TR201908817T4 - Nitrogliserin ile arteriyojenezin indüksiyonu. - Google Patents
Nitrogliserin ile arteriyojenezin indüksiyonu. Download PDFInfo
- Publication number
- TR201908817T4 TR201908817T4 TR2019/08817T TR201908817T TR201908817T4 TR 201908817 T4 TR201908817 T4 TR 201908817T4 TR 2019/08817 T TR2019/08817 T TR 2019/08817T TR 201908817 T TR201908817 T TR 201908817T TR 201908817 T4 TR201908817 T4 TR 201908817T4
- Authority
- TR
- Turkey
- Prior art keywords
- arteriogenesis
- nitroglycerin
- induction
- donor
- effective amount
- Prior art date
Links
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 title 1
- 239000000006 Nitroglycerin Substances 0.000 title 1
- 230000027746 artery morphogenesis Effects 0.000 title 1
- 229960003711 glyceryl trinitrate Drugs 0.000 title 1
- 230000006698 induction Effects 0.000 title 1
- 206010069729 Collateral circulation Diseases 0.000 abstract 2
- 239000002840 nitric oxide donor Substances 0.000 abstract 2
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Mevcut buluş diğerlerinin yanı sıra, bir süjeyi bir terapötik olarak etkili miktarda bir NO donörüne maruz bırakmaya yönelik bir adım içeren kollateral dolaşımı desteklemeye yönelik bir yöntem ile ilgilidir, burada terapötik olarak etkili miktarda NO donörü bir fizyolojik veya patolojik durumda artan kollateral dolaşım için yeterli ölçüde arteriyojenezi desteklemektedir.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261653595P | 2012-05-31 | 2012-05-31 | |
| EP12004187.6A EP2668947B1 (en) | 2012-05-31 | 2012-05-31 | Induction of arteriogenesis with a nitric oxide-donor such as nitroglycerin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201908817T4 true TR201908817T4 (tr) | 2019-07-22 |
Family
ID=46275671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/08817T TR201908817T4 (tr) | 2012-05-31 | 2013-05-29 | Nitrogliserin ile arteriyojenezin indüksiyonu. |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20150164845A1 (tr) |
| EP (3) | EP2668947B1 (tr) |
| JP (1) | JP6280106B2 (tr) |
| CN (2) | CN110251500A (tr) |
| AU (2) | AU2013269631B2 (tr) |
| CA (1) | CA2872465C (tr) |
| DE (1) | DE112013002717T5 (tr) |
| EA (1) | EA032534B1 (tr) |
| ES (2) | ES2617494T3 (tr) |
| HU (2) | HUE033092T2 (tr) |
| PL (2) | PL2668947T3 (tr) |
| TR (1) | TR201908817T4 (tr) |
| WO (1) | WO2013178715A1 (tr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2668947T3 (pl) | 2012-05-31 | 2017-06-30 | G. Pohl-Boskamp Gmbh & Co. Kg | Indukcja arteriogenezy donorem NO, takim jak nitrogliceryna |
| CA3040872A1 (en) * | 2016-12-14 | 2018-06-21 | G. Pohl-Boskamp Gmbh & Co. Kg | Reducing side effects of short acting no donors |
| TWI650326B (zh) * | 2017-10-24 | 2019-02-11 | 國立交通大學 | 醫藥組合物、化合物的用途及合成方法 |
| WO2021073535A1 (zh) * | 2019-10-16 | 2021-04-22 | 上海岸阔医药科技有限公司 | 预防或治疗与vegfr和/或vegf被抑制相关疾病的方法 |
| CN110934865A (zh) * | 2019-12-06 | 2020-03-31 | 牡丹江医学院 | 一种用于预防和治疗血液透析低血压的药物组合物及其用途 |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE632504A (tr) | 1962-05-24 | |||
| GB1205019A (en) | 1966-12-07 | 1970-09-09 | Sterwin Ag | Improvements in or relating to oral dosage forms |
| JPS599539B2 (ja) | 1979-11-13 | 1984-03-03 | 日本化薬株式会社 | ニトログリセリン水溶液及びその製造法 |
| CA1163195A (en) | 1980-06-26 | 1984-03-06 | Alec D. Keith | Polymeric diffusion matrix containing a vasodilator |
| US4542013A (en) | 1981-07-08 | 1985-09-17 | Key Pharmaceuticals, Inc. | Trinitroglycerol sustained release vehicles and preparation therefrom |
| DE3246081A1 (de) | 1982-12-13 | 1984-06-14 | G. Pohl-Boskamp GmbH & Co Chemisch-pharmazeutische Fabrik, 2214 Hohenlockstedt | Nitroglycerin-spray |
| US4671953A (en) | 1985-05-01 | 1987-06-09 | University Of Utah Research Foundation | Methods and compositions for noninvasive administration of sedatives, analgesics, and anesthetics |
| EP0583821B1 (en) | 1987-01-23 | 2000-03-29 | The General Hospital Corporation | Hydralazine as topical treatment for glaucoma |
| JPH0645538B2 (ja) | 1987-09-30 | 1994-06-15 | 日本化薬株式会社 | ニトログリセリンスプレー剤 |
| HU199678B (en) | 1988-07-08 | 1990-03-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing aerosols containing nitroglicerol |
| DE4007705C1 (tr) | 1990-03-10 | 1991-09-26 | G. Pohl-Boskamp Gmbh & Co. Chemisch-Pharmazeutische Fabrik, 2214 Hohenlockstedt, De | |
| US5370862A (en) | 1990-06-13 | 1994-12-06 | Schwarz Pharma Ag | Pharmaceutical hydrophilic spray containing nitroglycerin for treating angina |
| DE4018919C2 (de) | 1990-06-13 | 1994-08-25 | Sanol Arznei Schwarz Gmbh | Nitroglycerin-Spray |
| DE4026072A1 (de) | 1990-08-17 | 1992-02-20 | Sanol Arznei Schwarz Gmbh | Nitroglycerinhaltiger, hydrophiler, waessriger pumpspray |
| DE4038203A1 (de) | 1990-11-30 | 1992-06-04 | Kali Chemie Pharma Gmbh | Pharmazeutische spray-zubereitungen mit coronaraktiven wirkstoffen |
| US5698589A (en) | 1993-06-01 | 1997-12-16 | International Medical Innovations, Inc. | Water-based topical cream containing nitroglycerin and method of preparation and use thereof |
| EP1393723A3 (en) * | 1993-09-17 | 2004-10-20 | The Brigham And Women's Hospital, Inc. | Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces |
| US5869082A (en) | 1996-04-12 | 1999-02-09 | Flemington Pharmaceutical Corp. | Buccal, non-polar spray for nitroglycerin |
| US20010044584A1 (en) | 1997-08-28 | 2001-11-22 | Kensey Kenneth R. | In vivo delivery methods and compositions |
| US20030095925A1 (en) | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders |
| US6500456B1 (en) | 1997-10-03 | 2002-12-31 | Warner-Lambert Company | Compressed nitroglycerin tablet and its method of manufacture |
| US6796966B2 (en) | 1997-10-15 | 2004-09-28 | Jeffrey E. Thomas | Apparatus, and kits for preventing of alleviating vasoconstriction or vasospasm in a mammal |
| AU2479099A (en) | 1998-01-28 | 1999-08-16 | Seatrace Pharmaceuticals, Inc. | Topical vasodilatory gel composition and methods of use and production |
| US5989529A (en) | 1998-11-20 | 1999-11-23 | Schering-Plough Healthcare Products, Inc. | Substantive topical composition |
| IT1303793B1 (it) | 1998-11-27 | 2001-02-23 | Promefarm S R L | "composizione farmaceutica comprendente un composto organico donatoredi ossido nitrico (no)" |
| US6962691B1 (en) | 1999-05-20 | 2005-11-08 | U & I Pharmaceuticals Ltd. | Topical spray compositions |
| RU2174838C2 (ru) | 1999-11-04 | 2001-10-20 | Ивановская государственная медицинская академия | Способ лечения тяжелого бронхообструктивного синдрома у детей раннего возраста |
| US20020049188A1 (en) | 1999-12-15 | 2002-04-25 | Azarnoff Daniel L. | Nitroglycerin ointment for treatment of pain associated with anal disease |
| US6443307B1 (en) | 2000-01-25 | 2002-09-03 | Michael D. Burridge | Medication dispenser with an internal ejector |
| AU4916501A (en) | 2000-03-14 | 2001-09-24 | Noven Pharmaceuticals, Inc. | Packaging materials for transdermal drug delivery systems |
| US6538033B2 (en) | 2000-08-29 | 2003-03-25 | Huntington Medical Research Institutes | Nitric oxide donor compounds |
| TNSN03137A1 (en) | 2001-06-22 | 2005-12-23 | Pfizer Prod Inc | PHARMACEUTICAL COMPOSITIONS COMPRISING LOW SOLUBILITY AND / OR ACID SENSITIVE DRUGS AND NEUTRALIZED ACID POLYMERS. |
| JP3984225B2 (ja) | 2002-02-08 | 2007-10-03 | ザ プロクター アンド ギャンブル カンパニー | 子供用安全袋 |
| US20090118019A1 (en) * | 2002-12-10 | 2009-05-07 | Onlive, Inc. | System for streaming databases serving real-time applications used through streaming interactive video |
| US20050095278A1 (en) | 2003-01-14 | 2005-05-05 | Viorel Nicolaescu | Use of nitroglycerin to relieve nocturnal muscle cramps |
| US20040228883A1 (en) | 2003-02-21 | 2004-11-18 | Mitchell Karl | Prepackaged aqueous pharmaceutical formulation for the treatment of cardiac conditions containing at least two different active agents and method of formulation |
| US20070059346A1 (en) | 2003-07-01 | 2007-03-15 | Todd Maibach | Film comprising therapeutic agents |
| US20070053966A1 (en) | 2003-10-17 | 2007-03-08 | Robert Ang | Medicated orthopedic support structures for treatment of damaged musculoskeletal tissue |
| US7781226B2 (en) | 2004-02-27 | 2010-08-24 | The Board Of Regents Of The University Of Texas System | Particle on membrane assay system |
| CA2557814A1 (en) | 2004-03-01 | 2005-09-15 | Lumen Therapeutics, Llc | Compositions and methods for treating diseases |
| FR2868314B1 (fr) * | 2004-04-05 | 2008-10-24 | Therabel Pharmaceuticals Ltd | Nouvelle utilisation therapeutique de la molsidomine et de ses sels pharmaceutiquement acceptables |
| US20080260861A1 (en) | 2004-04-07 | 2008-10-23 | The General Hospital Corporation | Modulating Lymphatic Function |
| WO2007081206A1 (en) | 2006-01-09 | 2007-07-19 | Pantarhei Bioscience B.V. | A method of treating an acute vascular disorder |
| EP2015632B1 (en) | 2006-04-19 | 2015-12-02 | Mist Pharmaceuticals, LLC | Stable hydroalcoholic oral spray formulations and methods |
| KR20100014853A (ko) | 2007-02-26 | 2010-02-11 | 존 런드버그 | 아질산염 및 질산염의 신규 용도 및 이를 함유하는 조성물 |
| ES2393163T3 (es) * | 2007-12-18 | 2012-12-19 | Athera Biotechnologies Ab | Compuestos y métodos para el tratamiento de enfermedad vascular |
| CN101229148A (zh) | 2007-12-28 | 2008-07-30 | 天津医科大学 | 硝酸甘油口腔(舌下)崩解片的制剂及其制备方法 |
| DE102008005484A1 (de) | 2008-01-22 | 2009-07-23 | Schaper, Wolfgang, Dr. | Induktion und Förderung der Arteriogenese |
| SI2098249T1 (sl) | 2008-03-05 | 2013-02-28 | Rivopharm Sa | Nosilci nikorandila s povečano stabilnostjo |
| DE202008007318U1 (de) | 2008-03-14 | 2008-07-31 | G. Pohl-Boskamp Gmbh & Co. Kg | Langzeitstabile pharmazeutische Zubereitung mit dem Wirkstoff Glyceroltrinitrat |
| US20100184870A1 (en) | 2008-03-14 | 2010-07-22 | Rolf Groteluschen | Long-term stable pharmaceutical preparation containing the active ingredient glycerol trinitrate |
| US20100016446A1 (en) | 2008-07-21 | 2010-01-21 | Sylvia Gonda | Stable water-based topical pharmaceutical creams and methods of making and using same |
| US20120059245A1 (en) | 2008-12-23 | 2012-03-08 | Ivo Buschmann | Method and device for monitoring and improving arteriogenesis |
| AU2009202685B1 (en) | 2009-06-30 | 2010-08-19 | Ino Therapeutics Llc | Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension |
| ES2582309T3 (es) * | 2010-08-03 | 2016-09-12 | G. Pohl-Boskamp Gmbh & Co. Kg | Uso de trinitrato de glicerilo para el tratamiento de edema traumático |
| WO2012113564A1 (en) * | 2011-02-25 | 2012-08-30 | G. Pohl-Boskamp Gmbh & Co. Kg | Stabilized granules containing glyceryl trinitrate |
| PL2668947T3 (pl) * | 2012-05-31 | 2017-06-30 | G. Pohl-Boskamp Gmbh & Co. Kg | Indukcja arteriogenezy donorem NO, takim jak nitrogliceryna |
| CA2778679A1 (en) * | 2012-05-31 | 2013-11-30 | G. Pohl-Boskamp Gmbh & Co. Kg | Use of stabilized granules containing glyceryl trinitrate for arteriogenesis |
| US20140057977A1 (en) | 2012-05-31 | 2014-02-27 | G. Pohl-Boskamp Gmbh & Co. Kg | Induction of Arteriogenesis |
| US9248099B2 (en) * | 2012-05-31 | 2016-02-02 | Desmoid Aktiengesellschaft | Use of stabilized granules containing glyceryl trinitrate for arteriogenesis |
| EP2668948A1 (en) * | 2012-05-31 | 2013-12-04 | G. Pohl-Boskamp GmbH & Co. KG | Use of stabilized granules containing glyceryl trinitrate for arteriogenesis |
| JP5996371B2 (ja) | 2012-10-29 | 2016-09-21 | 株式会社東芝 | 電子機器 |
| EP2805730A1 (en) | 2013-05-21 | 2014-11-26 | Bergen Teknologioverforing AS | Nitric oxide donor for the treatment of chronic fatigue syndrome |
| EP2878310B1 (en) | 2013-11-29 | 2017-01-11 | G. Pohl-Boskamp GmbH & Co. KG | Sprayable aqueous composition comprising glyceryl trinitrate |
| CA3040872A1 (en) | 2016-12-14 | 2018-06-21 | G. Pohl-Boskamp Gmbh & Co. Kg | Reducing side effects of short acting no donors |
-
2012
- 2012-05-31 PL PL12004187T patent/PL2668947T3/pl unknown
- 2012-05-31 HU HUE12004187A patent/HUE033092T2/hu unknown
- 2012-05-31 EP EP12004187.6A patent/EP2668947B1/en not_active Not-in-force
- 2012-05-31 ES ES12004187.6T patent/ES2617494T3/es active Active
-
2013
- 2013-05-29 TR TR2019/08817T patent/TR201908817T4/tr unknown
- 2013-05-29 CN CN201910506944.9A patent/CN110251500A/zh active Pending
- 2013-05-29 DE DE112013002717.8T patent/DE112013002717T5/de not_active Withdrawn
- 2013-05-29 EP EP18179582.4A patent/EP3412285A3/en not_active Withdrawn
- 2013-05-29 AU AU2013269631A patent/AU2013269631B2/en not_active Ceased
- 2013-05-29 WO PCT/EP2013/061131 patent/WO2013178715A1/en not_active Ceased
- 2013-05-29 PL PL13726197T patent/PL2877170T3/pl unknown
- 2013-05-29 JP JP2015514497A patent/JP6280106B2/ja not_active Expired - Fee Related
- 2013-05-29 EA EA201492251A patent/EA032534B1/ru not_active IP Right Cessation
- 2013-05-29 ES ES13726197T patent/ES2731664T3/es active Active
- 2013-05-29 US US14/403,713 patent/US20150164845A1/en not_active Abandoned
- 2013-05-29 EP EP13726197.0A patent/EP2877170B1/en active Active
- 2013-05-29 HU HUE13726197A patent/HUE044056T2/hu unknown
- 2013-05-29 CA CA2872465A patent/CA2872465C/en active Active
- 2013-05-29 CN CN201380028543.8A patent/CN104519881A/zh active Pending
-
2017
- 2017-03-06 US US15/450,656 patent/US11166931B2/en not_active Expired - Fee Related
-
2018
- 2018-02-05 AU AU2018200831A patent/AU2018200831A1/en not_active Abandoned
-
2021
- 2021-09-22 US US17/448,508 patent/US20220096417A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2872465A1 (en) | 2013-12-05 |
| AU2018200831A1 (en) | 2018-02-22 |
| AU2013269631B2 (en) | 2018-03-01 |
| JP6280106B2 (ja) | 2018-02-14 |
| DE112013002717T5 (de) | 2015-02-26 |
| EA032534B1 (ru) | 2019-06-28 |
| EP2877170B1 (en) | 2019-04-10 |
| US20220096417A1 (en) | 2022-03-31 |
| US20150164845A1 (en) | 2015-06-18 |
| WO2013178715A1 (en) | 2013-12-05 |
| CN104519881A (zh) | 2015-04-15 |
| ES2731664T3 (es) | 2019-11-18 |
| CA2872465C (en) | 2021-02-16 |
| PL2668947T3 (pl) | 2017-06-30 |
| EA201492251A1 (ru) | 2015-05-29 |
| EP2877170A1 (en) | 2015-06-03 |
| US20170172966A1 (en) | 2017-06-22 |
| EP2668947B1 (en) | 2016-11-30 |
| US11166931B2 (en) | 2021-11-09 |
| AU2013269631A1 (en) | 2014-11-13 |
| HUE033092T2 (hu) | 2017-11-28 |
| PL2877170T3 (pl) | 2019-11-29 |
| EP3412285A3 (en) | 2019-02-20 |
| CN110251500A (zh) | 2019-09-20 |
| EP3412285A2 (en) | 2018-12-12 |
| ES2617494T3 (es) | 2017-06-19 |
| JP2015518030A (ja) | 2015-06-25 |
| EP2668947A1 (en) | 2013-12-04 |
| HUE044056T2 (hu) | 2019-09-30 |
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