobulin tekli değişken domenleri ve bunları ihtiva eden farmasötik bileşimler ve bunların, anjiyogenez üzerindeki Ang2 aracılı etkilerle ilişkili hastalıkların tedavisinde kullanımıdır. Ang2 bağlayıcı molekülleri, konak hücreleri kodlayan nükleik asitler ve bunları hazırlama yöntemleridir.
TR2019/08638T 2012-03-30 2013-03-27 Ang2 bağlayıcı moleküller. TR201908638T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12162615 2012-03-30

Publications (1)

Publication Number Publication Date
TR201908638T4 true TR201908638T4 (tr) 2019-07-22

Family

ID=48190468

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/08638T TR201908638T4 (tr) 2012-03-30 2013-03-27 Ang2 bağlayıcı moleküller.

Country Status (27)

Country Link
US (5) US20130259859A1 (tr)
EP (1) EP2831111B1 (tr)
JP (1) JP5970734B2 (tr)
KR (1) KR102020255B1 (tr)
CN (1) CN104321344B (tr)
AU (1) AU2013241769B2 (tr)
BR (1) BR112014023415B1 (tr)
CA (1) CA2865464C (tr)
CL (1) CL2014002393A1 (tr)
CY (1) CY1122007T1 (tr)
DK (1) DK2831111T3 (tr)
EA (1) EA031182B1 (tr)
ES (1) ES2729165T3 (tr)
HR (1) HRP20190817T1 (tr)
HU (1) HUE044263T2 (tr)
IL (1) IL234234B (tr)
IN (1) IN2014DN06904A (tr)
LT (1) LT2831111T (tr)
MX (1) MX350248B (tr)
NZ (1) NZ628584A (tr)
PH (1) PH12014502179A1 (tr)
PL (1) PL2831111T3 (tr)
PT (1) PT2831111T (tr)
RS (1) RS58732B1 (tr)
SI (1) SI2831111T1 (tr)
TR (1) TR201908638T4 (tr)
WO (1) WO2013144266A1 (tr)

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AU2015331602A1 (en) 2014-10-17 2017-04-27 Amgen Inc. Antibodies directed to angiopoietin-1 and angiopoietin-2 for ocular therapies
HK1250011A1 (zh) * 2015-03-31 2018-11-23 Sorriso Pharmaceuticals, Inc. 具有蛋白酶可切割接头的肽构建体
US10266589B2 (en) * 2015-07-29 2019-04-23 Allergan, Inc. Heavy chain only antibodies to ANG-2
CA3040194A1 (en) * 2016-10-13 2018-04-19 Dana-Farber Cancer Institute, Inc. Compositions and methods for predicting response and resistance to ctla4 blockade in melanoma using a gene expression signature
KR102143132B1 (ko) * 2016-12-26 2020-08-10 기초과학연구원 항 Ang2 항체를 포함하는 안구질환 예방 및 치료용 조성물
CN109071656B (zh) 2017-01-05 2021-05-18 璟尚生物制药公司 检查点调节物拮抗剂
MX2019014199A (es) * 2017-06-02 2020-01-23 Boehringer Ingelheim Int Tratamiento de combinacion antineoplasico.
CN108659130B (zh) * 2018-05-28 2021-09-10 长春力太生物技术有限公司 一种抗癌胚抗原纳米抗体及其应用
CN112739717B (zh) 2018-06-29 2025-02-11 璟尚生物制药公司 三特异性拮抗剂
CA3131250A1 (en) * 2019-02-25 2020-09-03 Pharmabcine Inc. Anti-ang2 antibody and use thereof
US20220185875A1 (en) * 2019-03-18 2022-06-16 Jiangsu Hengrui Medicine Co., Ltd. Bispecific antibody specifically bound to vegf and ang2
US10851157B2 (en) 2019-07-01 2020-12-01 Gensun Biopharma, Inc. Antagonists targeting the TGF-β pathway
JP2023516392A (ja) * 2020-03-03 2023-04-19 アプティテュード メディカル システムズ、インコーポレイテッド アプタマーおよびその使用
CN111875706B (zh) * 2020-07-16 2021-03-30 广州康盛生物科技股份有限公司 一种抗人IgE蛋白的单域抗体及其应用
US20240279324A1 (en) 2021-06-03 2024-08-22 Gensun Biopharma Inc. Multispecific antagonists
JP2024534964A (ja) * 2021-09-10 2024-09-26 ソーター・バイオファーマ・プライベイト・リミテッド 抗ａｎｇ２抗体、その調製方法及び使用
WO2024065268A1 (zh) 2022-09-28 2024-04-04 科兴生物制药股份有限公司 能够识别ang-2的抗体或抗原结合片段和同时识别vegf和ang-2的双抗
CN115819592B (zh) * 2022-12-27 2026-04-24 上海医药集团生物治疗技术有限公司 靶向ror1的抗原结合蛋白
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Also Published As

Publication number Publication date
KR102020255B1 (ko) 2019-09-10
HUE044263T2 (hu) 2019-10-28
HRP20190817T1 (hr) 2019-06-28
EP2831111A1 (en) 2015-02-04
AU2013241769A1 (en) 2014-08-28
DK2831111T3 (en) 2019-04-29
JP2015516805A (ja) 2015-06-18
CN104321344B (zh) 2017-11-21
PH12014502179B1 (en) 2014-12-10
CY1122007T1 (el) 2020-10-14
CN104321344A (zh) 2015-01-28
EA201401065A1 (ru) 2015-03-31
ES2729165T3 (es) 2019-10-30
PL2831111T3 (pl) 2019-09-30
AU2013241769B2 (en) 2017-05-11
PT2831111T (pt) 2019-05-31
IN2014DN06904A (tr) 2015-05-15
US20230203146A1 (en) 2023-06-29
JP5970734B2 (ja) 2016-08-17
NZ628584A (en) 2016-04-29
MX2014011171A (es) 2015-03-06
CL2014002393A1 (es) 2015-01-23
US20130259859A1 (en) 2013-10-03
US20200207845A1 (en) 2020-07-02
WO2013144266A1 (en) 2013-10-03
IL234234B (en) 2020-06-30
KR20140146606A (ko) 2014-12-26
PH12014502179A1 (en) 2014-12-10
EA031182B1 (ru) 2018-11-30
BR112014023415B1 (pt) 2022-04-12
US20170107281A1 (en) 2017-04-20
CA2865464A1 (en) 2013-10-03
MX350248B (es) 2017-08-31
LT2831111T (lt) 2019-05-10
CA2865464C (en) 2022-07-12
SI2831111T1 (sl) 2019-06-28
RS58732B1 (sr) 2019-06-28
US20190135907A1 (en) 2019-05-09
BR112014023415A2 (pt) 2017-07-11
EP2831111B1 (en) 2019-03-20

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