TR27016A - Bir yeni sefalosporin c asilaz. - Google Patents

Bir yeni sefalosporin c asilaz.

Info

Publication number: TR27016A
Authority: TR; Turkey
Prior art keywords: acylase; amino acid; ala; native; acid sequence
Prior art date: 1992-02-27

Application number

TR00192/93A

Other languages

English (en)

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-27

Filing date

1993-02-24

Publication date

1994-09-15

1993-02-24 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1994-09-15 Publication of TR27016A publication Critical patent/TR27016A/tr

Links

HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 title abstract 4
150000001413 amino acids Chemical class 0.000 abstract 4
125000003275 alpha amino acid group Chemical group 0.000 abstract 3
239000013604 expression vector Substances 0.000 abstract 2
244000005700 microbiome Species 0.000 abstract 2
239000002243 precursor Substances 0.000 abstract 2
238000012258 culturing Methods 0.000 abstract 1
235000015097 nutrients Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Cephalosporin Compounds (AREA)
Enzymes And Modification Thereof (AREA)

TR00192/93A 1992-02-27 1993-02-24 Bir yeni sefalosporin c asilaz. TR27016A (tr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929204439A GB9204439D0 (en)	1992-02-27	1992-02-27	A new cephalosporin c acylase

Publications (1)

Publication Number	Publication Date
TR27016A true TR27016A (tr)	1994-09-15

Family

ID=10711322

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TR00192/93A TR27016A (tr)	1992-02-27	1993-02-24	Bir yeni sefalosporin c asilaz.

Country Status (15)

Country	Link
US (1)	US5336613A (tr)
EP (1)	EP0558241B1 (tr)
JP (1)	JPH0614777A (tr)
KR (1)	KR100276541B1 (tr)
CN (1)	CN1062903C (tr)
AT (1)	ATE121784T1 (tr)
CA (1)	CA2090571A1 (tr)
DE (1)	DE69300123T2 (tr)
DK (1)	DK0558241T3 (tr)
ES (1)	ES2071527T3 (tr)
GB (1)	GB9204439D0 (tr)
GR (1)	GR3015943T3 (tr)
HU (1)	HU220460B1 (tr)
TR (1)	TR27016A (tr)
TW (1)	TW274565B (tr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE167520T1 (de) *	1990-04-18	1998-07-15	Gist Brocades Nv	Mutierte beta-lactamacylasegene
ES2135446T3 (es) *	1992-04-24	1999-11-01	Lilly Co Eli	Procedimiento para la preparacion de cefalosporinas.
TW400384B (en) *	1993-11-01	2000-08-01	Fujisawa Pharmaceutical Co	A new cephalosporin C acylase
AU3346295A (en) *	1994-08-12	1996-03-07	Gist-Brocades B.V.	Mutated penicillin g acylase genes
CN1065278C (zh) *	1994-08-27	2001-05-02	中国科学院上海植物生理研究所	一步两酶法制造7－氨基头孢烷酸
GB9423212D0 (en) *	1994-11-17	1995-01-04	Glaxo Group Ltd	Industrial enzymes
US6153429A (en) *	1996-04-05	2000-11-28	Vera Genics Ltd.	Cell lines useful for in vitro assay for indentification of carcinogens
US5821049A (en) *	1996-04-05	1998-10-13	Viratest Carcinogen Monitoring, Ltd	In vitro assay for identification of carcinogens
WO1998020120A1 (en)	1996-11-05	1998-05-14	Bristol-Myers Squibb Company	Mutant penicillin g acylases
KR100530299B1 (ko) *	2003-08-11	2005-11-22	산도즈 게엠베하	변이 세팔로스포린 ｃ 아실라제 및 이를 이용한 7-ａｃａ 제조방법
ITMI20040016A1 (it) *	2004-01-12	2004-04-12	Antibiotics S P A	Cefalosporina c acilasi
EP1974029A2 (en) *	2005-12-28	2008-10-01	DSMIP Assets B.V.	Mutant acylases
CN109913436B (zh) *	2017-12-12	2023-05-23	石药集团圣雪葡萄糖有限责任公司	含有一个或几个点突变的头孢菌素c酰化酶突变体及其制备方法
CN112662655B (zh) *	2020-12-29	2022-05-03	山东金城柯瑞化学有限公司	头孢菌素c酰化酶突变体及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61152286A (ja) *	1984-12-27	1986-07-10	Asahi Chem Ind Co Ltd	セフアロスポリンｃアシラ−ゼ産生遺伝情報を担うｄｎａ断片

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4959314A (en) *	1984-11-09	1990-09-25	Cetus Corporation	Cysteine-depleted muteins of biologically active proteins
US4752585A (en) *	1985-12-17	1988-06-21	Cetus Corporation	Oxidation-resistant muteins
US4835260A (en) *	1987-03-20	1989-05-30	Genetics Institute, Inc.	Erythropoietin composition
IL87276A (en)	1987-08-03	1995-07-31	Fujisawa Pharmaceutical Co	Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same
GB9019724D0 (en) *	1990-09-10	1990-10-24	Fujisawa Pharmaceutical Co	Cephalosporin c acylase

1992
- 1992-02-27 GB GB929204439A patent/GB9204439D0/en active Pending
1993
- 1993-02-19 US US08/019,870 patent/US5336613A/en not_active Expired - Fee Related
- 1993-02-19 AT AT93301250T patent/ATE121784T1/de not_active IP Right Cessation
- 1993-02-19 DE DE69300123T patent/DE69300123T2/de not_active Expired - Fee Related
- 1993-02-19 EP EP93301250A patent/EP0558241B1/en not_active Expired - Lifetime
- 1993-02-19 DK DK93301250.2T patent/DK0558241T3/da active
- 1993-02-19 TW TW082101170A patent/TW274565B/zh active
- 1993-02-19 ES ES93301250T patent/ES2071527T3/es not_active Expired - Lifetime
- 1993-02-24 TR TR00192/93A patent/TR27016A/tr unknown
- 1993-02-25 JP JP5037030A patent/JPH0614777A/ja active Pending
- 1993-02-26 CN CN93103483A patent/CN1062903C/zh not_active Expired - Fee Related
- 1993-02-26 CA CA002090571A patent/CA2090571A1/en not_active Abandoned
- 1993-02-26 HU HU9300557A patent/HU220460B1/hu not_active IP Right Cessation
- 1993-02-26 KR KR1019930002730A patent/KR100276541B1/ko not_active Expired - Fee Related
1995
- 1995-04-27 GR GR950401011T patent/GR3015943T3/el unknown

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61152286A (ja) *	1984-12-27	1986-07-10	Asahi Chem Ind Co Ltd	セフアロスポリンｃアシラ−ゼ産生遺伝情報を担うｄｎａ断片

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. FERMENT. BIOENG. vol. 72, no. 4, 1991, pages 227 - 231 ICHIRO ARAMORI E AL. 'ISOLATION OF SOIL STRAINS PRODUCING NEW CEPHALOSPORIN ACYLASE S' *
J. FERMENT. BIOENG. vol. 72, no. 4, 1991, pages 232 - 243 ICHIRO ARAMORI ET AL. 'CLONING AND NUCLEOTIDE SEQUENCING ...' *
The search has been performed among the documents dated prior to 24th February 1993. *

Also Published As

Publication number	Publication date
US5336613A (en)	1994-08-09
DE69300123T2 (de)	1996-03-28
DK0558241T3 (da)	1995-07-03
DE69300123D1 (de)	1995-06-01
TW274565B (tr)	1996-04-21
EP0558241B1 (en)	1995-04-26
ES2071527T3 (es)	1995-06-16
CN1085252A (zh)	1994-04-13
HU9300557D0 (en)	1993-05-28
HUT65664A (en)	1994-07-28
CA2090571A1 (en)	1993-08-28
KR930017918A (ko)	1993-09-20
JPH0614777A (ja)	1994-01-25
GB9204439D0 (en)	1992-04-15
CN1062903C (zh)	2001-03-07
EP0558241A3 (en)	1993-12-01
HU220460B1 (hu)	2002-02-28
EP0558241A2 (en)	1993-09-01
ATE121784T1 (de)	1995-05-15
GR3015943T3 (en)	1995-07-31
KR100276541B1 (ko)	2000-12-15

Publication	Publication Date	Title
TR27016A (tr)	1994-09-15	Bir yeni sefalosporin c asilaz.
DE3478469D1 (en)	1989-07-06	Maltogenic amylase enzyme product, preparation and use thereof
FI922493A0 (fi)	1992-05-29	Vattenfri, flytande, enzymer inne- haollande diskmedelskomposition foer automatiska diskmaskiner.
PT610474E (pt)	2002-04-29	Cultura de celulas animais
GR3002597T3 (en)	1993-01-25	Synthetic peptide with human interleukin 1 activity
ES2084117T3 (es)	1996-05-01	Cefalosporina c acilasa.
ES8602135A1 (es)	1985-11-16	Un procedimiento para la preparacion de un antibiotico bbm-2478.
GB9118664D0 (en)	1991-10-16	Cell culture
IE810114L (en)	1981-08-04	N-benzyloxycarbonyl-l-aspartic acid
IE801762L (en)	1981-03-22	Insulin-zinc crystals
ITRM920809A1 (it)	1994-05-06	Interleuchina-6 mutante con attivita' biologica migliorata rispetto all'interleuchina-6 selvatica.
GB1161988A (en)	1969-08-20	A Process for the Production of Inosine
JPS57171925A (en)	1982-10-22	Antibiotic compound
KR840007875A (ko)	1984-12-11	N-(3-트리플루오로메틸페닐)-n'-프로파르길 피페라진의 제조방법
JPS6174577A (ja)	1986-04-16	イースト菌細胞の透過性の増加法
ES2004804A6 (es)	1989-02-01	Un procedimiento para preparar derivados de carboxialquildipeptidos
TW243453B (en)	1995-03-21	Cloning and characterization of a cardiac adenylyl cyclase
JPS52156981A (en)	1977-12-27	Cultivation of d-cysteine-synthesizing enzyme-producing microorganisms
MD845G2 (ro)	1998-06-30	Metodă de determinare a activităţii enzimelor lipolitice în obiecte microbiologice
JPS5729288A (en)	1982-02-17	Preparation of d - -beta-hydroxyisobutyric acid
UA7845A1 (uk)	1995-12-26	Розчин для консервування клітинних культур