TW200420562A - Di and trifluoro-triazolo-pyridines anti-inflammatory compounds - Google Patents

Di and trifluoro-triazolo-pyridines anti-inflammatory compounds

Info

Publication number: TW200420562A
Authority: TW; Taiwan
Prior art keywords: alkyl; triazolo; pyridines; oxazol; difluoro
Prior art date: 2002-08-30

Application number

TW092123952A

Other languages

English (en)

Inventor

Mark Anthony Dombroski

Michael Anthony Letavic

Kim Francis Mcclure

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-30

Filing date

2003-08-29

Publication date

2004-10-16

2003-08-29 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2004-10-16 Publication of TW200420562A publication Critical patent/TW200420562A/zh

Links

150000001875 compounds Chemical class 0.000 title abstract 3
AIUXSZUEIAKPML-UHFFFAOYSA-N 5,6,7-trifluoro-2h-triazolo[4,5-b]pyridine Chemical class FC1=C(F)C(F)=NC2=C1NN=N2 AIUXSZUEIAKPML-UHFFFAOYSA-N 0.000 title 1
230000003110 anti-inflammatory effect Effects 0.000 title 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
YKVRZQFJVPFEAR-UHFFFAOYSA-N 4-(2,4-difluorophenyl)-5-(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1,3-oxazole Chemical compound C=1N2C(C(C)C)=NN=C2C=CC=1C=1OC=NC=1C1=CC=C(F)C=C1F YKVRZQFJVPFEAR-UHFFFAOYSA-N 0.000 abstract 1
ZGGQRNYKRGMQPU-UHFFFAOYSA-N 4-(3,4-difluorophenyl)-5-(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1,3-oxazole Chemical compound C=1N2C(C(C)C)=NN=C2C=CC=1C=1OC=NC=1C1=CC=C(F)C(F)=C1 ZGGQRNYKRGMQPU-UHFFFAOYSA-N 0.000 abstract 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
102000043136 MAP kinase family Human genes 0.000 abstract 1
108091054455 MAP kinase family Proteins 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
208000028867 ischemia Diseases 0.000 abstract 1
208000010125 myocardial infarction Diseases 0.000 abstract 1
201000008482 osteoarthritis Diseases 0.000 abstract 1
102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
150000008523 triazolopyridines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Communicable Diseases (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Oncology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Toxicology (AREA)

TW092123952A 2002-08-30 2003-08-29 Di and trifluoro-triazolo-pyridines anti-inflammatory compounds TW200420562A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US40717702P	2002-08-30	2002-08-30

Publications (1)

Publication Number	Publication Date
TW200420562A true TW200420562A (en)	2004-10-16

Family

ID=31978432

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW092123952A TW200420562A (en)	2002-08-30	2003-08-29	Di and trifluoro-triazolo-pyridines anti-inflammatory compounds

Country Status (17)

Country	Link
US (1)	US7259171B2 (zh)
EP (1)	EP1537108B1 (zh)
JP (1)	JP2006504680A (zh)
AR (1)	AR041078A1 (zh)
AT (1)	ATE414705T1 (zh)
AU (1)	AU2003259438A1 (zh)
BR (1)	BR0313965A (zh)
CA (1)	CA2494754A1 (zh)
DE (1)	DE60324806D1 (zh)
ES (1)	ES2315560T3 (zh)
GT (1)	GT200300187A (zh)
MX (1)	MXPA05002304A (zh)
PA (1)	PA8579601A1 (zh)
PE (1)	PE20040978A1 (zh)
TW (1)	TW200420562A (zh)
UY (1)	UY27961A1 (zh)
WO (1)	WO2004020440A1 (zh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2515190A1 (en) *	2003-02-14	2004-08-26	Pfizer Products Inc.	Triazolo-pyridines as anti-inflammatory compounds
BRPI0514391A (pt) *	2004-08-18	2008-06-10	Pharmacia & Upjohn Co Llc	compostos de triazolopiridina para o tratamento de inflamação
ES2301380B1 (es)	2006-08-09	2009-06-08	Laboratorios Almirall S.A.	Nuevos derivados de 1,7-naftiridina.
EP2086973B1 (en) *	2006-10-11	2012-01-25	Amgen Inc.,	Imidazo- and triazolo-pyridine compounds and methods of use therof
ES2320955B1 (es)	2007-03-02	2010-03-16	Laboratorios Almirall S.A.	Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
ES2329639B1 (es)	2007-04-26	2010-09-23	Laboratorios Almirall S.A.	Nuevos derivados de 4,8-difenilpoliazanaftaleno.
EP1992344A1 (en)	2007-05-18	2008-11-19	Institut Curie	P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
EP2108641A1 (en)	2008-04-11	2009-10-14	Laboratorios Almirall, S.A.	New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EP2113503A1 (en)	2008-04-28	2009-11-04	Laboratorios Almirall, S.A.	New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
US8952034B2 (en) *	2009-07-27	2015-02-10	Gilead Sciences, Inc.	Fused heterocyclic compounds as ion channel modulators
EP2322176A1 (en)	2009-11-11	2011-05-18	Almirall, S.A.	New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives
BR112012033402A2 (pt)	2010-07-02	2017-01-24	Gilead Sciences Inc	moduladores de canais de íons conforme os compostos heterocíclicos fundidos
CA2834164A1 (en)	2011-05-10	2012-11-15	Gilead Sciences, Inc.	Fused benzoxazinones as ion channel modulators
TW201837023A (zh)	2011-07-01	2018-10-16	美商基利科學股份有限公司	作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (zh)	2011-07-01	2018-04-28
WO2014015056A2 (en)	2012-07-17	2014-01-23	Washington University	Anti-mucus drugs and uses therefor
EP3842424B1 (en)	2013-03-15	2024-12-11	The Trustees of Columbia University in the City of New York	Map kinase modulators and uses thereof in the tretament of tauopathies
GB201511382D0 (en)	2015-06-29	2015-08-12	Imp Innovations Ltd	Novel compounds and their use in therapy
WO2017151409A1 (en)	2016-02-29	2017-09-08	University Of Florida Research Foundation, Incorporated	Chemotherapeutic methods
US10342786B2 (en)	2017-10-05	2019-07-09	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2019071147A1 (en)	2017-10-05	2019-04-11	Fulcrum Therapeutics, Inc.	INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD
CN109867617A (zh) *	2019-04-03	2019-06-11	南京格亚医药科技有限公司	一种4-甲氧基吡咯中间体的制备方法
JP2025530213A (ja)	2022-09-09	2025-09-11	ミリックスファーマリミテッド	Ｎｍｔ阻害剤を含む抗体薬物コンジュゲート及びその使用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5716972A (en)	1993-01-13	1998-02-10	Smithkline Beecham Corporation	Pyridyl substituted imidazoles
PT724588E (pt)	1993-09-17	2000-05-31	Smithkline Beecham Corp	Proteina de ligacao a farmacos
JPH09505055A (ja)	1993-11-08	1997-05-20	スミスクライン・ビーチャム・コーポレイション	サイトカイン媒介疾患治療用オキサゾール
US5717100A (en)	1995-10-06	1998-02-10	Merck & Co., Inc.	Substituted imidazoles having anti-cancer and cytokine inhibitory activity
ZA97175B (en)	1996-01-11	1997-11-04	Smithkline Beecham Corp	Novel substituted imidazole compounds.
PL187516B1 (pl)	1996-01-11	2004-07-30	Smithkline Beecham Corp	Nowe podstawione pochodne imidazolu, sposób ich wytwarzania oraz kompozycja farmaceutyczna zawierająca te związki
GB9713726D0 (en)	1997-06-30	1997-09-03	Ciba Geigy Ag	Organic compounds
WO1999061440A1 (en)	1998-05-26	1999-12-02	Smithkline Beecham Corporation	Novel substituted imidazole compounds
US6207687B1 (en)	1998-07-31	2001-03-27	Merck & Co., Inc.	Substituted imidazoles having cytokine inhibitory activity
US6350744B1 (en)	1998-11-20	2002-02-26	Merck & Co., Inc.	Compounds having cytokine inhibitory activity
WO2000035911A1 (en)	1998-12-16	2000-06-22	Aventis Pharma Limited	Heteroaryl-cyclic acetals
US6469018B1 (en)	1999-01-08	2002-10-22	Smithkline Beecham Corporation	Compounds
ATE538794T1 (de)	1999-01-13	2012-01-15	Bayer Healthcare Llc	Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer
CO5170501A1 (es) *	1999-04-14	2002-06-27	Novartis Ag	AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO
EE200300437A (et) *	2001-03-09	2004-02-16	Pfizer Products Inc.	Triasolopüridiinid kui põletikuvastased ained
CA2440211A1 (en)	2001-03-09	2002-09-19	Pfizer Products Inc.	Benzimidazole anti-inflammatory compounds
ES2247271T3 (es)	2001-04-04	2006-03-01	Pfizer Products Inc.	Nuevos benzotriazoles como compuestos antiinflamatorios.

2003
- 2003-08-05 PA PA20038579601A patent/PA8579601A1/es unknown
- 2003-08-19 CA CA002494754A patent/CA2494754A1/en not_active Abandoned
- 2003-08-19 BR BR0313965-4A patent/BR0313965A/pt not_active IP Right Cessation
- 2003-08-19 WO PCT/IB2003/003847 patent/WO2004020440A1/en not_active Ceased
- 2003-08-19 JP JP2004532622A patent/JP2006504680A/ja not_active Withdrawn
- 2003-08-19 MX MXPA05002304A patent/MXPA05002304A/es active IP Right Grant
- 2003-08-19 DE DE60324806T patent/DE60324806D1/de not_active Expired - Lifetime
- 2003-08-19 ES ES03791145T patent/ES2315560T3/es not_active Expired - Lifetime
- 2003-08-19 AT AT03791145T patent/ATE414705T1/de not_active IP Right Cessation
- 2003-08-19 EP EP03791145A patent/EP1537108B1/en not_active Expired - Lifetime
- 2003-08-19 AU AU2003259438A patent/AU2003259438A1/en not_active Abandoned
- 2003-08-25 PE PE2003000863A patent/PE20040978A1/es not_active Application Discontinuation
- 2003-08-27 US US10/649,236 patent/US7259171B2/en not_active Expired - Fee Related
- 2003-08-28 AR ARP030103118A patent/AR041078A1/es unknown
- 2003-08-29 TW TW092123952A patent/TW200420562A/zh unknown
- 2003-08-29 GT GT200300187A patent/GT200300187A/es unknown
- 2003-08-29 UY UY27961A patent/UY27961A1/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2315560T3 (es)	2009-04-01
EP1537108A1 (en)	2005-06-08
WO2004020440A1 (en)	2004-03-11
GT200300187A (es)	2004-06-23
DE60324806D1 (de)	2009-01-02
JP2006504680A (ja)	2006-02-09
EP1537108B1 (en)	2008-11-19
MXPA05002304A (es)	2005-06-08
UY27961A1 (es)	2004-03-31
PA8579601A1 (es)	2004-05-07
PE20040978A1 (es)	2004-12-28
US7259171B2 (en)	2007-08-21
AU2003259438A1 (en)	2004-03-19
CA2494754A1 (en)	2004-03-11
US20040053958A1 (en)	2004-03-18
ATE414705T1 (de)	2008-12-15
BR0313965A (pt)	2005-07-19
AR041078A1 (es)	2005-04-27

Publication	Publication Date	Title
TW200420562A (en)	2004-10-16	Di and trifluoro-triazolo-pyridines anti-inflammatory compounds
AP2002002463A0 (en)	2002-06-30	Novel triazolo-pyrimides anti-inflammatory compounds.
AP2002002460A0 (en)	2002-06-30	Novel benzimidazole anti-inflammatory compounds.
MX2022013223A (es)	2022-11-14	[1,3]diazino[5,4-d]pirimidinas como inhibidores de her2.
CA2379903A1 (en)	2002-10-04	Novel benzotriazoles anti-inflammatory compounds
CA2525214A1 (en)	2004-12-09	Macrocyclic quinazoline derivatives as antiproliferative agents
WO2007058832A3 (en)	2008-06-19	Pyrrolo (2, 3-b) pyridine derivatives useful as tec kinase inhibitors
IL183340A0 (en)	2007-09-20	[1,2,4] triazolo[4,3-a] pyridine derivatives and pharmaceutical compositions containing them
WO2005037825A3 (en)	2006-03-30	Protein kinase inhibitors
EA200600973A1 (ru)	2006-10-27	ПИРИДО[2,3-d] ПИРИМИДИН-2,4-ДИАМИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ PDE 2
IL163629A0 (en)	2005-12-18	Glutaminyl derivatives and pharmaceutical compositions containing the same
MXPA02011425A (es)	2004-09-06	Derivados sustituidos de pirrolopiridinona utiles como inhibidores de fosfodiesterasa.
BR0007447A (pt)	2002-04-09	2-aril-3-(heteroaril)-imidazo[1,2-a]pirimidinas substituìdas, composições farmacêuticas e métodos
CY1107747T1 (el)	2013-04-18	Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης
EA199800882A1 (ru)	1999-06-24	Производные замешенных индазолов, их применение в качестве ингибиторов фосфодиэстеразы (фдэ) iv и получение фактора некроза опухолей (фно)
MXPA06013164A (es)	2007-02-13	Derivados de pirimidina para el tratamiento de crecimiento de celulas anormal.
IL206514A (en)	2013-09-30	History of triazole oxadiazole, their preparation and their pharmaceutical preparations
CA2238875A1 (en)	1997-06-26	Tri-aryl ethane derivatives as pde iv inhibitors
EP1725536B8 (en)	2009-04-22	Imidazoline derivatives having cb1-antagonistic activity
WO2008142550A8 (en)	2009-12-23	Spirocyclic quinazoline derivatives and their use as pde7 inhibitors
WO2002059109A3 (en)	2002-09-19	Naphthostyril derivatives and their use as inhibitors of cyclin- dependent kinases
DOP2003000693A (es)	2004-02-29	Compuestos antiinflamatorios de di y trifluoro-triazolo-piridinas
GB0114699D0 (en)	2001-08-08	Organic compounds
PL1603907T3 (pl)	2007-03-30	Podstawione pirydo[1,2-a]pirymidyny i ich zastosowanie jako inhibitorów-NOS
SE9902147D0 (sv)	1999-06-08	Nya föreningar och farmaceutiska kompositioner innehållande desamma